Men, Women, and Ghosts in Science

Science suffers because, by favouring the self-confident of both sexes, we discriminate against women

Socio-Emotional Functioning and Face Recognition Ability in the Normal Population

Recent research indicates face recognition ability varies within the normal population. To date, two factors have been identified that influence this cognitive process: the age and gender of the perceiver. In this paper, we examine the influence of socio-emotional functioning on face recognition ability. We invited participants with high and low levels of empathy (as indicated by the Empathy Quotient) to take part in a face recognition test. Participants were asked to study a set of faces, and at test viewed the studied faces intermixed with novel faces. As predicted, high empaths achieved higher scores in the face recognition test compared to low empaths. This pattern of findings provides further evidence that face recognition ability varies within the normal population, and suggests socio-emotional functioning may be an additional factor that influences face recognition ability

Do adults with high functioning autism or Asperger Syndrome differ in empathy and emotion recognition?

The present study examined whether adults with high functioning autism (HFA) showed greater difficulties in (i) their self-reported ability to empathise with others and/or (ii) their ability to read mental states in others’ eyes than adults with Asperger syndrome (AS). The Empathy Quotient (EQ) and ‘Reading the Mind in the Eyes’ Test (Eyes Test) were compared in 43 adults with AS and 43 adults with HFA. No significant difference was observed on EQ score between groups, while adults with AS performed significantly better on the Eyes Test than those with HFA. This suggests that adults with HFA may need more support, particularly in mentalizing and complex emotion recognition, and raises questions about the existence of subgroups within autism spectrum conditions

The role of Gray’s revised RST in the P–psychopathy continuum: the relationships of Psychoticism with a lack of fear and anxiety, and increased impulsivity

Gray's revised Reinforcement Sensitivity Theory (rRST; Gray & McNaughton, 2000) may play a role in explaining deficits in Psychoticism (P) and psychopathy (Corr, 2010). In this paper, we examine the relationships of P with anxiety, fear, impulsivity and reward reactivity in normal populations to assess whether these associations mirror the hypothesized role of RST motivations in psychopathy. Two hundred and twelve participants completed measures of Psychoticism, impulsivity and rRST motivations (BIS-anxiety, FFFS-fear and BAS). BIS-anxiety mediated the association of P with FFFS-fear and BAS-fun seeking. An exploratory factor analysis distinguished between trait impulsivity (P, impulsivity and BIS) and reward reactivity (BAS-reward responsiveness and BAS-drive). Subsequent moderation analyses showed that whilst neither BIS nor BAS moderated the P-impulsivity link, the association between P and impulsivity was more pronounced in individuals with raised levels of FFFS-fear. Findings are discussed in terms of the roles of fear versus anxiety and impulsivity versus reward reactivity in the P-psychopathy continuum

Empathy and emotion recognition in people with autism, first-degree relatives, and controls

Empathy is the lens through which we view others' emotion expressions, and respond to them. In this study, empathy and facial emotion recognition were investigated in adults with autism spectrum conditions (ASC; N=314), parents of a child with ASC (N=297) and IQ-matched controls (N=184). Participants completed a self-report measure of empathy (the Empathy Quotient [EQ]) and a modified version of the Karolinska Directed Emotional Faces Task (KDEF) using an online test interface. Results showed that mean scores on the EQ were significantly lower in fathers (p0.05) of children with ASC compared to controls, whilst both males and females with ASC obtained significantly lower EQ scores (p0.05). Finally, results indicated significant differences between males and females with ASC for emotion recognition performance (p0.05). These findings suggest that self-reported empathy deficits in fathers of autistic probands are part of the 'broader autism phenotype'. This study also reports new findings of sex differences amongst people with ASC in emotion recognition, as well as replicating previous work demonstrating empathy difficulties in adults with ASC. The use of empathy measures as quantitative endophenotypes for ASC is discussed

