217 research outputs found
Ultrasonographic study and Doppler flow velocimetry of maternal kidneys and liver in low-risk pregnancy
- Author
- Almashhrawi AA
- Andrea Cavalanti Gomes
- Barros ML
- Borges VFA
- Calixto AC
- Cibele Helena Daher
- Cietak KA
- Dib FR
- Farias MS
- Faúndes A
- Fried AM
- Giovanni Guido Cerri
- Hertzberg BS
- Kara SA
- Kurjak A
- Loughlin KR
- Maria Cristina Chammas
- Masselli G
- McAleer SJ
- Monteiro AMV
- Ohnishi K
- Peake SL
- Pekindil G
- Resnik R
- Roobottom CA
- Santos OO
- Semins MJ
- Sergio Kobayashi
- Sohn C
- Sturgiss SN
- Wayment RO
- Woo JS
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Concordância entre os formatos impresso e eletrônico do IPAQ-L
- Author
- Andréia Antonia Padilha Pires
- Barros MG
- Benedetti TB
- Bland JM
- Farias Junior JC.
- Farias Júnior JC
- Fleiss JL.
- Gomes KV
- Haskell WL
- Landis JR
- Legnani E
- Looij-Jansen PM
- Mangunkusumo RT
- Mangunkusumo RT
- Masson CR
- Matsudo S
- Omote S
- Pardini R
- Pardini R
- Poppel MM
- Raat H
- Raymundo Pires Junior
- Rodrigo Franco de Oliveira
- Romero A
- Samara BS
- Scheers T
- Tenório MM
- Turner-Bowker DM
- Varo JJ
- Vasconcellos L
- Zanchetta LM
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Using Cerebrospinal Fluid Biomarker Testing to Target Treatment to Patients with Mild Cognitive Impairment: A Cost-Effectiveness Analysis
- Author
- A Sköldunger
- AH Briggs
- AH Briggs
- Alzheimer’s Association
- B Dubois
- B Dubois
- BG Koerkamp
- BS Diniz
- C Courtney
- C Green
- C Valcárcel-Nazco
- C-C Tan
- CL Leibson
- D Budd
- DE Spackman
- E Fenwick
- ER Peskind
- GD Sanders
- GR Barton
- GR Holt
- GW Torrance
- H Hampel
- H Hampel
- H Hampel
- H Zetterberg
- IA Rossum van
- J Leon
- JB Oostenbrink
- JD Goldhaber-Fiebert
- JH Barnett
- JL Molinuevo
- JP Higgins
- JT Cohen
- K Blennow
- K Blennow
- K Naveršnik
- L Standfield
- LM Shaw
- M Amanzio
- M Biasutti
- M Bruscoli
- MJ Ward
- MS Albert
- N Furiak
- N Mattsson
- N Mattsson
- P Doubilet
- P Neumann
- P Neumann
- P Vemuri
- PJ Neumann
- PJ Neumann
- PJ Neumann
- PJ Neumann
- PS Aisen
- R Brookmeyer
- R Brookmeyer
- R Doody
- R Raschetti
- R Tarawneh
- RC Petersen
- RC Petersen
- RC Petersen
- RC Petersen
- RL Handels
- S Djalalov
- S-K Herukka
- SG Santo Di
- ST Farias
- T Sobow
- TL Michaud
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Biased-corrected richness estimates for the Amazonian tree flora
- Author
- Ahuite Reategui MA
- Albuquerque BW
- Alexiades MN
- Alonso A
- Amaral IL
- Andrade A
- Araujo-Murakami A
- Arroyo L
- Assis RL
- Aymard C. GA
- Baider C
- Baker TR
- Balslev H
- Baraloto C
- Barbosa EM
- Barbosa FR
- Barlow J
- Berenguer E
- Brienen R
- Bánki OS
- Camargo JL
- Cano A
- Carrero Márquez YA
- Carvalho FA
- Casas LF
- Castaño Arboleda N
- Castellanos H
- Castilho CV
- Casula KR
- Cerón C
- Chave J
- Cintra BBL
- Comiskey JA
- Cornejo Valverde F
- Correa DF
- Costa FRC
- Costa JBP
- Cárdenas López D
- Cárdenas S
- da Silva Guimarães JR
- Dallmeier F
- Daly D
- Damasco G
- de Aguiar DPP
- de Andrade Lima Filho D
- de Andrade Miranda IP
- de Jesus Rodrigues D
- de Jesus Veiga Carim M
- de Leão Novo EMM
- de Lima RAF
- de Matos Bonates LC
- de Medeiros MB
- de Oliveira EA
- de Queiroz HL
- de Sousa Farias E
- de Souza Coelho L
- de Souza FC
- de Sá Carpanedo R
- de Toledo JJ
- Demarchi LO
- Dexter KG
- Di Fiore A
- Dionízia de Almeida Matos F
- do Amaral DD
- Doza HPD
- Draper F
- Duivenvoorden JF
- Duque A
- Dávila N
- Engel J
- Farfan-Rios W
- Farfan-Rios W
- Feeley KJ
- Feitosa YO
- Feldpausch TR
- Ferreira C
- Ferreira J
- Ferreira LV
- Fine PVA
- Flores BM
- Fonty É
- Fuentes A
- Galbraith D
- Gamarra LV
- Garcia-Cabrera K
- García-Villacorta R
- Gomes VHF
- Gonzales GPG
- Gonzales T
- Gribel R
- Guedes MC
- Guevara JE
- Gómez RZ
- Henkel TW
- Hernandez L
- Hilário RR
- Hoffman B
- Holmgren M
- Honorio Coronado EN
- Huamantupa-Chuquimaco I
- Irume MV
- Jimenez EM
- Junqueira AB
- Kalamandeen M
- Killeen TJ
- Klitgaard B
- Laurance SGW
- Laurance WF
- Levesley A
- Licona JC
- Linares-Palomino R
- Lloyd J
- Lopes A
- Lopes MA
- Lozada JR
- Luize BG
- Maas P
- Magalhães JLL
- Magnusson WE
- Malhi Y
- Manzatto AG
- Marimon BS
- Marimon-Junior BH
- Melgaço K
- Mendoza C
- Mesones I
- Milliken W
- Mogollón HF
- Molino J-F
- Monteagudo Mendoza A
- Montero JC
- Mostacedo B
- Nascimento HEM
- Nascimento MT
- Neill D
- Noronha JC
- Núñez Vargas P
- Oliveira AA
- Palacios Cuenca W
- Pansini S
- Pansonato MP
- Paredes MR
- Pauletto D
- Pena JLM
- Pennington T
- Peres CA
- Petronelli P
- Peñuela Mora MC
- Phillips JF
- Phillips OL
- Pickavance G
- Piedade MTF
