№ 14. Заключення секретаря 6-го відділення Секретного відділу ОДПУ СРСР щодо передачі справи О. Ярещенка на розгляд Особливої наради при Колегії ОДПУ СРСР від 25 травня 1926 р.

Публікація Д. Бойко, І. Бухарєвої, С. Кокіна, П. Кулаковського

Monitoring van biologische en abiotische parameters in zoute wateren in Nederland. Stand van zaken, de verplichtingen voortvloeiend uit Europese regelgeving en aanbevelingen voor de toekomst

Het is alweer enkele jaren geleden dat Alterra Texel onderzoek deed naar lopende monitorprogramma's in zoute wateren in Nederland. Dit onderzoek is in 2007 en 2008 besproken met vertegenwoordigers van zowel LNV als Waterstaat. De definitieve rapportage heeft geruime tijd op zich laten wachten, onder andere omdat lange tijd onduidelijk was welke parameters er in het kader van de rapportage over de habitatrichtlijn er voor de Europese Commissie nodig waren. Naast de Nederlandse gegevens worden in deze rapportage ook die van Denemarken, Zweden, Verenigd Koninkrijk en Duitsland gegeve

Frodo: Take off the ring! Practical, quantum-secure key exchange from LWE

Lattice-based cryptography offers some of the most attractive primitives believed to be resistant to quantum computers. Following increasing interest from both companies and government agencies in building quantum computers, a number of works have proposed instantiations of practical post-quantum key exchange protocols based on hard problems in ideal lattices, mainly based on the Ring Learning With Errors (R-LWE) problem. While ideal lattices facilitate major efficiency and storage benefits over their nonideal counterparts, the additional ring structure that enables these advantages also raises concerns about the assumed difficulty of the underlying problems. Thus, a question of significant interest to cryptographers, and especially to those currently placing bets on primitives that will withstand quantum adversaries, is how much of an advantage the additional ring structure actually gives in practice. Despite conventional wisdom that generic lattices might be too slow and unwieldy, we demonstrate that LWE-based key exchange is quite practical: our constant time implementation requires around 1.3ms computation time for each party; compared to the recent NewHope R-LWE scheme, communication sizes increase by a factor of 4.7×, but remain under 12 KiB in each direction. Our protocol is competitive when used for serving web pages over TLS; when partnered with ECDSA signatures, latencies increase by less than a factor of 1.6×, and (even under heavy load) server throughput only decreases by factors of 1.5× and 1.2× when serving typical 1 KiB and 100 KiB pages, respectively. To achieve these practical results, our protocol takes advantage of several innovations. These include techniques to optimize communication bandwidth, dynamic generation of public parameters (which also offers additional security against backdoors), carefully chosen error distributions, and tight security parameters

Genetic Evidence for a Causal Role of Serum Phosphate in Coronary Artery Calcification:The Rotterdam Study

BACKGROUND: Hyperphosphatemia has been associated with coronary artery calcification (CAC) mostly in chronic kidney dis-ease, but the association between phosphate levels within the normal phosphate range and CAC is unclear. Our objectives were to evaluate associations between phosphate levels and CAC among men and women from the general population and assess causality through Mendelian randomization. METHODS AND RESULTS: CAC, measured by electron-beam computed tomography, and serum phosphate levels were assessed in 1889 individuals from the RS (Rotterdam Study). Phenotypic associations were tested through linear models adjusted for age, body mass index, blood pressure, smoking, prevalent cardiovascular disease and diabetes, 25-hydroxyvitamin D, total calcium, C-reactive protein, glucose, and total cholesterol: high-density lipoprotein cholesterol ratio. Mendelian randomiza-tion was implemented through an allele score including 8 phosphate-related single-nucleotide polymorphisms. In phenotypic analyses, serum phosphate (per 1 SD) was associated with CAC with evidence for sex interaction (Pinteraction =0.003) (men β, 0.44 [95% CI, 0.30– 0.59]; P=3×10−9; n=878; women β, 0.24 [95% CI, 0.08– 0.40]; P=0.003; n=1011). Exclusion of hyperphos-phatemia, chronic kidney disease (estimated glomerular filtration rate &lt;60 mL/min per 1.73 m2) and prevalent cardiovascular disease yielded similar results. In Mendelian randomization analyses, instrumented phosphate was associated with CAC (total population β, 0.93 [95% CI: 0.07–1.79]; P=0.034; n=1693), even after exclusion of hyperphosphatemia, chronic kidney disease and prevalent cardiovascular disease (total population β, 1.23 [95% CI, 0.17– 2.28]; P=0.023; n=1224). CONCLUSIONS: Serum phosphate was associated with CAC in the general population with stronger effects in men. Mendelian randomization findings support a causal relation, also for serum phosphate and CAC in subjects without hyperphosphatemia, chronic kidney disease, and cardiovascular disease. Further research into underlying mechanisms of this association and sex differences is needed.</p

PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis

Polyploidization frequently precedes tumorigenesis but also occurs during normal development in several tissues. Hepatocyte ploidy is controlled by the PIDDosome during development and regeneration. This multi-protein complex is activated by supernumerary centrosomes to induce p53 and restrict proliferation of polyploid cells, otherwise prone for chromosomal instability. PIDDosome deficiency in the liver results in drastically increased polyploidy. To investigate PIDDosome-induced p53-activation in the pathogenesis of liver cancer, we chemically induced hepatocellular carcinoma (HCC) in mice. Strikingly, PIDDosome deficiency reduced tumor number and burden, despite the inability to activate p53 in polyploid cells. Liver tumors arise primarily from cells with low ploidy, indicating an intrinsic pro-tumorigenic effect of PIDDosome-mediated ploidy restriction. These data suggest that hyperpolyploidization caused by PIDDosome deficiency protects from HCC. Moreover, high tumor cell density, as a surrogate marker of low ploidy, predicts poor survival of HCC patients receiving liver transplantation. Together, we show that the PIDDosome is a potential therapeutic target to manipulate hepatocyte polyploidization for HCC prevention and that tumor cell density may serve as a novel prognostic marker for recurrence-free survival in HCC patients

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results