Are CT-Based Finite Element Model Predictions of Femoral Bone Strengthening Clinically Useful?

Purpose of Review: This study reviews the available literature to compare the accuracy of areal bone mineral density derived from dual X-ray absorptiometry (DXA-aBMD) and of subject-specific finite element models derived from quantitative computed tomography (QCT-SSFE) in predicting bone strength measured experimentally on cadaver bones, as well as their clinical accuracy both in terms of discrimination and prediction. Based on this information, some basic cost-effectiveness calculations are performed to explore the use of QCT-SSFE instead of DXA-aBMD in (a) clinical studies with femoral strength as endpoint, (b) predictor of the risk of hip fracture in low bone mass patients. Recent Findings: Recent improvements involving the use of smooth-boundary meshes, better anatomical referencing for proximal-only scans, multiple side-fall directions, and refined boundary conditions increase the predictive accuracy of QCT-SSFE. Summary: If these improvements are adopted, QCT-SSFE is always preferable over DXA-aBMD in clinical studies with femoral strength as the endpoint, while it is not yet cost-effective as a hip fracture risk predictor, although pathways that combine both QCT-SSFE and DXA-aBMD are promising

Charge-dependent flow and the search for the chiral magnetic wave in Pb-Pb collisions at root s(NN)=2.76 TeV

Peer reviewe

Modellierung und Handhabung versionierter Objekte

SIGLETIB: RO 1829(1989,26) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Parallel line segment intersection reporting

SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Ein Client/Server-System als Basiskomponente fuer ein kooperierendes Datenbanksystem

SIGLETIB: RO 1829(1990,26) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Controlling cooperation through design-object specification A database-oriented approach

SIGLEAvailable from TIB Hannover: RO 1829(1992,21) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Exact addition of floating-point numbers

SIGLETIB: RO 1829(1990,5) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Coupling engineering workstations to a database server

SIGLETIB Hannover: RO 1829 (1987, 24) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Using PRIMA-DBMS as a testbed for parallel complex-object processing

Available from TIB Hannover: RO1829(1991,24)+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman