15- #1058 ANÁLISIS DE LA INCORPORACIÓN DE CENIZA DE CASCARILLA DE ARROZ COMO MATERIAL CEMENTANTE SUPLEMENTARIO EN LA FABRICACIÓN DE CONCRETO MEDIANTE UN MODELO DE PROGRAMACIÓN ENTERA MIXTA

El aumento de la población y la expansión urbana son impulsores del crecimiento de la construcción. Dado que el cemento es el principal material utilizado en el concreto, las investigaciones actuales se centran en la reducción de las emisiones provenientes de su fabricación. El uso de Materiales Cementantes Suplementarios (MCS) es una de las alternativas (Aprianti et al, 2015). Por otro lado, en Colombia existen residuos agroindustriales con altos volúmenes de generación y difícil disposición, que no cuentan con alternativas de aprovechamiento. Uno de ellos es la cascarilla de arroz, la cual se puede incorporar como MCS una vez se realiza una combustión controlada que produce ceniza de cascarilla de arroz (CCA) con altos porcentajes de sílice amorfa.En este trabajo se presenta un modelo de programación entera mixta para el diseño de la cadena de abastecimiento que conecta de manera sostenible la generación de cascarilla de arroz en los molinos arroceros con la producción de concreto en las plantas de mezclado. Dicho modelo considera la optimización simultanea de la huella de carbono y el costo logístico y de producción de la cadena de abastecimiento. Además de las decisiones típicas de una cadena de abastecimiento (cantidades a producir y transportar en cada uno de los eslabones, Melo et al, 2009), el modelo considera como una de sus decisiones principales la elección de la ubicación y la tecnología empleada en las instalaciones de producción de CCA.Utilizando los datos de una compañía cementera colombiana, se evalúa el impacto de la incorporación de CCA como MCS. Se plantean distintos escenarios que analizan la política de compra de CCA y la posibilidad de generación de energía en la combustión. Así mismo, se analiza el trade-off entre la reducción de la huella de carbono y el costo de la cadena de suministro

Development, Characterization, and Applications of Capsaicin Composite Nanofiltration Membranes

Biofouling in reverse osmosis (RO) membranes is a severe problem, causing a decrease in both permeate flux and salt rejection and increasing transmembrane pressure. Capsaicin extract inhibits bacterial growth and is therefore used in this study to prepare a thin-film composite membrane and membrane support. Four types of nanofiltration (NF) membranes were prepared by interfacial polymerization onto a porous support prepared by the phase inversion method. Membrane A was the control membrane with no capsaicin extract, membrane B contains capsaicin in the polyamide thin film, membrane C contains capsaicin in the porous support, and membrane D contains capsaicin in both the thin film and support layers. Three different salts (Na2SO4, MgSO4, and NaCl) were used at different concentrations (1000, 3000, and 5000 ppm) to test the performance of the membranes in terms of salt rejection and permeate flux. Membrane B showed the highest rejection for all the salts and concentrations tested. For 5000 ppm NaCl, the permeate flux for membrane B was 14.81% higher, and salt rejection was 19.6% higher than membrane A. Future work will evaluate the anti-biofouling properties of the membranes prepared with capsaicin, when exposed to seawater microorganisms

Corrección de hernia de Amyand con malla y apendicetomía: reporte de caso

Amyand’s hernia is defined as the presence of the vermiform appendix within an inguinal hernial sac. Less than 1 % of the world medical publications on hernias address this disease, out of which very few come from Latin America and the Caribbean. This is the case of a 78-year-old male patient who experienced signs and symptoms for approximately five months. He felt a lump in the right inguinal region which progressively increased in size. Two days prior to admission to the intensive care unit, he said his pain level was 8/10. During the right inguinal approach, the hernial sac was opened, revealing parts of the right colon, cecum and appendix with edematous changes. Therefore, the patient underwent an appendectomy and repair with polypropylene mesh.La hernia de Amyand se define como la presencia de un apéndice vermiforme dentro de un saco herniario inguinal. Menos del 1 % de las publicaciones médicas sobre hernias en el mundo corresponde a este padecimiento, y los reportes en Latinoamérica y el Caribe son escasos. Este artículo describe el caso de un varón de 78 años con un cuadro clínico de cinco meses de evolución aproximadamente. El paciente refiere que sentía una masa en la región inguinal derecha de crecimiento progresivo. Luego se asoció un dolor (de escala 8/10) durante los dos días previos al ingreso en el departamento de urgencias. Durante la operación en la región inguinal derecha, se abre el saco herniario que muestra partes del colon derecho, el ciego y el apéndice (edematosos), por lo que se decide realizar una apendicectomía y la reconstrucción con una malla de polipropileno

