Warm stellar matter with deconfinement: application to compact stars

We investigate the properties of mixed stars formed by hadronic and quark matter in $\beta$-equilibrium described by appropriate equations of state (EOS) in the framework of relativistic mean-field theory. We use the non- linear Walecka model for the hadron matter and the MIT Bag and the Nambu-Jona-Lasinio models for the quark matter. The phase transition to a deconfined quark phase is investigated. In particular, we study the dependence of the onset of a mixed phase and a pure quark phase on the hyperon couplings, quark model and properties of the hadronic model. We calculate the strangeness fraction with baryonic density for the different EOS. With the NJL model the strangeness content in the mixed phase decreases. The calculations were performed for T=0 and for finite temperatures in order to describe neutron and proto-neutron stars. The star properties are discussed. Both the Bag model and the NJL model predict a mixed phase in the interior of the star. Maximum allowed masses for proto-neutron stars are larger for the NJL model ($\sim 1.9$ M$_{\bigodot}$) than for the Bag model ($\sim 1.6$ M$_{\bigodot}$).Comment: RevTeX,14 figures, accepted to publication in Physical Review

Magnetic Field Generation in Stars

Enormous progress has been made on observing stellar magnetism in stars from the main sequence through to compact objects. Recent data have thrown into sharper relief the vexed question of the origin of stellar magnetic fields, which remains one of the main unanswered questions in astrophysics. In this chapter we review recent work in this area of research. In particular, we look at the fossil field hypothesis which links magnetism in compact stars to magnetism in main sequence and pre-main sequence stars and we consider why its feasibility has now been questioned particularly in the context of highly magnetic white dwarfs. We also review the fossil versus dynamo debate in the context of neutron stars and the roles played by key physical processes such as buoyancy, helicity, and superfluid turbulence,in the generation and stability of neutron star fields. Independent information on the internal magnetic field of neutron stars will come from future gravitational wave detections. Thus we maybe at the dawn of a new era of exciting discoveries in compact star magnetism driven by the opening of a new, non-electromagnetic observational window. We also review recent advances in the theory and computation of magnetohydrodynamic turbulence as it applies to stellar magnetism and dynamo theory. These advances offer insight into the action of stellar dynamos as well as processes whichcontrol the diffusive magnetic flux transport in stars.Comment: 41 pages, 7 figures. Invited review chapter on on magnetic field generation in stars to appear in Space Science Reviews, Springe

Volume I. Introduction to DUNE

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE\u27s physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Deep Underground Neutrino Experiment (DUNE), far detector technical design report, volume III: DUNE far detector technical coordination

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume III of this TDR describes how the activities required to design, construct, fabricate, install, and commission the DUNE far detector modules are organized and managed. This volume details the organizational structures that will carry out and/or oversee the planned far detector activities safely, successfully, on time, and on budget. It presents overviews of the facilities, supporting infrastructure, and detectors for context, and it outlines the project-related functions and methodologies used by the DUNE technical coordination organization, focusing on the areas of integration engineering, technical reviews, quality assurance and control, and safety oversight. Because of its more advanced stage of development, functional examples presented in this volume focus primarily on the single-phase (SP) detector module

Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

The DUNE far detector vertical drift technology. Technical design report

DUNE is an international experiment dedicated to addressing some of the questions at the forefront of particle physics and astrophysics, including the mystifying preponderance of matter over antimatter in the early universe. The dual-site experiment will employ an intense neutrino beam focused on a near and a far detector as it aims to determine the neutrino mass hierarchy and to make high-precision measurements of the PMNS matrix parameters, including the CP-violating phase. It will also stand ready to observe supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector implements liquid argon time-projection chamber (LArTPC) technology, and combines the many tens-of-kiloton fiducial mass necessary for rare event searches with the sub-centimeter spatial resolution required to image those events with high precision. The addition of a photon detection system enhances physics capabilities for all DUNE physics drivers and opens prospects for further physics explorations. Given its size, the far detector will be implemented as a set of modules, with LArTPC designs that differ from one another as newer technologies arise. In the vertical drift LArTPC design, a horizontal cathode bisects the detector, creating two stacked drift volumes in which ionization charges drift towards anodes at either the top or bottom. The anodes are composed of perforated PCB layers with conductive strips, enabling reconstruction in 3D. Light-trap-style photon detection modules are placed both on the cryostat's side walls and on the central cathode where they are optically powered. This Technical Design Report describes in detail the technical implementations of each subsystem of this LArTPC that, together with the other far detector modules and the near detector, will enable DUNE to achieve its physics goals

