Samband mellan tidig ålder vid avskiljning och missriktat diande hos föl

By tradition horses are weaned at an age of 5-6 months. This study illuminates weaned foals misdirected suckling behaviour, which means that they try to suckle another foal. Since no information about this issue is presented, we decided to perform a behaviour study on weaned foals. The misdirected suckling behaviour was studied on a group with 7 foals, with both fillies and colts. In the group the weaning age varied between 147 days and 215 days, and the first time we observed them, they had been separated from the mares for 12 days. We found that age at weaning is correlated with the emergence of this non-nutritional suckling behaviour. It was revealed that the older colts were most frequent to give suck. Beside our behaviour study we review the natural relationship between mare and her offspring, natural weaning and the suckingbehaviour in foals. Suckling is an important factor for the foals´ social and emotional welfare. When human wean foals at a young age, they are exposed for stress that could lead to stereotypic and other behaviour problems

Характер регенерации костной ткани альвеолярного отростка нижней челюсти после удаления ретинированного зуба мудрости

ЗУБ МУДРОСТИ /ХИРАЛЬВЕОЛЯРНЫЙ ОТРОСТОКРЕГЕНЕРАЦИЯ ПЕРИОДОНТАЛЬНОЙ ТКАНИ НАПРАВЛЕННАЯЗУБ РЕТИНИРОВАННЫЙ /ХИРКОСТЬ И КОСТНЫЕ ТКАН

DNA building blocks: keeping control of manufacture

Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when dNTP levels are either unbalanced or elevated. RNR is the major player in this homeostasis, and with its four different substrates, four different allosteric effectors and two different effector binding sites, it has one of the most sophisticated allosteric regulations known today. In the past few years, the structures of RNRs from several bacteria, yeast and man have been determined in the presence of allosteric effectors and substrates, revealing new information about the mechanisms behind the allosteric regulation. A common theme for all studied RNRs is a flexible loop that mediates modulatory effects from the allosteric specificity site (s-site) to the catalytic site for discrimination between the four substrates. Much less is known about the allosteric activity site (a-site), which functions as an on-off switch for the enzyme's overall activity by binding ATP (activator) or dATP (inhibitor). The two nucleotides induce formation of different enzyme oligomers, and a recent structure of a dATP-inhibited α6β2 complex from yeast suggested how its subunits interacted non-productively. Interestingly, the oligomers formed and the details of their allosteric regulation differ between eukaryotes and Escherichia coli Nevertheless, these differences serve a common purpose in an essential enzyme whose allosteric regulation might date back to the era when the molecular mechanisms behind the central dogma evolved

Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project)

REIPI/INCREMENT-SOT Group.[Background] Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) bloodstream infection (BSI) secondary to urinary tract infection (UTI) in kidney transplant recipients (KTRs) remains unclear.[Methods] We retrospectively evaluated 306 KTR admitted to 30 centers from January 2014 to October 2016. Therapeutic failure (lack of cure or clinical improvement and/or death from any cause) at days 7 and 30 from ESBL-E BSI onset was the primary and secondary study outcomes, respectively.[Results] Therapeutic failure at days 7 and 30 occurred in 8.2% (25/306) and 13.4% (41/306) of patients. Hospital-acquired BSI (adjusted OR [aOR]: 4.10; 95% confidence interval [CI]: 1.50-11.20) and Pitt score (aOR: 1.47; 95% CI: 1.21-1.77) were independently associated with therapeutic failure at day 7. Age-adjusted Charlson Index (aOR: 1.25; 95% CI: 1.05-1.48), Pitt score (aOR: 1.72; 95% CI: 1.35-2.17), and lymphocyte count ≤500 cells/μL at presentation (aOR: 3.16; 95% CI: 1.42-7.06) predicted therapeutic failure at day 30. Carbapenem monotherapy (68.6%, primarily meropenem) was the most frequent active therapy, followed by BLBLI monotherapy (10.8%, mostly piperacillin-tazobactam). Propensity score (PS)-adjusted models revealed no significant impact of the choice of active therapy (carbapenem-containing vs any other regimen, BLBLI- vs carbapenem-based monotherapy) within the first 72 hours on any of the study outcomes.[Conclusions] Our data suggest that active therapy based on BLBLI may be as effective as carbapenem-containing regimens for ESBL-E BSI secondary to UTI in the specific population of KTR. Potential residual confounding and unpowered sample size cannot be excluded (ClinicalTrials.gov identifier: NCT02852902).This work was supported by: (1) Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III (ISCIII), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases [RD16/0016/0001, RD16/0016/0002, REIPI RD16/0016/0008; RD16/0016/00010], co-financed by European Development Regional Fund “A way to achieve Europe”, Operative Program Intelligent Growth 2014-2020; (2) European Society of Clinical Microbiology and Infectious diseases Study Group for Infections in Compromised Hosts (ESGICH, grant to J.M.A.); (3) Sociedad Andaluza de Trasplante de Órgano Sólido (SATOT, grant to L.M.M.); (4) Research project PI16/01631 integrated into the Plan Estatal de I+D+I 2013-2016 and co-financed by the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación and the Fondo Europeo de Desarrollo Regional (FEDER); (5) M.F.R. holds a research contract “Miguel Servet” (CP 18/00073) from ISCIII, Ministerio de Ciencia, Innovación y Universidades. The work was also supported by the following European Society of Clinical Microbiology and Infectious diseases (ESCMID) study groups: Infections in Compromised Hosts (ESGICH), Bloodstream Infections and Sepsis (ESGBIS) and Antimicrobial Resistance Surveillance (ESGARS).Peer reviewe

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Integrated libraries. A study of two possible organisations.

The aim of this master&apos;s degree dissertation is to compile examples of different ways of planning, implementing and following up the organisation of two integrated libraries, which serve both the general public and the school. In order to respond to this, we formulated the all-embracing question: How best can the integration of libraries for schools and the general public be planned, implemented and followed up? This formulation gave rise to four further questions. In order to answer these questions, the problem formulated and our basic aim, we have studied the relevant literature on school libraries, libraries for the general public, and integrated libraries. These sources comprise official reports on this theme, dissertations, and more topical articles. In addition empirical studies have been carried out in the form of interviews. As our theoretical basis we have used Gunnar Berg&apos;s organisational plan for schools, which we have extended and used for the integration of the library. Berg&apos;s scheme is based on Bengt Abrahamsson&apos;s attempt to rationalise, of which we give a short account. In addition we have used Romulo Enmark&apos;s blueprint, which shows the breadth of activities possible in libraries for schools and the general public. Our conclusion is that in order to acquire a smoothly-operating integrated library with potential for development, there is a need for fundamental planning, organised objectives for the work and its educational contribution to the school, agreement as to shared responsibility and finances between school and library, and continual follow-up of the work in hand. Marie Eriksson och Britt-Marie Jonth vann SKTF:s uppsatsstipendium 2002 med ovanstående uppsats.Uppsatsnivå:

Specifik nackmuskelträning som sjukgymnastisk behandling vid nacksmärta : en litteraturstudie

Validerat; 20101217 (root