46 research outputs found
Constraining dark energy with Sunyaev-Zel'dovich cluster surveys
We discuss the prospects of constraining the properties of a dark energy
component, with particular reference to a time varying equation of state, using
future cluster surveys selected by their Sunyaev-Zel'dovich effect. We compute
the number of clusters expected for a given set of cosmological parameters and
propogate the errors expected from a variety of surveys. In the short term they
will constrain dark energy in conjunction with future observations of type Ia
supernovae, but may in time do so in their own right.Comment: 5 pages, 3 figures, 1 table, version accepted for publication in PR
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CD1a autoreactive T cells recognize natural skin oils that function as headless antigens
CD1a autoreactive T cells are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids. After capturing CD1a-lipid complexes, we gently eluted ligands, while preserving unliganded CD1a for testing lipids from tissues. CD1a released hundreds of ligands of two types. Inhibitory ligands were ubiquitous membrane lipids with polar headgroups, whereas stimulatory compounds were apolar oils. CD1a autoantigens naturally accumulate in epidermis and sebum, where they were identified as squalene and skin waxes. T cell activation by skin oils suggests that headless mini-antigens nest within CD1a and displace non-antigenic resident lipids with large head groups. Oily autoantigens naturally coat the skin's surface, pointing to a new mechanism of barrier immunity
Detailed SZ study of 19 LoCuSS galaxy clusters: masses and temperatures out to the virial radius
We present 16-GHz AMI SZ observations of 19 clusters with L_X >7x10^37 W
(h50=1) selected from the LoCuS survey (0.142<z<0.295) and of A1758b, in the
FoV of A1758a. We detect 17 clusters with 5-23sigma peak surface brightnesses.
Cluster parameters are obtained using a Bayesian cluster analysis. We fit
isothermal beta-models to our data and assume the clusters are virialized (with
all the kinetic energy in gas internal energy). Our gas temperature, T_AMI, is
derived from AMI SZ data, not from X-ray spectroscopy. Cluster parameters
internal to r500 are derived assuming HSE. We find: (i) Different gNFW
parameterizations yield significantly different parameter degeneracies. (ii)
For h70 = 1, we find the virial radius r200 to be typically 1.6+/-0.1 Mpc and
the total mass M_T(r200) typically to be 2.0-2.5xM_T(r500).(iii) Where we have
found M_T X-ray (X) and weak-lensing (WL) values in the literature, there is
good agreement between WL and AMI estimates (with M_{T,AMI}/M_{T,WL}
=1.2^{+0.2}_{-0.3} and =1.0+/-0.1 for r500 and r200, respectively). In
comparison, most Suzaku/Chandra estimates are higher than for AMI (with
M_{T,X}/M_{T,AMI}=1.7+/-0.2 within r500), particularly for the stronger
mergers.(iv) Comparison of T_AMI to T_X sheds light on high X-ray masses: even
at large r, T_X can substantially exceed T_AMI in mergers. The use of these
higher T_X values will give higher X-ray masses. We stress that large-r T_SZ
and T_X data are scarce and must be increased. (v) Despite the paucity of data,
there is an indication of a relation between merger activity and SZ
ellipticity. (vi) At small radius (but away from any cooling flow) the SZ
signal (and T_AMI) is less sensitive to ICM disturbance than the X-ray signal
(and T_X) and, even at high r, mergers affect n^2-weighted X-ray data more than
n-weighted SZ, implying significant shocking or clumping or both occur even in
the outer parts of mergers.Comment: 45 pages, 33 figures, 13 tables Accepted for publication in MNRA
Sunyaev-Zel'dovich clusters in millennium gas simulations
Large surveys using the Sunyaev–Zel’dovich (SZ) effect to find clusters of galaxies are now starting to yield large numbers of systems out to high redshift, many of which are new dis- coveries. In order to provide theoretical interpretation for the release of the full SZ cluster samples over the next few years, we have exploited the large-volume Millennium gas cosmo- logical N-body hydrodynamics simulations to study the SZ cluster population at low and high redshift, for three models with varying gas physics. We confirm previous results using smaller samplesthattheintrinsic(spherical)Y500–M500relationhasverylittlescatter(σlog10Y ≃0.04), is insensitive to cluster gas physics and evolves to redshift 1 in accordance with self-similar expectations. Our preheating and feedback models predict scaling relations that are in excel- lent agreement with the recent analysis from combined Planck and XMM–Newton data by the Planck Collaboration. This agreement is largely preserved when r500 and M500 are derived using thehydrostaticmassproxy,YX,500,albeitwithsignificantlyreducedscatter(σlog10Y ≃0.02),a result that is due to the tight correlation between Y500 and YX,500. Interestingly, this assumption also hides any bias in the relation due to dynamical activity. We also assess the importance of projection effects from large-scale structure along the line of sight, by extracting cluster