59 research outputs found
Life Under the Japs: Stories from a Prisoner-of-War Camp
All physical materials associated with the New England Province Archive are currently held by the Jesuit Archives in St. Louis, MO. Any inquiries about these materials should be directed to the Jesuit Archives . Electronic versions of some items and the descriptions and finding aids to the Archives, which are hosted in CrossWorks, are provided only as a courtesy.
Life Under the Japs is the story of Rev. John J. Dugan, S.J., a military chaplain taken as a Japanese prisoner of war in the Philippines after the fall of Bataan in April 1942. His ordeal is relayed through a series of interviews conducted by William de Lue and originally published in the Boston Globe in April 1945. This publication was edited by Joseph P. Duffy, S.J.https://crossworks.holycross.edu/nenprovhistory/1007/thumbnail.jp
Semileptonic and nonleptonic B decays to three charm quarks: B->J/psi (eta_c) D l nu and J/psi (eta_c) D pi
We evaluate the form factors describing the semileptonic decays , within the framework of a QCD
relativistic potential model. This decay is complementary to in a phase space region where a pion factors out.We
estimate the branching ratio for these semileptonic and nonleptonic channels,
finding ,
and .Comment: 14 pages, 4 figure
RS1, Custodial Isospin and Precision Tests
We study precision electroweak constraints within a RS1 model with gauge
fields and fermions in the bulk. The electroweak gauge symmetry is enhanced to
SU(2)_L \times SU(2)_R \times U(1)_{B-L}, thereby providing a custodial isospin
symmetry sufficient to suppress excessive contributions to the T parameter. We
then construct complete models, complying with all electroweak constraints, for
solving the hierarchy problem, without supersymmetry or large hierarchies in
the fundamental couplings. Using the AdS/CFT correspondence our models can be
interpreted as dual to a strongly coupled conformal Higgs sector with global
custodial symmetry, gauge and fermionic matter being fundamental fields
external to the CFT. This scenario has interesting collider signals, distinct
from other RS models in the literature.Comment: 32 pages, 6 figures, latex2e, minor changes, references adde
Strong Phases and Factorization for Color Suppressed Decays
We prove a factorization theorem in QCD for the color suppressed decays B0->
D0 M0 and B0-> D*0 M0 where M is a light meson. Both the color-suppressed and
W-exchange/annihilation amplitudes contribute at lowest order in LambdaQCD/Q
where Q={mb, mc, Epi}, so no power suppression of annihilation contributions is
found. A new mechanism is given for generating non-perturbative strong phases
in the factorization framework. Model independent predictions that follow from
our results include the equality of the B0 -> D0 M0 and B0 -> D*0 M0 rates, and
equality of non-perturbative strong phases between isospin amplitudes,
delta(DM) = delta(D*M). Relations between amplitudes and phases for M=pi,rho
are also derived. These results do not follow from large Nc factorization with
heavy quark symmetry.Comment: 38 pages, 6 figs, typos correcte
Soft, collinear and non-relativistic modes in radiative decays of very heavy quarkonium
We analyze the end-point region of the photon spectrum in semi-inclusive
radiative decays of very heavy quarkonium (m alpha_s^2 >> Lambda_QCD). We
discuss the interplay of the scales arising in the Soft-Collinear Effective
Theory, m, m(1-z)^{1/2} and m(1-z) for z close to 1, with the scales of heavy
quarkonium systems in the weak coupling regime, m, m alpha_s and m alpha_s^2.
For 1-z \sim alpha_s^2 only collinear and (ultra)soft modes are seen to be
relevant, but the recently discovered soft-collinear modes show up for 1-z <<
alpha_s^2. The S- and P-wave octet shape functions are calculated. When they
are included in the analysis of the photon spectrum of the Upsilon (1S) system,
the agreement with data in the end-point region becomes excellent. The NRQCD
matrix elements and
are also obtained.Comment: Revtex, 11 pages, 6 figures. Minor improvements and references added.
Journal versio
Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program
While polygenic risk scores (PRSs) enable early identification of genetic risk for chronic obstructive pulmonary disease (COPD), predictive performance is limited when the discovery and target populations are not well matched. Hypothesizing that the biological mechanisms of disease are shared across ancestry groups, we introduce a PrediXcan-derived polygenic transcriptome risk score (PTRS) to improve cross-ethnic portability of risk prediction. We constructed the PTRS using summary statistics from application of PrediXcan on large-scale GWASs of lung function (forced expiratory volume in 1 s [FEV1] and its ratio to forced vital capacity [FEV1/FVC]) in the UK Biobank. We examined prediction performance and cross-ethnic portability of PTRS through smoking-stratified analyses both on 29,381 multi-ethnic participants from TOPMed population/family-based cohorts and on 11,771 multi-ethnic participants from TOPMed COPD-enriched studies. Analyses were carried out for two dichotomous COPD traits (moderate-to-severe and severe COPD) and two quantitative lung function traits (FEV1 and FEV1/FVC). While the proposed PTRS showed weaker associations with disease than PRS for European ancestry, the PTRS showed stronger association with COPD than PRS for African Americans (e.g., odds ratio [OR] = 1.24 [95% confidence interval [CI]: 1.08–1.43] for PTRS versus 1.10 [0.96–1.26] for PRS among heavy smokers with ≥ 40 pack-years of smoking) for moderate-to-severe COPD. Cross-ethnic portability of the PTRS was significantly higher than the PRS (paired t test p < 2.2 × 10−16 with portability gains ranging from 5% to 28%) for both dichotomous COPD traits and across all smoking strata. Our study demonstrates the value of PTRS for improved cross-ethnic portability compared to PRS in predicting COPD risk
Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,497 participants from population- and family-based studies, and 8499 individuals from COPD-enriched studies in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program. We identify at genome-wide significance 10 known GWAS loci and 22 distinct, previously unreported loci, including two common variant signals from stratified analysis of African Americans. Four novel common variants within the regions of PIAS1, RGN (two variants) and FTO show evidence of replication in the UK Biobank (European ancestry n ~ 320,000), while colocalization analyses leveraging multi-omic data from GTEx and TOPMed identify potential molecular mechanisms underlying four of the 22 novel loci. Our study demonstrates the value of performing WGS analyses and multi-omic follow-up in cohorts of diverse ancestry
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