1,224 research outputs found
LEDA 074886: A remarkable rectangular-looking galaxy
We report the discovery of an interesting and rare, rectangular-shaped
galaxy. At a distance of 21 Mpc, the dwarf galaxy LEDA 074886 has an absolute
R-band magnitude of -17.3 mag. Adding to this galaxy's intrigue is the presence
of an embedded, edge-on stellar disk (of extent 2R_{e,disk} = 12 arcsec = 1.2
kpc) for which Forbes et al. reported V_rot/sigma ~ 1.4. We speculate that this
galaxy may be the remnant of two (nearly edge-one) merged disk galaxies in
which the initial gas was driven inward and subsequently formed the inner disk,
while the stars at larger radii effectively experienced a dissipationless
merger event resulting in this `emerald cut galaxy' having very boxy isophotes
with a_4/a = -0.05 to -0.08 from 3 to 5 kpc. This galaxy suggests that
knowledge from simulations of both `wet' and `dry' galaxy mergers may need to
be combined to properly understand the various paths that galaxy evolution can
take, with a particular relevance to blue elliptical galaxies.Comment: To appear in ApJ. Six pages including references and figure
Efecto del incremento de la actividad física sobre la condición física en un grupo de adolescentes con sobrepeso y/u obesidad
This study evaluated the effect of increased physical activity (PA) to achieve PA recommendations according to the World Health Organization for improving health in a group of 42 adolescents (28 girls) with overweight / obesity (BMI = 29.37 ± 4.5 Kg / m²). The 12 weeks treatment consisted in the prescription and follow-up of the PA guidelines divided in two phases: intensive (weekly follow-up) and extensive (fortnightly follow-up). PA level was assessed using the Physician-based Assessment and Counseling questionnaire and the Physical Fitness using upper body isometric strength test, lower body explosive strength test and cardiorespiratory fitness test, all from the ALPHA battery fitness tests. After treatment, a significant improvement was observed (p <0.05) in cardiorespiratory fitness. In conclusion, this study shows that increasing PA practice and meeting the weekly recommendations of 300 minutes of moderate-vigorous PA, the adolescents’ group improved their cardiorespiratory fitness.Se analiza el efecto del incremento de actividad física (AF) para conseguir el cumplimiento de recomendaciones de AF para la mejora de la salud según la Organización Mundial de la Salud en un grupo de 42 adolescentes (28 chicas) con sobrepeso/obesidad (IMC=29.37±4.5 Kg/m²). El tratamiento de 12 semanas de duración consistió en la prescripción y seguimiento de AF en dos fases: intensiva (seguimiento semanal) y extensiva (seguimiento quincenal). El nivel de AF se valoró mediante el cuestionario Physician-based Assessment and Counseling y la condición física mediante pruebas de fuerza isométrica del tren superior, fuerza explosiva de piernas y capacidad cardiorrespiratoria de la batería ALPHA. Tras el tratamiento se observa una mejora significativa (p<0,05) en capacidad cardiorrespiratoria. En conclusión, se muestra que incrementando la práctica de AF y cumpliendo las recomendaciones semanales de 300 minutos de AF moderada-vigorosa los adolescentes mejoraron su capacidad cardiorrespiratoria
Telomere Length Shows No Association with BRCA1 and BRCA2 Mutation Status
This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrolment and blood donation, 21 of whom have developed prostate cancer whilst on study. The second group consisted of 283 female BRCA1/2 mutation carriers and controls (mean age 48 years), half of whom had been diagnosed with breast cancer prior to enrolment. TL was quantified by qPCR from DNA extracted from peripheral blood lymphocytes. Weighted and unweighted Cox regressions and linear regression analyses were used to assess whether TL was associated with BRCA1/2 mutation status or cancer risk. We found no evidence for association between developing cancer or being a BRCA1 or BRCA2 mutation carrier and telomere length. It is the first study investigating TL in a cohort of genetically predisposed males and although TL and BRCA status was previously studied in females our results don't support the previous finding of association between hereditary breast cancer and shorter TL
High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging
Progress in neuroscience constantly relies on the development of new
techniques to investigate the complex dynamics of neuronal networks. An ongoing
challenge is to achieve minimally-invasive and high-resolution observations of
neuronal activity in vivo inside deep brain areas. A perspective strategy is to
utilise holographic control of light propagation in complex media, which allows
converting a hair-thin multimode optical fibre into an ultra-narrow imaging
tool. Compared to current endoscopes based on GRIN lenses or fibre bundles,
this concept offers a footprint reduction exceeding an order of magnitude,
together with a significant enhancement in resolution. We designed a compact
and high-speed system for fluorescent imaging at the tip of a fibre, achieving
micron-scale resolution across a 50 um field of view, and yielding 7-kilopixel
images at a rate of 3.5 frames/s. Furthermore, we demonstrate in vivo
observations of cell bodies and processes of inhibitory neurons within deep
layers of the visual cortex and hippocampus of anesthetised mice. This study
forms the basis for several perspective techniques of modern microscopy to be
delivered deep inside the tissue of living animal models while causing minimal
impact on its structural and functional properties.Comment: 10 pages, 2 figures, Supplementary movie:
https://drive.google.com/file/d/1Fm0G3TAIC49LVX6FaEiAtlefkWx1T2a5/vie
