6 research outputs found

    Certification system in template climate

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    El objetivo de este trabajo es dar a conocer el campo normativo y herramientas vigentes que permiten certificar la eficiencia energética de edificios en España dentro de los países de clima templado, los documentos reconocidos para su realización, así como la vinculación de los mismos con directivas europeas encaminadas a cumplir los compromisos fijados por la Convención Marco de las Naciones Unidas sobre el Cambio Climático. La comparativa entre las diferentes herramientas y con otros países de clima templado permitirá identificar sus virtudes e inconvenientes a fin de obtener conclusiones sobre las mejoras que podrían plantearse, desde el proceso de certificación y materia de eficiencia energética hasta las normativas que las regulan.The aim of this paper is to present the regulatory field and existing tools to certify the energy efficiency of buildings in Spain, within countries in temperate climate. Moreover, it states the documents recognized for their realization. Besides, the paper establishes their link with the European directives designed to fulfill the commitments set by The United Nations Framework Convention on Climate Change. The comparison between the different tools and with other countries will identify their strengths and weaknesses, in order to draw conclusions about the improvements that could arise from the certification process and energy efficiency to the regulations governing them.Facultad de Arquitectura y Urbanism

    Sistemas de Certificación en Clima Templado

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    El objetivo de este trabajo es dar a conocer el campo normativo y herramientas vigentes que permiten certificar la eficiencia energética de edificios en España, dentro de los países en Clima Templado, los documentos reconocidos para su realización; así como la vinculación de los mismos con Directivas europeas encaminadas a cumplir los compromisos fijados por la Convención Marco de las Naciones Unidas sobre el Cambio Climático. La comparativa entre las diferentes herramientas y con otros países de climas templados, permitirá identificar sus virtudes e inconvenientes, a fin de obtener conclusiones sobre las mejoras que podrían plantearse, desde el proceso de certificación y materia de eficiencia energética hasta las normativas que las regulan. Palabras clave recursos energéticos, energía térmica, medio ambiente, climatizació

    Sistemas de Certificación en Clima Templado

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    El objetivo de este trabajo es dar a conocer el campo normativo y herramientas vigentes que permiten certificar la eficiencia energética de edificios en España, dentro de los países en Clima Templado, los documentos reconocidos para su realización; así como la vinculación de los mismos con Directivas europeas encaminadas a cumplir los compromisos fijados por la Convención Marco de las Naciones Unidas sobre el Cambio Climático. La comparativa entre las diferentes herramientas y con otros países de climas templados, permitirá identificar sus virtudes e inconvenientes, a fin de obtener conclusiones sobre las mejoras que podrían plantearse, desde el proceso de certificación y materia de eficiencia energética hasta las normativas que las regulan

    The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight

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    Background: The Iberian Peninsula stands out as having variable levels of population admixture and isolation, making Spain an interesting setting for studying the genetic architecture of neurodegenerative diseases. Objectives: To perform the largest PD genome-wide association study restricted to a single country. Methods: We performed a GWAS for both risk of PD and age at onset in 7,849 Spanish individuals. Further analyses included population-specific risk haplotype assessments, polygenic risk scoring through machine learning, Mendelian randomization of expression, and methylation data to gain insight into disease-associated loci, heritability estimates, genetic correlations, and burden analyses. Results: We identified a novel population-specific genome-wide association study signal at PARK2 associated with age at onset, which was likely dependent on the c.155delA mutation. We replicated four genome-wide independent signals associated with PD risk, including SNCA, LRRK2, KANSL1/MAPT, and HLA-DQB1. A significant trend for smaller risk haplotypes at known loci was found compared to similar studies of non-Spanish origin. Seventeen PD-related genes showed functional consequence by two-sample Mendelian randomization in expression and methylation data sets. Long runs of homozygosity at 28 known genes/loci were found to be enriched in cases versus controls. Conclusions: Our data demonstrate the utility of the Spanish risk haplotype substructure for future fine-mapping efforts, showing how leveraging unique and diverse population histories can benefit genetic studies of complex diseases. The present study points to PARK2 as a major hallmark of PD etiology in Spain.This research was supported, in part, by the Intramural Research Program of the National Institutes of Health (National Institute on Aging, National Institute of Neurological Disorders and Stroke; project numbers: 1ZIA‐NS003154‐03, Z01‐AG000949‐02, and Z01‐ES101986). In addition, this work was supported by the Department of Defense (award W81XWH‐09‐2‐0128), The Michael J Fox Foundation for Parkinson's Research, and the ISCIII Grants PI 15/0878 (Fondos Feder) to V.A. and PI 15/01013 to J,H. This study was supported by grants from the Spanish Ministry of Economy and Competitiveness (PI14/01823, PI16/01575, PI18/01898, [SAF2006‐10126 (2006‐2009), SAF2010‐22329‐C02‐01 (2010‐2012), and SAF2013‐47939‐R (2013‐2018)]), co‐founded by ISCIII (Subdirección General de Evaluación y Fomento de la Investigación) and by Fondo Europeo de Desarrollo Regional (FEDER), the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía (CVI‐02526, CTS‐7685), the Consejería de Salud y Bienestar Social de la Junta de Andalucía (PI‐0437‐2012, PI‐0471‐2013), the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, the Fundación Alicia Koplowitz, and the Fundación Mutua Madrileña. Pilar Gómez‐Garre was supported by the “Miguel Servet” (from ISCIII16 FEDER) and “Nicolás Monardes” (from Andalusian Ministry of Health) programmes. Silvia Jesús Maestre was supported by the “Juan Rodés” programme, and Daniel Macías‐García was supported by the “Río Hortega” programme (both from ISCIII‐FEDER). Cristina Tejera Parrado was supported by VPPI‐US from the Universidad de Sevilla. This research has been conducted using samples from the HUVR‐IBiS Biobank (Andalusian Public Health System Biobank and ISCIII‐Red de Biobancos PT13/0010/0056). This work was also supported by the grant PSI2014‐57643 from the Junta de Andalucía to the CTS‐438 group and a research award from the Andalusian Society of Neurology

    Delaying surgery for patients with a previous SARS-CoV-2 infection

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    Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

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