El espacio, la luz y lo santo. La arquitectura del templo cristiano

Es conciso y profundo el estudio que hace el autor de las variables religiosas que le cuadran, a pesar de aquella contradicción que también él registra (esta inevitable tensión entre la intemperie y la arquitectura religiosa), al diseño del templo cristiano. Con sentido pedagógico -y filosófico- parte de los conceptos previos a toda habitación -espacio, volumen, masa...- para luego aplicarse con brillante racionalidad técnica y religiosa, a proponer relaciones entre lo fijo y lo incontenible, entre lo construible y la liturgia que lo habitará. Accesible para profanos de uno y otro campo, el arquitectónico y el teológico, la obra que recomendamos con estas líneas, es un ejercicio, al que os invito, de contemplación e imaginación, que no otra cosa opera por debajo de los ritos, las palabras y los signos que hacen de los templos cristianos lugares de vida, esperanza y, ¡qué necesidad tenemos de ello...!, humanidad

Bench-to-bedside review : targeting antioxidants to mitochondria in sepsis

Peer reviewedPublisher PD

Comunicación local y nuevos formatos periodísticos en Internet : cibermedios, confidenciales y weblogs

208 p.Libro ElectrónicoEl libro es el resultado más reciente de un esfuerzo colectivo que comenzó con la creación de un grupo de investigación, apoyado por la Universidad de Valencia, en torno al análisis de los medios digitales valencianos. Se trataba (y sigue tratándose, en buena medida) de un ámbito de investigación casi inexplorado. Pero desde un principio consideramos que su interés no sólo radicaba en su carácter ignoto, sino en la constatación de que el ecosistema comunicativo valenciano, y más en general el ámbito de la comunicación local vehiculada a través de Internet, había adquirido ya una madurez suficiente como para constituirse en ámbito de estudio por sí mismo, sin apoyarse en estudios de tipo más general. En efecto, bien porque abarcasen el conjunto de los cibermedios en España -como es el caso de los estudios de Armañanzas, Díaz Noci y Meso (1996), Díaz Noci y Meso (1999) y Salaverría (2005), entre otros-, o bien porque se acometiesen estudios de estructura de la comunicación referidos a todo el sistema mediático valenciano, lo cierto es que el estudio de los cibermedios en la Comunidad Valenciana se mantenía en un plano muy secundario, que contrastaba vivamente con los estudios de ámbito regional que ya por entonces (2006) se habían llevado a cabo en otras comunidades autónomasSe trata de un libro colectivo, distribuido como publicación de libre acceso, que reúne las aportaciones de once investigadores provenientes de seis universidades españolas. El estudio comienza con una completa revisión del conjunto de los cibermedios españoles, que da paso a la cartografía de los casos catalán, vasco y valenciano. El análisis de los cibermedios valencianos se extiende a lo largo de otros cuatro capítulos, que se refieren, respectivamente, a las características de los contenidos que ofrecen y la forma de acceder a ellos, así como a dos estudios de caso específicos. Finalmente, los últimos tres capítulos abordan el análisis de algunos formatos periodísticos peculiares: los llamados “confidenciales” de Internet, por un lado, y las características de los weblogs como herramientas propiamente periodísticas, en las dos últimas aportaciones.ÍNDICE Introducción Guillermo López García I. LA SITUACIÓN DE LOS CIBERMEDIOS EN ESPAÑA. La investigación sobre ciberperiodismo en España: tendencias, resultados y perspectivas. El ciberperiodismo en Catalunya: apuntes sobre el estado de la cuestión. Tipología de los cibermedios vascos y modelos de producto. Estado de la cuestión del estudio del fenómeno del ciberperiodismo desde la UPV-EHU. II. EL CASO PARTICULAR DE LOS CIBERMEDIOS VALENCIANOS. Los medios valencianos en la Red: orígenes, evolución y balance de conjunto. Vicis de paper en el ciberperiodisme local. Dinàmiques i estils dels mitjans valencians a Internet. La recuperación de la información en los periódicos digitales valencianos. www.alcoidigital.com: un ejemplo de comunicación [local] en la red Internet. Les edicions locals de Vilaweb al País Valencià. III. NUEVOS FORMATOS PERIODÍSTICOS. Los confidenciales digitales como nuevos formatos de opinión en la Red. Un medio nacido de Internet: el weblog. La opinión en la web: de la columna al weblog

Piezo voltage controlled planar hall effect devices

The electrical control of the magnetization switching in ferromagnets is highly desired for future spintronic applications. Here we report on hybrid piezoelectric (PZT)/ferromagnetic (Co2FeAl) devices in which the planar Hall voltage in the ferromagnetic layer is tuned solely by piezo voltages. The change of planar Hall voltage is associated with magnetization switching through 90° in the plane under piezo voltages. Room temperature magnetic NOT and NOR gates are demonstrated based on the piezo voltage controlled Co2FeAl planar Hall effect devices without the external magnetic field. Our demonstration may lead to the realization of both information storage and processing using ferromagnetic materials

A PSTOL-like gene, TaPSTOL, controls a number of agronomically important traits in wheat

