154 research outputs found
Electron-correlation effects in appearance-potential spectra of Ni
Spin-resolved and temperature-dependent appearance-potential spectra of
ferromagnetic Nickel are measured and analyzed theoretically. The Lander
self-convolution model which relates the line shape to the unoccupied part of
the local density of states turns out to be insufficient. Electron correlations
and orbitally resolved transition-matrix elements are shown to be essential for
a quantitative agreement between experiment and theory.Comment: LaTeX, 6 pages, 2 eps figures included, Phys. Rev. B (in press
Theory of Spin-Resolved Auger-Electron Spectroscopy from Ferromagnetic 3d-Transition Metals
CVV Auger electron spectra are calculated for a multi-band Hubbard model
including correlations among the valence electrons as well as correlations
between core and valence electrons. The interest is focused on the
ferromagnetic 3d-transition metals. The Auger line shape is calculated from a
three-particle Green function. A realistic one-particle input is taken from
tight-binding band-structure calculations. Within a diagrammatic approach we
can distinguish between the \textit{direct} correlations among those electrons
participating in the Auger process and the \textit{indirect} correlations in
the rest system. The indirect correlations are treated within second-order
perturbation theory for the self-energy. The direct correlations are treated
using the valence-valence ladder approximation and the first-order perturbation
theory with respect to valence-valence and core-valence interactions. The
theory is evaluated numerically for ferromagnetic Ni. We discuss the
spin-resolved quasi-particle band structure and the Auger spectra and
investigate the influence of the core hole.Comment: LaTeX, 12 pages, 8 eps figures included, Phys. Rev. B (in press
Long-term psychosocial functioning after Ilizarov limb lengthening during childhood: 37 patients followed for 2–14 years
Background and purpose Few studies have been concerned with the patient's perception of the outcome of limb lengthening. We describe the psychological and social functioning after at least 2 years of follow-up in patients who had had a leg length discrepancy and who had undergone an Ilizarov limb lengthening procedure
Modelling CO formation in the turbulent interstellar medium
We present results from high-resolution three-dimensional simulations of
turbulent interstellar gas that self-consistently follow its coupled thermal,
chemical and dynamical evolution, with a particular focus on the formation and
destruction of H2 and CO. We quantify the formation timescales for H2 and CO in
physical conditions corresponding to those found in nearby giant molecular
clouds, and show that both species form rapidly, with chemical timescales that
are comparable to the dynamical timescale of the gas.
We also investigate the spatial distributions of H2 and CO, and how they
relate to the underlying gas distribution. We show that H2 is a good tracer of
the gas distribution, but that the relationship between CO abundance and gas
density is more complex. The CO abundance is not well-correlated with either
the gas number density n or the visual extinction A_V: both have a large
influence on the CO abundance, but the inhomogeneous nature of the density
field produced by the turbulence means that n and A_V are only poorly
correlated. There is a large scatter in A_V, and hence CO abundance, for gas
with any particular density, and similarly a large scatter in density and CO
abundance for gas with any particular visual extinction. This will have
important consequences for the interpretation of the CO emission observed from
real molecular clouds.
Finally, we also examine the temperature structure of the simulated gas. We
show that the molecular gas is not isothermal. Most of it has a temperature in
the range of 10--20 K, but there is also a significant fraction of warmer gas,
located in low-extinction regions where photoelectric heating remains
effective.Comment: 37 pages, 15 figures; minor revisions, matches version accepted by
MNRA
Absence of Metallization in Solid Molecular Hydrogen
Being the simplest element with just one electron and proton the electronic
structure of the Hydrogen atom is known exactly. However, this does not hold
for the complex interplay between them in a solid and in particular not at high
pressure that is known to alter the crystal as well as the electronic
structure. Back in 1935 Wigner and Huntington predicted that at very high
pressure solid molecular hydrogen would dissociate and form an atomic solid
that is metallic. In spite of intense research efforts the experimental
realization, as well as the theoretical determination of the crystal structure
has remained elusive. Here we present a computational study showing that the
distorted hexagonal P6/m structure is the most likely candidate for Phase
III of solid hydrogen. We find that the pairing structure is very persistent
and insulating over the whole pressure range, which suggests that metallization
due to dissociation may precede eventual bandgap closure. Due to the fact that
this not only resolve one of major disagreement between theory and experiment,
but also excludes the conjectured existence of phonon-driven superconductivity
in solid molecular hydrogen, our results involve a complete revision of the
zero-temperature phase diagram of Phase III
Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.
