Azimuthal temperature variations in ISO-Oph2 from multi-frequency ALMA observations

Environmental effects, such as stellar fly-bys and external irradiation, are thought to affect the evolution of protoplanetary disks in clustered star formation. Previous ALMA images at 225 GHz of the ISO-Oph 2 binary revealed a peculiar morphology in the disk of the primary, perhaps due to a possible fly-by with the secondary. Here we report on new ALMA continuum observations of this system at 97.5 GHz, 145 GHz and 405 GHz, which reveal strong morphological variations. Multi-frequency positional alignment allows to interpret these spectral variations in terms of underlying physical conditions. ISO-Oph 2A is remarkably offset from the centroid of its ring, at all frequencies, and the disk is lopsided, pointing at gravitational interactions. However, the dust temperature also varies in azimuth, with two peaks whose direction connects with HD 147889, the earliest-type star in the Ophiuchus complex, suggesting that it is the dominant heat source. The stellar environment of ISO-Oph 2 appears to drive both its density structure and its thermal balance.Simon Casassus, Lucas Cieza, Miguel C\'arcamo, \'Alvaro Ribas, Valentin Christiaens, Abigali Rodr\'iguez-Jim\'enez, Carla Arce-Tord, Trisha Bhowmik, Prachi Chavan, Camilo Gonz\'alez-Ruilova, Rafael Mart\'inez-Brunner, Valeria Guidotti, Mauricio LeivaComment: accepted in MNRA

Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation

Intercellular communication is crucial for collective regulation of cellular behaviors. While clustering T cells have been shown to mutually control the production of key communication signals, it is unclear whether they also jointly regulate their availability and degradation. Here we use newly developed reporter systems, bioinformatic analyses, protein structure modeling and genetic perturbations to assess this. We find that T cells utilize trogocytosis by competing antagonistic receptors to differentially control the abundance of immunoregulatory ligands. Specifically, ligands trogocytosed via CD28 are shuttled to the T cell surface, enabling them to co-stimulate neighboring T cells. In contrast, CTLA4-mediated trogocytosis targets ligands for degradation. Mechanistically, this fate separation is controlled by different acid-sensitivities of receptor-ligand interactions and by the receptor intracellular domains. The ability of CD28 and CTLA4 to confer different fates to trogocytosed ligands reveals an additional layer of collective regulation of cellular behaviors and promotes the robustness of population dynamics.Fil: Zenke, Simon. Albert Ludwigs University of Freiburg; AlemaniaFil: Sica, Mauricio Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Steinberg, Florian. Albert Ludwigs University of Freiburg; AlemaniaFil: Braun, Julia. Albert Ludwigs University of Freiburg; AlemaniaFil: Zink, Alicia. Albert Ludwigs University of Freiburg; AlemaniaFil: Gavrilov, Alina. Max Planck Institute of Immunobiology and Epigenetics; AlemaniaFil: Hilger, Alexander. Albert Ludwigs University of Freiburg; AlemaniaFil: Arra, Aditya. Otto-von-Guericke-Universität Magdeburg; AlemaniaFil: Brunner Weinzierl, Monika. Otto-von-Guericke-Universität Magdeburg; AlemaniaFil: Elling, Roland. Albert Ludwigs University of Freiburg; AlemaniaFil: Beyersdorf, Niklas. Universität Würzburg; AlemaniaFil: Lämmermann, Tim. Albert Ludwigs University of Freiburg; AlemaniaFil: Smulski, Cristian Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rohr, Jan C.. Albert Ludwigs University of Freiburg; Alemani

Type IIB orientifolds on Gepner points

We study various aspects of orientifold projections of Type IIB closed string theory on Gepner points in different dimensions. The open string sector is introduced, in the usual constructive way, in order to cancel RR charges carried by orientifold planes. Moddings by cyclic permutations of the internal N=2 superconformal blocks as well as by discrete phase symmetries are implemented. Reduction in the number of generations, breaking or enhancements of gauge symmetries and topology changes are shown to be induced by such moddings. Antibranes sector is also considered; in particular we show how non supersymmetric models with antibranes and free of closed and open tachyons do appear in this context. A systematic study of consistent models in D=8 dimensions and some illustrative examples in D=6 and D=4 dimensions are presented.Comment: 67 pages, no figures References added, typos correcte

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

Peer reviewe