233 research outputs found
Identification of Trypanosoma brucei RMI1/BLAP75 Homologue and Its Roles in Antigenic Variation
- Author
- A Bernards
- A Gunzl
- A Malkova
- A Sfeir
- B Llorente
- BM Shykind
- C Conway
- C Hertz-Fowler
- C Machado
- CE Boothroyd
- CE Smith
- CF Chen
- CZ Bachrati
- D Horn
- D Xu
- E Kratz
- E Pays
- E Shor
- E Wirtz
- EP Mimitou
- F Hartung
- F Wang
- G Ira
- G Liberi
- G Rudenko
- GAM Cross
- George A. M. Cross
- Hee-Sook Kim
- HS Kim
- HW Mankouri
- HW Mankouri
- J Palenchar
- J Stavnezer
- J Yin
- JA Cobb
- JD Barry
- JR Lydeard
- JR Mullen
- JW Wallis
- JY Lee
- JZ Dalgaard
- KA Bernstein
- KA Hoadley
- L Chelysheva
- L Wu
- L Wu
- M Chang
- M Cross
- M Oberholzer
- M Seki
- M Seki
- MD Scahill
- MT Duraisingh
- N Aitcheson
- Najib M. El-Sayed
- NF Neff
- P Cejka
- P Sung
- PM Watt
- S Gangloff
- S Le
- S Raynard
- SC Teng
- TR Singh
- VA Marrero
- W Bussen
- Y Bai
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
At any time, each cell of the protozoan parasite Trypanosoma brucei expresses a single species of its major antigenic protein, the variant surface glycoprotein (VSG), from a repertoire of >2,000 VSG genes and pseudogenes. The potential to express different VSGs by transcription and recombination allows the parasite to escape the antibody-mediated host immune response, a mechanism known as antigenic variation. The active VSG is transcribed from a sub-telomeric polycistronic unit called the expression site (ES), whose promoter is 40–60 kb upstream of the VSG. While the mechanisms that initiate recombination remain unclear, the resolution phase of these reactions results in the recombinational replacement of the expressed VSG with a donor from one of three distinct chromosomal locations; sub-telomeric loci on the 11 essential chromosomes, on minichromosomes, or at telomere-distal loci. Depending on the type of recombinational replacement (single or double crossover, duplicative gene conversion, etc), several DNA-repair pathways have been thought to play a role. Here we show that VSG recombination relies on at least two distinct DNA-repair pathways, one of which requires RMI1-TOPO3α to suppress recombination and one that is dependent on RAD51 and RMI1. These genetic interactions suggest that both RAD51-dependent and RAD51-independent recombination pathways operate in antigenic switching and that trypanosomes differentially utilize recombination factors for VSG switching, depending on currently unknown parameters within the ES
Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants?