Y500 values from 50 simulated 5 × 5-deg2 sky maps. Once the (model-dependent) mean signal is subtracted from the maps we find that the integrated SZ signal is unbiased with respect to the underlying clusters, although the scatter in the (cylindrical) Y500–M500 relation increases in the preheating case, where a significant amount of energy was injected into the intergalactic medium at high redshift. Finally, we study the hot gas pressure profiles to investigate the origin of the SZ signal and find that the largest contribution comes from radii close to r500 in all cases. The profiles themselves are well described by generalized Navarro, Frenk & White profiles but there is significant cluster-to-cluster scatter. In conclusion, our results support the notion that Y500 is a robust mass proxy for use in cosmological analyses with clusters
Sunyaev-Zel'dovich observations of galaxy clusters out to the virial radius with the Arcminute Microkelvin Imager
We present observations using the Small Array of the Arcminute Microkelvin
Imager (AMI; 14-18 GHz) of four Abell and three MACS clusters spanning
0.171-0.686 in redshift. We detect Sunyaev-Zel'dovich (SZ) signals in five of
these without any attempt at source subtraction, although strong source
contamination is present. With radio-source measurements from high-resolution
observations, and under the assumptions of spherical -model,
isothermality and hydrostatic equilibrium, a Bayesian analysis of the data in
the visibility plane detects extended SZ decrements in all seven clusters over
and above receiver noise, radio sources and primary CMB imprints. Bayesian
evidence ratios range from 10^{11}:1 to 10^{43}:1 for six of the clusters and
3000:1 for one with substantially less data than the others. We present
posterior probability distributions for, e.g., total mass and gas fraction
averaged over radii internal to which the mean overdensity is 1000, 500 and
200, r_200 being the virial radius. Reaching r_200 involves some extrapolation
for the nearer clusters but not for the more-distant ones. We find that our
estimates of gas fraction are low (compared with most in the literature) and
decrease with increasing radius. These results appear to be consistent with the
notion that gas temperature in fact falls with distance (away from near the
cluster centre) out to the virial radius.Comment: 18 pages, 10 figures, submitted to MNRAS (updated authors and fixed
Figure 1
Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of <i>Plasmodium falciparum</i> into human erythrocytes
An effective vaccine is a priority for malaria control and elimination. The leading candidate in the Plasmodium falciparum blood stage is PfRh5. PfRh5 assembles into trimeric complex with PfRipr and PfCyRPA in the parasite, and this complex is essential for erythrocyte invasion. In this study, we show that antibodies specific for PfRh5 and PfCyRPA prevent trimeric complex formation. We identify the EGF-7 domain on PfRipr as a neutralising epitope and demonstrate that antibodies against this region act downstream of complex formation to prevent merozoite invasion. Antibodies against the C-terminal region of PfRipr were more inhibitory than those against either PfRh5 or PfCyRPA alone, and a combination of antibodies against PfCyRPA and PfRipr acted synergistically to reduce invasion. This study supports prioritisation of PfRipr for development as part of a next-generation antimalarial vaccine
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) alpha-chain, TRAV1-2-TRAJ33, and are activated by vitamin B metabolites bound by the major histocompatibility complex (MHC)-related class I-like molecule, MR1. Understanding MAIT cell biology has been restrained by the lack of reagents to specifically identify and characterize these cells. Furthermore, the use of surrogate markers may misrepresent the MAIT cell population. We show that modified human MR1 tetramers loaded with the potent MAIT cell ligand, reduced 6-hydroxymethyl-8-D-ribityllumazine (rRL-6-CH2OH), specifically detect all human MAIT cells. Tetramer(+) MAIT subsets were predominantly CD8(+) or CD4(-)CD8(-), although a small subset of CD4(+) MAIT cells was also detected. Notably, most human CD8(+) MAIT cells were CD8 alpha(+)CD8 beta(-/lo), implying predominant expression of CD8 alpha alpha homodimers. Tetramer-sorted MAIT cells displayed a T(H)1 cytokine phenotype upon antigen-specific activation. Similarly, mouse MR1-rRL-6-CH2OH tetramers detected CD4(+), CD4(-)CD8(-) and CD8(+) MAIT cells in V. 19 transgenic mice. Both human and mouse MAIT cells expressed a broad TCR-beta repertoire, and although the majority of human MAIT cells expressed TRAV1-2-TRAJ33, some expressed TRAJ12 or TRAJ20 genes in conjunction with TRAV1-2. Accordingly, MR1 tetramers allow precise phenotypic characterization of human and mouse MAIT cells and revealed unanticipated TCR heterogeneity in this population
An X-ray Spectral Survey of Radio-Loud AGN With ASCA
We present a uniform and systematic analysis of the 0.6-10 keV X-ray spectra
of radio-loud active galactic nuclei (AGN) observed by ASCA. The sample 10
