89 research outputs found
Are cultural safety definitions culturally safe? A review of 42 cultural safety definitions in an Australian cultural concept soup
- Author
- Publication venue
- 'Research Square'
- Publication date
- 21/12/2021
- Field of study
Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity
- Author
- Adams
- Anil Thankappan
- Ann Marshak-Rothstein
- Anzelon
- Ballou
- Betty Mousseau
- Bommakanti
- Browne
- Cancro
- Carey
- Cariappa
- Charles E. Alpers
- Cyster
- Dalwadi
- David J. Rawlings
- Denny Liggitt
- Frances E. Lund
- Frey
- Fruman
- Goodnow
- Guixiu Shi
- Hamel
- Harris
- Howes
- Howes
- Hubbard
- Humphries
- Kelly L. Hudkins
- Kim Kusser
- Lesley
- Liggett
- Lindsley
- Mackay
- Manjarrez-Orduño
- Manning
- Marilyn R. Kehry
- Melvin Simon
- Meyer-Bahlburg
- Michael Tighe
- Miguel E. Moreno-Garcia
- Moyron-Quiroz
- Ngai
- Offermanns
- Patke
- Pogue
- Ravi S. Misra
- Robert Dunn
- Shi
- Shirly Becker-Herman
- Srinivasan
- Srivastava
- Stadanlick
- Su
- Tektonidou
- Thi-Sau Migone
- Thien
- Troy D. Randall
- Wettschureck
- Wilkie
- Wu
- Yanamadala
- Yu
- Publication venue
- The Rockefeller University Press
- Publication date
- Field of study
Survival of mature B cells is regulated by B cell receptor and BAFFR-dependent signals. We show that B cells from mice lacking the Gαq subunit of trimeric G proteins (Gnaq−/− mice) have an intrinsic survival advantage over normal B cells, even in the absence of BAFF. Gnaq−/− B cells develop normally in the bone marrow but inappropriately survive peripheral tolerance checkpoints, leading to the accumulation of transitional, marginal zone, and follicular B cells, many of which are autoreactive. Gnaq−/− chimeric mice rapidly develop arthritis as well as other manifestations of systemic autoimmune disease. Importantly, we demonstrate that the development of the autoreactive B cell compartment is the result of an intrinsic defect in Gnaq−/− B cells, resulting in the aberrant activation of the prosurvival factor Akt. Together, these data show for the first time that signaling through trimeric G proteins is critically important for maintaining control of peripheral B cell tolerance induction and repressing autoimmunity
Literature and Education in the Long 1930s
- Author
- 407Auden
- 409Bridson
- 416Greene
- 427Orwell
- 429Raymond
- Achebe
- Adorno
- Agraz
- Ahmad
- Ahmed
- Alexander
- Allan
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- Althusser
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- Anand
- Anand
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- Anderson
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- Zaagsma
- Zhdanov
- Çelik
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/01/2019
- Field of study
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana G.
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O.
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J.
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff Nidhi G.
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hutchison Robyn A.
- Hutton Paula J.
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
- Imperio María C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou Nicholas
- Iotti Giorgio A.
- Irvine Donald A.
- Ismail Dina
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
- Javeed Areej
- Javier-Blanco
- Jhamatthew Thomas Rajeev R.
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio G.
- Jochmans S. bastien
- Jog Sameer A.
- Jovanovic Bojan
- Judy Claine
- Jurado M. . Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kansuke-Koyama
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch Barrett T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon H.
- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John
- Laffey John G.
- Laffey John G.
- Lamb Keith D.
- Lanspa Michael J.
- Larsson Anders
- Larsson Niklas
- le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana S.
- Leon Yoshido Hector H.
- Li Bin
- Li Qingdong
- Li Qiong J.
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing L.
- Liu Ling
- Llano Miguel
- Llinares Moya David D.
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado Juan C.
- Lora Fredy S.
- Lora Pilar
- Lorente Jose A.
- Losada Elena Perez
- Lovazzano Pablo
- Lu Weihua
- Lu Yuanhua
- Luis Palazon Sanchez Eugenio
- Luo Xiaoming
- Lynch Joan M.
- López-Messa Juan B.
- Maazouzi Wajdi
- MacFadyen Rosaleen
- MacFie Caroline C.
- Madotto Fabiana
- Maeyama Hiroki N.
- Maghrabi Khalid A.
- Magret Monica
- Mahto Heera L.
- Mancebo Jordi
- Manoharan Venika
- Marcos Diego Pastor
- Marcu Alexandra
- Maria Villa
- Marin Julien
- Marin Maria C.
- Martinez Felipe T.
- Martinho Aurelia M.
- Marum Susan M.
- Massa Eleni V.
- Mataloun Sergio
- Matamis Dimitrios
- Matsumoto Shuhei
- Mattei Alessia
- May Martin M.
- McArthur Colin
- McAuley Daniel F.
- McAuley Daniel F.
