Nonlinear Alpha Effect in Dynamo Theory

We extend the standard two-scale theory of the turbulent dynamo coefficient $\alpha$ to include the nonlinear back reaction of the mean field $\bar B$ on the turbulence. We calculate the turbulent emf as a power series in $\bar B$, assuming that the base state of the turbulence ($\bar B=0$) is isotropic, and, for simplicity, that the magnetic diffusivity equals the kinematic viscosity. The power series converges for all $\bar B$, and for the special case that the spectrum of the turbulence is sharply peaked in $k$, our result is proportional to a tabulated function of the magnetic Reynolds number $R_M$ and the ratio $\beta$ of $\bar B$ (in velocity units) to the rms turbulent velocity $v_0$. For $\beta\to 0$ (linear regime) we recover the results of Steenbeck et al. (1966) as modified by Pouquet et al. (1976). For $R_M\gg 1$, the usual astrophysical case, $\alpha$ starts to decrease at $\beta \sim 1$, dropping like $\beta^{-2}$ as $\beta \to \infty$. Hence for large $R_M$, $\alpha$ saturates at $\bar B\sim v_0$, as estimated by Kraichnan (1979), rather than at $\bar B\sim R^{-1/2}_Mv_0$, as inferred by Cattaneo and Hughes (1996) from their numerical simulations at $R_M$=100. We plan to carry out simulations with various values of $R_M$ to investigate the discrepency.Comment: 41 pages, 1 Postscript figure, accepted for publication to Ap

Ionization structure and Fe Kα\alpha energy for irradiated accretion disks

We study the radial ionization structure at the surface of an X-ray illuminated accretion disk. We plot the expected iron K$\alpha$ line energy as a function of the Eddington ratio and of the distance of the emitting matter from the central source, for a non-rotating and a maximally-rotating black hole. We compare the predicted disk line energies with those measured in an archival sample of active galactic nuclei observed with {\it Chandra}, {\it XMM-Newton} and {\it Suzaku}, and discuss whether the line energies are consistent with the radial distances inferred from reverberation studies. We also suggest using rapidly-variable iron K$\alpha$ lines to estimate the viscosity parameter of an accretion disk. There is a forbidden region in the line energy versus Eddington ratio plane, at low Eddington ratios, where an accretion disk cannot produce highly-ionized iron K$\alpha$ lines. If such emission is observed in low-Eddington-ratio sources, it is either coming from a highly-ionized outflow, or is a blue-shifted component from fast-moving neutral matter.Comment: 5 pages, 2 figures, accepted by MNRA

Prospects for progress on health inequalities in England in the post-primary care trust era : professional views on challenges, risks and opportunities

Background - Addressing health inequalities remains a prominent policy objective of the current UK government, but current NHS reforms involve a significant shift in roles and responsibilities. Clinicians are now placed at the heart of healthcare commissioning through which significant inequalities in access, uptake and impact of healthcare services must be addressed. Questions arise as to whether these new arrangements will help or hinder progress on health inequalities. This paper explores the perspectives of experienced healthcare professionals working within the commissioning arena; many of whom are likely to remain key actors in this unfolding scenario. Methods - Semi-structured interviews were conducted with 42 professionals involved with health and social care commissioning at national and local levels. These included representatives from the Department of Health, Primary Care Trusts, Strategic Health Authorities, Local Authorities, and third sector organisations. Results - In general, respondents lamented the lack of progress on health inequalities during the PCT commissioning era, where strong policy had not resulted in measurable improvements. However, there was concern that GP-led commissioning will fare little better, particularly in a time of reduced spending. Specific concerns centred on: reduced commitment to a health inequalities agenda; inadequate skills and loss of expertise; and weakened partnership working and engagement. There were more mixed opinions as to whether GP commissioners would be better able than their predecessors to challenge large provider trusts and shift spend towards prevention and early intervention, and whether GPs’ clinical experience would support commissioning action on inequalities. Though largely pessimistic, respondents highlighted some opportunities, including the potential for greater accountability of healthcare commissioners to the public and more influential needs assessments via emergent Health & Wellbeing Boards. Conclusions - There is doubt about the ability of GP commissioners to take clearer action on health inequalities than PCTs have historically achieved. Key actors expect the contribution from commissioning to address health inequalities to become even more piecemeal in the new arrangements, as it will be dependent upon the interest and agency of particular individuals within the new commissioning groups to engage and influence a wider range of stakeholders.</p

Symbiotic starburst-black hole AGN -- I. Isothermal hydrodynamics of the mass-loaded ISM

