Cytogenetic and molecular analyses of de novo translocation dic(9;13)(p11.2;p12) in an infertile male

BACKGROUND: Whole arm t(9;13)(p11;p12) translocations are rare and have been described only a few times; all of the previously reported cases were familial. RESULTS: We present here an infertile male carrier with a whole-arm reciprocal translocation dic(9;13)(p11.2;p12) revealed by GTG-, C-, and NOR-banding karyotypes with no mature sperm cells in his ejaculate. FISH and genome-wide 400 K CGH microarray (Agilent) analyses demonstrated a balanced chromosome complement and further characterised the abnormality as a dicentric chromosome (9;13): dic(9;13)(pter→p11.2::p12→qter),neo(9)(pter→p12→neo→p11.2). An analysis of the patient’s ejaculated cells identified immature germ cells at different phases of spermatogenesis but no mature spermatozoa. Most (82.5%) of the germ cells were recognised as spermatocytes at stage I, and the cell nuclei were most frequently found in pachytene I (41.8%). We have also undertaken FISH analysis and documented an increased rate of aneuploidy of chromosomes 15, 18, X and Y in the peripheral blood leukocytes of our patient. To study the aneuploidy risk in leukocytes, we have additionally included 9 patients with non-obstructive azoospermia with normal karyotypes. CONCLUSIONS: We propose that the azoospermia observed in the patient with the dic(9;13)(p11.2;p12) translocation was most likely a consequence of a very high proportion (90%) of association between XY bivalents and quadrivalent formations in prophase I

Micro turbinas de gas con generadores de alta velocidad para sistemas de energia locales inteligentes

At present, the share of energy collected from renewable resources and low-power units is growing, and the generation becomes distributed, having many facilities that operate in co-generation mode. That is why the construction of an energy system with distributed heterogeneous sources and the improvement of its efficiency have become widely discussed issues. This paper proposes a solution of a local smart energy systemfortheTechnoEcoPark, a sciencepark of Rostov State Transport University, Rostov, Russia. The solution aims to integrate the distributed generation facilities, including environmentally friendly renewable resources, grid infrastructure and consumers with controllable and uncontrollable load. Theapproachtothe problem is the application of a smart control systemthatmanagesgeneration, distribution and consumptionof energy in a mini-CHP-based autonomous energy system. Such smart control systems reveal the trends of optimal energydistribution in a autonomousenergysystem. The study substantiates that installation of an in-house mini-CHP can solve the task of supplying heat and powertotheTechnoEcoPark. The important advantage of the solution is a significant reduction of expenses on energy consumption as the generation costs less compared to the grid tariffs. The proposed energy supply system of the TechnoEcoPark exemplifies the integration of heterogeneous heat and power sources and consumers into a commonnetwork. The paper outlines the mechanisms of the energy system efficiency improvement. These mechanisms make it possible to provide heat and power supply services to consumers and to return the generated power into the centralized grid. The materials of the paper can be of use to the specialists and researchers who are interested in generation and distribution of energy in autonomous systems.En la actualidad, la proporción de energía recolectada de recursos renovables y unidades de baja potencia está creciendo, y la generación se distribuye, teniendo muchas instalaciones que operan en modo de cogeneración. Es por eso que la construcción de un sistema de energía con fuentes heterogéneas distribuidas y la mejora de su eficiencia se han convertido en temas ampliamente discutidos. Este documento propone una solución de un sistema de energía inteligente local para TechnoEcoPark, un parque científico de la Universidad Estatal de Transporte de Rostov, Rostov, Rusia. La solución tiene como objetivo integrar las instalaciones de generación distribuida, incluidos los recursos renovables ecológicos, la infraestructura de la red y los consumidores con carga controlable e incontrolable. El enfoque del problema es la aplicación de un sistema de control inteligente que gestiona la generación, distribución y consumo de energía en un sistema de energía autónomo basado en mini-CHP. Tales sistemas de control inteligente revelan las tendencias de distribución óptima de energía en un sistema energético autónomo. El estudio confirma que la instalación de un mini-CHP interno puede resolver la tarea de suministrar calor y energía al TechnoEcoPark. La ventaja importante de la solución es una reducción significativa de los gastos en consumo de energía, ya que la generación cuesta menos en comparación con las tarifas de la red. El sistema de suministro de energía propuesto por TechnoEcoPark ejemplifica la integración de fuentes heterogéneas de calor y energía y consumidores en una red común. El documento describe los mecanismos de mejora de la eficiencia del sistema energético. Estos mecanismos permiten proporcionar servicios de suministro de calor y energía a los consumidores y devolver la energía generada a la red centralizada. Los materiales del documento pueden ser de utilidad para los especialistas e investigadores interesados ​​en la generación y distribución de energía en sistemas autónomos

