Contribution of Inflammation Process (Hscrp Levels) in Migraine During Ictal Phase

Introduction: C-reactive protein (CRP), an acute phase protein and a marker of inflammation,has been associated with the risk of cardiovascular disease. CRP has also been suggested tobe abnormal among migraineurs, possibly due to repeated vascular inflammation. Methods:This case-control study was conducted in Wahidin Sudirohusodo General Hospital, Makassar,Indonesia, from June 2013 to January 2014. The aim of this study is to investigate the role ofinflammation in the pathophysiology of an ictal and interictal period of migraine. A t otal of 82patients participated in this study [16 males (19.5%) and 66 females (80.5%)]. The age of ictalperiod patients range between 19-57 years old (median 28, mean 29.54 ± 8.92) and interictalperiod patients range between 20-48 years (median 26, 28,90 ± 7,91). Results: This studyshowed mean hs-CRP level was significantly higher in the ictal period compared to interictalperiod of migraine (6.64 vs 1.87 mg/L). hs-CRP >3mg/L (high risk of cardiovascular event) wasmore common in ictal (78.3%) compared to interictal patients (21,7%), while hs-CRP <1mg/L(low risk of cardiovascular event) was more common in interictal (64.9%) compared to ictalperiod patients (35.1%) (OR=6.646). The contribution of hs-CRP to the ictal period of a migrainewas 17.2%. Conclusion: This study reinforces the view that inflammation processplays some roles in the pathophysiology of a migraine, especially in the ictal period

OPTIMALISASI PERAN PEREMPUAN DALAM MENINGKATKAN POTENSI WISATA BAHARI MELALUI SEKOLAH PEREMPUAN DAN PENGEMBANGAN UMKM

Abstrak: Tambakbulusan merupakan desa di kawasan pesisir utara Jawa Tengah. Desa ini cukup potensial untuk dikembangkan, antara lain mangrove, keberagaman produk UMKM, dan Pantai Glagah Wangi yang menjadi tujuan wisata. Untuk itu, Badan Eksekutif Mahasiswa Fakultas Perikanan dan Ilmu Kelautan Universitas Diponegoro melalui kegiatan Program Peningkatan Kapasitas Organisasi Mahasiswa (PPK Ormawa)-nya bertujuan membentuk Sekolah Perempuan lengkap dengan kurikulumnya untuk meningkatkan softskill kelompok kader perempuan dan melakukan pemberdayaan UMKM di Desa Tambakbulusan. Kegiatan yang dilakukan selama 5 bulan ini telah berhasil membentuk kelompok baru Kader Perempuan dengan 20 orang anggota. Kelompok tersebut telah meningkat 60-70% pengetahuannya dan terampil dalam pembuatan batik. Pemberdayaan UMKM dilakukan dengan perbaikan kemasan dan pemasaran pada kader mitra dan telah berhasil menyelenggarakan Festival UMKM Desa Tambakbulusan Kabupaten Demak. Melalui kegiatan tersebut, selain pengetahuan dan penjualan UMKM meningkat 90%, Kader Perempuan yang telah terbentuk telah membuat beberapa desain batik mangrove khas Desa Tambakbulusan yang akan menjadi daya tarik wisatawan bahari yang berkunjung.Abstract: Tambakbulusan is located on the north coast of Central Java. This village has the potential to be developed, including mangroves, a variety of MSME products, and Glagah Wangi Beach which is a tourist destination. For this reason, the Student Executive Board of the Faculty of Fisheries and Marine Sciences, Diponegoro University through its Student Organization Capacity Building Program activities aims to form a Women’s School with its curriculum to improve the soft skills of women groups and empower MSMEs in Tambakbulusan Village. The activities carried out for 5 months have succeeded in forming a new group of female group with 20 members. The group has increased 60-70% in knowledge and skills in producing batik and understanding the batik wastewater treatment installation system. MSME empowerment is carried out by improving packaging and marketing and has successfully held the Tambakbulusan Village MSMEs Festival, Demak Regency. Through these activities, in addition to knowledge and saled of MSMEs increasing by 90%, the Women Group have succeeded in making several mangrove batik designs typical of Tambakbulusan Village which will become an attraction for visiting marine tourists.

Venerische Krankheiten: Redigirt von Prof. Neisser nd Dr. Schäffer in Breslau

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Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

Chronic mucocutaneous candidiasis disease (CMCD) may be caused by autosomal dominant (AD) IL-17F deficiency or autosomal recessive (AR) IL-17RA deficiency. Here, using whole-exome sequencing, we identified heterozygous germline mutations in STAT1 in 47 patients from 20 kindreds with AD CMCD. Previously described heterozygous STAT1 mutant alleles are loss-of-function and cause AD predisposition to mycobacterial disease caused by impaired STAT1-dependent cellular responses to IFN-γ. Other loss-of-function STAT1 alleles cause AR predisposition to intracellular bacterial and viral diseases, caused by impaired STAT1-dependent responses to IFN-α/β, IFN-γ, IFN-λ, and IL-27. In contrast, the 12 AD CMCD-inducing STAT1 mutant alleles described here are gain-of-function and increase STAT1-dependent cellular responses to these cytokines, and to cytokines that predominantly activate STAT3, such as IL-6 and IL-21. All of these mutations affect the coiled-coil domain and impair the nuclear dephosphorylation of activated STAT1, accounting for their gain-of-function and dominance. Stronger cellular responses to the STAT1-dependent IL-17 inhibitors IFN-α/β, IFN-γ, and IL-27, and stronger STAT1 activation in response to the STAT3-dependent IL-17 inducers IL-6 and IL-21, hinder the development of T cells producing IL-17A, IL-17F, and IL-22. Gain-of-function STAT1 alleles therefore cause AD CMCD by impairing IL-17 immunity

Transcription-replication conflicts: How they occur and how they are resolved

The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, between the transcription and replication machineries. These conflicts constitute a major intrinsic source of genome instability, which is a hallmark of cancer cells. How the replication machinery progresses along a DNA molecule occupied by an RNA polymerase is an old question. Here we review recent data on the biological relevance of transcription-replication conflicts, and the factors and mechanisms that are involved in either preventing or resolving them, mainly in eukaryotes. On the basis of these data, we provide our current view of how transcription can generate obstacles to replication, including torsional stress and non-B DNA structures, and of the different cellular processes that have evolved to solve them

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR&nbsp;=&nbsp;2.05, 95%CI&nbsp;=&nbsp;1.39–3.02, p&nbsp;&lt;&nbsp;0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR&nbsp;=&nbsp;0.42, 95%CI&nbsp;=&nbsp;0.18–0.99, p&nbsp;=&nbsp;0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

Quantifying system disturbance and recovery from historical mining-derived metal contamination at Brotherswater, northwest England

The final publication is available at Springer via https://doi.org/10.1007/s10933-016-9907-1Metal ore extraction in historical times has left a legacy of severe contamination in aquatic ecosystems around the world. In the UK, there are ongoing nationwide surveys of present-day pollution discharged from abandoned mines but few assessments of the magnitude of contamination and impacts that arose during historical metal mining have been made. We report one of the first multi-centennial records of lead (Pb), zinc (Zn) and copper (Cu) fluxes into a lake (Brotherswater, northwest England) from point-sources in its catchment (Hartsop Hall Mine and Hogget Gill processing plant) and calculate basin-scale inventories of those metals. The pre-mining baseline for metal contamination has been established using sediment cores spanning the past 1,500 years and contemporary material obtained through sediment trapping. These data enabled the impact of 250 years of local, small-scale mining (1696 – 1942) to be quantified and an assessment of the trajectory towards system recovery to be made. The geochemical stratigraphy displayed in twelve sediment cores show strong correspondence to the documented history of metal mining and processing in the catchment. The initial onset in 1696 was detected, peak Pb concentrations (>10,000 µg g-1) and flux (39.4 g m-2 y-1) corresponded to the most intensive mining episode (1863-1871) and 20th century technological enhancements were reflected as a more muted sedimentary imprint. After careful evaluation, we used these markers to augment a Bayesian age-depth model of the independent geochronology obtained using radioisotope dating (14C, 210Pb, 137Cs and 241Am). Total inventories of Pb, Zn and Cu for the lake basin during the period of active mining were 15,415 kg, 5,897 kg and 363 kg, respectively. The post-mining trajectories for Pb and Zn project a return to pre-mining levels within 54-128 years for Pb and 75-187 years for Zn, although future remobilisation of metal-enriched catchment soils and floodplain sediments could perturb this recovery. We present a transferable paleolimnological approach that highlights flux-based assessments are vital to accurately establish the baseline, impact and trajectory of mining-derived contamination for a lake catchment

Harmful Elements in Estuarine and Coastal Systems

Estuaries and coastal zones are dynamic transitional systems which provide many economic and ecological benefits to humans, but also are an ideal habitat for other organisms as well. These areas are becoming contaminated by various anthropogenic activities due to a quick economic growth and urbanization. This chapter explores the sources, chemical speciation, sediment accumulation and removal mechanisms of the harmful elements in estuarine and coastal seawaters. It also describes the effects of toxic elements on aquatic flora and fauna. Finally, the toxic element pollution of the Venice Lagoon, a transitional water body located in the northeastern part of Italy, is discussed as a case study, by presenting the procedures adopted to measure the extent of the pollution, the impacts on organisms and the restoration activities