- McAuley Danny
- McCalman Katie H.
- McKechnie Stuart
- McKee Raymond
- McKenna Toni E.
- McLeod Alex
- McNamee Lia
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- Yamaguchi Osamu
- Yamaji Yoshihiro
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- Yu Rongguo
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- Yumha Jacob S.
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- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua Kim S.
- Zazu Alan
- Zeggwagh Amine Ali
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- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
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- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie H.
- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
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- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
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- Bauchmuller Kris
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- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
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- Berry Scott
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- Buhr Heidi
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- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
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- Cazzola Federica
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- Chablani Manish
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- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
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- Claridge Helen
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- de Jager P
- de Jong Menno
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- Guilder E
- Guitton Christophe
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- Lawler Patrick R
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- van Bentum Puijk Wilma
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- Watpool Irene
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- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
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- Weissman Alexandra
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- Wetherill Bill
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- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
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- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Using research to prepare for outbreaks of severe acute respiratory infection
- Author
- Al Qasim Eman
- Ala-kokko Tero
- Angus Derek C
- Antoine Marchalot
- Arabi Yaseen M
- Awasthi Shally
- Bahinskaya Ilona
- Baillie John Kenneth
- Bentley Andrew
- Bory Sotharith
- Browne Troy
- Browne TS
- Bruel Cedric
- Bruyere Raomi
- Campbell Lewis
- Carrier Francois Martin
- Carson Gail
- Chan Wai Ming
- Chang Youjin
- Charles Anthony G
- Cheng Allen C
- Chiche Jean-Daniel
- Cho Jae Hwa
- Choi Won-Il
- Christian Michael D
- Cobb J Perren
- Daix Thomas
- Djillali Annane E
- Dunning Jake
- Egi Moritoki
- EllazarHumber Edward
- Erickson Simon
- Everett Dean
- Fabienne Taimon
- Farshait Nataly
- Florence Komurian-Pradel
- Forceville Xavier
- Forrest Annette
- Fowler Robert
- Ganeshalingham Anusha
- George Maya
- Giamarellos-Bourboulis Evangelos J
- Gilfoyle Elaine
- Goodson Jennifer
- Gordon Anthony C
- Green Karen
- Griesdale Donald
- Growl Gloria
- Guerrero M Lourdes
- Guillebaud Julia
- Hall Richard
- Henderson Seton
- Heraud Jean-Michel
- Horby Peter
- Hsu Li Yang
- Huh Jin-Won
- Investigators SPRINT-SARI
- Jarrvisalo Mikko J
- Jouvet Philippe
- Katz Kevin
- Kazemi Alex
- Kinh Nguyen Van
- Kol Mark
- Kuitunen Anne
- Lamontagne Francois
- Lee Heung Bum
- Lee Won-Yeon
- Li Iris Wai Sum
- Longuere Kajsa-Stina
- Mahesh Vinaya
- Malik Nadia
- Mambule Ivan
- Marshall John
- Martin Dori-Ann
- Maslove David
- McArthur Colin
- McCarthy Anne E
- McConnochie Rachael
- Melendez Javier Araujo
- Melto Sari
- Merson Laura
- Mich Vann
- Murthy Srinivas
- Muscedere John
- Nadjm Behzad
- Ngai Wallace Chun Wai
- Nichol Alistair
- Nicholas Sedillot
- O'Neill Genevieve
- Ochieng Otieno George
- Ohuma Eric
- Opaysky Mary Anne
- Osbourne-Townsend Joan
- Otieno Juilett Wambura
- Pardinaz-Solis Raul
- Park Seung Yong
- Park Tai Sun
- Parke Rachael
- Paterson David L
- Patrigeon Santiago Perez
- PedutemHumber Theresa
- Philippart Francois
- Pho Yaty
- Powis Jeff
- Prin Meghan
- Pulkkinen Anni
- Rabarison Joelinotahiana Hasina
- Raberahona Mihaja
- Ramirez-Venegas Alejandra
- Razanazatovo Norosoa
- Rello Jordi
- Rishu Asgar
- Riviello Elisabeth D
- Rowan Kathy
- Ruberto Aaron J
- Santamaria John
- Semple Calum
- Shindo Nahoko
- Siami Shidasp
- Sim Yun Su
- Sin Wai Ching
- Som Leakhann
- Sonawane Ravikiran
- Sylvain Habarurema
- Teav Bunlor
- Tiercelet Kelly
- Trung Nguyen Vu
- Twagirumugabe Theogene
- Ubiergo Sebastian Ugarte
- Umuhire Olivier Felix
- Uyeki Timothy M
- Valkonen Miia
- van Doom H Rogier
- Vann Mich
- Wallace David J
- Webb Steve AR
- Welters Ingeborg
- West T Eoin
- Young Paul
- Publication venue
- 'BMJ'
- Publication date
- 01/02/2019
- Field of study
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- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/01/2019
- Field of study
Postprin
The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study
- Author
- Abdullah Nasreen
- Abroaf Ahmed
- Acher Peter
- Adams Robert
- Adasonla Kelvin
- Adimonye Anthony
- Adwin Zainal
- Ager Michael
- Agrawal Sachin
- Ahmad Adnan
- Ahmed Hashim
- Akaln Mustafa Kaan
- Al?Ibraheem Nihad
- Aldiwani Mohammed
- Almpanis Stephanos
- Alonso Cristina Plaza
- Andres Rosado Mario
- Aning Jonathan
- Antón-Juanilla Marta
- Appanna Timson
- Assmus Mark A.
