Alison Smith-Palmer

AR Domingues

C Little

CC Tam

CR Friedman

DJ Wilson

E Scallan

Emma Sproston

FJ Gormley

Francois Roux

GL Nichols

IA Gillespie

ID Ogden

J Neimann

JE Moore

JK Pritchard

John Cowden

KE Dingle

Ken J. Forbes

KJ Forbes

L Mancino

Marion MacRae

Martin C. J. Maiden

MJ Blaser

N McCarthy

NJ Strachan

Norval J. C. Strachan

Ovidiu Rotariu

P Mullner

Paul Bessell

PR Bessell

PR Hunter

R Karenlampi

RS Kovats

Samuel K. Sheppard

SEF Spencer

SK Sheppard

SM Horrocks

Thomas Alter

X Didelot

Y Doorduyn

PLoS ONE

English

PubMed

Crossref

Elucidating the Aetiology of Human Campylobacter coli Infections

Roux Francois

Sproston Emma

Rotariu Ovidiu

MacRae Marion

Sheppard Samuel K.

Bessell Paul

Smith-Palmer Alison

Cowden John

Maiden Martin C. J.

Forbes Ken J.

Strachan Norval J. C.

Public Library of Science (PLOS)

 Infections

There has been little research on the determinants of Campylobacter coli infection, despite its contributing up to 10% of human Campylobacter infections. A case-control and two case-case study methods explored the aetiology of C. coli over a one year period across Scotland. The case-control multivariate model found an increased risk of C. coli infection in people older than 19 years (O.R. = 3.352), and during the summer months (O.R. = 2.596), while residing in an urban area decreased the risk (O.R. = 0.546). The first case-case study compared C. coli and C. jejuni cases and also showed a higher risk of C. coli during the summer (O.R. = 1.313) and in people older than 19 years (O.R. = 0.791). Living in an urban area was associated with a reduced risk of infection (O.R. = 0.769). Multi-locus sequence typing (MLST) indicated that sheep and chicken C. coli sequence types (STs) were most frequently found in humans whilst those from cattle and pigs were rarer. MLST diversity was high in isolates from pigs and chicken, intermediate in human isolates, and low in ruminant isolates. The second case-case study used MLST data to ascribe putative sources of infection to the cases. The putative source for 40% of cases was chicken, with 60% acquired from other sources (ruminants 54% and pigs 6%). The case-case analysis also showed that female gender was a risk factor (O.R. = 1.940), which may be explained by females being more likely to prepare poultry in the home. These findings indicate differences between the aetiology of C. coli and C. jejuni infections: this should be taken into account by public health professionals when developing strategies to reduce the burden of human campylobacteriosis.</p

Roux, Francois

Sproston, Emma

Rotariu, Ovidiu

MacRae, Marion

Sheppard, Samuel K.

Bessell, Paul

Smith-Palmer, Alison

Cowden, John

Maiden, Martin C. J.

Forbes, Ken J.

Strachan, Norval J. C.

Edinburgh Research Explorer

Sheppard, Samuel K

Maiden, Martin C J

Forbes, Ken J

Strachan, Norval J C

Aberdeen University Research

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Food Standards Agency report for the UK survey of Campylobacter and Salmonella contamination of fresh chicken at retail sale.

Food survey information sheet 04/09. A UK survey of Campylobacter and Salmonella contamination of fresh chicken at retail sale.

Foodborne illness acquired in the united states–unspecified agents.

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Identifying the seasonal origins of human campylobacteriosis. Epidemiology and Infection

Incidence and ecology of Campylobacter jejuni and coli in animals.

Inference of bacterial microevolution using multilocus sequence data.

Inference of population structure using multilocus genotype data.

Investigating vomiting and/or bloody diarrhoea in Campylobacter jejuni infection.

Longitudinal study of Finnish Campylobacter jejuni and C. coli isolates from humans, using multilocus sequence typing, including comparison with epidemiological data and isolates from poultry and cattle.

Longitudinal study of infectious intestinal disease in the UK (IID2 study): Incidence in the community and presenting to general practice.

National antimicrobial resistance system, enteric bacteria, human isolates final report

Niche segregation and genetic structure of Campylobacter jejuni populations from wild and agricultural host species.

Numerical index of the discriminatory ability of typing systems: An application of Simpson’s index of diversity.

