Congenital constriction band syndrome: a case report

Congenital constriction bands are anomalous bands formed during antenatal period that encircle a digit or an extremity in a fetus leading to a wide spectrum of manifestations, ranging from shallow grooves to acrosyndactyly and amputations. It is also associated with skeletal and other birth defects like craniofacial abnormalities, spinal dysraphism, porencephaly, hydrancephaly and visceral body wall malformations. We hereby present one such case which presented to us with below knee amputation of the lower limb and syndactyly

A review on distribution and importance of wetlands in the perspective of India

Biodiversity is not equally distributed across the world. It depends on the type of various habitats and food availability. In these habitats, wetlands play an import role to increase the biodiversity of the particular area. Many studies have focused on various habitats to conserve biodiversity. However, the wetland studies are very few due to the lack of information on their distribution and importance. The present review focusses on the wetland status and their importance in India. India has vibrant and diverse wetland ecosystems that support immense biodiversity. The wetlands are unique habitats which provide ecological, social and economic values. However, rapid urbanization, industrialization and uncontrolled agricultural practices have pressurized to shrink the wetlands in India. The present paper highlights the wetland habitats in India with their geographical location, distribution, avian species diversity and their significance. The paper also discusses the growing threats like climate change, land-use change and agriculture/ municipal waste to the wetlands and the conservation efforts by Indian government policies, i.e. National Wetland Conservation Programme, National Environmental Policy, and National Plan for conservation of the aquatic ecosystem. In addition, on the basis of previous studies on wetlands,  it is suggested that the role of stakeholders is very much responsible for wetland conservation

Scale modeling of dust capture through a flooded-bed dust scrubber integrated within a longwall shearer

Meeting federal dust standards at a longwall mine face is among the more difficult challenges for a longwall mine operator. With recent changes in federal dust regulations requiring lower worker exposure, maintaining compliance has become increasingly difficult. The authors recommend the concept of controlling respirable and float dust, which is inherent in longwall mining, through the application of a flooded-bed dust scrubber to a longwall shearer. A full-scale physical model of a longwall shearer, modified with an integrated flooded-bed scrubber, was designed and fabricated at the University of Kentucky to measure the effects of a flooded-bed scrubber on dust capture at a longwall face. The mockup was transported, assembled, and tested in the longwall dust gallery at the Pittsburgh Research Laboratory of the National Institute for Occupational Safety and Health (NIOSH). Test results indicated a dust reduction of up to 57% in the return airway of the longwall gallery. The test results were validated with Computational Fluid Dynamics (CFD) modeling with a maximum of 9.7% difference in results. The aim of the study was to test the flooded-bed scrubber concept with a longwall shearer on a half-scale model using the CFD modeling technique. The paper discusses the validation of the developed scaling laws through the results of CFD modeling on the full-scale porotype and half-scale model

Scale and numerical modeling to determine operating points of a non-clogging Vortecone filter in mining operation

Numerical and scale modeling studies of Vortecone, a pressure-driven wet-scrubber device for the efficient capture of over-sprayed paint in the automobile industry, are presented. In this manuscript, Vortecone was tested for removing dust particles from underground mining operations. The pressures required to operate Vortecone and the airflow rates through the Vortecone are the two most important factors for mine ventilation systems. This study used dry, no-particle conditions to obtain relationship between these two parameters and then designed a Vortecone filter ventilation system for mining operations. Commercial software, SC/Flow, was used to generate the CFD model with unstructured meshes and a series of numerical calculations were accomplished. Included in these were calculation of a 1/3rd scale model of Vortecone along with experimentation that was accomplished to validate the numerical predictions. The experiments were conducted to measure pressure drops for known airflow velocities at critical points within Vortecone. The scale model experimental results agreed very well with the CFD numerical calculations. For scaling the performance of the 1/3rd scale model to full scale, the scaling laws were developed using the law approach; they are discussed along with the feasibility of the Vortecone filter system for underground mining operations

Diversity and status of migratory and resident wetland birds in Haridwar, Uttarakhand, India