Compelling evidence associates the nuclei of active galaxies and massive starbursts. The symbiosis between a compact nuclear starburst stellar cluster and a massive black hole can self-consistently explain the properties of active nuclei. The young stellar cluster has a profound effect on the most important observable properties of active galaxies through its gravity, and by mass injection through stellar winds, supernovae and stellar collisions. Mass injection generates a nuclear ISM which flows under gravitational and radiative forces until it leaves the nucleus or is accreted onto the black hole or accretion disc. The radiative force exerted by the black hole--accretion disc radiation field is not spherically symmetric. This results in complex flows in which regions of inflow can coexist with high Mach number outflowing winds and hydrodynamic jets. We present two-dimensional hydrodynamic models of such nISM flows, which are highly complex and time variable. Shocked shells, jets and explosive bubbles are produced, with bipolar winds driving out from the nucleus. Our results graphically illustrate why broad emission line studies have consistently failed to identify any simple, global flow geometry. The real structure of the flows is _inevitably_ yet more complex.Comment: 51 pages, 85 postscript figures, Latex, using MNRAS macros, to be published in MNRAS. Postscript will full resolution pictures and mpeg simulations available via http://ast.leeds.ac.uk/~rjrw/agn.htm

XMM-Newton observation of an unusual iron line in the quasar Markarian 205

XMM-Newton observations of the low luminosity, radio-quiet quasar Markarian 205 have revealed a unique iron K emission line profile. In marked contrast to the broad and redshifted iron K line commonly seen in ASCA observations of Seyfert 1 galaxies, we find that a substantial amount of the line flux in Mrk 205 occurs above the neutral line energy of 6.4 keV. Furthermore, we find that the iron line emission has two distinct components, a narrow, unresolved neutral line at 6.4 keV and a broadened line centred at 6.7 keV. We suggest that the most likely origin of the 6.7 keV line is from X-ray reflection off the surface of a highly ionised accretion disk, whilst the 6.4 keV component may arise from neutral matter distant from the black hole, quite possibly in the putative molecular torus. Overall this observation underlines the potential of XMM-Newton for using the iron K line as a diagnostic of matter in the innermost regions of AGN.Comment: 6 pages, accepted for publication in Astronomy and Astrophysics Letter

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far

Detection and Characterization of Wolbachia Infections in Natural Populations of Aphids: Is the Hidden Diversity Fully Unraveled?

Aphids are a serious threat to agriculture, despite being a rather small group of insects. The about 4,000 species worldwide engage in highly interesting and complex relationships with their microbial fauna. One of the key symbionts in arthropods is Wolbachia, an α-Proteobacterium implicated in many important biological processes and believed to be a potential tool for biological control. Aphids were thought not to harbour Wolbachia; however, current data suggest that its presence in aphids has been missed, probably due to the low titre of the infection and/or to the high divergence of the Wolbachia strains of aphids. The goal of the present study is to map the Wolbachia infection status of natural aphids populations, along with the characterization of the detected Wolbachia strains. Out of 425 samples from Spain, Portugal, Greece, Israel and Iran, 37 were found to be infected. Our results, based mainly on 16S rRNA gene sequencing, indicate the presence of two new Wolbachia supergroups prevailing in aphids, along with some strains belonging either to supergroup B or to supergroup A

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

GWTC-1: A Gravitational-Wave Transient Catalog of Compact Binary Mergers Observed by LIGO and Virgo during the First and Second Observing Runs

We present the results from three gravitational-wave searches for coalescing compact binaries with component masses above 1  M⊙ during the first and second observing runs of the advanced gravitational-wave detector network. During the first observing run (O1), from September 12, 2015 to January 19, 2016, gravitational waves from three binary black hole mergers were detected. The second observing run (O2), which ran from November 30, 2016 to August 25, 2017, saw the first detection of gravitational waves from a binary neutron star inspiral, in addition to the observation of gravitational waves from a total of seven binary black hole mergers, four of which we report here for the first time: GW170729, GW170809, GW170818, and GW170823. For all significant gravitational-wave events, we provide estimates of the source properties. The detected binary black holes have total masses between 18.6−0.7+3.2  M⊙ and 84.4−11.1+15.8  M⊙ and range in distance between 320−110+120 and 2840−1360+1400  Mpc. No neutron star-black hole mergers were detected. In addition to highly significant gravitational-wave events, we also provide a list of marginal event candidates with an estimated false-alarm rate less than 1 per 30 days. From these results over the first two observing runs, which include approximately one gravitational-wave detection per 15 days of data searched, we infer merger rates at the 90% confidence intervals of 110−3840  Gpc−3 y−1 for binary neutron stars and 9.7−101  Gpc−3 y−1 for binary black holes assuming fixed population distributions and determine a neutron star-black hole merger rate 90% upper limit of 610  Gpc−3 y−1