Survival Benefits of Neoadjuvant Chemotherapy Followed by Radical Surgery versus Radiotherapy in Locally Advanced Chemoresistant Cervical Cancer
The aim of this study was to analyze long-term survivals in patients with stage IB to IIA cervical cancer treated by neoadjuvant chemotherapy setting. Between February 1989 and January 1998, 94 women with previously untreated stage IB to IIA carcinoma of the uterine cervix who received cisplatin based neoadjuvant chemotherapy were enrolled in this study. All of patients with chemoresponse (complete response, n=15; partial response, n=47) and 16 patients with chemoresistance received radical surgery (RS group). The other 16 patients with chemoresistance received radiotherapy for definite treatment (RT group). In the RS group, the 10 yr survival estimation in patients with bulky tumors (diameter ≥4 cm, n=26) was similar to that with non-bulky tumors (83.3% vs. 89.3%, p=NS). In selected patients with chemoresistance, those treated by radiotherapy (n=16) showed significantly poorer survivals than those treated by radical surgery (n=16) [10 yr survival rates of RT (25%) vs. RS (76.4%), p=0.0111]. Our results support that a possible therapeutic benefit of neoadjuvant chemotherapy plus radical surgery is only in patients with bulky stage IB to IIA cervical cancer. In cases of chemoresistance, radical surgery might be a better definite treatment option
Border skirmishes and the question of belonging: An authoethnographic account of everyday exclusion in multicultural society
Transnational migration has transformed most European countries, making the problem of how to 'integrate' an increasingly popular topic in public debates and social policy. It is assumed that as long as the newcomer learns the language, adapts to the local customs and finds work, s/he will be integrated and welcomed with open arms as a full-fledged member of society. Based on an autoethnography of our experiences as US-born, long-term and fully 'integrated' residents of the Netherlands, one of Europe's most multicultural societies, we have explored some of the subtle, well-intentioned practices of distancing and exclusion that are part of the fabric of everyday life. We will show how, contrary to the official discourse of integration, 'Dutch-ness' as a white/ethnic national identity is continuously constructed as a 'we', which excludes all 'others'. And, indeed, we have discovered that, paradoxically, the closer the 'other' comes to being completely assimilated into Dutch society, the more the symbolic borders of national belonging may need to be policed and tightened. © The Author(s) 2011
Duloxetine in the treatment of major depressive disorder: an open-label study
<p>Abstract</p> <p>Background</p> <p>Major depressive disorder (MDD) is a chronic and highly disabling condition. Existing pharmacotherapies produce full remission in only 30% to 40% of treated patients. Antidepressants exhibiting dual reuptake inhibition of both serotonin (5-HT) and norepinephrine (NE) may achieve higher rates of remission compared with those acting upon a single neurotransmitter. In this study, the safety and efficacy of duloxetine, a potent dual reuptake inhibitor of 5-HT and NE, were examined.</p> <p>Methods</p> <p>Patients (N = 533) meeting DSM-IV criteria for MDD received open-label duloxetine (60 mg once a day [QD]) for 12 weeks during the initial phase of a relapse prevention trial. Patients were required to have a 17-item Hamilton Rating Scale for Depression (HAMD<sub>17</sub>) total score ≥18 and a Clinical Global Impression of Severity (CGI-S) score ≥4 at baseline. Efficacy measures included the HAMD<sub>17 </sub>total score, HAMD<sub>17 </sub>subscales, the CGI-S, the Patient Global Impression of Improvement (PGI-I) scale, Visual Analog Scales (VAS) for pain, and the Symptom Questionnaire, Somatic Subscale (SQ-SS). Quality of life was assessed using the Sheehan Disability Scale (SDS) and the Quality of Life in Depression Scale (QLDS). Safety was evaluated by recording spontaneously-reported treatment-emergent adverse events, changes in vital signs and laboratory analytes, and the Patient Global Impression of Sexual Function (PGI-SF) scale.</p> <p>Results</p> <p>The rate of discontinuation due to adverse events was 11.3%. Treatment-emergent adverse events reported by ≥10% duloxetine-treated patients were nausea, headache, dry mouth, somnolence, insomnia, and dizziness. Following 12 weeks of open-label duloxetine therapy, significant improvements were observed in all assessed efficacy and quality of life measures. In assessments of depression severity (HAMD<sub>17</sub>, CGI-S) the magnitude of symptom improvement continued to increase at each study visit, while for painful physical symptoms the onset of improvement was rapid and reached a maximum after 2 to 3 weeks of treatment.</p> <p>Conclusion</p> <p>In this open-label phase of a relapse prevention study, duloxetine (60 mg QD) was shown to be safe and effective in the treatment of MDD.</p> <p>Trial registration</p> <p>NCT00036309.</p
On the buildup of massive early-type galaxies at z<~1. I- Reconciling their hierarchical assembly with mass-downsizing
Several studies have tried to ascertain whether or not the increase in
abundance of the early-type galaxies (E-S0a's) with time is mainly due to major
mergers, reaching opposite conclusions. We have tested it directly through
semi-analytical modelling, by studying how the massive early-type galaxies with
log(M_*/Msun)>11 at z~0 (mETGs) would have evolved backwards-in-time, under the
hypothesis that each major merger gives place to an early-type galaxy. The
study was carried out just considering the major mergers strictly reported by
observations at each redshift, and assuming that gas-rich major mergers
experience transitory phases of dust-reddened, star-forming galaxies (DSFs).
