2,557 research outputs found
Large deviation principles for the stochastic quasi-geostrophic equation
In this paper we establish the large deviation principle for the stochastic
quasi-geostrophic equation in the subcritical case with small multiplicative
noise. The proof is mainly based on the stochastic control and weak convergence
approach. Some analogous results are also obtained for the small time
asymptotics of the stochastic quasi-geostrophic equation.Comment: 29 pages; correct some misprints and small gap
In-Vivo Visualization of Tumor Microvessel Density and Response to Anti-Angiogenic Treatment by High Resolution MRI in Mice
Purpose: Inhibition of angiogenesis has shown clinical success in patients with cancer. Thus, imaging approaches that allow for the identification of angiogenic tumors and the detection of response to anti-angiogenic treatment are of high clinical relevance. Experimental Design: We established an in vivo magnetic resonance imaging (MRI) approach that allows us to simultaneously image tumor microvessel density and tumor vessel size in a NSCLC model in mice. Results: Using microvessel density imaging we demonstrated an increase in microvessel density within 8 days after tumor implantation, while tumor vessel size decreased indicating a switch from macro- to microvessels during tumor growth. Moreover, we could monitor in vivo inhibition of angiogenesis induced by the angiogenesis inhibitor PTK787, resulting in a decrease of microvessel density and a slight increase in tumor vessel size. Conclusions: We present an in vivo imaging approach that allows us to monitor both tumor microvessel density and tumor vessel size in the tumor. Moreover, this approach enables us to assess, early-on, treatment effects on tumor microvessel density as well as on tumor vessel size. Thus, this imaging-based strategy of validating anti-angiogenic treatment effects ha
Low-resolution spectroscopy of main sequence stars belonging to 12 Galactic globular clusters. I. CH and CN band strength variations
Globular clusters show abundance variations for light elements that are not
yet well understood. The preferred explanation involves a self-enrichment
scenario, with two subsequent generations of stars. Observations of main
sequence stars allow us to investigate the signature of this chemically
processed material without the complicating effects of internal mixing. Our
goal is to investigate the C-N anti-correlation with low-resolution
spectroscopy of 20-50 stars fainter than the first dredge-up in seven globular
clusters (NGC288, NGC1851, NGC5927, NGC6352, NGC6388, and Pal12) with different
properties. We complemented our observations with 47~Tuc archival data, with
four additional clusters from the literature (M15, M22, M55, NGC362), and with
additional literature data on NGC288. In this first paper, we measured the
strength of CN and CH band indices, and we investigated the anti-correlation
and bimodality of these indices. We compared r_CN, the ratio of stars belonging
to the CN-strong and weak groups, with 15 different cluster parameters. We
clearly see bimodal anti-correlation of the CH and CN band stregths in the
metal-rich clusters (Pal12, 47Tuc, NGC6352, NGC5927). Only M15 among the
metal-poor clusters shows a clearly bimodal anti-correlation. We found weak
correlations (sligthly above 1 sigma) of r_CN with the cluster orbital
parameters, present-day total mass, cluster concentration, and age. Our
findings support the self-enrichment scenario, and suggest that the occurrence
of more than two major generations of stars in a GGC should be rare. Small
additional generations (<10-20% of the total) would be difficult to detect with
our samples. The first generation, which corresponds to the CN-weak stars,
usually contains more stars than the second one (=0.82+/-0.29), as
opposed to results based on the Na-O anti-correlations.Comment: 18 pages, 10 figures, 1 electronic table, accepted for publication in
A&A (language edited version
Spin half fermions with mass dimension one: theory, phenomenology, and dark matter
We provide the first details on the unexpected theoretical discovery of a
spin-one-half matter field with mass dimension one. It is based upon a complete
set of dual-helicity eigenspinors of the charge conjugation operator. Due to
its unusual properties with respect to charge conjugation and parity, it
belongs to a non-standard Wigner class. Consequently, the theory exhibits
non-locality with (CPT)^2 = - I. We briefly discuss its relevance to the
cosmological `horizon problem'. Because the introduced fermionic field is
endowed with mass dimension one, it can carry a quartic self-interaction. Its
dominant interaction with known forms of matter is via Higgs, and with gravity.
