Interobserver Variation in the Diagnosis of Gastric Epithelial Dysplasia and Carcinoma between Two Pathologists in Japan and Korea

Although the biological potential of gastric epithelial dysplasia (GED) as a precursor of gastric cancer has never been in doubt, the classification of these lesions has been controversial and fraught with marked variations in approach to diagnosis across the world. The complexity of cyto-architectural features has been considered to be of paramount importance for the diagnosis of carcinoma in Japan, while breach of the basement membrane and invasion into the lamina propria has been considered the sine qua non of malignancy and hence a pre-requisite for the diagnosis of cancer in the West. In Korea, although the incidence of gastric cancer is similar to Japan, the diagnostic approach to GED or cancer seems to lie midway between Western and Japanese criteria. In this review, we will discuss the difference in the diagnosis of GED and cancer between two pathologists working in the comprehensive cancer center located in Japan and Korea, one of the most prevalent areas in the world for gastric cancer

Long-term effects of pregnancy and childbirth on sleep satisfaction and duration of first-time and experienced mothers and fathers

Study Objectives To examine the changes in mothers’ and fathers’ sleep satisfaction and sleep duration across pre-pregnancy, pregnancy, and the postpartum period of up to six years after birth; it also sought to determine potential protective and risk factors for sleep during that time. Methods Participants in a large population-representative panel study from Germany reported sleep satisfaction and sleep duration in yearly interviews. During the observation period (2008–2015), 2,541 women and 2,118 men reported the birth of their first, second, or third child and provided longitudinal data for analysis. Fixed-effects regression models were used to analyze changes in sleep associated with childbirth. Results Sleep satisfaction and duration sharply declined with childbirth and reached a nadir during the first three months postpartum, with women more strongly affected (sleep satisfaction reduction compared with pre-pregnancy: women, 1.81 points on a 0 to 10 scale, d = 0.79 vs. men, 0.37 points, d = 0.16; sleep duration reduction compared with pre-pregnancy: women, 62 min, d = 0.90 vs. men, 13 min, d = 0.19). In both women and men, sleep satisfaction and duration did not fully recover for up to six years after the birth of their first child. Breastfeeding was associated with a slight decrease in maternal sleep satisfaction (0.72 points, d = 0.32) and duration (14 min, d = 0.21). Parental age, household income, and dual vs. single parenting were unrelated, or only very weakly related, to improved sleep. Conclusion Following the sharp decline in sleep satisfaction and duration in the first months postpartum, neither mothers’ nor fathers’ sleep fully recovers to pre-pregnancy levels up to six years after the birth of their first child

Associations between age and sleep apnea risk among newborn infants

ObjectiveAmong older children, sleep‐disordered breathing (SDB) is associated with measurable neurocognitive consequences. However, diagnostic SDB thresholds are lacking for infants < 12 months. We sought to evaluate the relationship between SDB indices, gestational age (GA), and postmenstrual age (PMA) for infants who underwent clinically‐indicated polysomnograms at a tertiary care center.MethodsEvery infant < 3‐months chronological age whose first clinically‐indicated polysomnogram was between 2/2012 and 2/2017 was included. Linear regression was used to evaluate associations between apnea‐hypopnea index (AHI), obstructive‐apnea index (OAI), and GA and PMA for infants with and without obvious clinical risk factors for SDB (eg, micrognathia and cleft palate).ResultsFor 53 infants without obvious SDB risk factors (GA 35.6 ± 4.5 weeks; PMA 41.2 ± 4.0 weeks), mean AHI was 27 ± 18 and OAI 2.9 ± 4.5. There was a weak inverse relationship between AHI and PMA (r2 = 0.12, P = 0.01), but AHI was not predicted by GA (r2 = 0.04, P = 0.13). Conversely, OAI was more strongly associated with GA (r2 = 0.33, P < 0.0001) than PMA (r2 = 0.08, P = 0.036). For 28 infants with congenital structural anomalies that predispose to SDB (GA 38.0 ± 3.1 weeks, PMA 43.1 ± 3.3 weeks, AHI 37.7 ± 30, OAI 8.2 ± 11.8), neither AHI nor OAI were related to PMA or GA.ConclusionsAmong infants who received clinically‐indicated polysomnograms but did not have obvious structural risk for SDB, AHI declined with advancing PMA, but obstructive‐apnea was best predicted by prematurity. In contrast, the SDB risk did not improve with increasing GA or PMA for infants with congenital structural risk factors; such infants may not outgrow their risk for SDB.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150552/1/ppul24354_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150552/2/ppul24354.pd

Breastfeeding Duration Is Associated with Regional, but Not Global, Differences in White Matter Tracts

Extended breastfeeding through infancy confers benefits on neurocognitive performance and intelligence tests, though few have examined the biological basis of these effects. To investigate correlations with breastfeeding, we examined the major white matter tracts in 4–8 year-old children using diffusion tensor imaging and volumetric measurements of the corpus callosum. We found a significant correlation between the duration of infant breastfeeding and fractional anisotropy scores in left-lateralized white matter tracts, including the left superior longitudinal fasciculus and left angular bundle, which is indicative of greater intrahemispheric connectivity. However, in contrast to expectations from earlier studies, no correlations were observed with corpus callosum size, and thus no correlations were observed when using such measures of global interhemispheric white matter connectivity development. These findings suggest a complex but significant positive association between breastfeeding duration and white matter connectivity, including in pathways known to be functionally relevant for reading and language development

