Black hole spin: theory and observation

In the standard paradigm, astrophysical black holes can be described solely by their mass and angular momentum - commonly referred to as `spin' - resulting from the process of their birth and subsequent growth via accretion. Whilst the mass has a standard Newtonian interpretation, the spin does not, with the effect of non-zero spin leaving an indelible imprint on the space-time closest to the black hole. As a consequence of relativistic frame-dragging, particle orbits are affected both in terms of stability and precession, which impacts on the emission characteristics of accreting black holes both stellar mass in black hole binaries (BHBs) and supermassive in active galactic nuclei (AGN). Over the last 30 years, techniques have been developed that take into account these changes to estimate the spin which can then be used to understand the birth and growth of black holes and potentially the powering of powerful jets. In this chapter we provide a broad overview of both the theoretical effects of spin, the means by which it can be estimated and the results of ongoing campaigns.Comment: 55 pages, 5 figures. Published in: "Astrophysics of Black Holes - From fundamental aspects to latest developments", Ed. Cosimo Bambi, Springer: Astrophysics and Space Science Library. Additional corrections mad

Fabrication of Alginate-Based O/W Nanoemulsions for Transdermal Drug Delivery of Lidocaine: Influence of the Oil Phase and Surfactant

Transdermal drug delivery of lidocaine is a good choice for local anesthetic delivery. Microemulsions have shown great effectiveness for the transdermal transport of lidocaine. Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic molecules because of their ability to form stable and transparent delivery systems with good skin permeation. However, fabrication of nanoemulsions containing lidocaine to provide an extended local anesthetic effect is challenging. Hence, the aim of this study was to address this issue by employing alginate-based o/w nanocarriers using nanoemulsion template that is prepared by combined approaches of ultrasound and phase inversion temperature (PIT). In this study, the influence of system composition such as oil type, oil and surfactant concentration on the particle size, in vitro release and skin permeation of lidocaine nanoemulsions was investigated. Structural characterization of lidocaine nanoemulsions as a function of water dilution was done using DSC. Nanoemulsions with small droplet diameters (d < 150 nm) were obtained as demonstrated by dynamic light scattering (DLS) and cryo-TEM. These nanoemulsions were also able to release 90% of their content within 24-h through PDMS and pig skin and able to the drug release over a 48-h. This extended-release profile is highly favorable in transdermal drug delivery and shows the great potential of this nanoemulsion as delivery system

Toward the event horizon—the supermassive black hole in the galactic center

Contains fulltext : 122723.pdf (preprint version ) (Open Access

Processamento auditivo em indivíduos com epilepsia de lobo temporal Auditory processing in patients with temporal lobe epilepsy