Risk factors for campylobacteriosis of chicken, ruminant, and environmental origin: A combined case-control and source attribution analysis. PloS one 7:e 42599.

Risk factors for indigenous Campylobacter jejuni and Campylobacter coli infections in the Netherlands: A case-control study.

Risk factors for sporadic campylobacter infection in the united states: A case-control study in FoodNet sites.

Sequence typing and comparison of population biology of Campylobacter coli and Campylobacter jejuni.

Sexual dimorphism in campylobacteriosis.

Source attribution of human campylobacteriosis using a meta-analysis of case-control studies of sporadic infections.

The growing UK epidemic of human campylobacteriosis.

The molecular epidemiology of scottish campylobacter isolates from human cases of infection using multilocus sequence typing (MLST).

The spatial and temporal determinants of campylobacteriosis notifications in New Zealand,

Tracing the source of campylobacteriosis.

Using sequence data to identify alternative routes and risk of infection: A case-study of campylobacter in Scotland. BMC Infectious Diseases 12: 80. Aetiology of Human Campylobacter coli

Who has time to cook? How family resources influence food preparation.

Elucidating the aetiology of human Campylobacter coli infections

There has been little research on the determinants of Campylobacter coli infection, despite its contributing up to 10% of human Campylobacter infections. A case-control and two case-case study methods explored the aetiology of C. coli over a one year period across Scotland. The case-control multivariate model found an increased risk of C. coli infection in people older than 19 years (O.R. = 3.352), and during the summer months (O.R. = 2.596), while residing in an urban area decreased the risk (O.R. = 0.546). The first case-case study compared C. coli and C. jejuni cases and also showed a higher risk of C. coli during the summer (O.R. = 1.313) and in people older than 19 years (O.R. = 0.791). Living in an urban area was associated with a reduced risk of infection (O.R. = 0.769). Multi-locus sequence typing (MLST) indicated that sheep and chicken C. coli sequence types (STs) were most frequently found in humans whilst those from cattle and pigs were rarer. MLST diversity was high in isolates from pigs and chicken, intermediate in human isolates, and low in ruminant isolates. The second case-case study used MLST data to ascribe putative sources of infection to the cases. The putative source for 40% of cases was chicken, with 60% acquired from other sources (ruminants 54% and pigs 6%). The case-case analysis also showed that female gender was a risk factor (O.R. = 1.940), which may be explained by females being more likely to prepare poultry in the home. These findings indicate differences between the aetiology of C. coli and C. jejuni infections: this should be taken into account by public health professionals when developing strategies to reduce the burden of human campylobacteriosis

Marion Macrae

Samuel K Sheppard

Martin C J Maiden

Ken J Forbes

Norval J C Strachan

Directory of Open Access Journals

Elucidating the aetiology of human Campylobacter coli infections.

<div>There has been little research on the determinants of Campylobacter coli infection, despite its contributing up to 10% of human Campylobacter infections. A case-control and two case-case study methods explored the aetiology of C. coli over a one year period across Scotland. The case-control multivariate model found an increased risk of C. coli infection in people older than 19 years (O.R. = 3.352), and during the summer months (O.R. = 2.596), while residing in an urban area decreased the risk (O.R. = 0.546). The first case-case study compared C. coli and C. jejuni cases and also showed a higher risk of C. coli during the summer (O.R. = 1.313) and in people older than 19 years (O.R. = 0.791). Living in an urban area was associated with a reduced risk of infection (O.R. = 0.769). Multi-locus sequence typing (MLST) indicated that sheep and chicken C. coli sequence types (STs) were most frequently found in humans whilst those from cattle and pigs were rarer. MLST diversity was high in isolates from pigs and chicken, intermediate in human isolates, and low in ruminant isolates. The second case-case study used MLST data to ascribe putative sources of infection to the cases. The putative source for 40% of cases was chicken, with 60% acquired from other sources (ruminants 54% and pigs 6%). The case-case analysis also showed that female gender was a risk factor (O.R. = 1.940), which may be explained by females being more likely to prepare poultry in the home. These findings indicate differences between the aetiology of C. coli and C. jejuni infections: this should be taken into account by public health professionals when developing strategies to reduce the burden of human campylobacteriosis.</div

Elucidating the aetiology of human Campylobacter coli infections

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