Investigating Astromaterials Curation Applications for Dexterous Robotic Arms

The Astromaterials Acquisition and Curation office at NASA Johnson Space Center is currently investigating tools and methods that will enable the curation of future astromaterials collections. Size and temperature constraints for astromaterials to be collected by current and future proposed missions will require the development of new robotic sample and tool handling capabilities. NASA Curation has investigated the application of robot arms in the past, and robotic 3-axis micromanipulators are currently in use for small particle curation in the Stardust and Cosmic Dust laboratories. While 3-axis micromanipulators have been extremely successful for activities involving the transfer of isolated particles in the 5-20 micron range (e.g. from microscope slide to epoxy bullet tip, beryllium SEM disk), their limited ranges of motion and lack of yaw, pitch, and roll degrees of freedom restrict their utility in other applications. For instance, curators removing particles from cosmic dust collectors by hand often employ scooping and rotating motions to successfully free trapped particles from the silicone oil coatings. Similar scooping and rotating motions are also employed when isolating a specific particle of interest from an aliquot of crushed meteorite. While cosmic dust curators have been remarkably successful with these kinds of particle manipulations using handheld tools, operator fatigue limits the number of particles that can be removed during a given extraction session. The challenges for curation of small particles will be exacerbated by mission requirements that samples be processed in N2 sample cabinets (i.e. gloveboxes). We have been investigating the use of compact robot arms to facilitate sample handling within gloveboxes. Six-axis robot arms potentially have applications beyond small particle manipulation. For instance, future sample return missions may involve biologically sensitive astromaterials that can be easily compromised by physical interaction with a curator; other potential future returned samples may require cryogenic curation. Robot arms may be combined with high resolution cameras within a sample cabinet and controlled remotely by curator. Sophisticated robot arm and hand combination systems can be programmed to mimic the movements of a curator wearing a data glove; successful implementation of such a system may ultimately allow a curator to virtually operate in a nitrogen, cryogenic, or biologically sensitive environment with dexterity comparable to that of a curator physically handling samples in a glove box

Meca500 Robotic Arm Developments Towards Astromaterials Curation Applications

As a part of the ongoing efforts to develop new curation tools and techniques for astromaterials within the Astromaterials Acquisition and Curation office at NASAs Johnson Space Center, we are developing a variety of manually and electrically controlled micromanipulation systems. Most current techniques require manual manipulation, and in some cases the manipulation task is being done entirely freehand. The motorized systems avail-able are restricted to three degrees of freedom and use proprietary control systems. For example, the MicroSupport AxisPro manipulation system currently used in microscale particle experiments is limited in its range of motion, as it can only move the manipulators in a three axis Cartesian range over a predetermined area above microscope slides. While having an efficient user interface, the control system is proprietary and prevents custom development and optimization to extend the viable applications of the system. In order to address some of these limitations, we have been testing robotic designs with multiple degrees of freedom and of a variety of designs. We are currently investigating the Meca500 robotic arm by Mecademic as a potential manipulation system to overcome some of these obstacles

Lateral Gene Expression in Drosophila Early Embryos Is Supported by Grainyhead-Mediated Activation and Tiers of Dorsally-Localized Repression

The general consensus in the field is that limiting amounts of the transcription factor Dorsal establish dorsal boundaries of genes expressed along the dorsal-ventral (DV) axis of early Drosophila embryos, while repressors establish ventral boundaries. Yet recent studies have provided evidence that repressors act to specify the dorsal boundary of intermediate neuroblasts defective (ind), a gene expressed in a stripe along the DV axis in lateral regions of the embryo. Here we show that a short 12 base pair sequence (“the A-box”) present twice within the ind CRM is both necessary and sufficient to support transcriptional repression in dorsal regions of embryos. To identify binding factors, we conducted affinity chromatography using the A-box element and found a number of DNA-binding proteins and chromatin-associated factors using mass spectroscopy. Only Grainyhead (Grh), a CP2 transcription factor with a unique DNA-binding domain, was found to bind the A-box sequence. Our results suggest that Grh acts as an activator to support expression of ind, which was surprising as we identified this factor using an element that mediates dorsally-localized repression. Grh and Dorsal both contribute to ind transcriptional activation. However, another recent study found that the repressor Capicua (Cic) also binds to the A-box sequence. While Cic was not identified through our A-box affinity chromatography, utilization of the same site, the A-box, by both factors Grh (activator) and Cic (repressor) may also support a “switch-like” response that helps to sharpen the ind dorsal boundary. Furthermore, our results also demonstrate that TGF-β signaling acts to refine ind CRM expression in an A-box independent manner in dorsal-most regions, suggesting that tiers of repression act in dorsal regions of the embryo

AGED 539 Graduate Project

This internship report contains documented evidence required in meeting the quality criteria used to evaluate Community College Programs. These criteria were established by the Agriculture/Natural Resources Advisory Committee and are used to evaluate Community Colleges throughout California. In addition to documented evidence, the internship report also includes a special project on Program Effectiveness. The project created a degree qualification profile for the Agriculture Science and Technology degree at West Hills College, Coalinga which was approved by the DQPP committee at West Hills College, Coalinga. The DQP describes five basic areas of learning: Broad, Integrative Knowledge; Specialized Knowledge; Intellectual Skills; Applied Learning; and Civic Learning. Associates Degree DQP is as a framework for aligning institutional, program, and student learning outcomes, and for developing effective assessment strategies. The DQPP assists in the evaluation and revision of degree-level student learning outcomes for increased student achievement