Gender and Administration

Summary Public administration in development has been a poor instrument for implementing gender policies. Rural development administration in particular has tended to be indifferently accountable to female ‘publics’ in agrarian economies. Conventionally, this particular feature of institutional failure is explained by the suggestion that public administrations reflect gender relations in society. This paper, however, argues that the role of public administration in the organization of gender provokes questions about the gender of organization. It sketches out the conceptual premises for a theory of the gender of organization, looking at the way organizational structures, cultures, and purposes institutionalize male dominance. This perspective may help illuminate the processes and relationships through which other inequalities, such as those of class, race, and the North?South divide, are reproduced in public administration. Résumé Le Genre et l'insuccès des institutions dans le développement: l'organisation du Genre et le Genre dans l'organisation Au sein du développement, les administrations publiques ont constitué un outil peu utile pour la mise en oeuvre des politiques relatives au genre. Les administrations de développement rural notamment ont eu tendance à comptabiliser de manière indifférente les ‘publics’ féminins dans les économies agraires. Classiquement, et notoirement, cette caractéristique de l'insuccès des institutions est expliquée par la suggestion que les administrations publiques reflètent les rapports entre les genres dans la société. Le présent article, par contre, revendique que le rôle des administrations publiques dans l'organisation des genres soulève certaines questions le genre dans l'organisation même. L'auteur ébauche les prémisses d'une éventuelle théorie du genre dans l'organisation, et examine comment les structures, les cultures et les objectifs mêmes de ces organisations tendent à institutionnaliser la dominance masculine. Cette perspective veut aider à mettre en lumière des procédés et des rapports par l'influence desquels d'autres inégalités, par exemples celles des classes, des races et du partage nord?sud, viennent à se reproduire dans les administrations publiques. Resumen El Género y las fallas institucionales en el desarrollo: la organización del género y el género de la organización La administración pública en el desarrollo ha sido un instrumento muy pobre para la implementación de criterios relativos al género. En las economías agrarias en particular la administración del desarrollo rural tiende a ser poco responsable para con el ‘público’ femenino. Tradicionalmente, este rasgo característico del fracaso institucional se explica sugiriendo que la administración pública refleja las relaciones entre los sexos en la sociedad. Este artículo, sin embargo, argumenta que el papel de la administración pública en la organización del género suscita interrogantes sobre el género de la organización. Se bosquejan las premisas conceptuales para una teoría del género en la organización, analizando la forma en que las culturas, estructuras organizativas y objetivos institucionalizan la dominación masculina. Esta perspectiva puede arrojar luz sobre los procesos y relaciones a través de los cuales otras desigualdades — clase, raza, la división Norte?Sur — se reproducen en la administración pública

Impairments in Attention in Occasionally Snoring Children: An Event-Related Potential Study

Objective—To determine whether minimal snoring is benign in children. Procedure—22 rarely snoring children (mean age=6.9 years, 11 females) and age- and sexmatched controls participated in an auditory oddball task wearing 128-electrode nets. Parents completed Conner’s Parent Rating Scales-Revised Long (CPRS-R:L). Results—Snorers scored significantly higher on 4 CPRS-R:L subscales. Stepwise regression indicated that two ERP variables from a region of the ERP that peaked at 844 ms post-stimulus onset predicted CPRS-R:L ADHD Index scores. Conclusions—Occasional snorers according to parental report do exhibit ADHD-like behaviors. Basic sensory processing is longer than in controls, suggesting that delayed frontal activation requires more effort in snorers

On preventive blood pressure self-monitoring at home

Self-monitoring activities are increasingly becoming part of people’s everyday lives. Some of these measurements are taken voluntarily rather than being referred by a physician and conducted because of either a preventive health interest or to better understand the body and its functions (the so-called Quantified Self). In this article, we explore socio-technical complexities that may occur when introducing preventive health-measurement technologies into older adults’ daily routines and everyday lives. In particular, the original study investigated blood pressure (BP) measurement in non-clinical settings, to understand existing challenges, and uncover opportunities for self-monitoring technologies to support preventive healthcare activities among older adults. From our study, several important aspects emerged to consider when designing preventive self-monitoring technology, such as the complexity of guidelines for self-measuring, the importance of interpretation, understanding and health awareness, sharing self-monitoring information for prevention, various motivational factors, the role of the doctor in prevention, and the home as a distributed information space. An awareness of these aspects can help designers to develop better tools to support people’s preventive self-monitoring needs, compared to existing solutions. Supporting the active and informed individual can help improve people’s self-care, awareness, and implementation of preventive care. Based on our study, we also reflect on the findings to illustrate how these aspects can both inform people engaged in Quantified Self activities and designers alike, and the tools and approaches that have sprung from the so-called Quantified Self movement

The relationship between prior night's sleep and measures of infant imitation.

We examined whether sleep quality during the night and naps during the day preceding a learning event are related to memory encoding in human infants. Twenty-four 6- and twenty-four 12-month-old infants' natural sleeping behavior was monitored for 24 hr using actigraphy. After the recording period, encoding was assessed using an imitation paradigm. In an initial baseline phase, infants were allowed to interact with the stimulus to assess spontaneous production of any target actions. Infants then watched an experimenter demonstrate a sequence of three target actions and were immediately given the opportunity to reproduce the demonstrated target actions to assess memory encoding. Analyses revealed significant correlations between nighttime sleep quality variables (sleep efficiency, sleep fragmentation) and immediate imitation in 6-month-olds, but not in 12-month-olds. High sleep quality in the preceding night was thus positively associated with next day's memory encoding in 6-month-old infants. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 9999: 1-12, 2016