HST Morphologies of z ~ 2 Dust-Obscured Galaxies II: Bump Sources

We present Hubble Space Telescope (HST) imaging of 22 ultra-luminous infrared galaxies (ULIRGs) at z~2 with extremely red R-[24] colors (called dust-obscured galaxies, or DOGs) which have a local maximum in their spectral energy distribution (SED) at rest-frame 1.6um associated with stellar emission. These sources, which we call "bump DOGs", have star-formation rates of 400-4000 Msun/yr and have redshifts derived from mid-IR spectra which show strong polycyclic aromatic hydrocarbon emission --- a sign of vigorous on-going star-formation. Using a uniform morphological analysis, we look for quantifiable differences between bump DOGs, power-law DOGs (Spitzer-selected ULIRGs with mid-IR SEDs dominated by a power-law and spectral features that are more typical of obscured active galactic nuclei than starbursts), sub-millimeter selected galaxies (SMGs), and other less-reddened ULIRGs from the Spitzer extragalactic First Look Survey (XFLS). Bump DOGs are larger than power-law DOGs (median Petrosian radius of 8.4 +/- 2.7 kpc vs. 5.5 +/- 2.3 kpc) and exhibit more diffuse and irregular morphologies (median M_20 of -1.08 +/- 0.05 vs. -1.48 +/- 0.05). These trends are qualitatively consistent with expectations from simulations of major mergers in which merging systems during the peak star-formation rate period evolve from M_20 = -1.0 to M_20 = -1.7. Less obscured ULIRGs (i.e., non-DOGs) tend to have more regular, centrally peaked, single-object morphologies rather than diffuse and irregular morphologies. This distinction in morphologies may imply that less obscured ULIRGs sample the merger near the end of the peak star-formation rate period. Alternatively, it may indicate that the intense star-formation in these less-obscured ULIRGs is not the result of a recent major merger.Comment: Accepted to ApJ; 22 pages, 8 Figures, 7 Table

Integral field optical spectroscopy of a representative sample of ULIRGs: I. The Data

We present a project aimed at studying the structure, dust distribution, ionization state, and kinematics of a representative sample of 22 ULIRGs. The galaxies in the sample undergo different merger phases (they are evenly divided between pre- and post-coalescence systems) and ionization stages (27% HII, 32% LINER, 18% Seyfert, and 23% mixed classifications) over a wide infrared luminosity range (11.8<Lir/Lsun<12.6), which also includes some galaxies of low luminosity. The main aims of this paper are to present the sample and discuss the structure of the stellar and ionized gas components. Our results imply that evolution caused by a merger is occurring in the ionized gas structure of ULIRGs. The present study relies on the use of integral field optical spectroscopy data obtained with the INTEGRAL instrument at the 4.2 m William Herschel Telescope.Comment: To appear in A&A. Paper with higher quality images can be found at http://hera.ph1.uni-koeln.de/ftpspace/maca/Catalog

Mid-infrared spectroscopy of infrared-luminous galaxies at z~0.5-3

We present results on low-resolution mid-infrared (MIR) spectra of 70 infrared-luminous galaxies obtained with the Infrared Spectrograph (IRS) onboard Spitzer. We selected sources from the European Large Area Infrared Survey (ELAIS) with S15 > 0.8 mJy and photometric or spectroscopic z > 1. About half of the sample are QSOs in the optical, while the remaining sources are galaxies, comprising both obscured AGN and starbursts. We classify the spectra using well-known infrared diagnostics, as well as a new one that we propose, into three types of source: those dominated by an unobscured AGN (QSOs), obscured AGN, and starburst-dominated sources. Starbursts concentrate at z ~ 0.6-1.0 favored by the shift of the 7.7-micron PAH band into the selection 15 micron band, while AGN spread over the 0.5 < z < 3.1 range. Star formation rates (SFR) are estimated for individual sources from the luminosity of the PAH features. An estimate of the average PAH luminosity in QSOs and obscured AGN is obtained from the composite spectrum of all sources with reliable redshifts. The estimated mean SFR in the QSOs is 50-100 Mo yr^-1, but the implied FIR luminosity is 3-10 times lower than that obtained from stacking analysis of the FIR photometry, suggesting destruction of the PAH carriers by energetic photons from the AGN. The SFR estimated in obscured AGN is 2-3 times higher than in QSOs of similar MIR luminosity. This discrepancy might not be due to luminosity effects or selection bias alone, but could instead indicate a connection between obscuration and star formation. However, the observed correlation between silicate absorption and the slope of the near- to mid-infrared spectrum is compatible with the obscuration of the AGN emission in these sources being produced in a dust torus.Comment: 32 pages, 24 figures, 15 tables, accepted for publication in MNRA

Intelligent Systems for Geosciences: An Essential Research Agenda

A research agenda for intelligent systems that will result in fundamental new capabilities for understanding the Earth system. Many aspects of geosciences pose novel problems for intelligent systems research. Geoscience data is challenging because it tends to be uncertain, intermittent, sparse, multiresolution, and multiscale. Geosciences processes and objects often have amorphous spatiotemporal boundaries. The lack of ground truth makes model evaluation, testing, and comparison difficult. Overcoming these challenges requires breakthroughs that would significantly transform intelligent systems, while greatly benefitting the geosciences in turn

Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts.