- Austin Tomas
- Ayres Ben
- Bagley Joseph
- Balderas Olga
- Barcelos André
- Bardet Florian
- Barratt Rachel
- Bass Edward
- Bdesha Amar
- Beder Daniel
- Bedi Nishant
- Bele Uros
- Benitez Cayo Augusto Estigarribia
- Bennett Adam
- Bhatt Nikita
- Bi Hai
- Black Peter C
- Blick Chris
- Boltri Matteo
- Bonnin Thierry
- Boxall Nicholas E.
- Brittain James
- Brophy Tom
- Brown Christian
- Brown Kevin
- Browne Clíodhna
- Bullock Nicholas
- Burden Helena
- Burnhope Tara
- Cadena Iván Revelo
- Campain Nicholas
- Capoun Otakar
- Carrion Diego M
- Castillo Elba Canelon
- Catto James
- Cebola Ana
- Chahal Rohit
- Challacombe Ben
- Chan Luke
- Chau Edwin
- Chaudry Aasem
- Chin Yew Fung
- Chippagiri Arvinda
- Chlosta Piotr L
- Chu Timothy Shun Man
- Chuchu Naomi
- Cimarra Fernando
- Claps Francesco
- Clark Jennifer
- Clarke Holly
- Clarke Holly
- Clarke Laurence
- Cohen Daniel
- Cooper Meghan
- Cormier Luc
- Cortes Victor Parejo
- Courcier Jean
- Crawford-Smith Hugh
- Crespo-Atín Víctor
- Crockett Matthew
- Crockett Matthew
- Cruz Ricardo
- Czech Anna K
- Cózar-Olmo Jose Manuel
- Das Arighno
- Davenport Kim
- David Rotimi
- Day Elizabeth
- Deeks Jon
- Deem Samuel
- Dell'Atti Lucio
- Derbyshire Laura
- Desai Ankit
- Desouky Elsayed
- Dhanasekaran Ananda Kumar
- Dhera Karishma
- Dinneen Eoin
- Dowling Catherine
- Downey Alison P.
- Drake Tamsin
- During Vinnie
- Ebur Andrea
- Edison Eric
- Ellis Ricky
- Ellul Tom
- Emberton Mark
- Erotocritou Paul
- Esler Rachel
- Fen Koo Hui
- Feneley Mark
- Fiala Vojtech
- Figueiredo Arnaldo
- Filtekin Yigit
- Forster Luke
- Frankel Jason
- Freire Maria José
- Gadiyar Neha
- Gaines Emily
- Gallagher Kevin M.
- Gallego Maria Camacho
- Gallegos Christopher
- Galosi Andrea B
- Gao Chuanyu
- García de Jalón Ángel
- Garg Tullika
- Gauhar Vineet
- Gillams Kathryn
- Gillams Kathryn
- Glaser Zachary A
- Gnanapragasam Vincent
- Goldsmith Louise
- Gontero Paolo
- Goonewardene Sanchia
- Gordon Daniel
- Gordon Danny
- Green James
- Gresty Helena
- Grigorakis Alkiviadis
- Gronostaj Katarzyna
- Gómez Rivas Juan
- Hale Nathan
- Hamid Syed Sami
- Haroon Usman
- Hawkins Rosalyn
- Hawlina Simon
- He Ming
- Hellawell Giles
- Hernandez Juan
- Hernando Jamie Borrego
- Herranz-Yagüe José Antonio
- Hessell Robert
- Higgs Claire
- Ho Cherrie Wing Yin
- Hobbs Catherine
- Hori Satoshi
- Horie Shigeo
- Houlton Kathleen
- Hrouda David
- Hsu Ray
- Iacovou John
- Ibrahim Ibrahim
- Ibrahim Youssed
- Inder Shakeel Mohammud
- Irani Jacques
- Jain Sunjay
- Jarimba Roberto
- Jefferies Matthew
- Jelski Joseph
- Jones Jennifer
- Joniau Steven
- Kalsi Jas
- Karsza Dávid
- Kasivisvanathan Veeru
- Kata Slawomir Grzegorz
- Kelly John
- Khadhouri Sinan
- Khalid Raihan
- Khan Shahid
- Khawaja Faizan
- Kilic Enes
- Kitamura Kosuke
- Knight Allen
- Kocher Neil
- Kond?a Andra?