- Pinto LFM
- Pires Martins M
- Pitman NCA
- Pos E
- Prado PI
- Prieto A
- Quaresma A
- Ramirez Arevalo F
- Ramirez-Angulo H
- Ramos JF
- Reis NFC
- Revilla JDC
- Rincón LM
- Rivas-Torres G
- Rocha M
- Rudas A
- Ruschel AR
- Sabatier D
- Salomão RP
- Sampaio AF
- Schietti J
- Schöngart J
- Scudeller VV
- Sierra R
- Silman MR
- Silva N
- Silva TSF
- Silveira M
- Simon MF
- Sousa TR
- Stevenson PR
- Stropp J
- Tello JS
- ter Steege H
- Terborgh J
- Thomas R
- Tirado M
- Torres-Lezama A
- Umaña MN
- Urrego Giraldo LE
- Valderrama Sandoval EH
- van Andel TR
- van der Heijden G
- Vasquez R
- Vela CIA
- Venticinque EM
- Vicentini A
- Vieira ICG
- Vilanova Torre E
- Villa B
- Villarroel D
- von Hildebrand P
- Vos VA
- Vriesendorp C
- Wang O
- Wittmann F
- Young KR
- Zagt R
- Zartman CE
- Zent EL
- Zent S
- Publication venue
- Nature Research
- Publication date
- 01/01/2020
- Field of study
Amazonian forests are extraordinarily diverse, but the estimated species richness is very much debated. Here, we apply an ensemble of parametric estimators and a novel technique that includes conspecific spatial aggregation to an extended database of forest plots with up-to-date taxonomy. We show that the species abundance distribution of Amazonia is best approximated by a logseries with aggregated individuals, where aggregation increases with rarity. By averaging several methods to estimate total richness, we confirm that over 15,000 tree species are expected to occur in Amazonia. We also show that using ten times the number of plots would result in an increase to just ~50% of those 15,000 estimated species. To get a more complete sample of all tree species, rigorous field campaigns may be needed but the number of trees in Amazonia will remain an estimate for years to come
Population genetic analysis of Caiman crocodilus (Linnaeus, 1758) from South America
- Author
- Ab’Saber AN
- Benoit de Thoisy
- Bernatchez L
- Boris Marioni
- Brisbin Jr. IL
- Brochu CA
- Busack SD
- Cantanhede AM
- Castelloe J
- Clement M
- Cockerham CC
- Da Silveira R
- Da Silveira R
- Da Silveira R
- Diniz-Filho JAF
- Excoffier L
- Farias IP
- Fu Y-X
- Glenn TC
- Goulding M
- Hall T
- Hartl DL
- Herron JC
- Hrbek T
- Izeni P. Farias
- Janke A
- Koenig WD
- Mantel N
- Mayr E
- Myers N
- Nei M
- Posada D
- Rand DM
- Raymond M
- Rebêlo GH
- Rice WR
- Ronis da Silveira
- Ross JP
- Rozas J
- Ruffeil LAADS
- Sambrook J
- Schneider S
- Sioli H
- Smith NJH
- Smith TB
- Smith TB
- Staton MA
- Swofford DL
- Tajima F
- Taplin LE
- Templeton AR
- Templeton AR
- Templeton AR
- Templeton AR
- Templeton AR
- Templeton AR
- Templeton AR
- Tomas Hrbek
- Verdade LM
- Watterson GA
- Weir BS
- William R. Vasconcelos
- Zhang D-X
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2006
- Field of study
Molecular characterization of 'sweet' cassavas (Manihot esculenta) from a germplasm bank in Brazilian Eastern Amazonia
- Author
- Alves-Pereira A
- Bradbury EJ
- Cardoso EMR
- Carvalho AV
- Ceballos H
- Chavarriaga-Aguirre PP
- Costa TR
- Doyle JJ
- Elias M
- Emperaire L
- Evanno G
- Farias-Neto JT
- Ferguson M
- Fukuda WMG
- Hammer Ø
- Kalinowski ST
- Lanaud C
- Mba REC
- McKey D
- Missiaggia A
- Mkumbira J
- Moyib OK
- Mühlen GS
- Oetting WS
- Paetkau D
- Peakall R
- Peroni N
- Pritchard JK
- Ribeiro MNO
- Siqueira MVBM
- Siqueira MVBM
- Sneath PH
- Vieira EA
- Vieira EA
- Wagner HW
- Weir BS
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The Combined Effect of Neuropsychological and Neuropathological Deficits on Instrumental Activities of Daily Living in Older Adults: a Systematic Review
- Author
- AH Wicklund
- AL Christman
- AR Kaup
- B Stubbs
- B Yoon
- BR Reed
- BS Fogel
- BT Baune
- C Liu
- CF Hybels
- D Inzitari
- D Inzitari
- D Yoshida
- DA Cahn
- DA Cahn
- DA Cahn-Weiner
- DA Cahn-Weiner
- DA Cahn-Weiner
- DC Steffens
- DN Kiosses
- DN Kiosses
- DR Royall
- E Skurla
- ED Richardson
- ED Vidoni
- Eduard J. Overdorp
- EJ Burton
- EJ Dunn
- F Franco-Marina
- FS Pereira
- G Bartzokis
- G Goldstein
- GA Marshall
- GH Kim
- GO Einstein
- H Hénon
- HP Bennett
- HP Bennett
- HR Griffith
- J Grigsby
- J Razani
- J Schmeidler
- JC Stout
- JD Nadler
- JE Tan
- Joukje M. Oosterman
- Jurgen A. Claassen
- K Pérès
- K Sonohara
- KB Walhovd
- KH Park
- L Pantoni
- L Wang
- LE Stoeckel
- LG Apostolova
- M Brennan
- M McCue
- MF Folstein
- MP Lawton
- MP Lawton
- N Kandiah
- NA Kochan
- O Matsuda
- P Barberger-Gateau
- PA Boyle
- PA Boyle
- PA Boyle
- PA Boyle
- PH Vetter
- PJ Brown
- R Herzog
- R Schmidt
- Roy P. C. Kessels
- S Artero
- S Bell-McGinty
- S Gauthier
- ST Chen
- ST Farias
- ST Farias
