Basic hardware interconnection mechanisms for building multiple microcomputer systems

This report presents the current results of a research project which has been concerned with methods for designing and implementing multiple microcomputer systems. The design method is based upon identifying hardware interconnection primitives which may be used to construct the interconnection subsystem which characterizes a given multicomputer architecture. An actual experimental system has been constructed which will permit building nine of ten systems in the Anderson and Jensen architecture taxonomy. (Author)Supported in part by the Department of Electrical Engineering and Computer Science, University of Connecticut, Storrs, Connecticut and in part by the Department of Computer Science, Naval Postgraduate School, Monterey, Californiahttp://archive.org/details/basichardwareint00careNAApproved for public release; distribution is unlimited

Mupirocin and chlorhexidine resistance in Staphylococcus aureus in patients with community-onset skin and soft tissue infections

Decolonization measures, including mupirocin and chlorhexidine, are often prescribed to prevent Staphylococcus aureus skin and soft tissue infections (SSTI). The objective of this study was to determine the prevalence of high-level mupirocin and chlorhexidine resistance in S. aureus strains recovered from patients with SSTI before and after mupirocin and chlorhexidine administration and to determine whether carriage of a mupirocin- or chlorhexidine-resistant strain at baseline precluded S. aureus eradication. We recruited 1,089 patients with community-onset SSTI with or without S. aureus colonization. In addition to routine care, 483 patients were enrolled in a decolonization trial: 408 received intranasal mupirocin (with or without antimicrobial baths), and 258 performed chlorhexidine body washes. Patients were followed for up to 12 months with repeat colonization cultures. All S. aureus isolates were tested for high-level mupirocin and chlorhexidine resistance. At baseline, 23/1,089 (2.1%) patients carried a mupirocin-resistant S. aureus strain and 10/1,089 (0.9%) patients carried chlorhexidine-resistant S. aureus. Of 4 patients prescribed mupirocin, who carried a mupirocin-resistant S. aureus strain at baseline, 100% remained colonized at 1 month compared to 44% of the 324 patients without mupirocin resistance at baseline (P = 0.041). Of 2 patients prescribed chlorhexidine, who carried a chlorhexidine-resistant S. aureus strain at baseline, 50% remained colonized at 1 month compared to 48% of the 209 patients without chlorhexidine resistance at baseline (P = 1.0). The overall prevalence of mupirocin and chlorhexidine resistance is low in S. aureus isolates recovered from outpatients, but eradication efforts were less successful in patients carrying a mupirocin-resistant S. aureus strain at baseline

Twofold efficiency increase in nanocrystalline-TiO2/polymer photovoltaic devices by interfacial modification with a lithium salt

Modification of the interface of titanium dioxide/poly[2-(2-ethylhexyloxy)-5-methoxy-1,4,-phenylenevinylene] (TiO2/MEH-PPV) nanocomposite photovoltaic devices with a lithium salt, Li[CF3SO2](2)N, is shown to result in a twofold increase in device efficiency. The devices are of the type ITO/TiO2/MEH-PPV/Au. The TiO2 layer is deposited by doctor blading a colloidal anatase paste, and the polymer is then spin-coated on top followed by thermal evaporation of gold contacts. Careful control of manufacturing conditions and use of a 35 nm polymer layer leads to a device efficiency of 0.48% for un-modified devices. The increased efficiency following Li treatment is the result of a 40% increase in both the short-circuit current and fill factor, while the open-circuit voltage remains unchanged. A maximum efficiency of 1.05% has been achieved under 80% sun illumination. This represents a record efficiency for this type of cell. Photoconductivity experiments show a substantial increase in conductivity of the TiO2 layer following Li modification. Interfacial modification is done via a simple soaking procedure, and the effect of varying the concentration of Li[CF3SO2](2)N is discussed. We report investigations into optimization and the mechanism of such improvement, for example by varying processing parameters of the modification procedure or the ionic species themselves