While aspirin is generally effective for prevention of cardiovascular disease, considerable variation in drug response exists, resulting in some individuals displaying high on-treatment platelet reactivity. We used pharmacometabolomics to define pathways implicated in variation of response to treatment. We profiled serum samples from healthy subjects pre- and postaspirin (14 days, 81 mg/day) using mass spectrometry. We established a strong signature of aspirin exposure independent of response (15/34 metabolites changed). In our discovery (N = 80) and replication (N = 125) cohorts, higher serotonin levels pre- and postaspirin correlated with high, postaspirin, collagen-induced platelet aggregation. In a third cohort, platelets from subjects with the highest levels of serotonin preaspirin retained higher reactivity after incubation with aspirin than platelets from subjects with the lowest serotonin levels preaspirin (72 ± 8 vs. 61 ± 11%, P = 0.02, N = 20). Finally, ex vivo, serotonin strongly increased platelet reactivity after platelet incubation with aspirin (+20%, P = 4.9 × 10(-4), N = 12). These results suggest that serotonin is implicated in aspirin response variability.Analytical BioScience
An Analysis and Improvement of the Predictive Control Integrating Component
integrator wind-up and, therefore, it is recommended that separate weighting be used with a modified integrating component predictive controller. The separate weighting also improves the designers intuition with respect to tuning the controller, significantly reducing the time required to generate desired closed loop responses. References Clarke, D. W., and Mohtadi, C, 1987, "Properties of Generalized Predictive Control," World Congress IFAC, Munich. Cutler, C. R., and Ramaker, B. L., 1979, "Dynamic Matrix Control-A Computer Control Algorithm," A.I.Ch.E., 86th National Meeting, Apr. Kurfess, T. R., Whitney, D. E., and Brown, M. L., 1988, "Verification of a Dynamic Grinding Model," ASME JOURNAL OF DYNAMIC SYSTEMS, MEAS-UREMENT, AND CONTROL, Dec., Vol. 110, Kurfess, T. R., 1989 "Predictive Control of a Robotic Weld Bead Grinding System," Ph.D. thesis, MIT Department of Mechanical Engineering. Kurfess, T. R., and Whitney, D. E., 1989, "Predictive Control of a Robotic Grinding System," Proceedings of the NMTBA Eastern Manufacturing Technology Conference, Hartford, CT, Oct. Kurfess, T. R., Whitney, D. E., 1989, "An Analysis and Improvement of the Predictive Control Integrating Component," ASME JOURNAL OF DYNAMIC SYS-TEMS, MEASUREMENT, AND CONTROL, submitted Dec. Kwakernaak, H., and Sivan, R., 1972 Introduction The usefulness of observers for real-time state estimation of linear dynamic systems based on measured system outputs is well known. Procedures for designing observers Another approach to robust state estimation has centered upon the fact that the estimated state is often used for feedback control. Hence, the criterion for observer design in these cases is to reduce the effect of modeling errors on the controlled system response. The work of The current work on robust state estimation using observers is motivated by the need to estimate pressure and temperature fields in thermoplastic injection molding processes, based on a few measurement locations in the mold cavity. Robustness of the estimate to errors in the process model is essential for this application given the complexity of the process. The initial use of the estimated pressure and temperature fields is for more effective process monitoring rather than for feedback control. The robustness of the state estimates obtained using observers, in the presence of system modeling error, is examined in this paper following the procedure of Determination of State Estimation Error Bound • Consider the linear time-invariant system described by x{t)=Ax(t) + Bu(t) y(t)=Cx(t) (1) subject to the initial condition x(0) = x 0 where A, B, and C are (nxn), (nxp), and (mxn) matrices, respectively, and x(t), u{t), and y(t) are («xl), (pxl) and (m x 1) vectors, respectively. A full order observer is designed Copyright © 1993 by ASME based on this model to estimate the state x(t). The observer is described by x(t) =AJt(t) +B c u(t)+L(y(t) -y(t)) y(t)=Cx(t) (2) subject to the initial condition Note that modeling errors are permitted only in the A and B matrices and not in the C matrix. Let the estimation error be defined by Manipulation of subject to the initial condition e(0) = x(0)-x(0) = e 0 (5) The eigenvalues of the augmented system described by (1) and (4) are those of A and F c . We assume that the input u{f) is bounded in magnitude and that all the eigenvalues of A have negative real parts, thus ensuring that the estimation error is bounded if all the eigenvalues of F c also have negative real parts. The solution of where M being the modal matrix corresponding to F c and A a diagonal matrix with the eigenvalues of F c as the diagonal elements. Extension of the results obtained here to the case of repeated eigenvalues is relatively straightforward. Taking norms of both sides of Eq. (6), we get C[ being the real part of the observer pole farthest to the right in the complex plane, assumed to be negative here. Id represents the Euclidean norm of any (n x 1) vector v and IIP! represents the spectral norm of any (n x ri) matrix P above. Also, k(M) is the condition number of the (n x ri) matrix M and is equal to IIMII. HAT 1 ! Note that the expression within curly brackets on the right hand side of Eq. (7) depends on the observer eigenvalues and not on the