- ST Farias
- ST Farias
- SY Moon
- T Heijer Den
- T Hope
- T Pohjasvaara
- TI Pohjasvaara
- V Senanarong
- VC Mok
- VJ Verlinden
- WD Taylor
- YK Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
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- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
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- Adhikari NK
- Adriano G
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- Affatato R
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- Agarossi A
- Agarwal LK
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- Aguilar AL
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- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
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- AKI Research Group
- Akiduki N
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- Giannopoulos A
- Giesinger RE
- Gigorro RG
- Gil EM
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- Gimillo MR
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- Gioia A
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- Gomez SE
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- Gonzalez JA
- Gonzalez V
- Gonzalez-Engroba R
- González AS
- González BS
- González JC
- González-Jiménez AI
- Gonçalves B
- Goodwin S
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- Gordon M
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- Gouveia J
- Gracia RM
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- Granados PR
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- Grassi L
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- Green RS
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- Grossestreuer A
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- Guerrero-López F
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- Guidet B
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- Henschel B
- Heras G
- Hernandis V
- Hernández A
- Hernández AA
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- Hernández G
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- Herpain A
- Herrera AN
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- Hillier SD
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- Himpe D
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- Hoppu S
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- Hraiech S
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- Huber W
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- Hull AM
- Hung CY
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- Huot B
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- Hutchings S
- Hutchison R
- Hwang GS
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- Ibañes PG
- Ibsen M
- Idei M
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- Idone FA
- Iesu E
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- Ignacio ML
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- IPREA Study Group
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- Itenov TS
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- Jang BH
- Janotka M
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- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
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- Juez A
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- Jung K
- Jung KW
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- Kaczirek K
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- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
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- Kappler F
- Kara A
- Karachi F
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- Karsten E
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- Kashiya S
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- Kawano S
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- Kayambu G
- Kazutoshi F
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- Kleinpell R
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- Kobayashi A
- Koco E
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- Komuro T
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- Kongpolprom N
- Kooner G
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- Kox M
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- Kristof J
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- Labra C
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
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- Abusleme Hoffman AC
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- Zhemchugov A
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
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