448 research outputs found
An evaluation of the site specificity of soil elemental signatures for identifying and interpreting former functional areas
Soil multi-element analysis is now a routine technique employed to help answer questions about space use and function in and around archaeological sites. The pattern of enhancement of certain elements, including P, Pb, Ca, Zn, and Cu, has been shown by numerous studies to correlate closely with the archaeological and historical record. Interpretation of these soil signatures, however, has generally been more problematic. One approach to the problem has been the use of ethnographic or âknownâ sites to guide interpretation, but how confidently can results from one site be extrapolated to another? This study of abandoned farms tests the site specificity of soil multi-element signatures of past space use through the use of discriminant models. Data analysis suggests that one to one comparisons of similar sites are much less accurate (38% accuracy) than comparisons based on a wider range of sites (59.3% accuracy), even when the latter have contrasting geology. The results highlight the importance of individual anthropogenic practices during occupation and abandonment in the development of diagnostic soil geochemical signatures
Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1
Gonadal failure, along with early pregnancy loss and perinatal death, may be an important filter that limits the propagation
of harmful mutations in the human population. We hypothesized that men with spermatogenic impairment, a disease with
unknown genetic architecture and a common cause of male infertility, are enriched for rare deleterious mutations
compared to men with normal spermatogenesis. After assaying genomewide SNPs and CNVs in 323 Caucasian men with
idiopathic spermatogenic impairment and more than 1,100 controls, we estimate that each rare autosomal deletion
detected in our study multiplicatively changes a manâs risk of disease by 10% (OR 1.10 [1.04â1.16], p,261023), rare X-linked
CNVs by 29%, (OR 1.29 [1.11â1.50], p,161023), and rare Y-linked duplications by 88% (OR 1.88 [1.13â3.13], p,0.03). By
contrasting the properties of our case-specific CNVs with those of CNV callsets from cases of autism, schizophrenia, bipolar
disorder, and intellectual disability, we propose that the CNV burden in spermatogenic impairment is distinct from the
burden of large, dominant mutations described for neurodevelopmental disorders. We identified two patients with
deletions of DMRT1, a gene on chromosome 9p24.3 orthologous to the putative sex determination locus of the avian ZW
chromosome system. In an independent sample of Han Chinese men, we identified 3 more DMRT1 deletions in 979 cases of
idiopathic azoospermia and none in 1,734 controls, and found none in an additional 4,519 controls from public databases.
The combined results indicate that DMRT1 loss-of-function mutations are a risk factor and potential genetic cause of human
spermatogenic failure (frequency of 0.38% in 1306 cases and 0% in 7,754 controls, p = 6.261025). Our study identifies other
recurrent CNVs as potential causes of idiopathic azoospermia and generates hypotheses for directing future studies on the
genetic basis of male infertility and IVF outcomes.This work was partially funded by the Portuguese Foundation for Science and Technology FCT/MCTES (PIDDAC) and co-financed by European funds (FEDER) through the COMPETE program, research grant PTDC/SAU-GMG/101229/2008. IPATIMUP is an Associate Laboratory of the Portuguese Ministry of Science, Technology, and Higher Education and is partially supported by FCT. AML is the recipient of a postdoctoral fellowship from FCT (SFRH/BPD/73366/2010). CO is supported by a grant from the United States National Institutes of Health (R01 HD21244), JDS is supported by Damon Runyon Clinical Investigator Award, Alex's Lemonade Stand Foundation Epidemiology Award, and the Eunice Kennedy Shriver Children's Health Research Career Development Award NICHD 5K12HD001410. Support for humans studies and specimens were provided by the NIH/NIDDK George M. O'Brien Center for Kidney Disease Kidney Translational Research Core (P30DK079333) grant to Washington University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays
Average charged multiplicities have been measured separately in , and
light quark () events from decays measured in the SLD experiment.