Linking pan-European land cover change to pressures on biodiversity - Biopress final report 1st January 2003 - 31st December 2005, sections 1 to 4

BIOPRESS – Linking pan-European land cover change to pressures on biodiversity – is a 3 year EC-FPV project funded in the framework of the GMES ‘Global Monitoring for Environment and Security’ initiative (http://gmes.fdc.fr/what_is/home.html). It was the only GMES project under the priority theme "Land cover change in Europe”. BIOPRESS’s main goal was to provide the EU-user community with quantitative information on how changes in land cover and land use has affected the environment and biodiversity in Europe. The project aimed at producing consistent and coherent sets of historical (1950 – 1990 – 2000) land cover change information in and around circa 75 Natura2000 sites located from the boreal to the Mediterranean, and from the Atlantic to the continental regions of Europe. These land cover change statistics would be converted into quantitative measures of pressures on biodiversity through the integration of socio-economic indicators. The impact of the land cover changes on biodiversity would also be assessed. The change statistics were produced by means of two parallel activities, the backdating of CORINE land cover 1990 of circa 75 windows (30km x30km) with aerial photography of the 1950’ies and, the interpretation of aerial photography from 1950, 1990 and 2000 for circa 50 transects (2km x 15km). The windows were interpreted to identify the CORINE level 3 land cover and use classes to a minimum mapping unit of 25 ha. The transects, at the other hand, were interpreted to a minimum mapping unit of 0.5 ha. Scientific achievements: Data access The BIOPRESS team established an operational online access point for metadata and data of relevant European datasets. The European data policy appears to be the major obstacle for easy access to European datasets even in case of projects that are financed by the European Commission. The INSPIRE initiative as well as the GMES framework could benefit from the experiences made in the BIOPRESS project in order to streamline access to European wide data relevant for environmental monitoring. Land Cover change The methodological development for production of land cover change matrices was completed successfully ensuring the BIOPRESS team had the appropriate tools (list of 30km x 30km window sites, list of 2km x 15km transect sites, interpretation manual, quality assurance protocol and meta database designed to follow progress) and material (aerial photography) to successfully carry out the photo to photo (1950 – 1990 – 2000) interpretation of transects and CORINE Land Cover 1990 backdating (1950-1990). Several of the tools, in particular the interpretation manuals, have the potential of being adopted by GMES services and future EU projects (The GEOLAND and GSELAND projects were given copies of the manuals on request). A total of 57 transects and 73 windows were interpreted. The results were stored in a database. The database will be made available to the wider research community in 2007. The total extent of land cover changes that have occurred within all BIOPRESS windows account only to 9,62 % of the total measured area. In other words, 90,38% of the measured area within the BIOPRESS windows have shown no change of land cover at all. Overall the most important land cover conversions based on CORINE level 2 nomenclature can be summarised as one of the following: • FROM shrub and/or herbaceous vegetation association TO forests, and its inverse conversion, FROM forest TO shrub and/or herbaceous vegetation association • FROM heterogeneous agricultural areas TO urban fabric, as well as TO forest • FROM arable land TO industrial, commercial, and transport units. Because the focus was on biodiversity and historical land cover changes, it was clear from the start that Europe had to be sampled. Bias was introduced in the BIOPRESS samples by (1) relying on an expert to select a superset of samples including Natura 2000 sites and (2) the availability of aerial photography. The project’s resources limited the total number of samples acquired. As a result some bio-geographical regions were under represented in the sample (Boreal and Mediterranean) whilst other regions were over represented (the Alpine, Atlantic, and Continental). So the development of an appropriate extrapolation approach was seen as a challenge from the beginning of the project. The key was to produce information which is useable in the data integration and which is meaningful, and reliable enough for use by our key stakeholder, the EEA. An extensive sensitivity analysis and the development of minimum land cover accordance maps have provided an excellent insight in the acquired land cover change data with respect to samples’ representativeness of biogeographical areas and land cover. Quality assurance and error propagation The following problems were identified as the main sources of possible mistakes and lack of correspondence in windows: • Ambiguity of CLC classes delineation. • Quality of B&W AP. • Availability of ancillary data. • Separation of CLC classes in B&W AP (E.g. burnt areas). • Diversity within class definition. • Occurrence of polygon less than 0.5 ha. • Amalgamation of objects less than 0.5 ha. • Real changes omitted. • Identification of questionable changes. • Identification of point and linear features, questionable, ambiguity and unknown relevance The quality of the input data was comparable for all transects, indicating that the comparability of results between partners and transects was unlikely to have been influenced by the quality of the input data. The date of the aerial photos (1950, 1990 or 2000) proved to have no influence on the thematic consistency of the interpretations whereas the level of thematic detail did have a high impact. The geometric accuracy was more difficult to evaluated, still we found that the controllers identified more spatial structures than the local interpreters. The quality of the interpretation depends on the land cover characteristics of the individual transects or windows. An error model was developed describing each step of the land cover change production chain. We found that most error sources which reduced the interpretation quality such as image quality, unclear class definition and confusion caused by lax use of land cover and land use attributes in the definitions, can be almost completely reduced by using modern data sources and adjusting the interpretation methodology. However, knowledge and experience of the interpreter play an important role in manual visual interpretation of remotely sensed data. Land cover change and pressures A land cover change - pressure association matrix was developed. This matrix enabled the grouping of types of land cover changes related to one of the six pressures under consideration in BIOPRESS: Urbanisation, intensification, afforestation, deforestation, abandonment and drainage. This cross-tabulation matrix is a fundamental starting point in the analysis of land cover change, because it provides a national-scale assessment of not only the losses or gains in the area of specific land categories but what these changes represent in terms of types of pressures However, additional research is needed to analyse this matrix according to its various components in order to gain more insight into the potential processes that determine a pattern of land cover change. It was impossible to derive a simple and practical list of indicators that would consistently explain the pressures on biodiversity. It was clear that there were multiple potential indicators, and the best indicators have not simply appeared out from the extensive data and information that already existed. In essence, the search for a coherent set of pressure indicators was a frustrating and time-consuming activity. It is clear from our effort that a single set of indicators would never explain the whole dynamics of anthropogenic pressures on biodiversity, and would go only some way towards meeting the needs for understanding the observed land cover changes. The main research challenge faced was to define a pattern-process model of land cover dynamics in space and time in order to combine the local level measurement of the land cover changes (e.g. BIOPRESS windows) and the socio-economic indicators of a larger region (e.g. the countries). The proposed multi-representation model is based on the degree of variability in the behaviour of generalised statistics and their dependency of the spatial generalisation of the variable values at different spatial scales. A systematic analysis of spatial coincidence between land cover types in CLC1990 and Annex1 habitat types recorded in Natura 2000 sites was carried out, translated into the EUNIS habitat classification and summarised per Biogeographical region. The work showed that a significant improvement could be made by adopting a regional approach providing neater and more specific links between CLC classes and habitats than what has been available so far. It also identifies what the limitations are in attributing habitat types to CLC classes. We found that the BIOPRESS land cover change product was suitable for quantifying some pressures on biodiversity but quite insufficient for the interpretation of land cover change related to other pressures: • BIOPRESS contributed very positively to the quantification of urbanization across Europe between 1950 and 1990/2000. • BIOPRESS land cover product made a useful contribution to the quantification of afforestation and deforestation across Europe between 1950 and 1990 but that these pressures could be better understood if (i) we had more points in time, closer together and (ii) more information on the condition of forest was derived from remote sensing and/or ancillary data was used to evaluate the ecological value of forested