Notes concerning K\"ahler and anti-K\"ahler structures on quasi-statistical manifolds

Let $(\acute{N},g,\nabla )$\ be a $2n$-dimensional quasi-statistical manifold that admits a pseudo-Riemannian metric $g$ (or $h)$ and a linear connection $\nabla$ with torsion. This paper aims to study an almost Hermitian structure $(g,L)$ and an almost anti-Hermitian structure $(h,L)$ on a quasi-statistical manifold that admit an almost complex structure $L$. Firstly, under certain conditions, we present the integrability of the almost complex structure $L$. We show that when $d^\nabla L =0$ and the condition of torsion-compatibility are satisfied, $(\acute{N},g,\nabla ,$ $L)$ turns into a K\"{a}hler manifold. Secondly, we give necessary and sufficient conditions under which $(\acute{N},h,\nabla ,L)$ is an anti-K\"{a}% hler manifold, where $h$ is an anti-Hermitian metric. Moreover, we search the necessary conditions for $(\acute{N},h,\nabla ,L)$ to be a quasi-K\"{a}hler-Norden manifold

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Acute kidney injury in patients treated with immune checkpoint inhibitors

Background: Immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI) has emerged as an important toxicity among patients with cancer. Methods: We collected data on 429 patients with ICPi-AKI and 429 control patients who received ICPis contemporaneously but who did not develop ICPi-AKI from 30 sites in 10 countries. Multivariable logistic regression was used to identify predictors of ICPi-AKI and its recovery. A multivariable Cox model was used to estimate the effect of ICPi rechallenge versus no rechallenge on survival following ICPi-AKI. Results: ICPi-AKI occurred at a median of 16 weeks (IQR 8-32) following ICPi initiation. Lower baseline estimated glomerular filtration rate, proton pump inhibitor (PPI) use, and extrarenal immune-related adverse events (irAEs) were each associated with a higher risk of ICPi-AKI. Acute tubulointerstitial nephritis was the most common lesion on kidney biopsy (125/151 biopsied patients [82.7%]). Renal recovery occurred in 276 patients (64.3%) at a median of 7 weeks (IQR 3-10) following ICPi-AKI. Treatment with corticosteroids within 14 days following ICPi-AKI diagnosis was associated with higher odds of renal recovery (adjusted OR 2.64; 95% CI 1.58 to 4.41). Among patients treated with corticosteroids, early initiation of corticosteroids (within 3 days of ICPi-AKI) was associated with a higher odds of renal recovery compared with later initiation (more than 3 days following ICPi-AKI) (adjusted OR 2.09; 95% CI 1.16 to 3.79). Of 121 patients rechallenged, 20 (16.5%) developed recurrent ICPi-AKI. There was no difference in survival among patients rechallenged versus those not rechallenged following ICPi-AKI. Conclusions: Patients who developed ICPi-AKI were more likely to have impaired renal function at baseline, use a PPI, and have extrarenal irAEs. Two-thirds of patients had renal recovery following ICPi-AKI. Treatment with corticosteroids was associated with improved renal recovery

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Introducing New Exponential Zagreb Indices for Graphs

New graph invariants, named exponential Zagreb indices, are introduced for more than one type of Zagreb index. After that, in terms of exponential Zagreb indices, lists on equality results over special graphs are presented as well as some new bounds on unicyclic, acyclic, and general graphs are obtained. Moreover, these new graph invariants are determined for some graph operations

Design Science Perspective on NFC Research: Review and Research Agenda

Near Field Communication (NFC), as one of the emerging and promising technological developments, provides means to short range contactless communication for mobile phones and other devices alike. NFC has become an attractive design science research area for many academicians due to its exploding growth and its promising applications and related services. A better understanding of the current status of NFC research is necessary to maintain the advancement of knowledge in NFC research and to identify the gap between theory and practice. In this paper, we present a literature review on NFC. To facilitate the analysis of the literature, we propose a research framework and organize the NFC literature into four major categories (theory and development, applications and services, infrastructure, ecosystem). We contend that due to the nature of NFC (industry high stakes, multidisciplinary research, artifacts development), the design science research paradigm serves an appropriate ground to investigate an extent to which relevance and rigor is achieved. By employing the proposed research framework and design science perspective, we set up a research agenda (research directions and promising research questions) which may help practitioners and academics to achieve a substantial progress in NFC. Povzetek: Predstavljen je strokovni okvir za NFC, komunikacijo kratkega dosega.

Evaluation of relationships, self-evaluation and self-esteem of women’s with histerectomy

Purpose: To evaluate the marital relationships, the thoughts about femininity and sexual identity, and the self-evaluation and changes in the self-esteem of women having a hysterectomy operation, during the period of both before and after surgery. Material and methods: This study was designed according to the principles of the comparative descriptive research carried out between 15 January 2013 – 15 June 2014 at Ondokuz Mayis University, Faculty of Medicine Clinic of Obstetrics and Gynaecology. The power sample size was determined to be 72. The research included 88 contactable women who were admitted to the clinic at the time of the research, who had agreed to participate in the study, and who lived in the province where the research was conducted (as the final tests were done via home visits). A questionnaire form, the Coopersmith Self Esteem Scale, and the Social Comparison Scale were used in the collection of the data. Descriptive statistics and x2 and Paired t tests were used in the data analysis. Results: Changes in the self-esteem of women having a hysterectomy were examined before surgery, one week after surgery, and three months after surgery; while there weren’t any changes in self-esteem one week after surgery, a significant decrease in the women’s self-esteem was discovered three months after surgery (p<0.01). Conclusion: It was discovered that a change in self-evaluation and self-esteem occurs after hysterectomy surgery in women

An Analysis Levels of Professional Self Esteem, Continual Anxiety and Life Satisfaction

The purpose of this research is analysis in line with determined some variables on professional self esteem, continual anxiety and life satisfaction. The research has been conducted at a state university in Akdeniz region. Participants of the research are 360 volunteer university students, (207 female 57.5% and 153 male 42.5%) who have studied different faculties and departments. It has been used Professional Self Esteem Questionnaire (PSEQ) which had been adapted to Turkish by Arıcak (1999), Constiunal Anxiety Questionnaire (CAQ) which had been adapted to Turkish by Öner and Le Compte, Life Satisfaction Questionnaire (LSQ) which had been adapted to Turkish by Köker (1991) in this research. The data were analysed using by SPSS 22.0 statistical program. According to the results; it had been found significant positive relation (r=0.416) between life satisfaction and professional self esteem points of females. It had been found significant and negative relation (r=-0.317) between continual anxiety and professional self esteem points of males. Besides it had been found that continual anxiety, professional self esteem and gender variables which all of them were predicted to the life satisfaction variable. The conclusions of research were discussed in line with literatur

Fostering teachers' career education competencies: test of a training programme

In this study, we aimed to develop and test the effectiveness of a training programme to foster teachers' competencies in the provision of career development learning (CDL) programmes for children. Forty-eight middle school teachers working with socioeconomically disadvantaged students in Eastern Turkey participated in the study. The Wilcoxon Signed Rank Test indicated the positive effects of the training on the teachers' efficacy in providing career education but no significant effect on the teachers' communication skills . The qualitative results addressed the improvements made in teachers' professional and personal development, and perceived self-efficacy in providing career programmes. The results revealed the need for upskilling of teachers to improve their facilitation of CDL for students and to support their own professional development