Impact parameters of charged tracks were used to select enriched samples of
and light quark events, and reconstructed charmed mesons were used to select
quark events. We measured the charged multiplicities:
,
, from
which we derived the differences between the total average charged
multiplicities of or quark events and light quark events: and . We compared
these measurements with those at lower center-of-mass energies and with
perturbative QCD predictions. These combined results are in agreement with the
QCD expectations and disfavor the hypothesis of flavor-independent
fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters
Time-integrated luminosity recorded by the BABAR detector at the PEP-II e+e- collider
This article is the Preprint version of the final published artcile which can be accessed at the link below.We describe a measurement of the time-integrated luminosity of the data collected by the BABAR experiment at the PEP-II asymmetric-energy e+e- collider at the Ï(4S), Ï(3S), and Ï(2S) resonances and in a continuum region below each resonance. We measure the time-integrated luminosity by counting e+e-âe+e- and (for the Ï(4S) only) e+e-âÎŒ+ÎŒ- candidate events, allowing additional photons in the final state. We use data-corrected simulation to determine the cross-sections and reconstruction efficiencies for these processes, as well as the major backgrounds. Due to the large cross-sections of e+e-âe+e- and e+e-âÎŒ+ÎŒ-, the statistical uncertainties of the measurement are substantially smaller than the systematic uncertainties. The dominant systematic uncertainties are due to observed differences between data and simulation, as well as uncertainties on the cross-sections. For data collected on the Ï(3S) and Ï(2S) resonances, an additional uncertainty arises due to Ïâe+e-X background. For data collected off the Ï resonances, we estimate an additional uncertainty due to time dependent efficiency variations, which can affect the short off-resonance runs. The relative uncertainties on the luminosities of the on-resonance (off-resonance) samples are 0.43% (0.43%) for the Ï(4S), 0.58% (0.72%) for the Ï(3S), and 0.68% (0.88%) for the Ï(2S).This work is supported by the US Department of Energy and National Science Foundation, the Natural Sciences and Engineering Research Council (Canada), the Commissariat Ă lâEnergie Atomique and Institut National de Physique NuclĂ©aire et de Physiquedes Particules (France), the Bundesministerium fĂŒr Bildung und Forschung and Deutsche Forschungsgemeinschaft (Germany), the Istituto Nazionale di Fisica Nucleare (Italy), the Foundation for Fundamental Research on Matter (The Netherlands), the Research Council of Norway, the Ministry of Education and Science of the Russian Federation, Ministerio de Ciencia e InnovaciĂłn (Spain), and the Science and Technology Facilities Council (United Kingdom). Individuals have received support from the Marie-Curie IEF program (European Union) and the A.P. Sloan Foundation (USA)
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Component and system tests of the SLD Cerenkov Ring Imaging Detector
The components of the SLD barrel Cerenkov Ring Imaging Detector (CRID) are now built and are being installed. We report on tests of these, including tests of the fiber optic calibration system, detailed studies of electron drift paths on production drift boxes and detectors, tests of the dynamic gating system and its effect on drift path distortions due to space-charge, and a measurement of the electron lifetime in a production drift box. In addition, we report on the UV transmission of recirculated liquid C{sub 6}F{sub 14} and on the effects of CRID construction materials on electron lifetime. 9 refs., 11 figs
Observation of the baryonic decay B \uaf 0 \u2192 \u39bc+ p \uaf K-K+
We report the observation of the baryonic decay B\uaf0\u2192\u39bc+p\uafK-K+ using a data sample of 471
7106 BB\uaf pairs produced in e+e- annihilations at s=10.58GeV. This data sample was recorded with the BABAR detector at the PEP-II storage ring at SLAC. We find B(B\uaf0\u2192\u39bc+p\uafK-K+)=(2.5\ub10.4(stat)\ub10.2(syst)\ub10.6B(\u39bc+))
710-5, where the uncertainties are statistical, systematic, and due to the uncertainty of the \u39bc+\u2192pK-\u3c0+ branching fraction, respectively. The result has a significance corresponding to 5.0 standard deviations, including all uncertainties. For the resonant decay B\uaf0\u2192\u39bc+p\uaf\u3c6, we determine the upper limit B(B\uaf0\u2192\u39bc+p\uaf\u3c6)<1.2
710-5 at 90% confidence level
Determination of the Form Factors for the Decay B0 --> D*-l+nu_l and of the CKM Matrix Element |Vcb|
We present a combined measurement of the Cabibbo-Kobayashi-Maskawa matrix element and of the parameters , , and , which fully characterize the form factors of the decay in the framework of HQET, based on a sample of about 52,800 decays recorded by the BABAR detector. The kinematical information of the fully reconstructed decay is used to extract the following values for the parameters (where the first errors are statistical and the second systematic): , , , . By combining these measurements with the previous BABAR measurements of the form factors which employs a different technique on a partial sample of the data, we improve the statistical accuracy of the measurement, obtaining: and Using the lattice calculations for the axial form factor , we extract , where the third error is due to the uncertainty in
Study of the Exclusive Initial-State Radiation Production of the System
A study of exclusive production of the system through initial-state r adiation is performed in a search for charmonium states, where or . The mesons are reconstructed in the , , and decay modes. The is reconstructed through the decay mode. The analysis makes use of an integrated luminosity of 288.5 fb collected by the BaBar experiment. The mass spectrum shows a clear signal. Further structures appear in the 3.9 and 4.1 GeV/ regions. No evidence is found for Y(4260) decays to , implying an up per limit \frac{\BR(Y(4260)\to D \bar D)}{\BR(Y(4260)\to J/\psi \pi^+ \pi^-)} < 7.6 (95 % confidence level)
Search for Darkonium in e+e- Collisions
Collider searches for dark sectors, new particles interacting only feebly with ordinary matter, have largely focused on identifying signatures of new mediators, leaving much of dark sector structures unexplored. In particular, the existence of dark matter bound states (darkonia) remains to be investigated. This possibility could arise in a simple model in which a dark photon (A0 ) is light enough to generate an attractive force between dark fermions. We report herein a search for a JPC ÂŒ 1ââ darkonium state, the ÏD, produced in the reaction eĂŸeâ â ÎłÏD, ÏD â A0 A0 A0 , where the dark photons subsequently decay into pairs of leptons or pions, using 514 fbâ1 of data collected with the BABAR detector. No significant signal is observed, and we set bounds on the Îł â A0 kinetic mixing as a function of the dark sector coupling constant for 0.001 < mA0 < 3.16 GeV and 0.05 < mÏD < 9.5 GeV.publishedVersio
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