- Author
- A Asase
- A Ishih
- AA Njan
- AU Krettli
- B Graz
- B Graz
- B Graz
- BA Iwalokun
- CF Tsu
- D Diallo
- D Diallo
- D Diallo
- Dennis Fowler
- DJ Leaman
- E Deharo
- E Hsu
- EP Hicks
- F Benoit-Vical
- Françoise Benoit-Vical
- GA Butcher
- Gemma Burford
- Geneviève Bourdy
- GL Boye
- I Landau
- JB Ouedraogo
- JE Adjanohoun
- JO Kokwaro
- JR Tabuti
- LH Carvalho
- M Adriaens
- M Baerts
- M Vigneron
- M Willcox
- M Willcox
- M Willcox
- M Willcox
- Merlin Willcox
- MGL Brandão
- Milijaona Randrianarivelojosia
- ML Willcox
- ML Willcox
- ML Willcox
- MS Mueller
- N Bugmann
- P Rasoanaivo
- P Sharma
- P Whiting
- Peter Houghton
- Philippe Rasoanaivo
- PK Panda
- PN Soh
- Rocky Graziose
- S Challand
- S Challand
- S Siegel
- SC Masaba
- Sergio Giani
- T Gedif
- W Fletcher
- W Peters
- WHO
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Over 1200 plant species are reported in ethnobotanical studies for the treatment of malaria and fevers, so it is important to prioritize plants for further development of anti-malarials.</p> <p>Methods</p> <p>The “RITAM score” was designed to combine information from systematic literature searches of published ethnobotanical studies and laboratory pharmacological studies of efficacy and safety, in order to prioritize plants for further research. It was evaluated by correlating it with the results of clinical trials.</p> <p>Results and discussion</p> <p>The laboratory efficacy score correlated with clinical parasite clearance (r<sub>s</sub>=0.7). The ethnobotanical component correlated weakly with clinical symptom clearance but not with parasite clearance. The safety component was difficult to validate as all plants entering clinical trials were generally considered safe, so there was no clinical data on toxic plants.</p> <p>Conclusion</p> <p>The RITAM score (especially the efficacy and safety components) can be used as part of the selection process for prioritising plants for further research as anti-malarial drug candidates. The validation in this study was limited by the very small number of available clinical studies, and the heterogeneity of patients included.</p
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
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- Anderson KJ
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- Yilmaz M
- Yoosootiniya R
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- Zarzhitsky P
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- Zhemchugov A
- Zheng S
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- Zhuravlov V
- Zieminska D
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- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Khalek SA
- Abdelalim AA
- Abdinov O
- Aben R
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- Aleksandrov IN
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- Allbrooke BMM
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- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Smit GVY
- Ye J
- Ye S
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zinonos Z
- Zerwas D
- della Porta GZ
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb−1 of s=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40
Search for high-mass resonances decaying to dilepton final states in pp collisions at s√=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
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- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albert J
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- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
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- Allbrooke BMM