BLRGs, 5 QSRs, 9 NLRGs, and 10 RGs. At soft X-rays, about half of the NLRGs and
all of the RGs exhibit a thermal plasma component, with a bimodal distribution
of temperatures and luminosities, suggesting an origin either in a surrounding
cluster or loose group or in a hot corona. At energies above 2 keV, a hard
power-law component is detected in 90% of cases. The power-law photon indices
and luminosities in BLRGs, QSRs, and NLRGs are similar, consistent with
orientation-based unification schemes. Significant excess cold absorption is
detected in most NLRGs, but also in some BLRGS and QSRs, which was somewhat
unexpected. In contrast to Seyfert galaxies, only one object showss the
signature of a warm absorber. The nuclear X-ray luminosity is correlated with
the luminosity of the [O III] emission line, the FIR emission at 12 microns,
and the lobe radio power at 5 GHz. The Fe K line is detected in 50% of BLRGs,
one QSR, and a handful of NLRGs. This sample also includes 6 Weak Line Radio
Galaxies (WLRGs). Their spectra WLRGs can be generally decomposed into a soft
thermal component with hard absrorbed power-law component, which is
significantly flatter than any other radio-loud AGNs. Their intrinsic
luminosities are two orders of magnitude lower than in other sources of the
sample. An interesting possibility is that WLRGs represent an extreme
population of radio galaxies in which the central black hole is accreting at a
rate well below the Eddington rate.Comment: To appear in the Astrophysical Journal. 72 pages, including many
tables and figures. Fig 1 is separate, in TIFF format. Postscript version of
fig 1 and postscript version of entire preprint can be obtained from
http://www.astro.psu.edu/users/mce/preprint_index.htm
Parameterization Effects in the analysis of AMI Sunyaev-Zel'dovich Observations
Most Sunyaev--Zel'dovich (SZ) and X-ray analyses of galaxy clusters try to
constrain the cluster total mass and/or gas mass using parameterised models and
assumptions of spherical symmetry and hydrostatic equilibrium. By numerically
exploring the probability distributions of the cluster parameters given the
simulated interferometric SZ data in the context of Bayesian methods, and
assuming a beta-model for the electron number density we investigate the
capability of this model and analysis to return the simulated cluster input
quantities via three rameterisations. In parameterisation I we assume that the
T is an input parameter. We find that parameterisation I can hardly constrain
the cluster parameters. We then investigate parameterisations II and III in
which fg(r200) replaces temperature as a main variable. In parameterisation II
we relate M_T(r200) and T assuming hydrostatic equilibrium. We find that
parameterisation II can constrain the cluster physical parameters but the
temperature estimate is biased low. In parameterisation III, the virial theorem
replaces the hydrostatic equilibrium assumption. We find that parameterisation
III results in unbiased estimates of the cluster properties. We generate a
second simulated cluster using a generalised NFW (GNFW) pressure profile and
analyse it with an entropy based model to take into account the temperature
gradient in our analysis and improve the cluster gas density distribution. This
model also constrains the cluster physical parameters and the results show a
radial decline in the gas temperature as expected. The mean cluster total mass
estimates are also within 1 sigma from the simulated cluster true values.
However, we find that for at least interferometric SZ analysis in practice at
the present time, there is no differences in the AMI visibilities between the
two models. This may of course change as the instruments improve.Comment: 19 pages, 13 tables, 24 figure
The Atacama Cosmology Telescope: Sunyaev Zel'dovich Selected Galaxy Clusters at 148 GHz in the 2008 Survey
We report on twenty-three clusters detected blindly as Sunyaev-Zel'dovich
(SZ) decrements in a 148 GHz, 455 square-degree map of the southern sky made
with data from the Atacama Cosmology Telescope 2008 observing season. All SZ
detections announced in this work have confirmed optical counterparts. Ten of
the clusters are new discoveries. One newly discovered cluster, ACT-CL
J0102-4915, with a redshift of 0.75 (photometric), has an SZ decrement
comparable to the most massive systems at lower redshifts. Simulations of the
cluster recovery method reproduce the sample purity measured by optical
follow-up. In particular, for clusters detected with a signal-to-noise ratio
greater than six, simulations are consistent with optical follow-up that
demonstrated this subsample is 100% pure. The simulations further imply that
the total sample is 80% complete for clusters with mass in excess of 6x10^14
solar masses referenced to the cluster volume characterized by five hundred
times the critical density. The Compton y -- X-ray luminosity mass comparison
for the eleven best detected clusters visually agrees with both self-similar
and non-adiabatic, simulation-derived scaling laws.Comment: 13 pages, 7 figures, Accepted for publication in Ap