Community Cohesion, Communitarianism and Neoliberalism

Policy discourse around ‘community cohesion’ has displaced liberal multiculturalist and anti-racist approaches with a much narrower focus on the promotion of ‘British values’ and, for minority communities, through a ‘faith’ agenda. We argue that these developments derive from the predominance of the doctrine of communitarianism within the contemporary policy terrain, influencing both New Labour and the Conservatives. The convergence of this with neoliberal social and economic imperatives has created a discourse of ‘conditional citizenship’ for Muslim communities particularly. There is a major policy contradiction where faith based approaches are promoted on one hand, but, in the context of transnational Islamist terror, lead to whole Muslim communities being pathologised as ‘insufficiently British’ on the other. We discuss the ‘Trojan Horse schools’ affair in Birmingham in 2014 as an example of this. We conclude in calling for an urgent refocussing of the debate toward secular approaches in policy, alongside looking at the specific economic and social conditions that we argue are the root cause of breakdowns in community cohesion

Letter, Elliot C. Cowden to Salmon P. Chase, September 2, 1862

This handwritten letter, dated September 2, 1862, is written from Elliot C. Cowden to Salmon P. Chase discussing the incompetence of the newly elected U. S. Collector for the 4th District of New York, John Mack, and requests Chase to investigate a possible removal. The letter is written on Elliot C. Cowdin and Co. letterhead.https://scholarsjunction.msstate.edu/fvw-manuscripts-original-manuscripts/1129/thumbnail.jp

Mental Toughness in South African Youth: Relationships With Forgivingness and Attitudes Towards Risk

Young people are particularly vulnerable to health risk behaviors and interpersonal violence, stimulating scholars’ attention towards identifying factors that may reduce the likelihood that these actions will occur. Associated with positive outcomes in a variety of domains, mental toughness in young people might protect them from engaging in potentially deleterious interpersonal or health-risk behaviors, while potentially promoting positive psychological behaviors. Within this framework, the present study investigated the relationships between mental toughness, attitudes towards physical and psychological risk-taking, and trait forgiveness in a sample of 123 (males = 54, females = 69) South African youth (M age = 23.97 years, SD = 4.46). Univariate and multivariate analyses indicated higher levels of mental toughness were associated with being more forgiving, (η2pηp2 = .036), perceiving physical risk-taking more positively (η2pηp2 = .062), but having more negative attitudes towards psychological risk-taking (η2pηp2 = .036). These findings give credence to mental toughness as a psychological characteristic involved in youth risk-taking perceptions and interpersonal functioning. Future research might explore the integration of mental toughness into the development of future youth risk behavior interventions

Elucidating the aetiology of human Campylobacter coli infections

Peer reviewedPublisher PD

Measurement of the top quark-pair production cross section with ATLAS in pp collisions at \sqrt{s}=7\TeV

A measurement of the production cross-section for top quark pairs(\ttbar) in $pp$ collisions at \sqrt{s}=7 \TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in two different topologies: single lepton (electron $e$ or muon $\mu$) with large missing transverse energy and at least four jets, and dilepton ($ee$, $\mu\mu$ or $e\mu$) with large missing transverse energy and at least two jets. In a data sample of 2.9 pb-1, 37 candidate events are observed in the single-lepton topology and 9 events in the dilepton topology. The corresponding expected backgrounds from non-\ttbar Standard Model processes are estimated using data-driven methods and determined to be $12.2 \pm 3.9$ events and $2.5 \pm 0.6$ events, respectively. The kinematic properties of the selected events are consistent with SM \ttbar production. The inclusive top quark pair production cross-section is measured to be \sigmattbar=145 \pm 31 ^{+42}_{-27} pb where the first uncertainty is statistical and the second systematic. The measurement agrees with perturbative QCD calculations.Comment: 30 pages plus author list (50 pages total), 9 figures, 11 tables, CERN-PH number and final journal adde

Inclusive search for same-sign dilepton signatures in pp collisions at root s=7 TeV with the ATLAS detector

An inclusive search is presented for new physics in events with two isolated leptons (e or mu) having the same electric charge. The data are selected from events collected from p p collisions at root s = 7 TeV by the ATLAS detector and correspond to an integrated luminosity of 34 pb(-1). The spectra in dilepton invariant mass, missing transverse momentum and jet multiplicity are presented and compared to Standard Model predictions. In this event sample, no evidence is found for contributions beyond those of the Standard Model. Limits are set on the cross-section in a fiducial region for new sources of same-sign high-mass dilepton events in the ee, e mu and mu mu channels. Four models predicting same-sign dilepton signals are constrained: two descriptions of Majorana neutrinos, a cascade topology similar to supersymmetry or universal extra dimensions, and fourth generation d-type quarks. Assuming a new physics scale of 1 TeV, Majorana neutrinos produced by an effective operator V with masses below 460 GeV are excluded at 95% confidence level. A lower limit of 290 GeV is set at 95% confidence level on the mass of fourth generation d-type quarks