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- von der Schmitt H
- von Radziewski H
- von Toerne E
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- Vos M
- Voss R
- Voss TT
- Vossebeld JH
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wahlen H
- Wahrmund S
- Wakabayashi J
- Walch S
- Walder J
- Walker R
- Walkowiak W
- Wall R
- Waller P
- Walsh B
- Wang C
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- Warburton A
- Ward CP
- Wardrope DR
- Warsinsky M
- Washbrook A
- Wasicki C
- Watanabe I
- Watkins PM
- Watson AT
- Watson IJ
- Watson MF
- Watts G
- Watts S
- Waugh AT
- Waugh BM
- Weber MS
- Webster JS
- Weidberg AR
- Weigell P
- Weingarten J
- Weiser C
- Wells PS
- Wemans ADV
- Wenaus T
- Wendland D
- Wengler T
- Wengu Z
- Wenig S
- Wermes N
- Werner M
- Werner P
- Werth M
- Wessels M
- Wetter J
- Weydert C
- Whalen K
- White A
- White MJ
- White S
- Whitehead SR
- Whiteson D
- Whittington D
- Wicek F
- Wicke D
- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik-Fuchs LAM
- Wijeratne PA
- Wildauer A
- Wildt MA
- Wilhelm I
- Wilkens HG
- Will JZ
- Williams E
- Williams HH
- Willis W
- Willocoq S
- Wilson A
- Wilson JA
- Wilson MG
- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong WC
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wraight K
- Wright M
- Wrona B
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wynne BM
- Xella S
- Xiao M
- Xie S
- Xu C
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yagci KD
- Yamada M
- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 23/11/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral Z′ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/γ bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fb−1 in the e + e − channel and 5.0 fb−1 in the μ + μ −channel. A Z ′ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal Z′ Models
Surface pretreatments for medical application of adhesion
- Author
- AJ Kinloch
- AM Halder
- B Haller
- B Haller
- B Haller
- CA Zeman
- D Huguet
- DC Wirtz
- DC Wirtz
- DH Jenkins
- DH Jenkins
- DH Pashley
- Dieter C Wirtz
- DM Brewis
- E Hiss
- EJ Olson
- EL Bahm
- EP Plueddemann
- ES Grood
- F Lange
- F Stetter
- FJ Cotton
- Fritz U Niethard
- G Haas
- G Habenicht
- GK McPherson
- GR Barrett
- H Fischer
- H Herø
- H Malchau
- Hans J Erli
- HC Hudson
- HG Willert
- HG Willert
- J Mockwitz
- J Tinschert
- JC Kennedy
- JC Kennedy
- JC Kennedy
- JH Roth
- JJ Warner
- JR Parsons
- K Miyasaka
- K Müller
- K Nakanuma
- KL Ohashi
- L Claes
- L Yahia
- LE Paulos
- M Denti
- M Jasty
- M Kern
- M Kurosaka
- M Pfahler
- M Rickert
- MA Emery
- MF Guidoin
- MF Macnicol
- Michael Weber
- N Rushton
- N Verdonschot
- Othmar Paar
- P Lobenhoffer
- P Pfeiffer
- P Spencer
- PJ Fowler
- PM Young
- PP Anthony
- R Letsch
- R Marx
- R Marx
- R Marx
- R Marx
- R Marx
- R Musil
- RD Crowninshield
- RT Müller
- Rudolf Marx
- SA Yerby
- SK Ahlfeld
- SL James
- SS Mironova
- V Ostkamp
- W Beldner
- Y Marois
- Publication venue
- BioMed Central
- Publication date
- 01/01/2003
- Field of study
Medical implants and prostheses (artificial hips, tendono- and ligament plasties) usually are multi-component systems that may be machined from one of three material classes: metals, plastics and ceramics. Typically, the body-sided bonding element is bone. The purpose of this contribution is to describe developments carried out to optimize the techniques , connecting prosthesis to bone, to be joined by an adhesive bone cement at their interface. Although bonding of organic polymers to inorganic or organic surfaces and to bone has a long history, there remains a serious obstacle