Evidence for dust evolution within the Taurus Complex from Spitzer images

We present Spitzer images of the Taurus Complex (TC) and take advantage of the sensitivity and spatial resolution of the observations to characterize the diffuse IR emission across the cloud. This work highlights evidence of dust evolution within the translucent sections of the archetype reference for studies of quiescent molecular clouds. We combine Spitzer 160 um and IRAS 100 um observations to produce a dust temperature map and a far-IR dust opacity map at 5' resolution. The average dust temperature is about 14.5K with a dispersion of +/-1K across the cloud. The far-IR dust opacity is a factor 2 larger than the average value for the diffuse ISM. This opacity increase and the attenuation of the radiation field (RF) both contribute to account for the lower emission temperature of the large grains. The structure of the TC significantly changes in the mid-IR images that trace emission from PAHs and VSGs. We focus our analysis of the mid-IR emission to a range of ecliptic latitudes where the zodiacal light residuals are small. Within this cloud area, there are no 8 and 24 um counterparts to the brightest 160 um emission features. Conversely, the 8 and 24 um images reveal filamentary structure that is strikingly inconspicuous in the 160 um and extinction maps. The IR colors vary over sub-parsec distances across this filamentary structure. We compare the observed colors with model calculations quantifying the impact of the RF intensity and the abundance of stochastically heated particles on the dust SED. To match the range of observed colors, we have to invoke variations by a factor of a few of both the interstellar RF and the abundance of PAHs and VSGs. We conclude that within this filamentary structure a significant fraction of the dust mass cycles in and out the small size end of the dust size distribution.Comment: 43 pages, 13 figures, accepted for publication in Ap

Concordance among gene expression-based predictors for ER-positive breast cancer treated with adjuvant tamoxifen

Funding: NCI Breast SPORE program (P50-CA58223-09A1); (RO1-420 CA138255) Breast Cancer Research Foundation, the Sociedad Española de Oncología Médica (SEOM) and the V Foundation for Cancer Research. AP is affiliated to the Medicine PhD program of the Autonomous University of Barcelona, Spain.ER-positive (ER+) breast cancer includes all of the intrinsic molecular subtypes, although the luminal A and B subtypes predominate. In this study, we evaluated the ability of six clinically relevant genomic signatures to predict relapse in patients with ER+ tumors treated with adjuvant tamoxifen only. Four microarray datasets were combined and research-based versions of PAM50 intrinsic subtyping and risk of relapse (PAM50-ROR) score, 21-gene recurrence score (OncotypeDX), Mammaprint, Rotterdam 76 gene, index of sensitivity to endocrine therapy (SET) and an estrogen-induced gene set were evaluated. Distant relapse-free survival (DRFS) was estimated by Kaplan-Meier and log-rank tests, and multivariable analyses were done using Cox regression analysis. Harrell's C-index was also used to estimate performance. All signatures were prognostic in patients with ER+ node-negative tumors, whereas most were prognostic in ER+ node-positive disease. Among the signatures evaluated, PAM50-ROR, OncotypeDX, Mammaprint and SET were consistently found to be independent predictors of relapse. A combination of all signatures significantly increased the performance prediction. Importantly, low-risk tumors (>90% DRFS at 8.5 years) were identified by the majority of signatures only within node-negative disease, and these tumors were mostly luminal A (78%-100%). Most established genomic signatures were successful in outcome predictions in ER+ breast cancer and provided statistically independent information. From a clinical perspective, multiple signatures combined together most accurately predicted outcome, but a common finding was that each signature identified a subset of luminal A patients with node-negative disease who might be considered suitable candidates for adjuvant endocrine therapy alone

EGFR associated expression profiles vary with breast tumor subtype

<p>Abstract</p> <p>Background</p> <p>The epidermal growth factor receptor (EGFR/HER1) and its downstream signaling events are important for regulating cell growth and behavior in many epithelial tumors types. In breast cancer, the role of EGFR is complex and appears to vary relative to important clinical features including estrogen receptor (ER) status. To investigate EGFR-signaling using a genomics approach, several breast basal-like and luminal epithelial cell lines were examined for sensitivity to EGFR inhibitors. An EGFR-associated gene expression signature was identified in the basal-like SUM102 cell line and was used to classify a diverse set of sporadic breast tumors.</p> <p>Results</p> <p><it>In vitro</it>, breast basal-like cell lines were more sensitive to EGFR inhibitors compared to luminal cell lines. The basal-like tumor derived lines were also the most sensitive to carboplatin, which acted synergistically with cetuximab. An EGFR-associated signature was developed <it>in vitro</it>, evaluated on 241 primary breast tumors; three distinct clusters of genes were evident <it>in vivo</it>, two of which were predictive of poor patient outcomes. These EGFR-associated poor prognostic signatures were highly expressed in almost all basal-like tumors and many of the HER2+/ER- and Luminal B tumors.</p> <p>Conclusion</p> <p>These results suggest that breast basal-like cell lines are sensitive to EGFR inhibitors and carboplatin, and this combination may also be synergistic. <it>In vivo</it>, the EGFR-signatures were of prognostic value, were associated with tumor subtype, and were uniquely associated with the high expression of distinct EGFR-RAS-MEK pathway genes.</p

Circumstellar Structure around Evolved Stars in the Cygnus-X Star Formation Region