eigenvectors associates with these eigenvalues. The dependence of the state estimation error bound on these eigenvectors is solely via the condition number k(M) of the modal matrix corresponding to F c . Therefore, for competing observer designs with the same eigenvalues, the only difference is in the modal matrix M. The other terms within the curly brackets would be identical for such competing designs. Equation The result obtained here that the eigenvectors corresponding to the observer eigenvalues be chosen to be as nearly mutually orthogonal as possible to reduce the norm of the state estimation error seems to be a natural extension of a result obtained by The suggested observer design guideline does not address the issue of observer eigenvalue selection despite the fact that eigenvalue selection affects the estimation error. Thus, selection of observer eigenvalues without reference to consequences for estimation error may well lead to more robust observer designs being overlooked. Futhermore, Eq. (7) provides only a bound on the estimation error norm. Therefore, it is possible that even if two observer designs differ only in their eigenvector selections, the actual state estimation error norm may in some cases be lower for the design which yields a higher value of k(M) and hence of the error bound. This is less likely to occur, however, if the difference in the values of k(M) for the competing designs is large. Finally, the results obtained here are valid only for cases where the C matrix is known exactly. The procedure for eigenvector selection and observer gain computation follows that of D'Azzo and Houpis (1988). Since the eigenvectors and reciprocal eigenvectors of a matrix are known to be mutually orthogonal, the procedure begins with selection of the reciprocal eigenvectors of F c to be as nearly orthogonal as possible and normalized to have Euclidean norms of unity. S(\ i ) = (A c T -\ i IC T ) for the n specified eigenvalues of F c . At this point in the observer design, the available freedom in eigenvector assignment is used to obtain as nearly mutually orthogonal a set of reciprocal eigenvectors as is possible. The observer gain matrix is then given by Example of Observer Design Consider one dimensional heat conduction in a bar insulated at both ends, governed by the equation where c is the thermal diffusivity of the bar and u(r, t) is the temperature at the location r and time t. It is assumed here that two temperature sensors are located on the bar, one at each end. Using the two measurements provided by the sensors, we need to estimate the temperature distribution in the bar. It is also assumed that the initial temperature distribution in the bar may be unknown. A third order lumped parameter approximation of the distributed parameter system is developed using the modal expansion method. This lumped parameter model is described in a normalized form by The elements of x are the normalized weighting factors on the responses of the corresponding modes, c' is a normalized version of c. It is assumed that the actual value of c' is 0.11, while for observer design, a value of 0.09 is assumed, indicating about 18 percent error. The elements of the C matrix depend only on the boundary conditions and the form of the partial differential Eq. and yields a condition number of the modal matrix of F c , after equilibration, of 3.43. In design 2, the reciprocal eigenvectors are chosen to get a poorer condition number of the modal matrix of F c , equal to 31.44. The observer gain matrix for this design is given by It should be noted here, as an indication of the restricted nature of the results of There is no guarantee, however, that the norm of the state estimation error will always be lower if the observer is designed as indicated here. In fact, if the initial state estimation error vector is dominated by one component, or if the errors in some of the parameters of the A and B matrices are dominant over the others, the relationship between the state estimation error norms may not be the same as the relationship between the error bounds indicated by Eq. Conclusions In this paper, we have derived an expression for an upper bound on the norm of the estimation error for an observer, in the presence of errors in the system A and B matrices and in the estimated initial conditions. It is shown that, in designing observers for multi-output systems using eigenstructure assignment, if the eigenvectors of the F c matrix are chosen to be as nearly mutually orthogonal as possible, a smaller bound on the state estimation error is obtained and thus may lead to more accurate state estimation. This is demonstrated by means of an example. The approach presented seems most appropriate in the absence of any a priori information on the initial state or the nature of the modeling errors. References Introduction This paper is concerned with the problem of identifying the input-output relationship of an unknown nonlinear dynamical system. Classical adaptive control of deterministic linear systems whose state variables are not all observed makes use of the separation principle (Narendra and Annaswamy, 1989) which says, in effect, that the problems of constructing an observer and parameter estimator can be considered separately. When the system is not observable it is not possible to construct an observer to recover the full state. Furthermore, when the system is nonlinear the separation principle no longer applies, and hence conventional adaptive identification and control techniques offer little hope of effective control of partially observed nonlinear systems. In this paper we show that these difficulties can be avoided by using neural networks instead. Neural networks are already successfully applied in control theory and system identification. In a recent paper, Narandra and Parthasarathy (1990) formalized a unified approach to solving nonlinear identification and control problems using multilayered neural networks. Chen (1990) applied multilayer neural network to nonlinear self-tuning tracking problems. Chu et al. (1990) implemented a Hopfield network on identifying time-varying linear systems. Various learning architectures for training neural net controller are outlined in Psaltis et al. (1988) and some interesting applications of neural networks in adaptive control can be found in Goldenthal an