in realizing long-term high-bonding strengths in the in vivo body environment of ever present high humidity. Therefore, different pretreatments, individually adapted to the actual combination of materials, are needed to assure long term adhesive strength and stability against hydrolysis. This pretreatment for metal alloys may be silica layering; for PE-plastics, a specific plasma activation; and for bone, amphiphilic layering systems such that the hydrophilic properties of bone become better adapted to the hydrophobic properties of the bone cement. Amphiphilic layering systems are related to those developed in dentistry for dentine bonding. Specific pretreatment can significantly increase bond strengths, particularly after long term immersion in water under conditions similar to those in the human body. The bond strength between bone and plastic for example can be increased by a factor approaching 50 (pealing work increasing from 30 N/m to 1500 N/m). This review article summarizes the multi-disciplined subject of adhesion and adhesives, considering the technology involved in the formation and mechanical performance of adhesives joints inside the human body
Sports-related wrist and hand injuries: a review
- Author
- A Badia
- A Chauhan
- A Elsaftawy
- A Minami
- A Moermans
- A Schweizer
- AA Bendre
- AB Grundberg
- AC Rettig
- AC Rettig
- AC Rettig
- AJ MacLennan
- AJ Weiland
- AK Palmer
- AL Osterman
- BA Kumar
- BD Bushnell
- BE Etier
- BE Rosenstadt
- BG Elliot
- BN Devers
- C Gerber
- C Hovgaard
- C Martinoli
- CD Jarrett
- Centers for Disease Control and Prevention
- Cory M. Edgar
- CP Melone Jr
- Craig M. Rodner
- CS Campbell
- D Campbell
- D Guntern
- D Simpson
- Daniel M. Avery
- DJ Nagle
- DK Bynum Jr
- DM Swenson
- DP Hanlon
- DW Smith
- EP Estrella
- EP Hofmeister
- F Demirkan
- G Bodner
- GA Buijze
- GH Bark
- GJ Hickey
- GM Lourie
- GM Rayan
- GM Rayan
- GT Lin
- H Matsuzaki
- HG Stack
- HH Stark
- HH Stark
- HK Watson
- I Immerman
- I Roloff
- IH Cotterell
- J Elfar
- J Pike
- J Rubin
- JA Clavero
- JA Nilsson
- JB Samora
- JG Seiler III
- JJ Peterson
- JL Whalen
- JM Aldridge III
- JP Leddy
- JP Leddy
- JR Fowler
- JR Gladden
- JS Rumball
- JT Capo
- JT Marino
- JT McMurtry
- JY Chu
- K Nakamura
- K Williams
- KN Waninger
- LW Catalano III
- M Burtscher
- M Figl
- M Nagaoka
- M Shahabpour
- MA Baskies
- MA Brzezienski
- MA Posner
- ML Bernstein
- MM Tomaino
- MM Tomaino
- MN Nakashian
- MR Belsky
- N Iwasaki
- O Hauger
- P Tang
- P To
- PC Amadio
- PC Rhee
- PG Lunn
- PP Tekkis
- PR Brink
- PR Manske
- R Nakamura
- R Sendher
- RA Warren
- RD Parker
- RE Carroll
- RG Gaston
- RG Gaston
- RJ Strauch
- RM Curtis
- RM Garcia
- S Araki
- S Corso
- S El-Sallakh
- S Pahwa
- SD Richards
- SF Garberman
- SG Royle
- SL Friedman
- SL Hame
- SM Patterson
- SR Bollen
- SS Burkhart
- SZ Glickel
- T Futami
- TE Trumble
- TT Dovan
- TT Dovan
- V Finsen
- VR Schoffl
- W DeAraujo
- WA Eckhardt
- WB Geissler
- WB Geissler
- WB Geissler
- WB Geissler
- WB Geissler
- WC Shim
- WH Mallee
- WJ Morgan
- WP Cooney III
- WV McCallister
- Y Oka
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cross-tolerance to abiotic stresses in halophytes: Application for phytoremediation of organic pollutants
- Author
- A Ben Hassine
- A Debez
- A Debez
- A Meudec
- A Parida
- A Rouached
- A Smaoui
- A Vaziri
- Abdelhak El Amrani
- AC Vanhove
- AD Dooki
- AI Alet
- AK Chaturvedi
- AK Parida
- AM Kipopoulou
- BB Buchanan
- C Bowler
- C Hafsi
- C Howes Keiffer
- CE Cerniglia
- Chedly Abdelly
- CR Leach
- CS Cobbett
- D Li
- DE Salt
- DG Mendoza-Cózatl
- DM Al-Mailem
- E Manousaki
- E Wild