- Kouli Omar
- Kovács Gábor
- Kulkarni Meghana
- Kum Francesca
- Kumar Vivek
- Kumaradeevan Jeevan
- Kynaston Howard
- La Montagna Giuseppe
- Lai Billy
- Lal Asim A
- Lam Chon Meng
- Lam Gitte
- Lam Wayne
- Lau David H. W.
- Lau David Hua Wu
- Leask Jamie
- Lebacle Cédric
- Lee Taeweon
- Lee Taeweon
- Lehman Kathleen
- Leminski Artur
- Lenart Gordan
- Li Mo
- Liew Matthew
- Lillaz Beatrice
- Lloyd Aimee
- Lobo Niyati
- Lopes Sofia Pinheiro
- Lyons Hannah
- Ma Lulin
- MacKay Alison
- MacKenzie Kenneth R.
- MacLennan Graeme
- MacLennan Graeme
- Mahmalji Wasim
- Mains Edward
- Mainwaring Anna
- Mak David
- Mallett Susan
- Manecksha Rustom P
- Mangat Reshma
- Manjavacas Pablo Oteo
- Mannas Miles P.
- Marathe Shekhar
- Marchiñena Patricio Garcia
- Mariappan Paramananthan
- Marra Giancarlo
- Martin-Way David
- Martinez Levin
- Martinez-Piñeiro Luis
- Matanhelia Mudit
- Maw Jonny
- Mazzoli Simone
- McCann Conor
- McConkey Robert
- McGrath John S.
- McKay Alastair
- Meeks Joshua
- Minervini Andrea
- Mistry Kiki
- Moore Madeline
- Moore Sacha
- Morris Steve
- Morton Lawrie
- Mostafid Hugh
- Mount Chloe
- Muilwijk Tim
- Mukhtar Bashir
- Murtagh Kevin
- Nagle Amy
- Nambiar Arjun
- Nellensteijn Brechtje
- Ng ChiFai
- Nielsen Matthew
- Nikles Sven
- Nkwam Nkwam
- Nolazco Jose Ignacio
- Norris Joseph
- Nyanhongo Donald
- O'Meara Sorcha
- O'Rourke John
- Olivier Jonathan
- Olivier Jonathan
- Omran Breish Mohamed
- Oo Aye Moh Moh
- Oomen Robert J.A.
- Osei?Bonsu Peter K
- Otaola-Arca Hugo
- Ouzaid Idir
- Palagonia Erika
- Papworth Emma
- Paramore Louise
- Parker Sidney
- Parson Sian
- Pasha Muhammad
- Patel Dhruv
- Patel Trushar
- Pavan Nicola
- Peters Francesca
- Phan Yih Chyn
- Pira Matea
- Pita Hernado Rios
- Pizzuto Giuseppe
- Planelles Paula
- Plo Teresa Cabañuz
- Poves Victoria Capapé
- Puche-Sanz Ignacio
- Qin Zijian
- Rai Sonpreet
- Raman Jay D
- Ramos Sónia
- Randhawa Karen
- Raveenthiran Sheliyan
- Rico Luis
- Rintoul-Hoad Sophie
- Ristau Benjamin
- Ritchie Robert
- Rivero Marta Viridiana Muñoz
- Rowe Tracey
- Russell Andrew
- Sahibzada Iqbal
- Sangaralingam Shanthi
- Schneider Alexandre
- Schreiter Brielle
- Selph John P
- Sengupta Shomik
- Serag Hosam
- Shah Taimur T.
- Sharma Abhishek
- Sherwood Benedict
- Shrotri Nitin
- Silva Alberto
- Simmons Lucy
- Simpson Helen
- Smith Peter
- Smrkolj Toma
- Stamirowski Remigiusz
- Sukhu Troy
- Suliman Ahmed M
- Suthaharan Denula
- Swami Satchi Kuchibhotla
- Sweeney Paul
- Takwoingi Yemisi
- Tallè Matteo
- Tanasescu George
- Tanasescu Geroge
- Tarin Mohamed
- Tasso Giovanni
- Teoh Jeremy YuenChun
- Testa Joseph
- Thangasamy Isaac
- Tinay Ilker
- Toma Tarq
- Tomakovi Igor
- Toniolo Jason
- Trail Matthew
- Trombetta Carlo
- Turner Stacey
- Tweedle James
- Udzik Jakub
- Ul Ain Qurrat
- Uzan Audrey
- Uçar Taha
- Uçar Taha
- Venturini Stefano
- Villers Arnauld
- Voulgaris Athanasios M
- Vásquez Juan Luis
- Warren Hannah
- Webb Andrew
- Wilby Daniel
- Willemse Peter-Paul Michiel
- Williams Simon
- Wollin Tim
- Wong Albert
- Xylinas Evanguelos
- Y?ld?r?m As?f
- Yan Shahzad Sylvia
- Younis Ayman
- Yuruk Emrah
- Zainuddin Zulkifli
- Zelhof Bachar
- Zimmermann Eleanor F.