Towards a Synthesis of Core-Collapse Supernova Theory

New insights into the mechanism and character of core--collapse supernova explosions are transforming the approach of theorists to their subject. The universal realization that the direct hydrodynamic mechanism does not work and that a variety of hydrodynamic instabilities can influence the viability of theoretical explosions has ushered in a new era in supernova modeling. In this paper, I discuss the important physical and technical issues that remain. I review the neutrino--driven mechanism, the possible roles of Rayleigh--Taylor instabilities, questions in neutrino transport, and the various observational constraints within which theorists must operate. However, a consensus has yet to be achieved among active workers concerning many important details and some essential phenomenology. This synopsis is meant to accomplish two things: 1) to focus attention on the interesting problems whose resolution will bring needed progress, and 2) to assess the current status of the theoretical art.Comment: Eighteen Pages, Elsevier Elsart LaTeX format, no figures, to appear in Nucl. Phys. A, as a contribution to the Festschrift in honor of Gerald E. Brown's 70'th Birthday. PostScript version available from [email protected]

A pilot telephone intervention to increase uptake of breast cancer screening in socially deprived areas in Scotland (TELBRECS):study protocol for a randomised controlled trial

BACKGROUND Breast cancer accounts for almost 30% of all cancers and is the second leading cause of cancer deaths in women in Scotland. Screening is key to early detection. The Scottish Breast Screening Programme is a nationwide, free at point of delivery screening service, to which all women aged between 50 and 70 years are invited to attend every 3 years. Currently over three-quarters of invited women regularly attend screening. However, women from more deprived areas are much less likely to attend: for example in the 3 years from 2010-2012 only 63% of women in the most deprived area attended the East of Scotland Breast Screening programme versus 81% in the least deprived. Research has suggested that reminders (telephone or letter) and brief, personalised interventions addressing barriers to attendance may be helpful in increasing uptake in low-income women. METHODS/DESIGN We will employ a brief telephone reminder and support intervention, whose purpose is to elicit and address any mistaken beliefs women have about breast screening, with the aim that the perceived benefits of screening come to outweigh any perceived barriers for individuals. We will test whether this intervention, plus a simple anticipated regret manipulation, will lead to an increase in the uptake of breast cancer screening amongst low-income women who have failed to attend a first appointment, in a randomised controlled trial with 600 women. Participants will be randomly allocated to one of four treatment arms i.e. 1) Letter reminder (i.e. Treatment as usual: CONTROL); 2) Telephone reminder (TEL), 3) Telephone reminder plus telephone support (TEL-SUPP) and 4) Telephone reminder plus support plus AR (TEL-SUPP-AR). The primary outcome will be attendance at breast screening within 3 months of the reminder letter. DISCUSSION If this simple telephone support intervention (with or without AR intervention) leads to a significant increase in breast screening attendance, this would represent a rare example of a theoretically-driven, relatively simple psychological intervention that could result in earlier detection of breast cancer amongst an under-served group of lower socio-economic women. TRIAL REGISTRATION Current Controlled trials: ISRCTN06039270. Registered 16th January 2014

Learning effective amino acid interactions through iterative stochastic techniques

The prediction of the three-dimensional structures of the native state of proteins from the sequences of their amino acids is one of the most important challenges in molecular biology. An essential ingredient to solve this problem within coarse-grained models is the task of deducing effective interaction potentials between the amino acids. Over the years several techniques have been developed to extract potentials that are able to discriminate satisfactorily between the native and non-native folds of a pre-assigned protein sequence. In general, when these potentials are used in actual dynamical folding simulations, they lead to a drift of the native structure outside the quasi-native basin. In this study, we present and validate an approach to overcome this difficulty. By exploiting several numerical and analytical tools we set up a rigorous iterative scheme to extract potentials satisfying a pre-requisite of any viable potential: the stabilization of proteins within their native basin (less than 3-4 \AA$$ cRMS). The scheme is flexible and is demonstrated to be applicable to a variety of parametrizations of the energy function and provides, in each case, the optimal potentials.Comment: Revtex 17 pages, 10 eps figures. Proteins: Structure, Function and Genetics (in press