An inventory of the Marine and Transitional Middle/Upper Eocene Deposits of the Southeastern Pyrenean Foreland Basin (NE spain)

In the southeastern Ebro Foreland Basin, the marine deposits of Lutetian and Bartonian age show excellent outcrop conditions, with a great lateral and horizontal continuity of lithostratigraphic units. In addition, the rich fossil record -mainly larger foraminifers-, provides iostratigraphic data of regional relevance for the whole Paleogene Pyrenean Basin, that can be used for the Middle Eocene biocorrelation of the western Tethys. This contribution is a sedimentary and biostratigraphic synthesis of the basic outcrops and sections of the Lutetian and Bartonian marine and transitional deposits in the southeastern sector of the Ebro Foreland Basin

An Overview of the IberSpeech-RTVE 2022 Challenges on Speech Technologies

Evaluation campaigns provide a common framework with which the progress of speech technologies can be effectively measured. The aim of this paper is to present a detailed overview of the IberSpeech-RTVE 2022 Challenges, which were organized as part of the IberSpeech 2022 conference under the ongoing series of Albayzin evaluation campaigns. In the 2022 edition, four challenges were launched: (1) speech-to-text transcription; (2) speaker diarization and identity assignment; (3) text and speech alignment; and (4) search on speech. Different databases that cover different domains (e.g., broadcast news, conference talks, parliament sessions) were released for those challenges. The submitted systems also cover a wide range of speech processing methods, which include hidden Markov model-based approaches, end-to-end neural network-based methods, hybrid approaches, etc. This paper describes the databases, the tasks and the performance metrics used in the four challenges. It also provides the most relevant features of the submitted systems and briefly presents and discusses the obtained results. Despite employing state-of-the-art technology, the relatively poor performance attained in some of the challenges reveals that there is still room for improvement. This encourages us to carry on with the Albayzin evaluation campaigns in the coming years.This work was partially supported by Radio Televisión Española through the RTVE Chair at the University of Zaragoza, and Red Temática en Tecnologías del Habla (RED2022-134270-T), funded by AEI (Ministerio de Ciencia e Innovación); It was also partially funded by the European Union’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie Grant 101007666; in part by MCIN/AEI/10.13039/501100011033 and by the European Union “NextGenerationEU”/ PRTR under Grants PDC2021-120846C41 PID2021-126061OB-C44, and in part by the Government of Aragon (Grant Group T3623R); it was also partially funded by the Spanish Ministry of Science and Innovation (OPEN-SPEECH project, PID2019-106424RB-I00) and by the Basque Government under the general support program to research groups (IT-1704-22), and by projects RTI2018-098091-B-I00 and PID2021-125943OB-I00 (Spanish Ministry of Science and Innovation and ERDF) as well

An inventory of the marine and transitional Middle/Upper Eocene deposits of the Southeastern Pyrenean Foreland Basin (NE Spain)

In the southeastern Ebro Foreland Basin, the marine deposits of Lutetian and Bartonian age show excellent outcrop conditions, with a great lateral and horizontal continuity of lithostratigraphic units. In addition, the rich fossil record -mainly larger foraminifers-, provides iostratigraphic data of regional relevance for the whole Paleogene Pyrenean Basin, that can be used for the Middle Eocene biocorrelation of the western Tethys. This contribution is a sedimentary and biostratigraphic synthesis of the basic outcrops and sections of the Lutetian and Bartonian marine and transitional deposits in the southeastern sector of the Ebro Foreland Basin

Metsäkoneurakoitsijoiden mielipide työssäoppijoiden työelämätaidoista

Tämä tutkimus on tehty selvittämään Tampereen ammattiopiston metsäkonealan koulutusta, jota annetaan Kurun metsäoppilaitoksessa. Tutkimuksessa pyrittiin selvittämään työssäoppimisen kautta sitä, miten metsäkonealan työnantajat arvioivat koulutuksen antamat työelämävalmiudet ja mitä puutteita vastaajat mahdollisesti kokevat ja näkevät oppilaiden koulutuksessa. Aineisto tutkimukseen kerättiin kyselylomakkeen avulla, joka lähetettiin vastaajille postitse keväällä 2009. Tavoitteena oli, että saadun tiedon perusteella opetuksen niihin osiin, joissa koettiin puutteita, voitaisiin keskittää enemmän huomiota ja miettiä, mitä voitaisiin tehdä, jotta opiskelijoille ja työelämälle koituisi mahdollisimman paljon hyötyä osaamisen kasvamisena. Tutkimustulosten mukaan työnantajat olivat suurimmaksi osaksi tyytyväisiä oppilaiden taitoihin heidän saapuessaan työssäoppimisjaksolle. Työnantajien mielestä suurimmat puutteet opiskelijoilla olivat työskentelyssä tarvittavissa taidoissa, vastuussa sekä asenteessa työhön. Antamalla vastuullisia tehtäviä oppilaalle jo kouluaikana voitaisiin hänet saada ottamaan enemmän vastuuta omista tekemisistään. Jos halutaan palvella työlämää paremmin, tulisi tämän tutkimuksen perusteella saada oppilaalle opetettua riittävä taitotaso jo ennen työssäoppimisjaksolle siirtymistä. Tämä asettaa erityisiä vaatimuksia opetushenkilöstön osaamiselle niin ammattitaidollisesti kuin pedagogisestikin.This research has been made to show how effective Tampere Vocational school's forest machinery education given at Kuru Institute of Forestry is. The research was aimed at how the employers estimate the working life skills of forest machine drivers gained during in their education and what shortcomings the employers experience and see within the education system. The material was collected with the help of questionnaires sent to defendants by post in the summer of 2009. The aim based on information obtained, was to concentrate on areas where it was felt the shortcomings were and to consider what could be done so that students and the working life would benefit the most from increasing knowledge. According to the research results, the employers were mostly satisfied with the skills of the students starting their work placements, however; they felt that the biggest shortcomings were within skills needed whilst working i.e.: responsibility and attitude towards work. By giving tasks involving responsibility to students as early as possible in their education, they could be made to take more responsibility for their own actions. If the wish is to serve the working life better, the students, according to this study, should be taught adequate skills level before starting the work placement. This puts particular demands on the skills of the teaching personnel within both craftsmanship and pedagogical skills. Keywords: forest machinery driver education, work readiness, working skill

Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics

The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the development of antimicrobials. Here we describe a solid-phase multicomponent approach which enabled the discovery of potent ePepN inhibitors. The on-resin protocol, developed in the frame of the Distributed Drug Discovery (D3) program, comprises the implementation of parallel Ugi-azide four-component reactions with resin-bound amino acids, thus leading to the rapid preparation of a focused library of tetrazole-peptidomimetics (TPMs) suitable for biological screening. By dose-response studies, three compounds were identified as potent and selective ePepN inhibitors, as little inhibitory effect was exhibited for the porcine ortholog aminopeptidase. The study allowed for the identification of the key structural features required for a high ePepN inhibitory activity. The most potent and selective inhibitor (TPM 11) showed a non-competitive inhibition profile of ePepN. We predicted that both diastereomers of compound TPM 11 bind to a site distinct from that occupied by the substrate. Theoretical models suggested that TPM 11 has an alternative inhibition mechanism that doesn't involve Zn coordination. On the other hand, the activity landscape analysis provided a rationale for our findings. Of note, compound TMP 2 showed in vitro antibacterial activity against Escherichia coli. Furthermore, none of the three identified inhibitors is a potent haemolytic agent, and only two compounds showed moderate cytotoxic activity toward the murine myeloma P3X63Ag cells. These results point to promising compounds for the future development of rationally designed TPMs as antibacterial agents

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe