Relationship between PASE score with anthropometrics and cardiovascular variables associated to obesity in an older Mexican population

INTRODUCTION: Obesity in Older Adults (OA) increases the risk to acquire non-communicable diseases such as metabolic and cardiovascular diseases. Some reports indicate that sedentary habits or low physical activity is one of the main factor that induce obesity in elderly state. PURPOSE: Determine the relationship between the level of physical activity via Physical Activity Scale for the Elderly (PASE) test, anthropometric and cardiovascular variables associated to obesity in an older Mexican population. METHODS: Fourteen OA (63.4 ± 1.78 years) from Ensenada city, Baja California were recruited. The PASE was applied individually, in each participants was determined the waist circumference (WC) and body mass index (BMI). In the same sense, the Systolic Blood Pressure (SBP) and resting Heart Rate (HR) were evaluated. Spearman correlation test was employed to determine the relationship between variables. RESULTS: The PASE score was 10.58 ± 1.52. The WC was 87.72 ± 2.15 cm. The BMI showed by the participants was 27.3 ± 0.84 kg/m2. On the other hand, the SBP was 131.07 ± 4.38 mmHg. The HR was 72.07 ± 2.50 ppm. The PASE score does not showed statistical correlation with the BMI (r=0.34; p=0.22). In the same sense, there was not significate association between PASE and WC (r=-0.06; p=0.8). The HR showed negative correlation with the PASE (r=-0.45) however, this association was not significant (p=0.1). Finally, the PASE does not correlation with the SBP (r=0.13; p=0.65). CONCLUSION: The preliminary data showed that the PASE questionnaire cannot be used to predict the variables associated to obesity in older Mexican population

The relationship between aerobic fitness and depression level determined with Hamilton scale in older adults

INTRODUCTION: Depression is a major public health problem associated with both morbidity and mortality throughout the world, in Mexico epidemiological reports show a prevalence of depression in older adults of 9.5% in women and 5% in men; it is widely held that regular exercise and physical activity in older subjects have a significant impact on psychological health and well-being. PURPOSE: To determine whether if higher aerobic fitness is associated with decreased symptoms of clinical depression in older adults. METHODS: Participants (n=21) included individuals raging ages from 61 to 72 years old and were not regular exercisers. The 6 minute walking test was used to determine the aerobic fitness, the total distance covered during the test was determined with pedometers; all subjects were free of unstable cardiovascular symptoms and disabilities that could interfere with performance in the sub-maximal exercise test. Indirect Peak Oxygen Consumption (VO2peak) was obtained with the equation stablished by Burr et al. (2011). Depression Symptoms were evaluated using the Hamilton Depression Scale which consisted of an interview of the subjects and scoring 17 items defined in terms of a series of categories of increasing intensity. Statistical analyses included a non-parametric Spearman correlation test to determine the association between predicted VO2peak and depression, level of significance was stablished at P≤0.05. RESULTS: Twenty one overweight (BMI 29.3±3.7 kg/m2) subjects that presented mild clinical depression symptoms were included in the study. A moderate negative correlation between predicted peak VO2 and depression was obtained, with a coefficient of r= -0.5099 (P≤0.05). A regression analysis was performed to establish the significant predictor of VO2 entering the analysis a psychological variable as a dependent factor (P value 0.0102). CONCLUSION: Based on the results, there is evidence that aerobic exercise could be a plausible and healthy strategy to avert depressive symptoms in the appearance of clinical depression in older adults

Interstellar C60+

Buckminsterfullerene (C60) was recently detected through its infrared emission bands in the interstellar medium (ISM), including in the proximity of massive stars, where physical conditions could favor the formation of the cationic form, C60+. In addition, C60+ was proposed as the carrier of two diffuse interstellar bands in the near-IR, although a firm identification still awaits for gas-phase spectroscopic data. We examined in details the Spitzer IRS spectra of the NGC 7023 reflection nebula, at a position close (7.5") to the illuminating B star HD 200775, and found four previously unreported bands at 6.4, 7.1, 8.2 and 10.5 \mu m in addition to the classical bands attributed to Polycylic Aromatic Hydrocarbons (PAHs) and neutral C60. These 4 bands are observed only in this region of the nebula, while C60 emission is still present slightly further away from the star, and PAH emission even further away. Based on this observation, on theoretical calculations we perform, and on laboratory studies, we attribute these bands to C60+. The detection of C60+ confirms the idea that large carbon molecules exist in the gas-phase in these environments. In addition, the relative variation of the C60, and C60+, band intensities constitutes a potentially powerful probe of the physical conditions in highly UV-irradiated regions.Comment: Accepted for publication in A&A, v2: minor corrections of typos and language and additional reference include

Concurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequency

Background: Human brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise training. Selected features of the exercise prescription for improving brain health are missing; therefore, the aim of this study was to determine the effects of concurrent exercise training frequency on serum BDNF levels in healthy older adults. Methods: Nineteen volunteers (age: 65 ± 4 year; body mass index: 28.0 ± 4.5 kg/m2) completed either a three times/week (3-t/w) (n = 8) or five times/week (5-t/w) (n = 11) concurrent exercise program. The exercise program lasted 11 weeks and all exercise sessions were performed for 50 min at moderate intensity. Serum BDNF, body composition, cardiovascular, and physical fitness variables were assessed before and after the exercise training program. Results: Regardless of the group, the serum BDNF increased following the intervention (p < 0.001), and there were no significant group (p = 0.827) or interaction (p = 0.063) effects. The maximal oxygen consumption (VO2max) increased regardless of the group (p = 0.007), with a non-significant group (p = 0.722) or interaction (p = 0.223) effects. Upper- and lower-body strength increased in both groups (p = 0.003); however, there was no effect of the training frequency (p = 0.53). For the skeletal muscle mass, there was a trend in the interaction effect (p = 0.053). Finally, the body fat percentage was unchanged. Conclusion: Eleven weeks of combined exercise training increased serum BDNF levels in healthy older adults, a response independent of the training frequency. The overall fitness level improved similarly in both exercise groups. These data reveal that a minimal dosage of concurrent exercise enhance functional capacity and a brain health biomarker in older adults

Test beam results of a stereo preshower integrated in the liquid argon accordion calorimeter

This paper describes the construction of an integrated preshower within the RD3 liquid argon accordion calorimeter. It has a stereo view which enables the measurement of two transverse coordinates. The prototype was tested at CERN with electrons, photons and muons to validate its capability to work at LHC ( Energy resolution, impact point resolution, angular resolution, $\pi^o$/$\gamma$ rejection )

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection

This work is licensed under a Creative Commons Attribution 4.0 International License.Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that emerged in 2012, causing severe pneumonia and acute respiratory distress syndrome (ARDS), with a case fatality rate of ~36%. When expressed in isolation, CoV accessory proteins have been shown to interfere with innate antiviral signaling pathways. However, there is limited information on the specific contribution of MERS-CoV accessory protein 4b to the repression of the innate antiviral response in the context of infection. We found that MERS-CoV 4b was required to prevent a robust NF-κB dependent response during infection. In wild-type virus infected cells, 4b localized to the nucleus, while NF-κB was retained in the cytoplasm. In contrast, in the absence of 4b or in the presence of cytoplasmic 4b mutants lacking a nuclear localization signal (NLS), NF-κB was translocated to the nucleus leading to the expression of pro-inflammatory cytokines. This indicates that NF-κB repression required the nuclear import of 4b mediated by a specific NLS. Interestingly, we also found that both in isolation and during infection, 4b interacted with α-karyopherin proteins in an NLS-dependent manner. In particular, 4b had a strong preference for binding karyopherin-α4 (KPNA4), which is known to translocate the NF-κB protein complex into the nucleus. Binding of 4b to KPNA4 during infection inhibited its interaction with NF-κB-p65 subunit. Thereby we propose a model where 4b outcompetes NF-κB for KPNA4 binding and translocation into the nucleus as a mechanism of interference with the NF-κB-mediated innate immune response

Performance of the ATLAS Electromagnetic Calorimeter End-cap Module 0

The construction and beam test results of the ATLAS electromagnetic end-cap calorimeter pre-production module 0 are presented. The stochastic term of the energy resolution is between 10% GeV^1/2 and 12.5% GeV^1/2 over the full pseudorapidity range. Position and angular resolutions are found to be in agreement with simulation. A global constant term of 0.6% is obtained in the pseudorapidity range 2.5 < eta < 3.2 (inner wheel)

Supplement: "Localization and broadband follow-up of the gravitational-wave transient GW150914" (2016, ApJL, 826, L13)

This Supplement provides supporting material for Abbott et al. (2016a). We briefly summarize past electromagnetic (EM) follow-up efforts as well as the organization and policy of the current EM follow-up program. We compare the four probability sky maps produced for the gravitational-wave transient GW150914, and provide additional details of the EM follow-up observations that were performed in the different bands