Occupancy maps of 208 chromatin-associated proteins in one human cell type
Transcription factors are DNA-binding proteins that have key roles in gene regulation. Genome-wide occupancy maps of transcriptional regulators are important for understanding gene regulation and its effects on diverse biological processes. However, only a minority of the more than 1,600 transcription factors encoded in the human genome has been assayed. Here we present, as part of the ENCODE (Encyclopedia of DNA Elements) project, data and analyses from chromatin immunoprecipitation followed by high-throughput sequencing (ChIP–seq) experiments using the human HepG2 cell line for 208 chromatin-associated proteins (CAPs). These comprise 171 transcription factors and 37 transcriptional cofactors and chromatin regulator proteins, and represent nearly one-quarter of CAPs expressed in HepG2 cells. The binding profiles of these CAPs form major groups associated predominantly with promoters or enhancers, or with both. We confirm and expand the current catalogue of DNA sequence motifs for transcription factors, and describe motifs that correspond to other transcription factors that are co-enriched with the primary ChIP target. For example, FOX family motifs are enriched in ChIP–seq peaks of 37 other CAPs. We show that motif content and occupancy patterns can distinguish between promoters and enhancers. This catalogue reveals high-occupancy target regions at which many CAPs associate, although each contains motifs for only a minority of the numerous associated transcription factors. These analyses provide a more complete overview of the gene regulatory networks that define this cell type, and demonstrate the usefulness of the large-scale production efforts of the ENCODE Consortium
Response to Therapeutic Sleep Deprivation: A Naturalistic Study of Clinical and Genetic Factors and Post-treatment Depressive Symptom Trajectory
Research has shown that therapeutic sleep deprivation (SD) has rapid antidepressant effects in the majority of depressed patients. Investigation of factors preceding and accompanying these effects may facilitate the identification of the underlying biological
mechanisms. This exploratory study aimed to examine clinical and genetic factors predicting response to SD and determine the impact of SD on illness course. Mood during SD was also assessed via visual analogue scale. Depressed inpatients (n = 78) and healthy controls (n = 15) underwent ~36 h of SD. Response to SD was defined as a score of ≤ 2 on the Clinical Global Impression
Scale for Global Improvement. Depressive symptom trajectories were evaluated for up to a month using self/expert ratings. Impact of genetic burden was calculated using polygenic risk scores for major depressive disorder. In total, 72% of patients responded to SD. Responders and non-responders did not differ in baseline self/expert depression symptom ratings, but mood differed. Response was associated with lower age (p = 0.007) and later age at life-time disease onset (p = 0.003). Higher genetic burden of depression
was observed in non-responders than healthy controls. Up to a month post SD, depressive symptoms decreased in both patients groups, but more in responders, in whom effects were sustained. The present findings suggest that re-examining SD with a greater focus on biological mechanisms will lead to better understanding of mechanisms of depression
Selectivity control in Pt-catalyzed cinnamaldehyde hydrogenation
Chemoselectivity is a cornerstone of catalysis, permitting the targeted modification of specific functional groups within complex starting materials. Here we elucidate key structural and electronic factors controlling the liquid phase hydrogenation of cinnamaldehyde and related benzylic aldehydes over Pt nanoparticles. Mechanistic insight from kinetic mapping reveals cinnamaldehyde hydrogenation is structure-insensitive over metallic platinum, proceeding with a common Turnover Frequency independent of precursor, particle size or support architecture. In contrast, selectivity to the desired cinnamyl alcohol product is highly structure sensitive, with large nanoparticles and high hydrogen pressures favoring C=O over C=C hydrogenation, attributed to molecular surface crowding and suppression of sterically-demanding adsorption modes. In situ vibrational spectroscopies highlight the role of support polarity in enhancing C=O hydrogenation (through cinnamaldehyde reorientation), a general phenomenon extending to alkyl-substituted benzaldehydes. Tuning nanoparticle size and support polarity affords a flexible means to control the chemoselective hydrogenation of aromatic aldehydes
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