Cardiac fibroblasts (CF) play a key role in orchestrating the structural remodeling of the myocardium in response to injury or stress, in part through direct regulation of extracellular matrix (ECM) turnover. The matrix metalloproteinases (MMPs) are a family of over 25 zinc‐dependent proteases that together have the capacity to degrade all the protein components of the ECM. Fibroblasts are a major source of several MMPs in the heart, thereby representing a viable therapeutic target for regulating ECM turnover in cardiac pathologies characterized by adverse remodeling, such as myocardial infarction, cardiomyopathy, hypertension and heart failure. This review summarizes current knowledge on the identity and regulation of MMPs expressed by CF and discusses future directions for reducing adverse myocardial remodeling by modulating the expression and/or activity of CF‐derived MMPs. © 2012 IUBMB IUBMB Life, 2012

Immigrant status and increased risk of heart failure: the role of hypertension and life-style risk factors

<p>Abstract</p> <p>Background</p> <p>Studies from Sweden have reported association between immigrant status and incidence of cardiovascular diseases. The nature of this relationship is unclear. We investigated the relationship between immigrant status and risk of heart failure (HF) hospitalization in a population-based cohort, and to what extent this is mediated by hypertension and life-style risk factors. We also explored whether immigrant status was related to case-fatality after HF.</p> <p>Methods</p> <p>26,559 subjects without history of myocardial infarction (MI), stroke or HF from the community-based Malmö Diet and Cancer (MDC) cohort underwent a baseline examination during 1991-1996. Incidence of HF hospitalizations was monitored during a mean follow-up of 15 years.</p> <p>Results</p> <p>3,129 (11.8%) subjects were born outside Sweden. During follow-up, 764 subjects were hospitalized with HF as primary diagnosis, of whom 166 had an MI before or concurrent with the HF. After adjustment for potential confounding factors, the hazard ratios (HR) for foreign-born were 1.37 (95% CI: 1.08-1.73, <it>p </it>= 0.009) compared to native Swedes, for HF without previous MI. The results were similar in a secondary analysis without censoring at incident MI. There was a significant interaction (<it>p </it>< 0.001) between immigrant status and waist circumference (WC), and the increased HF risk was limited to immigrants with high WC. Although not significant foreign-born tended to have lower one-month and one-year mortality after HF.</p> <p>Conclusions</p> <p>Immigrant status was associated with long-term risk of HF hospitalization, independently of hypertension and several life-style risk factors. A significant interaction between WC and immigrant status on incident HF was observed.</p

The Role of Antioxidation and Immunomodulation in Postnatal Multipotent Stem Cell-Mediated Cardiac Repair

Oxidative stress and inflammation play major roles in the pathogenesis of coronary heart disease including myocardial infarction (MI). The pathological progression following MI is very complex and involves a number of cell populations including cells localized within the heart, as well as cells recruited from the circulation and other tissues that participate in inflammatory and reparative processes. These cells, with their secretory factors, have pleiotropic effects that depend on the stage of inflammation and regeneration. Excessive inflammation leads to enlargement of the infarction site, pathological remodeling and eventually, heart dysfunction. Stem cell therapy represents a unique and innovative approach to ameliorate oxidative stress and inflammation caused by ischemic heart disease. Consequently, it is crucial to understand the crosstalk between stem cells and other cells involved in post-MI cardiac tissue repair, especially immune cells, in order to harness the beneficial effects of the immune response following MI and further improve stem cell-mediated cardiac regeneration. This paper reviews the recent findings on the role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair following ischemic heart disease, particularly acute MI and focuses specifically on mesenchymal, muscle and blood-vessel-derived stem cells due to their antioxidant and immunomodulatory properties

Ultraluminous Infrared Galaxies

Ever since their discovery in the 1970's, UltraLuminous InfraRed Galaxies (ULIRGs; classically Lir>10^12Lsun) have fascinated astronomers with their immense luminosities, and frustrated them due to their singularly opaque nature, almost in equal measure. Over the last decade, however, comprehensive observations from the X-ray through to the radio have produced a consensus picture of local ULIRGs, showing that they are mergers between gas rich galaxies, where the interaction triggers some combination of dust-enshrouded starburst and AGN activity, with the starburst usually dominating. Very recent results have thrown ULIRGs even further to the fore. Originally they were thought of as little more than a local oddity, but the latest IR surveys have shown that ULIRGs are vastly more numerous at high redshift, and tantalizing suggestions of physical differences between high and low redshift ULIRGs hint at differences in their formation modes and local environment. In this review we look at recent progress on understanding the physics and evolution of local ULIRGs, the contribution of high redshift ULIRGs to the cosmic infrared background and the global history of star formation, and the role of ULIRGs as diagnostics of the formation of massive galaxies and large-scale structures.Comment: Review article, published in "Astrophysics Update 2 - topical and timely reviews on astronomy and astrophysics". Ed. John W. Mason. Springer/Praxis books. ISBN: 3-540-30312-X. 53 pages, 5 figures. Higher quality figures available on reques

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3&nbsp;years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0&nbsp;years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013