Trigonal-bipyramidal Anion [Ph2Cl3Sn]- in the Structure of N-[(Diethylphosphoryl)methyl] piperidinium Diphenyltrichlorostannate(IV)

Crystal structure of N-(diethylphosphoryl)methyl-piperidinium diphenyltrichlorostannate(IV), C10H23NO3P+ C12H10Cl3Sn- has been determined, a = 11.416(2), b = 11.582(2), c = 12.491(2) Å, α = 69.82(2), β = 81.22(2), γ = 60.73(2)°, space group P1̅, 4493 reflections, R(F) = 0.0271, wR(F2) = 0.0712. The structure consists of isolated trigonal-bipyramidal anions and hydrogen-bonded dimers formed by cations. The impact of secondary Sn⋅⋅⋅Cl interactions on the geometry of complex anions is discussed

DataJoint: managing big scientific data using MATLAB or Python

The rise of big data in modern research poses serious challenges for data management: Large and intricate datasets from diverse instrumentation must be precisely aligned, annotated, and processed in a variety of ways to extract new insights. While high levels of data integrity are expected, research teams have diverse backgrounds, are geographically dispersed, and rarely possess a primary interest in data science. Here we describe DataJoint, an open-source toolbox designed for manipulating and processing scientific data under the relational data model. Designed for scientists who need a flexible and expressive database language with few basic concepts and operations, DataJoint facilitates multi-user access, efficient queries, and distributed computing. With implementations in both MATLAB and Python, DataJoint is not limited to particular file formats, acquisition systems, or data modalities and can be quickly adapted to new experimental designs. DataJoint and related resources are available at http://datajoint.github.com

Ultrabright and narrowband intra-fiber biphoton source at ultralow pump power

Nonclassical photon sources of high brightness are key components of quantum communication technologies. We here demonstrate the generation of narrowband, nonclassical photon pairs by employing spontaneous four-wave mixing in an optically-dense ensemble of cold atoms within a hollow-core fiber. The brightness of our source approaches the limit of achievable generated spectral brightness at which successive photon pairs start to overlap in time. For a generated spectral brightness per pump power of up to 2 × 10⁹ pairs/(s MHz mW) we observe nonclassical correlations at pump powers below 100 nW and a narrow bandwidth of 2π × 6.5 MHz. In this regime we demonstrate that our source can be used as a heralded single-photon source. By further increasing the brightness we enter the regime where successive photon pairs start to overlap in time and the cross-correlation approaches a limit corresponding to thermal statistics. Our approach of combining the advantages of atomic ensembles and waveguide environments is an important step toward photonic quantum networks of ensemble-based elements

DataJoint: managing big scientific data using MATLAB or Python

The rise of big data in modern research poses serious challenges for data management: Large and intricate datasets from diverse instrumentation must be precisely aligned, annotated, and processed in a variety of ways to extract new insights. While high levels of data integrity are expected, research teams have diverse backgrounds, are geographically dispersed, and rarely possess a primary interest in data science. Here we describe DataJoint, an open-source toolbox designed for manipulating and processing scientific data under the relational data model. Designed for scientists who need a flexible and expressive database language with few basic concepts and operations, DataJoint facilitates multi-user access, efficient queries, and distributed computing. With implementations in both MATLAB and Python, DataJoint is not limited to particular file formats, acquisition systems, or data modalities and can be quickly adapted to new experimental designs. DataJoint and related resources are available at http://datajoint.github.com

Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT