Deflection control for reinforced recycled aggregate concrete beams: Experimental database and extension of the fib Model Code 2010 model

Recycled aggregate concrete (RAC) has emerged as a viable solution for solving some of the environmental problems of concrete production. However, design guidelines for deflection control of reinforced RAC members have not yet been proposed. This study presents a comprehensive analysis of the applicability of the fib Model Code 2010 (MC2010) deflection control model to reinforced RAC beams. Three databases of long-term studies on natural aggregate concrete (NAC) and RAC beams were compiled and meta-analyses of deflection predictions by MC2010 were performed. First, the MC2010 deflection control model was tested against a large database of long-term tests on NAC beams. Second, a database of RAC and companion NAC beams was compiled and initial and long-term deflections were calculated using the MC2010 model. It was shown that deflections of RAC beams are significantly underestimated relative to NAC beams. Previously proposed modifications for MC2010 equations for shrinkage strain and creep coefficient were used, and new modifications for the modulus of elasticity and empirical coefficient β were proposed. The improved MC2010 deflection control model on RAC beams was shown to have equal performance to that on companion NAC beams. The proposals presented in this paper can help engineers to more reliably perform deflection control of reinforced RAC members.This is the peer-reviewed version of the article: N. Tošić, S. Marinković, and J. de Brito, ‘Deflection control for reinforced recycled aggregate concrete beams: Experimental database and extension of the fib Model Code 2010 model’, Structural Concrete, vol. 20, no. 6, pp. 2015–2029, 2019 [https://doi.org/10.1002/suco.201900035

Cytotoxic activity of supercritical CO2 extract of old man’s beard in L929 fibrosarcoma cell line

Usnea barbata (old man’s beard) is one of the most investigated lichens which biological properties (such as antimicrobial, anti-inflammatory and cytotoxic activities) have been proven in several scientific studies. Stated properties of old man’s beard have been attributed mainly to its major secondary metabolite - a dibenzofuran derivative, usnic acid. The aim of the current study was to examine cytotoxic activity of the quantified supercritical CO2 extract and pure usnic acid in parallel against L929 fibrosarcoma cells. Our results indicated the tested extract to be more toxic towards the investigated cell line compared to usnic acid per se, despite the high amount of this compound (81.41 (% (w/w)) revealed in the extract using HPLC. Such result may be connected to the unidentified compound(s) present in the supercritical CO2 extract that could be responsible for apoptosis and oxidative stress in the exerted cytotoxicity of the investigated extract, but not usnic acid. Our study supports further investigations of supercritical CO2 extract of U. barbata as a prospective therapeutic agent with potential relevance in the treatment of sarcoma

Novel insights to the anti-proliferative activity of rosemary (Rosmarinus officinalis L.) co-treatment

The aim of this study was to characterize volatile and non-volatile compounds of rosemary from the North Adriatic region and to determine its antiproliferative activity, alone or in combination with radiomimetic bleomycin (BLM) on three malignant and one non-transformed human cell line. Chemical analysis of the volatile compounds revealed the presence of monoterpenes (93.8%), in which 1.8-cineol (32.9%) and camphor (15.5%) were the dominant compounds. Also, obtained results showed that the major polyphenolic constituents in rosemary extract were phenolic acids (rosmarinic acid and its derivatives up to 69.2 mg 100 g-1), as well as flavones and flavonols in the following order: luteolin>isorhamnetin>quercetin>kaempferol>apigenin. Cell growth test showed that rosemary extract alone exerted moderate antiproliferative activity, as well as a synergistic antiproliferative effect with bleomycin (EC50 344.3-461.5 µg mL-1 and 58.6-292 µg mL-1, respectively). The anti-tumor effect of rosemary extract in combination with BLM was much stronger, compared to BLM itself on the breast cancer cells. Through their proposed sensitizing effect, rosemary extracts, in combination with the standard chemotherapeutics, could be used for the investigations of possible therapeutic modalities

Dziecko z niepełnosprawnością w przedszkolu i w szkole ogólnodostępnej

Publikacja wspólfinansowana przez Unię Europejską w ramach Europejskiego Funduszu Społecznego. Publikacja przygotowana w ramach projektu systemowego "Doskonalenie strategii zarządzania oświatą na poziomie regionalnym i lokalnym" II etap, Priorytet III, Działanie 3.1. Poddziałanie 3.1.2. Programu Operacyjnego Kapitał Ludzki, realizowanego przez Ośrodek Rozwoju Edukacji w partnerstwie z firmą VULCAN Sp..z o.o

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Performance of missing transverse momentum reconstruction in proton-proton collisions at root s=13 TeV using the CMS detector

The performance of missing transverse momentum ((p) over right arrow (miss)(T)) reconstruction algorithms for the CMS experiment is presented, using proton-proton collisions at a center-of-mass energy of 13 TeV, collected at the CERN LHC in 2016. The data sample corresponds to an integrated luminosity of 35.9 fb(-1). The results include measurements of the scale and resolution of (p) over right arrow (miss)(T), and detailed studies of events identified with anomalous (p) over right arrow (miss)(T). The performance is presented of a (p) over right arrow (miss)(T) reconstruction algorithm that mitigates the effects of multiple proton-proton interactions, using the "pileup per particle identification" method. The performance is shown of an algorithm used to estimate the compatibility of the reconstructed (p) over right arrow (miss)(T) with the hypothesis that it originates from resolution effects.Peer reviewe

Drug treatment of vertigo in neurological disorders

ABSTRACTVertigo is a common symptom in everyday clinical practice. The treatment depends on the specific etiology. Vertigo maybe secondary to inner ear pathology, or any existing brainstem or cerebellar lesion but may also be psychogenic. Centralvertigo is a consequence of a central nervous system lesion. It is often associated with a focal neurological deficit. Peripheralvertigo is secondary to dysfunction of the peripheral vestibular system and is usually characterized by an acute vertigo withloss of balance, sensation of spinning in the space or around self, and is exaggerated with changes of the head and bodyposition; no other neurological deficit is present. Some medications may also cause vertigo. Depending on the cause ofthe vertigo, drugs with different mechanisms of action, physical therapy, psychotherapy, as well as surgery may be usedto combat this disabling malady. Symptomatic treatment has a particularly important role, regardless of the etiology ofvertigo. We reviewed the current medications recommended for patients with vertigo, their mechanisms of action and theirmost frequent side effect

Influence of Min-a-zel Plus on biochemical, microbiological and mycotoxicological parameters of lucerne silage

Lucerne of the 5th cut in the budding phase was ensiled in the experiment as fresh and wilted (DM= 220 and 360 g/kg), with two degrees of compression (520 and 380 g/dm3) and with added Min-a-zel plus as 2 g/kg green mass. The experiment was performed as the statistical model 2K. Min-a-zel plus used as 2 g/kg green mass had no influence on biochemical, microbiological and mycotoxicological parameters of lucerne silage. Compared to the beginning material, silages had more diverse microflora and more mycotoxins. All silages had high pH values and fermentation of the acetic acid type. Some improvement was achieved with wilting of the ensiling material. The least quality (V class) was obtained with fresh lucerne, which was less compressed, while others were ranked as IV quality class. The obtained results fortify the need for further investigations in developing correct doses of Min-a-zel plus to be used in ensiling of lucerne and other materials