Migration is the seasonal habitual movement, exhibited by many avian species along a flyway from breeding to wintering grounds and vice versa all over the world. Migratory birds are very sensitive to even small changes in water level which may be affected by flood or drought on their breeding and wintering grounds. High rains during monsoon season can cause flood conditions in the lower hills and Gangetic plains including Haridwar district. In our study, conducted during last ten years (2009-2018), we covered Bheemgoda Barrage and Missarpur Ganga Ghat of Haridwar, Uttarakhand, where 46 species of Migratory (M) and Resident Migratory (RM) wetland birds were observed. Bird survey indicated that there was a significant increase (p = 0.064, t-test) in the population of certain species such as Bhraminy Shelduck (67%), Black Headed Gull (31%), Gadwall (7%), Northern Pintail (59%), Red Crested Pochard (10%) and Tufted Pochard (47%) in Missarpur Ganga Ghat as compared to Bheemgoda Barrage (based on the average abundance of the species observed during study period). It may be pointed out that after flood and loss of vegetated island, there was significant decrease (p= 0.023, t-test) in the population of species such as Black necked stork (76%), Great crested grebe (56), Pallas gull (47%) at Bheemgoda barrage, while some species such as Bar headed goose, Common pochard did not arrive in Bheemgoda barrage after the flood. The study would help to understand the effect of climatic change on water birds species distribution in natural and man-made wetlands

ANTIBACTERIAL ACTIVITY FROM HAEMOLYMPH OF FRESHWATER CRAB OF GENUS MAYDELLIATHELPHUSA AGAINST RESPIRATORY TRACT PATHOGENS

Objective: To study the antibacterial activity using haemolymph from a freshwater crab species of genus Maydelliathelphusa against respiratory tract pathogens.Methods: 3 ml of haemolymph was collected from the live animal with a fine sterile syringe and tested for antibacterial assay by the well diffusion method. Different quantities viz. 10μl, 20μl and 30μl of haemolymph were loaded in agar plates having bacterial strains and kept for incubation at 37 °C for 24 h to test the development of bacteria. Further, the efficacy of haemolymph against bacteria was compared with antibiotic erythromycin, used as positive control.Results: The results reported the strong inhibitory action of the haemolymph against the pathogens in the present study. The lowest zone of inhibition was observed against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) and the highest zone of inhibition was observed against Streptococcus pneumoniae (S. pneumoniae). Erythromycin, as a positive control and Di-Methyl Sulfoxide (DMSO), as a negative control were used to check the sensitivity of pathogens. The minimum inhibition concentration (MIC) of the haemolymph for the studied bacteria was ranged between 6.25 mg/ml and 12.5 mg/ml. Maximum inhibition % (151.12) and minimum inhibition % (12.87) of haemolymph was calculated for S. pneumoniae and K. pneumoniae respectively during the study.Conclusion: Study concluded that the haemolymph has a good antibacterial activity as it suppresses the growth of the bacteria completely at very low concentrations.Keywords: Freshwater Crab, Haemolymph, Antibacterial activity, Respiratory tract pathogens

Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years : an analysis of the Global Burden of Disease Study 2017

Background Many countries have shown marked declines in diarrhoea! disease mortality among children younger than 5 years. With this analysis, we provide updated results on diarrhoeal disease mortality among children younger than 5 years from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) and use the study's comparative risk assessment to quantify trends and effects of risk factors, interventions, and broader sociodemographic development on mortality changes in 195 countries and territories from 1990 to 2017. Methods This analysis for GBD 2017 had three main components. Diarrhoea mortality was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive, Bayesian, ensemble modelling tool; and the attribution of risk factors and interventions for diarrhoea were modelled in a counterfactual framework that combines modelled population-level prevalence of the exposure to each risk or intervention with the relative risk of diarrhoea given exposure to that factor. We assessed the relative and absolute change in diarrhoea mortality rate between 1990 and 2017, and used the change in risk factor exposure and sociodemographic status to explain differences in the trends of diarrhoea mortality among children younger than 5 years. Findings Diarrhoea was responsible for an estimated 533 768 deaths (95% uncertainty interval 477 162-593 145) among children younger than 5 years globally in 2017, a rate of 78.4 deaths (70.1-87.1) per 100 000 children. The diarrhoea mortality rate ranged between countries by over 685 deaths per 100 000 children. Diarrhoea mortality per 100 000 globally decreased by 69.6% (63.1-74.6) between 1990 and 2017. Among the risk factors considered in this study, those responsible for the largest declines in the diarrhoea mortality rate were reduction in exposure to unsafe sanitation (13.3% decrease, 11.2-15.5), childhood wasting (9.9% decrease, 9.6-10.2), and low use of oral rehydration solution (6.9% decrease, 4-8-8-4). Interpretation Diarrhoea mortality has declined substantially since 1990, although there are variations by country. Improvements in sociodemographic indicators might explain some of these trends, but changes in exposure to risk factors-particularly unsafe sanitation, childhood growth failure, and low use of oral rehydration solution-appear to be related to the relative and absolute rates of decline in diarrhoea mortality. Although the most effective interventions might vary by country or region, identifying and scaling up the interventions aimed at preventing and protecting against diarrhoea that have already reduced diarrhoea mortality could further avert many thousands of deaths due to this illness

Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years : an analysis for the Global Burden of Disease Study 2017

Background Despite large reductions in under-5 lower respiratory infection (LRI) mortality in many locations, the pace of progress for LRIs has generally lagged behind that of other childhood infectious diseases. To better inform programmes and policies focused on preventing and treating LRIs, we assessed the contributions and patterns of risk factor attribution, intervention coverage, and sociodemographic development in 195 countries and territories by drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) LRI estimates. Methods We used four strategies to model LRI burden: the mortality due to LRIs was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive ensemble modelling tool; the incidence of LRIs was modelled using population representative surveys, health-care utilisation data, and scientific literature in a compartmental meta-regression tool; the attribution of risk factors for LRI mortality was modelled in a counterfactual framework; and trends in LRI mortality were analysed applying changes in exposure to risk factors over time. In GBD, infectious disease mortality, including that due to LRI, is among HIV-negative individuals. We categorised locations based on their burden in 1990 to make comparisons in the changing burden between 1990 and 2017 and evaluate the relative percent change in mortality rate, incidence, and risk factor exposure to explain differences in the health loss associated with LRIs among children younger than 5 years. Findings In 2017, LRIs caused 808 920 deaths (95% uncertainty interval 747 286-873 591) in children younger than 5 years. Since 1990, there has been a substantial decrease in the number of deaths (from 2 337 538 to 808 920 deaths; 65.4% decrease, 61.5-68.5) and in mortality rate (from 362.7 deaths [3304-392.0] per 100 000 children to 118.9 deaths [109.8-128.3] per 100 000 children; 67.2% decrease, 63.5-70.1). LRI incidence dedined globally (32.4% decrease, 27.2-37.5). The percent change in under-5 mortality rate and incidence has varied across locations. Among the risk factors assessed in this study, those responsible for the greatest decrease in under-5 LRI mortality between 1990 and 2017 were increased coverage of vaccination against Haemophilus influenza type b (11.4% decrease, 0.0-24.5), increased pneumococcal vaccine coverage (6.3% decrease, 6.1-6.3), and reductions in household air pollution (8.4%, 6 8-9.2). Interpretation Our findings show that there have been substantial but uneven declines in LRI mortality among countries between 1990 and 2017. Although improvements in indicators of sociodemographic development could explain some of these trends, changes in exposure to modifiable risk factors are related to the rates of decline in LRI mortality. No single intervention would universally accelerate reductions in health loss associated with LRIs in all settings, but emphasising the most dominant risk factors, particularly in countries with high case fatality, can contribute to the reduction of preventable deaths

Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years : an analysis of the Global Burden of Disease Study 2017

Background Many countries have shown marked declines in diarrhoea! disease mortality among children younger than 5 years. With this analysis, we provide updated results on diarrhoeal disease mortality among children younger than 5 years from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) and use the study's comparative risk assessment to quantify trends and effects of risk factors, interventions, and broader sociodemographic development on mortality changes in 195 countries and territories from 1990 to 2017. Methods This analysis for GBD 2017 had three main components. Diarrhoea mortality was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive, Bayesian, ensemble modelling tool; and the attribution of risk factors and interventions for diarrhoea were modelled in a counterfactual framework that combines modelled population-level prevalence of the exposure to each risk or intervention with the relative risk of diarrhoea given exposure to that factor. We assessed the relative and absolute change in diarrhoea mortality rate between 1990 and 2017, and used the change in risk factor exposure and sociodemographic status to explain differences in the trends of diarrhoea mortality among children younger than 5 years. Findings Diarrhoea was responsible for an estimated 533 768 deaths (95% uncertainty interval 477 162-593 145) among children younger than 5 years globally in 2017, a rate of 78.4 deaths (70.1-87.1) per 100 000 children. The diarrhoea mortality rate ranged between countries by over 685 deaths per 100 000 children. Diarrhoea mortality per 100 000 globally decreased by 69.6% (63.1-74.6) between 1990 and 2017. Among the risk factors considered in this study, those responsible for the largest declines in the diarrhoea mortality rate were reduction in exposure to unsafe sanitation (13.3% decrease, 11.2-15.5), childhood wasting (9.9% decrease, 9.6-10.2), and low use of oral rehydration solution (6.9% decrease, 4-8-8-4). Interpretation Diarrhoea mortality has declined substantially since 1990, although there are variations by country. Improvements in sociodemographic indicators might explain some of these trends, but changes in exposure to risk factors-particularly unsafe sanitation, childhood growth failure, and low use of oral rehydration solution-appear to be related to the relative and absolute rates of decline in diarrhoea mortality. Although the most effective interventions might vary by country or region, identifying and scaling up the interventions aimed at preventing and protecting against diarrhoea that have already reduced diarrhoea mortality could further avert many thousands of deaths due to this illness. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.Peer reviewe

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure the incidence, prevalence, and years of life lived with disability (YLDs) for TBI and SCI from all causes of injury in every country, to describe how these measures have changed between 1990 and 2016, and to estimate the proportion of TBI and SCI cases caused by different types of injury. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016 to measure the global, regional, and national burden of TBI and SCI by age and sex. We measured the incidence and prevalence of all causes of injury requiring medical care in inpatient and outpatient records, literature studies, and survey data. By use of clinical record data, we estimated the proportion of each cause of injury that required medical care that would result in TBI or SCI being considered as the nature of injury. We used literature studies to establish standardised mortality ratios and applied differential equations to convert incidence to prevalence of long-term disability. Finally, we applied GBD disability weights to calculate YLDs. We used a Bayesian meta-regression tool for epidemiological modelling, used cause-specific mortality rates for non-fatal estimation, and adjusted our results for disability experienced with comorbid conditions. We also analysed results on the basis of the Socio-demographic Index, a compound measure of income per capita, education, and fertility. FINDINGS: In 2016, there were 27·08 million (95% uncertainty interval [UI] 24·30-30·30 million) new cases of TBI and 0·93 million (0·78-1·16 million) new cases of SCI, with age-standardised incidence rates of 369 (331-412) per 100 000 population for TBI and 13 (11-16) per 100 000 for SCI. In 2016, the number of prevalent cases of TBI was 55·50 million (53·40-57·62 million) and of SCI was 27·04 million (24·98-30·15 million). From 1990 to 2016, the age-standardised prevalence of TBI increased by 8·4% (95% UI 7·7 to 9·2), whereas that of SCI did not change significantly (-0·2% [-2·1 to 2·7]). Age-standardised incidence rates increased by 3·6% (1·8 to 5·5) for TBI, but did not change significantly for SCI (-3·6% [-7·4 to 4·0]). TBI caused 8·1 million (95% UI 6·0-10·4 million) YLDs and SCI caused 9·5 million (6·7-12·4 million) YLDs in 2016, corresponding to age-standardised rates of 111 (82-141) per 100 000 for TBI and 130 (90-170) per 100 000 for SCI. Falls and road injuries were the leading causes of new cases of TBI and SCI in most regions. INTERPRETATION: TBI and SCI constitute a considerable portion of the global injury burden and are caused primarily by falls and road injuries. The increase in incidence of TBI over time might continue in view of increases in population density, population ageing, and increasing use of motor vehicles, motorcycles, and bicycles. The number of individuals living with SCI is expected to increase in view of population growth, which is concerning because of the specialised care that people with SCI can require. Our study was limited by data sparsity in some regions, and it will be important to invest greater resources in collection of data for TBI and SCI to improve the accuracy of future assessments