This aspect leads us to contemplate the new fermion as a prime dark matter
candidate. Taking this suggestion seriously we study a supernova-like explosion
of a galactic-mass dark matter cloud to set limits on the mass of the new
particle and present a calculation on relic abundance to constrain the relevant
cross-section. The analysis favours light mass (roughly 20 MeV) and relevant
cross-section of about 2 pb. Similarities and differences with the WIMP and
mirror matter proposals for dark matter are enumerated. In a critique of the
theory we bare a hint on non-commutative aspects of spacetime, and
energy-momentum space.Comment: 78 pages [Changes: referee-suggested improvements, additional
important references, and better readability
Bias in MRI Measurements of Apparent Diffusion Coefficient and Kurtosis: Implications for Choice of Maximum Diffusion Encoding
Tissue water diffusion is non-Gaussian and the expressions used to calculate diffusion parameters are approximations which introduce systematic errors dependent on the maximum diffusion encoding, diffusion time, etc. This study aimed at characterizing biases in estimates of both apparent diffusion coefficient and kurtosis, and determines their dependence on these parameters. Similar to the approach of several previous studies, Taylor expansion of the diffusion signal was used to calculate biases. Predicted errors were compared with data from one volunteer. Predicted errors agreed well with the measured errors and also the published diffusion tensor imaging measurements. The equations derived predict biases in measured diffusion parameters and explain much of the discrepancy between measurements obtained with different acquisition protocols. The equations may also be used to choose appropriate diffusion encoding for diffusion weighted, tensor, and kurtosis imaging
Magnetic resonance imaging of brain angiogenesis after stroke
Stroke is a major cause of mortality and long-term disability worldwide. The initial changes in local perfusion and tissue status underlying loss of brain function are increasingly investigated with noninvasive imaging methods. In addition, there is a growing interest in imaging of processes that contribute to post-stroke recovery. In this review, we discuss the application of magnetic resonance imaging (MRI) to assess the formation of new vessels by angiogenesis, which is hypothesized to participate in brain plasticity and functional recovery after stroke. The excellent soft tissue contrast, high spatial and temporal resolution, and versatility render MRI particularly suitable to monitor the dynamic processes involved in vascular remodeling after stroke. Here we review recent advances in the field of MR imaging that are aimed at assessment of tissue perfusion and microvascular characteristics, including cerebral blood flow and volume, vascular density, size and integrity. The potential of MRI to noninvasively monitor the evolution of post-ischemic angiogenic processes is demonstrated from a variety of in vivo studies in experimental stroke models. Finally, we discuss some pitfalls and limitations that may critically affect the accuracy and interpretation of MRI-based measures of (neo)vascularization after stroke
Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at = 5.02 TeV
Two-particle angular correlations between unidentified charged trigger and
associated particles are measured by the ALICE detector in p-Pb collisions at a
nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum
range 0.7 5.0 GeV/ is examined,
to include correlations induced by jets originating from low
momen\-tum-transfer scatterings (minijets). The correlations expressed as
associated yield per trigger particle are obtained in the pseudorapidity range
. The near-side long-range pseudorapidity correlations observed in
high-multiplicity p-Pb collisions are subtracted from both near-side
short-range and away-side correlations in order to remove the non-jet-like
components. The yields in the jet-like peaks are found to be invariant with
event multiplicity with the exception of events with low multiplicity. This
invariance is consistent with the particles being produced via the incoherent
fragmentation of multiple parton--parton scatterings, while the yield related
to the previously observed ridge structures is not jet-related. The number of
uncorrelated sources of particle production is found to increase linearly with
multiplicity, suggesting no saturation of the number of multi-parton
interactions even in the highest multiplicity p-Pb collisions. Further, the
number scales in the intermediate multiplicity region with the number of binary
nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/161
Multi-particle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider
Measurements of multi-particle azimuthal correlations (cumulants) for charged
particles in p-Pb and Pb-Pb collisions are presented. They help address the
question of whether there is evidence for global, flow-like, azimuthal
correlations in the p-Pb system. Comparisons are made to measurements from the
larger Pb-Pb system, where such evidence is established. In particular, the
second harmonic two-particle cumulants are found to decrease with multiplicity,
characteristic of a dominance of few-particle correlations in p-Pb collisions.
However, when a gap is placed to suppress such correlations,
the two-particle cumulants begin to rise at high-multiplicity, indicating the
presence of global azimuthal correlations. The Pb-Pb values are higher than the
p-Pb values at similar multiplicities. In both systems, the second harmonic
four-particle cumulants exhibit a transition from positive to negative values
when the multiplicity increases. The negative values allow for a measurement of
to be made, which is found to be higher in Pb-Pb collisions at
similar multiplicities. The second harmonic six-particle cumulants are also
found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find
which is indicative of a Bessel-Gaussian
function for the distribution. For very high-multiplicity Pb-Pb
collisions, we observe that the four- and six-particle cumulants become
consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and
Pb-Pb are measured. These are found to be similar for overlapping
multiplicities, when a gap is placed.Comment: 25 pages, 11 captioned figures, 3 tables, authors from page 20,
published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/87
Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at TeV
The elliptic, , triangular, , and quadrangular, , azimuthal
anisotropic flow coefficients are measured for unidentified charged particles,
pions and (anti-)protons in Pb-Pb collisions at TeV
with the ALICE detector at the Large Hadron Collider. Results obtained with the
event plane and four-particle cumulant methods are reported for the
pseudo-rapidity range at different collision centralities and as a
function of transverse momentum, , out to GeV/.
The observed non-zero elliptic and triangular flow depends only weakly on
transverse momentum for GeV/. The small dependence
of the difference between elliptic flow results obtained from the event plane
and four-particle cumulant methods suggests a common origin of flow
fluctuations up to GeV/. The magnitude of the (anti-)proton
elliptic and triangular flow is larger than that of pions out to at least
GeV/ indicating that the particle type dependence persists out
to high .Comment: 16 pages, 5 captioned figures, authors from page 11, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186
- …