- EP Glenn
- F Cardinale
- F Kaplan
- F Rolland
- F Shaikh
- FA Kondrashov
- G Masciandaro
- G Wyn Jones
- H Colinet
- H Ellouzi
- H Ellouzi
- H Liu
- H Ribeiro
- H Sandermann Jr
- H Sandermann Jr
- H Zaier
- HJ Wu
- I Aranjuelo
- I Nawaz
- I Slama
- I Zepeda-Jazo
- J Bose
- J Bose
- J Burken
- J Cao
- J Chen
- J Fismes
- J Martin-Tanguy
- J O’Leary
- J Yu
- J Yu
- J Zhan
- JC D’Auria
- JJ Casal
- JK Zhu
- JP Anderson
- K Ben Hamed
- K Ben Hamed
- K Iseki
- K Kavitha
- K Koch
- K Kosová
- KC Snowden
- KH Sohn
- L Szabados
- L Xiong
- LC Cidade
- M Al-Oudat
- M Alkio
- M Bitrián
- M Dassanayake
- M Rabhi
- M Rabhi
- M Rabhi
- M Rabhi
- M Sargeant
- M Shiri
- M Sobrado
- M Zhan
- MA Hossain
- MA Sobrado
- MJ Oliver
- MKF Campos de
- MN Jithesh
- Moez Shiri
- Mokded Rabhi
- N Farhat
- N Farhat
- N Labidi
- N Singh
- NJ Saibo
- O Talbi-Zribi
- P Agarwal
- P Kremer
- P Udawat
- PH Gleick
- R An
- R El-Bakatoushi
- R Gil
- R Karan
- R Mittler
- R Mittler
- R Mittler
- R Munns
- R Munns
- R Tommasini
- RA Kanaly
- RE Sharp
- RM Poecke Van
- S Gulzar
- S Komatsu
- S Mahajan
- S Nagaoka
- S Shabala
- S Shabala
- S Witt
- S Yousfi
- SG Fowler
- SI Allakhverdiev
- SL Simonich
- T Boriboonkaset
- T Genoud
- T Ghnaya
- T Ghnaya
- T Komives
- TJ Flowers
- TJ Flowers
- TS Gechev
- V Arbona
- V Arbona
- V Arbona
- V Demidchik
- WW Wenzel
- Y Yoshiba
- YL Ruan
- Z Barhoumi
- Z Lu
- ZN Oztürk
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2015
- Field of study
International audienceHalopytes are plants able to tolerate high salt concentrations but no clear definition was retained for them. In literature, there are more studies that showed salt-enhanced tolerance to other abiotic stresses compared to investigations that found enhanced salt tolerance by other abiotic stresses in halophytes. The phenomenon by which a plant resistance to a stress induces resistance to another is referred to as cross-tolerance. In this work, we reviewed cross-tolerance in halophytes at the physiological, biochemical, and molecular levels. A special attention was accorded to the cross-tolerance between salinity and organic pollutants that could allow halophytes a higher potential of xenobiotic phytoremediation in comparison with glycophytes
Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease
- Author
- Aban I
- Abzug MJ
- Acosta EP
- Ahmed A
- Arav-Boger R
- Ashouri N
- Bocchini JA
- Caserta MT
- DeBiasi RL
- Dennehy PH
- Englund JA
- Estrada B
- Finn A
- Fowler S
- Giles D
- Griffin J
- Griffiths PD
- Gutierrez K
- Halasa N
- Han J-Y
- Homans J
- Jacobs RF
- James SH
- Jester PM
- Kimberlin DW
- Kuo H
- Luck S
- Lujan-Zilbermann J
- Michaels MG
- Palmer A
- Prichard MN
- Romero JR
- Sabo DL
- Sanchez PJ
- Shane AL
- Sharland M
- Simonsen K
- Sood SK
- Storch GA
- Vanchiere JA
- Weiner LB
- Whitley RJ
- Whitworth MS
- Woods CR
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 05/03/2015
- Field of study
BACKGROUND: The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous
ganciclovir for 6 weeks has been shown to improve audiologic outcomes at 6 months, but the benefits wane over time.
METHODS: We conducted a randomized, placebo-controlled trial of valganciclovir therapy in neonates with symptomatic congenital CMV disease, comparing 6 months of therapy with 6 weeks of therapy. The primary end point was the change in hearing in the better ear
(“best-ear” hearing) from baseline to 6 months. Secondary end points included the change in hearing from baseline to follow-up at 12 and 24 months and neurodevelopmental
outcomes, with each end point adjusted for central nervous system involvement at baseline.
