Optimización y mejoramiento de la calidad de vida de las familias del barrio Bello Horizonte a través de la conformación de redes de apoyo que contribuyan a la minimización de los factores que generan inseguridad

TablasLa inseguridad ciudadana se ha convertido en el diario vivir de nuestro país y especialmente en nuestro municipio por ser la capital de un departamento que en los últimos años ha aumentado su crecimiento poblacional y por consiguiente su desarrollo económico; lo cual ha generado una alta problemática de inseguridad, es por esto que este proyecto se enfoca en mejorar y optimizar la calidad de vida de las familias del barrio bello horizonte del municipio de Yopal a través del fortalecimiento de las redes de apoyo que existen en la comunidad para empoderar a cada uno de sus habitantes de tal forma que puedan ser agentes activos del cambio de su propia realidad, de sus problemas y necesidades; con el objetivo de promover cambios en la comunidad articulando los diferentes factores internos y externos para el desarrollo de estrategias que permitan el involucramiento integral la comunidad en la identificación de sus problemas, necesidades definición y puesta en marcha de alternativas para contribuir a la transformación de sus problemas a partir de sus habilidades, recursos propios y el trabajo mancomunado.The citizen insecurity is present daily situation of our country and it is present especially in our town because of it is the capital of the department that during the past few years it accelerates your grown in population by implication your economic development, whereby it generates a problem high of insecurity for that reason this project wants improve and optimize the quality of life of families in the “Bello Horizonte” neighborhood of the Yopal town, through the strengthening of some support network that they exist in the community for give power to each people such that, they can be agents of change of your home grown life with the objective to promote changes in the community connect it with the different factors internals and externals for development of strategies that it allows involve integral of community in the identify of your problems , needs, definition and they can implement alternatives to contribute the transformation of your problems based on skills, self-resourcing and the work of all community

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Taller de Instrumento II - MS198 - 202102

Taller de Instrumento II es un curso práctico dirigido a los estudiantes de tercer ciclo de la carrera de música. Se dicta de manera individual y se fundamenta en la ejecución de un instrumento musical a partir de la aplicación de elementos teóricos del lenguaje musical tales como el ritmo, melodía y armonía profundizando en los modos de la escala mayor, las cuatriadas, el ejercicio de la lectura musical instrumental y la interpretación de géneros musicales peruanos y contemporáneos. El propósito del curso es dar al estudiante una base sólida para la ejecución instrumental a partir del trabajo técnico, el desarrollo de un repertorio y la aplicación de los fundamentos técnicos de ejecución en diversos géneros musicales contemporáneos. El curso se dicta en nivel 1 y trabaja dos competencias específicas: Destreza musical sobre el instrumento y destreza musical sobre el lenguaje musical. Tiene como prerrequisito el curso Taller de Instrumento I y Lectura 1y Entrenamiento Auditivo II. Es requisito para Taller de Instrumento III