The model is able to reproduce the observed evolution of the galaxy LFs at
z<~1, simultaneously for different rest-frame bands (B, I, and K) and for
different selection criteria on color and morphology. It also provides a
framework in which apparently-contradictory results on the recent evolution of
the luminosity function (LF) of massive, red galaxies can be reconciled, just
considering that observational samples of red galaxies can be significantly
contaminated by DSFs. The model proves that it is feasible to build up ~50-60%
of the present-day mETG population at z<~1 and to reproduce the observational
excess by a factor of ~4-5 of late-type galaxies at 0.8<z<1 through the
coordinated action of wet, mixed, and dry major mergers, fulfilling global
trends that are in general agreement with mass-downsizing. The bulk of this
assembly takes place during ~1 Gyr elapsed at 0.8<z<1. The model suggests that
major mergers have been the main driver for the observational migration of mass
from the massive-end of the blue galaxy cloud to that of the red sequence in
the last ~8 Gyr.(Abridged)Comment: Accepted for publication in Astronomy & Astrophysics; 21 pages, 8
figures. Minor corrections included, shortened title. Results and conclusions
unchange
Time-trend and variations in the proportion of second-eye cataract surgery
<p>Abstract</p> <p>Background</p> <p>Despite recommendations for greater use of second-eye cataract surgery and the bilateral progression of the disease, there is a substantial proportion of unmet need for this treatment. Few studies have explored the factors associated with second-eye cataract surgery utilisation. The objective of our study was to estimate the proportion of second-eye cataract surgery, evaluate its time-trend, and explore differences in utilisation by patients' gender, age, and region of residence.</p> <p>Methods</p> <p>All senile cataract surgeries performed between 1999 and 2002 in the public health system of Catalonia (Spain) were obtained from the Minimum Data Set. The proportion of second-eye surgery from November 2000 to December 2002 was calculated. The time-trend of this proportion was characterised through linear regression models with the logarithmic transformation of time.</p> <p>Results</p> <p>The proportion of second-eye surgery was 30.0% and showed an increasing trend from 24.8% (95% Confidence Interval [CI] 21.6; 26.1) in November 2000 to 31.8% (95% CI 31.4; 33.6) in December 2002. This proportion was 1.9% (95% CI 0.9; 2.9) higher in women (p < 0.001) and held constant across time. Male patients aged less than 60 had the lowest proportion (22.6%; 95% CI 22.4; 22.9) and females between 70 and 79 had the highest proportion (27.4%; 95% CI 26.9; 27.9). The time-trend for the proportion of second-eye surgery in those aged over 80 years was greater than for younger ages, showing an increase of 9% at the end of the period for both males and females. Variations between regions decreased over time because regions with the lowest initial proportions of second-eye surgery (approximately 17%) showed a greater increase over the study period.</p> <p>Conclusion</p> <p>We predict greater utilization of second-eye surgery in patients aged 70 to 79 years and in women. A greater increase in the utilisation rates of second-eye surgery is expected in the regions with lower proportions and in older patients. The observed trend suggests that there will be a substantial proportion of unmet need for bilateral surgery.</p
The Seventh Data Release of the Sloan Digital Sky Survey
This paper describes the Seventh Data Release of the Sloan Digital Sky Survey
(SDSS), marking the completion of the original goals of the SDSS and the end of
the phase known as SDSS-II. It includes 11663 deg^2 of imaging data, with most
of the roughly 2000 deg^2 increment over the previous data release lying in
regions of low Galactic latitude. The catalog contains five-band photometry for
357 million distinct objects. The survey also includes repeat photometry over
250 deg^2 along the Celestial Equator in the Southern Galactic Cap. A
coaddition of these data goes roughly two magnitudes fainter than the main
survey. The spectroscopy is now complete over a contiguous area of 7500 deg^2
in the Northern Galactic Cap, closing the gap that was present in previous data
releases. There are over 1.6 million spectra in total, including 930,000
galaxies, 120,000 quasars, and 460,000 stars. The data release includes
improved stellar photometry at low Galactic latitude. The astrometry has all
been recalibrated with the second version of the USNO CCD Astrograph Catalog
(UCAC-2), reducing the rms statistical errors at the bright end to 45
milli-arcseconds per coordinate. A systematic error in bright galaxy photometr
is less severe than previously reported for the majority of galaxies. Finally,
we describe a series of improvements to the spectroscopic reductions, including
better flat-fielding and improved wavelength calibration at the blue end,
better processing of objects with extremely strong narrow emission lines, and
an improved determination of stellar metallicities. (Abridged)Comment: 20 pages, 10 embedded figures. Accepted to ApJS after minor
correction
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