land. • BIOPRESS will have underestimated the extent to which the pressure land abandonment is threatening biodiversity in Europe, in comparison to other existing assessments (e.g. MIRABEL but also national scale statements). However, it would be possible to increase the accuracy and the generic value of the BIOPRESS estimates by (i) broadening the definition of land abandonment i.e. modifying the pressure matrix, so that it matches what is meant in other assessments and (ii) by increasing the number of points in time. • BIOPRESS was probably the first project to provide quantitative estimates about the shift from small scale to more large scale agriculture for such a large sample area across Europe and in this respect, this is a very important contribution to understanding changes in European biodiversity. However it is important to keep in mind that what has been quantified within BIOPRESS was only a small part of what is usually understood by farming intensification in biodiversity assessments. This means that, as was the case for land abandonment, BIOPRESS results will greatly underestimate the pressure farming intensification, compared to other assessments. The main conclusion is that remote sensing products such as the BIOPRESS land cover change product can provide very helpful information in the field of biodiversity assessment. There is potential for improving this information, e.g. by adding time steps in the monitoring or using external data to help in the interpretation of land cover change. However, our work also shows that there are clear limitations in this contribution and that remote sensing will only provide part of the information. One important recommendation that would lead to improve facilities for large scale biodiversity monitoring would be the integration of remote sensing products with in situ information. This recommendation forms the basis of a position paper produced jointly by BIOHAB (FP5 funded Concerted Action) and BIOPRESS. Socio-economic relevance and policy implications: The project supported the needs of DG-Environment and EEA in helping to implement and assess European policy on nature and biodiversity and contribute to the objective of enhancing the quality of the environment by helping to understand pressures on biodiversity arising from land cover change in the member states and accession countries. The state of the environment is perceived as an important indicator of a high quality of life by a majority of European citizens. The European public increasingly expresses the wish to be informed by policy on the perceived threats to biodiversity. BIOPRESS supported the development of a European capacity for monitoring the state of the environment (GMES) to meet these information needs. Conclusions: BIOPRESS was one of the first wave of thematic projects which were funded through the GMES initiative. As a result its main objective was to produce information at European level which in the case of BIOPRESS was information on historical land cover change for the purpose of assessing past pressures on habitats and their associated biodiversity. A large part of the project’s resources were used to deliver the land cover change database successfully and the outcome has not only been the delivery of data but also a set of tools for future European wide land cover monitoring. The real challenge was when trying to establish a link between land cover change and pressures on biodiversity. The development of the land cover change - pressure association matrix as a first step enabled the grouping of types of land cover changes related to one of the six pressures under consideration in BIOPRESS. This matrix has the potential to enhance the similar ‘Land Cover Flow’ matrix developed by the EEA as part of the EEA Land Accounting System. In theory the idea of integrating socio-economic data with land cover change data made sense but in practice the team struggled with the wide variety of data types, spatial and temporal resolutions. To assess the consequences of the observed Land cover changes on habitats and their biodiversity, BIOPRESS impact tables were developed using the same conceptual approach as that establish for the DPSIR assessment MIRABEL. The overall agreement between MIRABEL and the BIOPRESS tables, which unlike MIRABLE provided quantitative estimates for a selected sample of land in each region, was an important result. This part of the work concluded that a land cover change product such as that produced by BIOPRESS was suitable for quantifying some pressures on biodiversity but quite insufficient for the interpretation of land cover change related to other pressures. The error propagation, quality assessment and data search exercises highlighted the importance of the availability of good quality, affordable data (e.g. aerial photography, digital elevation data, social and economic indicators) which for long term monitoring should be continuously collected in a consistent manner