- Zotter Zsuzsanna
- Çakurlu Turhan
- Özgür Günal
- Østergren Peter
- Publication venue
- 'Wiley'
- Publication date
- 31/10/2021
- Field of study
Objective
To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation.
Patients and Methods
This was an international multicentre prospective observational study. We included patients aged ≥16 years, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex, and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals, and countries.
Results
Of the 11 059 patients assessed for eligibility, 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3–34.1), bladder cancer (n = 1951) 24.7% (95% CI 19.1–30.2), UTUC (n = 128) 1.14% (95% CI 0.77–1.52), renal cancer (n = 107) 1.05% (95% CI 0.80–1.29), and prostate cancer (n = 124) 1.75% (95% CI 1.32–2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03–1.05; P < 0.001), visible haematuria 3.47 (95% CI 2.90–4.15; P < 0.001), male sex 1.30 (95% CI 1.14–1.50; P < 0.001), and smoking 2.70 (95% CI 2.30–3.18; P < 0.001).
Conclusions
A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care, adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer
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- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
- Blanc Agnès
- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
- Bogarin Javier
- Bogoevska-Miteva Zaneta
- Bonaccorso Luciano
- Bongiorno Benjamin
- Bonsignore Pablo Julio Maldonaldo
- Borgognoni Cinzia
- Borin Christophe
- Borkowska Marta
- Bormans Laura
- Boroli Filippo
- Borys Michal
- Boschetto Margherita
- Bossolasco Matteo
- Bota Marc
- Boulanger Carole
- Boulton Karen
- Bowes Bonnie
- Boyer Laetitia
- Bozbay Suha
- Bozena Armanda
- Bratsberg Bjorn
- Bravo Silvina
- Brett Carole
- Brett Stephen
- Brett Stephen J.
- Briva Arturo
- Brizio Elisabetta
- Brizuela Patricia
- Broadhurst Phil
- Brown Wendy
- Browne Troy
- Bruel Cédric
- Bruhn Louise
- Brumwell Sarah
- Bruni Andrea
- Bruno Anna Vita
- Buckley Sarah
- Bull Rhian
- Bumbasirevic Vesna
- Buregeya Egide
- Burns Karen
- Butcher Rand
- Byers Heather
- Bösl Kathrin
- Cabral Dolly Mabel Bordon
- Cabral João
- Cabrita Paula
- Caddell Paul
- Caicedo Nestor
- Calamai Italo
- Calili Duygu Kayar
- Caliskan Gulbahar
- Calleja Pablo Lopez-Arcas
- Calpe Neus
- Calvino-Gunther Silvia
- Campanili Ticiane
- Campbell Elizabeth
- Campos Pierina Arias
- Campos-Perez Margarita
- Camputaro Luis
- Camsooksai Julie
- Canales Julieta
- Canete Fidelina
- Cani Alma
- Cano Anastasio Espejo
- Cao Deyan
- Cao Wenzhen
- Cao Ying
- Cao Zu Qing
- Capuzzi Fabio
- Cardenas Yenny
- Carey Annette
- Carney Dominic
- Carter Charlotte
- Casaioli Simona
- Castelain Vincent
- Castiglione Giacomo
- Cata Juan
- Cavaco Raquel
- Cengiz Melike
- Cerezo Franklin Dean
- Cesar Helena
- Cespedes Laura
- Chaboyer Wendy
- Chadwick Llesley
- Chang Shu Chuan
- Chang Youjin
- Chantziara Vasiliki
- Chao Yu
- Chaparro Javiera
- Chaparro Silvia
- Chapeta Edwin
- Chapman Carmel
- Charalabous Iwy
- Chatzis Marinos
- Chee Hyun Keun
- Chen Feifei
- Chen Haiyan
- Chen Hongjuan
- Chen Jingfang
- Chen Lei
- Chen Meili
- Chen Tianfei
- Chen Wenmin
- Chen Xiaoyan
- Chen Zhihong
- Cheng
- Cheng Jiyin
- Chime Christiana
- Chimunda Tim
- Chinardet Benoît
- Chovas Achilleas
- Christ Martin
- Christofis Christos
- Chueca Ramon Molina
- Chunhua Gao
- Cinel İsmail
- Ciorba Paolo
- Clark Michele
- Clement Ana Isabel
- Clesi Tara
- Cody Caitriona
- Collet Marie
- Collins Amy
- Coman Mary
- Conde Belen Burgos
- Conejo Isabel
- Constantinou Constantina
- Corcoran Ailesh
- Coremans Stefano
- Correia Malcolm C.
