An Approach to Teaching Object-Oriented Analysis and Design

This paper presents a syllabus that attempts to address the problem of teaching systems analysis and design in the changing world of today. In the first part of the paper, major issues and constraints that affect the development of a syllabus for this discipline are identified and analyzed. The second part of the paper focuses on the key points of a methodology constructed from traditional and object-oriented techniques, designed to satisfy the academic demands of the subject and reflect current practice, while providing students with a coherent and organized approach to systems analysis and design. Analysis of the outcomes and experience of implementing the syllabus provide the basis for conclusions and identification of possible areas for future research

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Disubstituted 1‑Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch and Flow Technologies

A platform that incorporates computational library design, parallel solution-phase synthesis, continuous flow hydrogenation, and automated high throughput purification and reformatting technologies was applied to the production of a 120-member library of 1-aryl-4-aminopiperidine analogues for drug discovery screening. The application described herein demonstrates the advantages of computational library design coupled with a flexible, modular approach to library synthesis. The enabling technologies described can be readily adopted by the traditional medicinal chemist without extensive training and lengthy process development times