Using a Modified \u3ci\u3eIn-Vitro\u3c/i\u3e Procedure to Measure Corn Bran Buoyancy

An in vitro procedure was modified to estimate rumen buoyancy of corn bran and fiber types. Inoculum was obtained from two beef heifers and mixed with McDougall’s buffer then distributed to the in vitro tubes for 30 hours incubation at 100 °F. Fibrous material formed a matte layer which was measured to describe buoyancy. Tubes contained 6g of a feedlot-type diet with 7.5% fiber type (alfalfa hay, grass hay, corn silage, or corn stalks), with no replacement or 25% replacement of the remaining corn with corn bran. Buoyancy declined over time. Alfalfa hay had the most positive effect on buoyancy of corn bran. This new method offers promise for describing rumen buoyancy

Ruminal Degradable Sulfur and Hydrogen Sulfide in Cattle Finishing Diets

The relationship between ruminal degradable sulfur intake (RDSI) and ruminal hydrogen sulfide concentration ([H2S]) as well as ruminal parameters were evaluated. Steers were fed diets containing organic, inorganic, and wet distiller grains with solubles (WDGS) sources of sulfur, as well as a control diet. A laboratory procedure was developedto measure RDS of ingredients. RDSI explained 65% of [H2S] variation, whereas total sulfur intake and ruminal pH, individually, explained 29 and 12%, respectively. Availability of sulfur for ruminal reduction is more important than total sulfur in the diet

Establishing Moderators And Biosignatures Of Antidepressant Response In Clinical Care (embarc): Rationale And Design

Remission rates for Major Depressive Disorder (MDD) are low and unpredictable for any given antidepressant. No biological or clinical marker has demonstrated sufficient ability to match individuals to efficacious treatment. Biosignatures developed from the systematic exploration of multiple biological markers, which optimize treatment selection for individuals (moderators) and provide early indication of ultimate treatment response (mediators) are needed. The rationale and design of a multi-site, placebocontrolled randomized clinical trial of sertraline examining moderators and mediators of treatment response is described. The target sample is 300 participants with early onset ( 30 years) recurrent MDD. Non-responders to an 8-week trial are switched double blind to either bupropion (for sertraline nonresponders) or sertraline (for placebo non-responders) for an additional 8 weeks. Clinical moderators include anxious depression, early trauma, gender, melancholic and atypical depression, anger attacks, Axis II disorder, hypersomnia/fatigue, and chronicity of depression. Biological moderator and mediators include cerebral cortical thickness, task-based fMRI (reward and emotion conflict), resting connectivity, diffusion tensor imaging (DTI), arterial spin labeling (ASL), electroencephalograpy (EEG), cortical evoked potentials, and behavioral/cognitive tasks evaluated at baseline and week 1, except DTI, assessed only at baseline. The study is designed to standardize assessment of biomarkers across multiple sites as well as institute replicable quality control methods, and to use advanced data analytic methods to integrate these markers. A Differential Depression Treatment Response Index (DTRI) will be developed. The data, including biological samples (DNA, RNA, and plasma collected before and during treatment), will become available in a public scientific repository

Collective mental time travel: remembering the past and imagining the future together

International audienceBringing research on collective memory together with research on episodic future thought, Szpunar and Szpunar (Mem Stud 9(4):376–389, 2016) have recently developed the concept of collective future thought. Individual memory and individual future thought are increasingly seen as two forms of individual mental time travel, and it is natural to see collective memory and collective future thought as forms of collective mental time travel. But how seriously should the notion of collective mental time travel be taken? This article argues that, while collective mental time travel is disanalogous in important respects to individual mental time travel, the concept of collective mental time travel nevertheless provides a useful means of organizing existing findings, while also suggesting promising directions for future research

Resting-State Connectivity Predictors of Response to Psychotherapy in Major Depressive Disorder

Despite the heterogeneous symptom presentation and complex etiology of major depressive disorder (MDD), functional neuroimaging studies have shown with remarkable consistency that dysfunction in mesocorticolimbic brain systems are central to the disorder. Relatively less research has focused on the identification of biological markers of response to antidepressant treatment that would serve to improve the personalized delivery of empirically supported antidepressant interventions. In the present study, we investigated whether resting-state functional brain connectivity (rs-fcMRI) predicted response to Behavioral Activation Treatment for Depression, an empirically validated psychotherapy modality designed to increase engagement with rewarding stimuli and reduce avoidance behaviors. Twenty-three unmedicated outpatients with MDD and 20 matched nondepressed controls completed rs-fcMRI scans after which the MDD group received an average of 12 sessions of psychotherapy. The mean change in Beck Depression Inventory-II scores after psychotherapy was 12.04 points, a clinically meaningful response. Resting-state neuroimaging data were analyzed with a seed-based approach to investigate functional connectivity with four canonical resting-state networks: the default mode network, the dorsal attention network, the executive control network, and the salience network. At baseline, the MDD group was characterized by relative hyperconnectivity of multiple regions with precuneus, anterior insula, dorsal anterior cingulate cortex (dACC), and left dorsolateral prefrontal cortex seeds and by relative hypoconnectivity with intraparietal sulcus, anterior insula, and dACC seeds. Additionally, connectivity of the precuneus with the left middle temporal gyrus and connectivity of the dACC with the parahippocampal gyrus predicted the magnitude of pretreatment MDD symptoms. Hierarchical linear modeling revealed that response to psychotherapy in the MDD group was predicted by pretreatment connectivity of the right insula with the right middle temporal gyrus and the left intraparietal sulcus with the orbital frontal cortex. These results add to the nascent body of literature investigating pretreatment rs-fcMRI predictors of antidepressant treatment response and is the first study to examine rs-fcMRI predictors of response to psychotherapy