- Corso Amalia
- Cortegiani Andrea
- Cortellazi Paolo
- Cosano Rosario
- Cossu Maria
- Costa Humberto
- Cotoia Antonella
- Coyer Fiona
- Craig Geraldine
- Craig Jayne
- Cranmer Karen
- Cranshaw Julius
- Creber Peter
- Crone Petra
- Cui Xia
- Cummings Donna
- Cupitt Jason
- Curilen Veronica
- Czuczwar Miroslaw
- Dagooc Rica
- Dai Zhaoxing
- Dal Hayriye Cankar
- Dallaire Julie
- Das Sasidharan Nair Vishnu
- Daubin Cédric
- Davidow Jon
- Davidson Cheryl
- Dawn Frances
- Dayan Meneses
- de Almeida Angelica Olivetto
- de Anda Gilberto Felipe Vazquez
- De Bels David
- de Ceballos José Peral Gutierrez
- De Decker Koen
- De Haan Marina
- de Jesús Ortiz Alberto
- de la Ventana Ana Belén Sánchez
- De lange Dylan
- De Lange Dylan
- de Molina Serrano José Ivan Rodriguez
- De Montmollin Etienne
- De Pablo Ana María
- De Rosa Silvia
- De Sanctis Francesca
- De Schryver Nicolas
- De Wit Irene
- Dean Emiliano
- Debue Anne-Sophie
- Del Bosque Diez Rosa
- del Cotillo Mercedes
- del Mar Diaz Salcedo Maria
- Del Moral Armengol Mario
- Del Rio Cabajo Lorena
- del Rosario Villar Redondo M.
- del Valle Gimenez Graciela
- Delgado Carlos Castro
- Delgado Patricia
- Dellafiore Federica
- Delossantos Shella
- Delve Peter
- Demarré Liesbet
- Demirkiran Oktay
- Dendane Tarek
- Deng Xiaoqiong
- Depuydt Tanja
- Derbyshire Claire
- Derrick Helen
- Deschepper Mieke
- Deva Shanti Rudra
- Dhaliwal Jasdeep
- Di Gravio Valentina
- Di Risio Alessandro
- Di Yanhong
- Diakaki Chrisi
- Dias Sofia
- Diaz Ana
- Diaz Anna
- Diaz Monica Garcia
- Dieperink Willem
- Diers Anja
- Dikmen Yalım
- Dikmen Yalim
- Dilek Ozcengiz
- Dimoula Aikaterini
- Dimski Thomas
- Ding Min
- Ding Xinran
- Ding Yajun
- Ding Yanming
- Dlamini-Sserumaga Lomangisi
- Dobric Milena
- Dolenc Simon
- Dolgusevs Mihails
- Domenech Laura Claramunt
- Dong Jingwen
- Dong Yunchun
- Donvito Maria
- Dormans Tom
- Douschan Philipp
- Doyle Deirdre
- Dragoumanis Christos
- Du Guifang
- Duan Huan
- Dugernier Thierry
- Duggal Abhijit
- Dullenkopf Alexander
- Dungca Adonis
- Dunne Lisa
- Duran Karely
- Déserts Marc Danguy des
- D’Ambrosio Francesco
- D’Ambrosio Paolo
- Ebaid Maie
- Ebaid Maie Salem
- Efe Serdar
- Efthimiou Aikaterini
- Efthymiou Anna
- Egi Moritoki
- Egorova Natalya
- Ei Poe Poe
- Elatrous Souheil
- Elay Gülseren
- Elgammudi Mala
- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
- Eneas Antony
- Eng Timothy
- Erdivanli Başar
- Erdogan Elif
- Eroglu Ahmet
- Ershova Olga
- Escalante Rosana Gabriela
- Espinosa Cristina Paños
- Esposito Romina
- Essardy Fatiha
- Etourneau Fabienne
- Evers Mirjam
- Fadeeva Liudmila
- Fan Limei
- Fang Xiuhua
- Farkas Jean-christophe
- Farmakis Epaminontas
- Farnell-Ward Sarah
- Farre Olga
- Fartoukh Muriel
- Favre René
- Feghaly Michel El
- Fei Qin
- Feng ZhangXia
- Feng Zhaoxia
- Feranandes Ana Margarida
- Fernadez Inmaculada Lorenzo
- Fernandes Fatima
- Fernandez Alejandra Azahara Marguello
- Fernandez Maria Alejandra
- Fernandez Maria Cristina Iglesias
- Fernandez Oscar
- Fernandez Ruben
- Fernandez Silvia
- Fernández Ana Wensell
- Ferreira Amelia
- Ferreira Fatima
- Ferreira Hilaryano
- Ferreira Susana
- Ferretti Christian
- Ffarcsi Madiha Hashmi
- Fiedler Christine
- Fielding Clare
- Fielding Mark
- Figaro-Barclay Dianne
- Figueiredo Margarida Ferreira
- Fijen Jan-Willem
- Filipescu Daniela Carmen
- Filipović-Grčić Ina
- Finn Damien O’Connell Rosemary
- Finnstrom Inger Johanne
- Fioretti Audrey
- Firment Peter
- Fischer Susanne
- Fishman Anne
- Fister Misa
- Fitzpatrick Gerry
- Fivecoat Pauline
- Flessel Nadine
- Fletcher Kelly
- Fleury Yvan
- Flevari Aikaterini
- Flores Leah
- Foka Maria
- Fonseca Imelda Perdomo
- Foong Kit Weng
- Fores Meritxell Tapia
- Fox Natalie
- Fox Nathalie
- Fraipont Vincent
- Franco Natalia
- Frandsen Tine Melgaard
- François Guy
- Frey Christian
- From Mette
- Fu Jing
- Fujimoto Koji
- Galaaen Britt
- Galazzi Alessandro
- Galiana Maria
- Galishevskiy Dmitriy
- Gallart Elisabet
- Gallegos-Perez Humberto
- Gallion Marc
- Gama Luz Marina Silva
- Ganeshalingam Vaarisan
- Gao Guangyuan
- Gao Jie
- Gao Li
- Gao Yan
- Garcia Amilcar
- Garcia Barbara
- Garcia Paulo Carlos
- Garcia Rosa
- García Maria Fernanda
- Garofalo Eugenio
- Garzón-Tovar Carolina
- Gatti Chiara
- Gautam Prabha
- Gautheret Nathalie
- Gavrilovic Srđan
- Gawda Ryszard
- Ge Liuyan
- Geijer Sebastian
- Georgakas Ioannis
- George Shaly
- Georgiev Carmel
- Georgiou Marios
- Gerretsen Benjamin
- Gerritsen Rik T.
- Gharios Elie
- Ghioldi Davide Massimo
- Ghosh Rishi
- Ghula Mohamed Abdurazzag Ali
- Giacardi Christophe
- Giampaoletti Andrea
- Gievski Vanja
- Gilder Eileen
- Gill Sirley
- Gils Fränk
- Girianni Salvatore
- Girona Mercè
- Giusti Gian Domenico
- Gkiokas Georgios
- Glinka Lidia
- Goksu Senay
- Goller Stefan
- Gomes Vitor
- Gomez Monica
- Gomez Saira
- Gong Yue Ying
- Gonzalez Ana Laura
- Gonzalez Daira
- Gonzalez Jeniffer
- Gonzalez Juan Ignacio Torres
- Gonzalez Rafael
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- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
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- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
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- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
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- Aydemir Semih
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- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
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- Balbay Abidin Oner
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- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
- Eneas Antony
- Eng Timothy
- Erdivanli Başar
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- Escalante Rosana Gabriela
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- Nava Luis Pedro Ambriz
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- Negro Alessandra
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- Newby Lynette
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- Ni Dongshu
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- Nikolaou Charikleia
- Nishime Yoshimasa
- Noblezada-Uy Debbie
- Nocheretti Mariangeles Gabriela
- Noguchi Ayako
- Nogueira Paula Cristina
- Nor Basri Mat
- Nor Mohd Basri Mat
- North Samantha
- Nshimyumuremyi Isaac
- Nunes Catarina
- Nuñez Cesar Rodriguez
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- Ogbeide Vongayi
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- Pagella Gonzalo
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- Pan Fuqun
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- Panka Bernardo
- Pantaleao Taís
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- Papadopoulos Dimitrios
- Papageorgiou Eirini
- Papanikolaou Metaxia
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- Papavasilopoulou Theonymfi
- Parag Nivisha
- Parente Isabel
- Park Jisoo
- Park Seung Yong
- Park So Young
- Park Sunghoon
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- Parke Rachael
- Parkin Emma
- Parsons Leanne
- Parsons Penny
- Pascual-Bielsa Ana
- Pastore Beatrice
- Pastores Stephen M.
- Pathak Sabina Dhakal
- Patrichi Tatiana
- Patsalos Artemis
- Patsiou Eirini-Chysovalanto
- Pavlisa Gordana
- Pedersen Anne Sofie Bomholt
- Pedersen Karin Rehnholt
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- Peratoner Alberto
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- Perme Janja
- Peterson Jessica
- Petosic Antonija
- Petrisor Cristina
- Petrushin Maxim
- Pečenković Suzana
- Philippart François
- Piergentili Federica
- Pili-Floury Sébastien
- Pillard Cindy
- Pineda Ana Alícia Velarde
- Pinheiro Cristiana Mota
- Pinto Susana
- Pinto Vitor Manuel Vaz
- Piradov Michael
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- Powell Madeleine
- Preda Gabriel
- Prol-Silva Estefanía
- Prowle John
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- Pulak Paul
- Pulletz Mark
- Putruele Sofia
- Qawasmeh Khaled Al
- Qiao Hongmei
- Quagliotto Catia
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- Quintard Hervé
- Quiroga Cristian
- Rabarova Daria
- Radavidson Anthony
- Radivojevic Renata Curic
- Rahim Azmin Huda Abdul
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- Reece-Anthony Rosie
- Reidinga Auke
- Reijntjens Jennifer
- Remor Natalie
- Ren Aiua
- Reyes Amylkar Garay
- Reyes Amylkar José Garay
- Reyes Laura Martinez
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- Ribas Antoni Margarit
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- Riessen Reimer
- Ringdal Mona
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- Rocco Monica
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- Rodriguez Gabriel Enrique
- Rojas-Suarez José
- Rokosh Ella
- Roller Martin
- Roman-Pognuz Erik
- Romero-Gonzalez Juan P.
- Ronchini Ana Lucia Vitti
- Rooney Glenda
- Rosado Ines
- Rosalia Rodney
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- Rose Bernd Oliver
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- Rostello Oscar Fernández
- Rothenfusser Monika
- Rubulotta Francesca
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- Saager Leif
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- Sakuramoto Hideaki
- Salazar Janel
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- Salvà-Costa Vicent
- Samat Noryani Mohd
- Sanchez Losune Cano
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- Sanchez-Hurtado Luis Alejandro
- Sandberg Ulla
- Sandesc Dorel
- Sankar-Maharaj Sasha
- Sankey Babangida John
- Santiago Eleanor
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- Sanz Luz Coronado
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- Sarkar Nikki
- Saul Pablo
- Sawawiboon Chaiwut
- Schaller Stefan
- Schallom Marilyn
- Schefold Joerg C.
- Schmidt Raysa Cristina
- Schmollgruber Shelley
- Schmukler Armando
- Schmutz René
- Schulze Tobias
- Schüppel Sebastian
- Scire Giovanni
- Scutariu Monica Adriana
- Sellami Walid
- Sepulveda Maria Idalia
- Sergeev Dmitry
- Serin Sibel Ocak
- Seromenho Vanda
- Serpa Leticia
- Sertznig Claude
- Setten Mariano
- Shah Bhagyesh
- Shao Hongyan
- Shaw David
- Shawish Sabah Abu
- Shayamano Rosina
- Sheehan Christine
- Shen Yanling
- Sherwin James
- Shi Guanxiu
- Shi Zeya
- Shime Nobuaki
- Shimizu Masako
- Short Jack
- Shosholcheva Mirjana
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- Thankamma Bindu
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- Thompson Amy
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- Thomsen Tina Damgaar
- Thorpe Elaine
- Tian Eryun
- Tian Xiao Fang
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- Timsit Jean-Francois
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- Tirado Celia
- Toellefsen Annette
- Tokareva Ekaterina
- Tokur Murat Emre
- Tole Eunice
- Tomescu Dana
- Tong Jenny May Geok
- Tonkovic Dinko
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- Traina Lidia
- Tranello Francesca Paola
- Tribulev Maksim
- Tridente Ascanio
- Triki Ahmed Ramadan
- Tripathy Swagata
- Trongtrakul Konlawij
- Trongtratul Konlawij
- Trposak Angela
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- Trueman-Dawkins Treiza
- Tsarev Alexander
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- Tsikritsaki Kyriaki
- Tsujimoto Mayumi
- Tubacka Marta
- Tuinstra Binny
- Tuo Lili
- Turan Can
- Turan Sema
- Turc Jean
- Turner Sarah Jane
- Turčan Anton
- Tutillo Diego Rolando Morocho
- Twagirumugabe Theogene
- Twiggs Hilary
- Uba Stella
- Uccelli Francesco
- Udiljak Nikolina
- Ugwu Innocent
- Umek Nejc
- Undar Hasan Nabi
- Vakalos Aristeidis
- Valerio Idália
- Valgolio Emanuel
- Valta Maija
- Valta Maija Anniina
- van Axel Alisha
- Van Cotthem Ilse
- Van de Velde Stijn
- Van Den Berg Lettie
- Van Den Brink Mark
- Van Den Elst Arlette
- van der Kuil Mark
- Van Gulik Laura
- Van Regenmortel Niels
- Van Vliet Peter
- Vanroest Margijske
- Varela Maria
- Vaschetto Rosanna
- Vasquez Alexandra
- Vaughan-Jones Nicola
- Velickovic Jelena
- Veličković Dejan
- Ventour Dale
- Vermeijden Jan Wytze
- Vieira João
- Villa Robert
- Villafuerte Missael Vladimir Espinoza
- Villanueva Ximena
- Villegas Paula
- Viveiros Abel
- Vizcaychipi Marcela
- Vlaovic Janko
- Vochin Ana
- Volta Carlo Alberto
- von der Osten Ingrid
- Von Der Osten Ingrid
- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
- Vullum Sylvi
- Vymazal Tamas
- Vymazal Tomas
- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
- Wang Damei
- Wang Fanglan
- Wang GuoXian
- Wang Hai Yun
- Wang Haiyan
- Wang Jing
- Wang Kefang
- Wang LingLing
- Wang RuiXia
- Wang Shuhui
- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
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