Analysis and Prediction of Electromobility and Energy Supply by the Example of Stuttgart

This paper seeks to identify bottlenecks in the energy grid supply regarding different market penetration of battery electric vehicles in Stuttgart, Germany. First, medium-term forecasts of electric and hybrid vehicles and the corresponding charging infrastructure are issued from 2017 to 2030, resulting in a share of 27% electric vehicles by 2030 in the Stuttgart region. Next, interactions between electric vehicles and the local energy system in Stuttgart were examined, comparing dif-ferent development scenarios in the mobility sector. Further, a travel demand model was used to generate charging profiles of electric vehicles under consideration of mobility patterns. The charg-ing demand was combined with standard household load profiles and a load flow analysis of the peak hour was carried out for a quarter comprising 349 households. The simulation shows that a higher charging capacity can lead to a lower transformer utilization, as charging and household peak load may fall temporally apart. Finally, it was examined whether the existing infrastructure is suitable to meet future demand focusing on the transformer reserve capacity. Overall, the need for action is limited; only 10% of the approximately 560 sub-grids were identified as potential weak points

Capnography Improves Detection of Apnea During Procedural Sedation for Percutaneous Transhepatic Cholangiodrainage

BACKGROUND: Capnography provides noninvasive monitoring of ventilation and can enable early recognition of altered respiration patterns and apnea

Attosecond Delays in X-ray Molecular Ionization

The photoelectric effect is not truly instantaneous, but exhibits attosecond delays that can reveal complex molecular dynamics. Sub-femtosecond duration light pulses provide the requisite tools to resolve the dynamics of photoionization. Accordingly, the past decade has produced a large volume of work on photoionization delays following single photon absorption of an extreme ultraviolet (XUV) photon. However, the measurement of time-resolved core-level photoionization remained out of reach. The required x-ray photon energies needed for core-level photoionization were not available with attosecond tabletop sources. We have now measured the x-ray photoemission delay of core-level electrons, and here report unexpectedly large delays, ranging up to 700 attoseconds in NO near the oxygen K-shell threshold. These measurements exploit attosecond soft x-ray pulses from a free-electron laser (XFEL) to scan across the entire region near the K-shell threshold. Furthermore, we find the delay spectrum is richly modulated, suggesting several contributions including transient trapping of the photoelectron due to shape resonances, collisions with the Auger-Meitner electron that is emitted in the rapid non-radiative relaxation of the molecule, and multi-electron scattering effects. The results demonstrate how x-ray attosecond experiments, supported by comprehensive theoretical modelling, can unravel the complex correlated dynamics of core-level photoionization

Cold atoms in space: community workshop summary and proposed road-map

We summarise the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with the European Space Agency (ESA) and national space and research funding agencies.publishedVersio

Cold atoms in space: community workshop summary and proposed road-map

We summarise the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with the European Space Agency (ESA) and national space and research funding agencies

Cold atoms in space: community workshop summary and proposed road-map

We summarise the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with the European Space Agency (ESA) and national space and research funding agencies

Straflose Suizidassistenz trotz aktiver Tötungshandlung? | Über Widersprüche zwischen § 216 StGB und dem Grundrecht auf selbstbestimmtes Sterben

In the highly regarded so-called Insulin-Decision, the German Federal Court of Justice acquitted the defendant from homicide on demand, who injected her husband with six lethal doses of insulin at his request. The Regional Court, at first instance, had sentenced the defendant to one year’s imprisonment under Section 216 of the German Criminal Code for homicide on demand, because she had “actively” assisted her husband’s death by injecting him with insulin. The Federal Court based the acquittal of the defendant on a novel description of the doctrine of perpetration, according to which the normative question of who “controls” a suicide event depends on the “overall plan”. The decision fits into a series of rulings that began with the so called Putz-Decision in 2010 and, in the overall view, increasingly herald a paradigm shift for the criminal law assessment of “assisted dying,” not least because the German Federal Constitutional Court recently, in February 2020, even made explicit a fundamental right to self-determined dying. The Insulin-Decision proves that the crime of homicide on demand in § 216 of the German Criminal Code needs to be redefined in the context of the fundamental right to self-determined dying, since this necessarily involves the right to have recourse to the help of third parties in order to realize it

Analysis and Prediction of Electromobility and Energy Supply by the Example of Stuttgart

This paper seeks to identify bottlenecks in the energy grid supply regarding different market penetration of battery electric vehicles in Stuttgart, Germany. First, medium-term forecasts of electric and hybrid vehicles and the corresponding charging infrastructure are issued from 2017 to 2030, resulting in a share of 27% electric vehicles by 2030 in the Stuttgart region. Next, interactions between electric vehicles and the local energy system in Stuttgart were examined, comparing different development scenarios in the mobility sector. Further, a travel demand model was used to generate charging profiles of electric vehicles under consideration of mobility patterns. The charging demand was combined with standard household load profiles and a load flow analysis of the peak hour was carried out for a quarter comprising 349 households. The simulation shows that a higher charging capacity can lead to a lower transformer utilization, as charging and household peak load may fall temporally apart. Finally, it was examined whether the existing infrastructure is suitable to meet future demand focusing on the transformer reserve capacity. Overall, the need for action is limited; only 10% of the approximately 560 sub-grids were identified as potential weak points

Neurocognition and quality of life after reinitiating antiretroviral therapy in children randomized to planned treatment interruption

Item does not contain fulltextOBJECTIVE: Understanding the effects of antiretroviral treatment (ART) interruption on neurocognition and quality of life (QoL) are important for managing unplanned interruptions and planned interruptions in HIV cure research. DESIGN: Children previously randomized to continuous (continuous ART, n = 41) vs. planned treatment interruption (PTI, n = 47) in the Pediatric European Network for Treatment of AIDS (PENTA) 11 study were enrolled. At study end, PTI children resumed ART. At 1 and 2 years following study end, children were assessed by the coding, symbol search and digit span subtests of Wechsler Intelligence Scale for Children (6-16 years old) or Wechsler Adult Intelligence Scale (>/=17 years old) and by Pediatrics QoL questionnaires for physical and psychological QoL. Transformed scaled scores for neurocognition and mean standardized scores for QoL were compared between arms by t-test and Mann-Whitney U test, respectively. Scores indicating clinical concern were compared (<7 for neurocognition and <70 for QoL tests). RESULTS: Characteristics were similar between arms with a median age of 12.6 years, CD4(+) of 830 cells/mul and HIV RNA of 1.7 log10copies/ml. The median cumulative ART exposure was 9.6 in continuous ART vs. 7.7 years in PTI (P = 0.02). PTI children had a median of 12 months off ART and had resumed ART for 25.2 months at time of first assessment. Neurocognitive scores were similar between arms for all tests. Physical and psychological QoL scores were no different. About 40% had low neurocognitive and QoL scores indicating clinical concern. CONCLUSION: No differences in information processing speed, sustained attention, short-term memory and QoL functioning were observed between children previously randomized to continuous ART vs. PTI in the PENTA 11 trial