We present observations of newly discovered 24 micron circumstellar structures detected with the Multiband Imaging Photometer for Spitzer (MIPS) around three evolved stars in the Cygnus-X star forming region. One of the objects, BD+43 3710, has a bipolar nebula, possibly due to an outflow or a torus of material. A second, HBHA 4202-22, a Wolf-Rayet candidate, shows a circular shell of 24 micron emission suggestive of either a limb-brightened shell or disk seen face-on. No diffuse emission was detected around either of these two objects in the Spitzer 3.6-8 micron Infrared Array Camera (IRAC) bands. The third object is the luminous blue variable candidate G79.29+0.46. We resolved the previously known inner ring in all four IRAC bands. The 24 micron emission from the inner ring extends ~1.2 arcmin beyond the shorter wavelength emission, well beyond what can be attributed to the difference in resolutions between MIPS and IRAC. Additionally, we have discovered an outer ring of 24 micron emission, possibly due to an earlier episode of mass loss. For the two shell stars, we present the results of radiative transfer models, constraining the stellar and dust shell parameters. The shells are composed of amorphous carbon grains, plus polycyclic aromatic hydrocarbons in the case of G79.29+0.46. Both G79.29+0.46 and HBHA 4202-22 lie behind the main Cygnus-X cloud. Although G79.29+0.46 may simply be on the far side of the cloud, HBHA 4202-22 is unrelated to the Cygnus-X star formation region.Comment: Accepted by A

The <i>Herschel</i> view of the massive star-forming region NGC 6334

Aims: Fundamental to any theory of high-mass star formation are gravity and turbulence. Their relative importance, which probably changes during cloud evolution, is not known. By investigating the spatial and density structure of the high-mass star-forming complex NGC 6334 we aim to disentangle the contributions of turbulence and gravity. Methods: We used Herschel PACS and SPIRE imaging observations from the HOBYS key programme at wavelengths of 160, 250, 350, and 500 μm to construct dust temperature and column density maps. Using probability distribution functions (PDFs) of the column density determined for the whole complex and for four distinct sub-regions (distinguished on the basis of differences in the column density, temperature, and radiation field), we characterize the density structure of the complex. We investigate the spatial structure using the Δ-variance, which probes the relative amount of structure on different size scales and traces possible energy injection mechanisms into the molecular cloud. Results: The Δ-variance analysis suggests that the significant scales of a few parsec that were found are caused by energy injection due to expanding HII regions, which are numerous, and by the lengths of filaments seen everywhere in the complex. The column density PDFs have a lognormal shape at low densities and a clearly defined power law at high densities for all sub-regions whose slope is linked to the exponent α of an equivalent spherical density distribution. In particular with α = 2.37, the central sub-region is largly dominated by gravity, caused by individual collapsing dense cores and global collapse of a larger region. The collapse is faster than free-fall (which would lead only to α = 2) and thus requires a more dynamic scenario (external compression, flows). The column density PDFs suggest that the different sub-regions are at different evolutionary stages, especially the central sub-region, which seems to be in a more evolved stage

Multi-wavelength diagnostic properties of Galactic Planetary Nebulae detected by GLIMPSE-I

We uniformly analyze 136 optically detected PNe and candidates from the GLIMPSE-I survey in order to to develop robust, multi-wavelength, classification criteria to augment existing diagnostics and provide pure PN samples. PNe represent powerful astrophysical probes. They are important dynamical tracers, key sources of ISM chemical enrichment, windows into late stellar evolution, and potent cosmological yardsticks. But their utility depends on separating them unequivocally from the many nebular mimics which can strongly resemble bona fide PNe in traditional optical images and spectra. We merge new PNe from the carefully evaluated, homogeneous MASH-I and MASH-II surveys, which offer a wider evolutionary range of PNe than hitherto available, with previously known PNe classified by SIMBAD. Mid-infrared (MIR) measurements vitally complement optical data because they reveal other physical processes and morphologies via fine-structure lines, molecular bands and dust. MIR colour-colour planes, optical emission line ratios and radio fluxes show the unambiguous classification of PNe to be complex, requiring all available evidence. Statistical trends provide predictive value and we offer quantitative MIR criteria to determine whether an emission nebula is most likely to be a PN or one of the frequent contaminants such as compact HII regions or symbiotic systems. Prerequisites have been optical images and spectra but MIR morphology, colours, environment and a candidate's MIR/radio flux ratio provide a more rigorous classification. Our ultimate goal is to recognize PNe using only MIR and radio characteristics, enabling us to trawl for PNe effectively even in heavily obscured regions of the Galaxy.Comment: 32 pages, 18 figures, 10 table