Background Phosphorus (P) is an essential macronutrient for plant growth, and is required in large quantities by elite varieties of crops to maintain yields. Approximately 70% of global cultivated land suffers from P deficiency, and it has recently been estimated that worldwide P resources will be exhausted by the end of this century, increasing the demand for crops more efficient in their P usage. A greater understanding of how plants are able to maintain yield with lower P inputs is, therefore, highly desirable to both breeders and farmers. Here, we clone the wheat (Triticum aestivum L.) homologue of the rice PSTOL gene (OsPSTOL), and characterize its role in phosphate nutrition plus other agronomically important traits. Results TaPSTOL is a single copy gene located on the short arm of chromosome 5A, encoding a putative kinase protein, and shares a high level of sequence similarity to OsPSTOL. We re-sequenced TaPSTOL from 24 different wheat accessions and (3) three T. durum varieties. No sequence differences were detected in 26 of the accessions, whereas two indels were identified in the promoter region of one of the durum wheats. We characterised the expression of TaPSTOL under different P concentrations and demonstrated that the promoter was induced in root tips and hairs under P limiting conditions. Overexpression and RNAi silencing of TaPSTOL in transgenic wheat lines showed that there was a significant effect upon root biomass, flowering time independent of P treatment, tiller number and seed yield, correlating with the expression of TaPSTOL. However this did not increase PUE as elevated P concentration in the grain did not correspond to increased yields. Conclusions Manipulation of TaPSTOL expression in wheat shows it is responsible for many of the previously described phenotypic advantages as OsPSTOL except yield. Furthermore, we show TaPSTOL contributes to additional agronomically important traits including flowering time and grain size. Analysis of TaPSTOL sequences from a broad selection of wheat varieties, encompassing 91% of the genetic diversity in UK bread wheat, showed that there is very little genetic variation in this gene, which would suggest that this locus may have been under high selection pressure

The chromatin remodelling enzymes SNF2H and SNF2L position nucleosomes adjacent to CTCF and other transcription

Within the genomes of metazoans, nucleosomes are highly organised adjacent to the binding sites for a subset of transcription factors. Here we have sought to investigate which chromatin remodelling enzymes are responsible for this. We find that the ATP-dependent chromatin remodelling enzyme SNF2H plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding. At many other factor binding sites SNF2H and the related enzyme SNF2L contribute to nucleosome organisation. The action of SNF2H at CTCF sites is functionally important as depletion of CTCF or SNF2H affects transcription of a common group of genes. This suggests that chromatin remodelling ATPase's most closely related to the Drosophila ISWI protein contribute to the function of many human gene regulatory elements

New Results at JLab Describing Operating Lifetime of GaAs Photo-Guns

Polarized electrons from GaAs photocathodes have been key to some of the highest-impact results of the Jefferson Lab science program over the past 30 years. During this time, various studies have given insight into improving the operational lifetime of these photocathodes in DC high-voltage photo-guns while using lasers with spatial Gaussian profiles of typically 0.5 mm to 1 mm FWHM, cathode voltages of 100 kV to 130 kV, and a wide range of beam currents up to multiple mA. In this contribution, we show recent experimental data from a 100 kV to 180 kV setup and describe our progress at predicting the lifetime based on the calculable dynamics of ionized gas molecules inside the gun. These new experimental studies at Jefferson Lab are specifically aimed at exploring the ion damage of higher-voltage guns being built for injectors

Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus

Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood. In mammalian genomes, cohesin co-localizes with CCCTC binding factor (CTCF), a zinc finger protein implicated in multiple gene regulatory events. At the imprinted IGF2-H19 locus, CTCF plays an important role in organizing allele-specific higher-order chromatin conformation and functions as an enhancer blocking transcriptional insulator. Here we have used chromosome conformation capture (3C) assays and RNAi-mediated depletion of cohesin to address whether cohesin affects higher order chromatin conformation at the IGF2-H19 locus in human cells. Our data show that cohesin has a critical role in maintaining CTCF-mediated chromatin conformation at the locus and that disruption of this conformation coincides with changes in IGF2 expression. We show that the cohesin-dependent, higher-order chromatin conformation of the locus exists in both G1 and G2 phases of the cell cycle and is therefore independent of cohesin's function in sister chromatid cohesion. We propose that cohesin can mediate interactions between DNA molecules in cis to insulate genes through the formation of chromatin loops, analogous to the cohesin mediated interaction with sister chromatids in trans to establish cohesion

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

K0S and Λ production in Pb-Pb collisions at sNN−−−−√=2.76 TeV

The ALICE measurement of K0S and Λ production at midrapidity in Pb-Pb collisions at sNN−−−√=2.76  TeV is presented. The transverse momentum (pT) spectra are shown for several collision centrality intervals and in the pT range from 0.4  GeV/c (0.6  GeV/c for Λ) to 12  GeV/c. The pT dependence of the Λ/K0S ratios exhibits maxima in the vicinity of 3  GeV/c, and the positions of the maxima shift towards higher pT with increasing collision centrality. The magnitude of these maxima increases by almost a factor of three between most peripheral and most central Pb-Pb collisions. This baryon excess at intermediate pT is not observed in pp interactions at s√=0.9  TeV and at s√=7  TeV. Qualitatively, the baryon enhancement in heavy-ion collisions is expected from radial flow. However, the measured pT spectra above 2  GeV/c progressively decouple from hydrodynamical-model calculations. For higher values of pT, models that incorporate the influence of the medium on the fragmentation and hadronization processes describe qualitatively the pT dependence of the Λ/K0S ratio