RESULTS: A total of 96 neonates underwent randomization, of whom 86 had follow-up data at 6 months that could be evaluated. Best-ear hearing at 6 months was similar in the 6-month group and the 6-week group (2 and 3 participants, respectively, had improvement; 36 and 37 had no change; and 5 and 3 had worsening; P=0.41). Totalear hearing (hearing in one or both ears that could be evaluated) was more likely to be improved or to remain normal at 12 months in the 6-month group than in the
6-week group (73% vs. 57%, P=0.01). The benefit in total-ear hearing was maintained at 24 months (77% vs. 64%, P=0.04). At 24 months, the 6-month group, as compared
with the 6-week group, had better neurodevelopmental scores on the Bayley Scales of Infant and Toddler Development, third edition, on the language-composite component (P=0.004) and on the receptive-communication scale (P=0.003). Grade 3 or 4 neutropenia occurred in 19% of the participants during the first 6 weeks. During the
next 4.5 months of the study, grade 3 or 4 neutropenia occurred in 21% of the participants in the 6-month group and in 27% of those in the 6-week group (P=0.64).
CONCLUSIONS: Treating symptomatic congenital CMV disease with valganciclovir for 6 months, as compared with 6 weeks, did not improve hearing in the short term but appeared to improve hearing and developmental outcomes modestly in the longer term. (Funded by the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov number,
NCT00466817.
A comprehensive overview of radioguided surgery using gamma detection probe technology
- Author
- A Agrawal
- A Ayhan
- A Ayhan
- A Bembenek
- A Bembenek
- A Benevento
- A Blom
- A Chella
- A Cuschieri
- A Gil-Moreno
- A Gonfiotti
- A Gruaz-Guyon
- A Hubalewska
- A Hubalewska-Dydejczyk
- A Häcker
- A Iagaru
- A Lal
- A Leibovitz
- A Luini
- A Meyer
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- A Patel
- A Renda
- A Sardi
- A Sardi
- A Schattner
- A Seal
- A Sherif
- A Sherif
- A Thor
- A Thor
- A Thor
- A Woznick
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- AC Barros
- AC Federico
- AC Morris Jr
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- ACG Mitchell
- AD Hill
- AF Kovács
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- GW Carlson
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- HT Harcke
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- HY Tien
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- I Brenot-Rossi
- I Brenot-Rossi
- I Düker
- I Roca
- I Sarikaya
- I Sarikaya
- I Stárek
- IA Jacobs
- IA Jacobs
- ICRP Publication 103
- ICRP Publication 60
- IG Sergides
- IM van der Ploeg
- J Arbizu
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- J Burdine
- J Fass
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- J Norman
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- J Ortin-Perez
- J Packeisen
- J Serrano
- J van de Lande
- J Xiao
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- JA de Hullu
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- JA Norton
- JA Werner
- JB McHugh
- JC Alex
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- JY Bobin
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- K Nouri
- K Pityñski
- K Placzkowski
- K Sugi
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- KA Schwarz
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- KL Molpus
- KM McMasters
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- KU Sian
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- L Abramova
- L Fang
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- L Mansi
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- LK Rodrigues
- LM Puig-Tintoré
- LR Petty
- LY Cheng
- M Amato
- M Ballester
- M Baroody
- M Burian
- M Catarci
- M Egawa
- M Etchebehere
- M Frumovitz
- M Frumovitz
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- M Fukuda
- M Grazia
- M Hampl
- M Harwood
- M Herlyn
- M Lacheretz
- M Maccauro
- M Manner
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- M Mistrangelo
- M Mistrangelo
- M Moreno
- M Nap
- M Nuti
- M Piert
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- M Plante
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- M Rudoni
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- N Fersis
- N Hernández-Toris
- N Mozzillo
- N Nijhawan
- N Ohuchi
- N Pateisky
- N Pelaez
- N Silva Jr
- N Wada
- Nathan C Hall
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- O Albores-Zúñiga
- O Kraft
- O Olsha
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- P Carcoforo
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- S Adams
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- S Adams
- S Ariyan
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- S Bertoglio
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- S Hammarström
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- S Vidal-Sicart
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- S Yamamoto
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- SS Gambhir
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- T Aikou
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- YA Chung
- YJ Lee
- YK Chen
- YQ Wang
- YS Lin
- ZR Shi
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology
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