A epilepsia do lobo temporal ocasiona descargas elétricas excessivas onde a via auditiva tem sua estação final. É uma das formas mais comuns e de mais difícil controle da doença. O correto processamento dos estímulos auditivos necessita da integridade anatômica e funcional de todas as estruturas envolvidas na via auditiva. OBJETIVO: Verificar o Processamento Auditivo de pacientes portadores de epilepsia do lobo temporal quanto aos mecanismos de discriminação de sons em seqüência e de padrões tonais, discriminação da direção da fonte sonora e atenção seletiva para sons verbais e não-verbais. MÉTODO: Foram avaliados oito indivíduos com epilepsia do lobo temporal confirmada e com foco restrito a essa região, através dos testes auditivos especiais: Teste de Localização Sonora, Teste de Padrão de Duração, Teste Dicótico de Dígitos e Teste Dicótico Não-Verbal. O seu desempenho foi comparado ao de indivíduos sem alteração neurológica (estudo caso-controle). RESULTADO: Os sujeitos com epilepsia do lobo temporal apresentaram desempenho semelhante aos do grupo controle quanto ao mecanismo de discriminação da direção da fonte sonora e desempenho inferior quanto aos demais mecanismos avaliados. CONCLUSÃO: Indivíduos com epilepsia do lobo temporal apresentaram maior prejuízo no processamento auditivo que os sem danos corticais, de idades semelhantes.<br>Temporal epilepsy, one of the most common presentation of this pathology, causes excessive electrical discharges in the area where we have the final station of the auditory pathway. Both the anatomical and functional integrity of the auditory pathway structures are essential for the correct processing of auditory stimuli. AIM: to check the Auditory Processing in patients with temporal lobe epilepsy regarding the auditory mechanisms of discrimination from sequential sounds and tone patterns, discrimination of the sound source direction and selective attention to verbal and nonverbal sounds. METHOD: eight individuals with temporal lobe epilepsy were assessed, after excluding those with non-confirmed diagnosis or with the focus of discharges not limited to this lobe. The evaluation was carried out through special auditory tests: Sound Localization Test, Duration Pattern Test, Digits Dichotic Test and Non-Verbal Dichotic Test. Their performances were compared to the performances of individuals without neurological diseases (case-control study). RESULTS: similar performances were observed between patients with temporal lobe epilepsy and the control group regarding the auditory mechanism of sound source direction discrimination. Comparing the other auditory mechanisms assessed, the patients with temporal lobe epilepsy presented worse results. CONCLUSION: individuals with temporal lobe epilepsy had more deficits in auditory processing than those without cortical damage

Paving the way to simultaneous multi-wavelength astronomy

Whilst astronomy as a science is historically founded on observations at optical wavelengths, studying the Universe in other bands has yielded remarkable discoveries, from pulsars in the radio, signatures of the Big Bang at submm wavelengths, through to high energy emission from accreting, gravitationally-compact objects and the discovery of gamma-ray bursts. Unsurprisingly, the result of combining multiple wavebands leads to an enormous increase in diagnostic power, but powerful insights can be lost when the sources studied vary on timescales shorter than the temporal separation between observations in different bands. In July 2015, the workshop "Paving the way to simultaneous multi-wavelength astronomy" was held as a concerted effort to address this at the Lorentz Center, Leiden. It was attended by 50 astronomers from diverse fields as well as the directors and staff of observatories and spaced-based missions. This community white paper has been written with the goal of disseminating the findings of that workshop by providing a concise review of the field of multi-wavelength astronomy covering a wide range of important source classes, the problems associated with their study and the solutions we believe need to be implemented for the future of observational astronomy. We hope that this paper will both stimulate further discussion and raise overall awareness within the community of the issues faced in a developing, important field

Relativistic Jets in Active Galactic Nuclei and Microquasars

Collimated outflows (jets) appear to be a ubiquitous phenomenon associated with the accretion of material onto a compact object. Despite this ubiquity, many fundamental physics aspects of jets are still poorly understood and constrained. These include the mechanism of launching and accelerating jets, the connection between these processes and the nature of the accretion flow, and the role of magnetic fields; the physics responsible for the collimation of jets over tens of thousands to even millions of gravitational radii of the central accreting object; the matter content of jets; the location of the region(s) accelerating particles to TeV (possibly even PeV and EeV) energies (as evidenced by (Formula presented.)-ray emission observed from many jet sources) and the physical processes responsible for this particle acceleration; the radiative processes giving rise to the observed multi-wavelength emission; and the topology of magnetic fields and their role in the jet collimation and particle acceleration processes. This chapter reviews the main knowns and unknowns in our current understanding of relativistic jets, in the context of the main model ingredients for Galactic and extragalactic jet sources. It discusses aspects specific to active Galactic nuclei (especially blazars) and microquasars, and then presents a comparative discussion of similarities and differences between them.Fil: Romero, Gustavo Esteban. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomia; ArgentinaFil: Boettcher, Markus. North-West University; SudáfricaFil: Markoff, Sera. University of Amsterdam; Países BajosFil: Tavecchio, Fabrizio. Osservatorio Astronomico Di Brera; Itali