Erosion Control in Chaco Canyon, New Mexico for the Preservation of Archaeological Sites

No accurate maps have been made of the whole region covered by this report. A very excellent aerial survey has been made of the Navajo Reservation, but this does not extend more than eight miles east of Wijiji, and does not show quite all of the Chaco canyon. No profile or cross-section of Chaco Canyon exists, except for the maps made by the National Parks Service. As these cover only about three-quarters of a mile, they are not of great assistance in matters concerned with the grade of the stream bed. They are a valuable start, however, and they have been drawn on freely for any information which they contain

Letter from W[illia]m M. Chauvenet to John Muir, 1909 Dec 28.

REGIS CHAUTENET. W. M. CHAUVENET.REGIS CHAUVENET & BROTHER.MINING ENGINEERSANALYTICAL CHEMISTS AND ASSAYERS.937 EQUITABLE BUILDING,DENVER.LABORATORIES:620 CHESTNUT STREET.St. Louis, Dec. 28-1909,John Muir,President of Society for the preservation of National Parks. 302 Mills Building, San Francisco. Dear Professor Muir,The information conveyed in your Statement of the Hetch-Hetchy case to date shocks me so deeply that I feel equal, could I get the chance, to eloquence enough and rage enough to stay any congress or to sway any convention.Your work, on mountain and on glacier I have delighted in from my college days, and my work in the mining school. With you and your dog Stickeen, I, too, have followed to the fountains of the Fairweather mountains- such a dog and such a man are worth following to the death- and so in many other adventures when the earth was shaking and the loose stones rolling from their ledges, have I run in with you to [dep ?] gorges, to see them rock and fall. In brief, my dear Sir, you have often made me glad in spirit and more brave in courage by your beautiful descriptions of things I love the best and to any cause,that is your cause, I would bring what help I can.The writing of letters to, officials in Washington has proved quite useless in the past, and yet again have I set some of my friends on the trail of this outrage which is sought by certain unnatural men in the West and whatever influence our Missouri Senators may exercise, I think I can command in some measure.The purpose of the men who would destroy the Hetch-Hetchy valley being the enrichment of themselves I do not think you need fear that the people will stand behind, any legislation which will allow such a crime. I send you Five dollars, only asking that you personally indorse the check and that you will command me in the service of this work when ever I may help here in Missouri. Would that it were more, and that I might in person talk with you about the matter in which I am so deeply interested.With great respect,[Illegible]0466

Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells

Methotrexate (MTX) is widely used for the treatment of childhood acute lymphoblastic leukemia (ALL). The accumulation of MTX and its active metabolites, methotrexate polyglutamates (MTXPG), in ALL cells is an important determinant of its antileukemic effects. We studied 194 of 356 patients enrolled on St. Jude Total XV protocol for newly diagnosed ALL with the goal of characterizing the intracellular pharmacokinetics of MTXPG in leukemia cells; relating these pharmacokinetics to ALL lineage, ploidy and molecular subtype; and using a folate pathway model to simulate optimal treatment strategies. Serial MTX concentrations were measured in plasma and intracellular MTXPG concentrations were measured in circulating leukemia cells. A pharmacokinetic model was developed which accounted for the plasma disposition of MTX along with the transport and metabolism of MTXPG. In addition, a folate pathway model was adapted to simulate the effects of treatment strategies on the inhibition of de novo purine synthesis (DNPS). The intracellular MTXPG pharmacokinetic model parameters differed significantly by lineage, ploidy, and molecular subtypes of ALL. Folylpolyglutamate synthetase (FPGS) activity was higher in B vs T lineage ALL (p<0.005), MTX influx and FPGS activity were higher in hyperdiploid vs non-hyperdiploid ALL (p<0.03), MTX influx and FPGS activity were lower in the t(12;21) (ETV6-RUNX1) subtype (p<0.05), and the ratio of FPGS to γ-glutamyl hydrolase (GGH) activity was lower in the t(1;19) (TCF3-PBX1) subtype (p<0.03) than other genetic subtypes. In addition, the folate pathway model showed differential inhibition of DNPS relative to MTXPG accumulation, MTX dose, and schedule. This study has provided new insights into the intracellular disposition of MTX in leukemia cells and how it affects treatment efficacy

Training future generations to deliver evidence-based conservation and ecosystem management

1. To be effective, the next generation of conservation practitioners and managers need to be critical thinkers with a deep understanding of how to make evidence-based decisions and of the value of evidence synthesis. 2. If, as educators, we do not make these priorities a core part of what we teach, we are failing to prepare our students to make an effective contribution to conservation practice. 3. To help overcome this problem we have created open access online teaching materials in multiple languages that are stored in Applied Ecology Resources. So far, 117 educators from 23 countries have acknowledged the importance of this and are already teaching or about to teach skills in appraising or using evidence in conservation decision-making. This includes 145 undergraduate, postgraduate or professional development courses. 4. We call for wider teaching of the tools and skills that facilitate evidence-based conservation and also suggest that providing online teaching materials in multiple languages could be beneficial for improving global understanding of other subject areas.Peer reviewe

A Manual of Spherical and Practical Astonomy

Contiene: T.I. Spherical Astronomy -- T.II. Theory and use of Astronomical Instruments Method of Least Square

A treatise on plane and spherical trigonometry.

Mode of access: Internet

A manual of spherical and practical astronomy, embracing the general problems of spherical astronomy, the special applications to nautical astronomy, and the theory and use of fixed and portable astronomical instruments, with an appendix on the method of least squares.

At head of title: University edition.v. 1. Spherical astronomy.--v. 2. Theory and use of astronomical instruments. Methods of least squares.Mode of access: Internet