ROCSAT-3 Constellation Mission

ROCSAT-3 mission is an international collaboration of Taiwan and the United States to deploy in 2005 a constellation of six microsatellites equipped with GPS occultation receivers in low Earth orbits to collect the GPS signal as passing through the atmosphere. The satellites would generate thousands of sounding data everyday uniformly distributed over the world. The satellites will then downlink the GPS occultation measurements to the ground receiving stations for processing and assimilated into the weather forecast model with minimal delay. The design of ROCSAT-3 constellation takes into consideration factors such as the capability of the available launch vehicle, the mass of the propellant, the locations of ground receiving stations, and the deployment period to achieve the final constellation. The six ROCSAT-3 satellites will be delivered by a single Minotaur launch into the same orbit plane initially. The dispersion of the satellites into the target constellation utilizes the principle that satellites at different altitudes will precess into different orbits over the time. By adjusting the altitude profiles, the six ROCSAT-3 microsatellites would be placed into six orbit planes. Considering ionospheric research, the fuel constraint, and the launcher lifting capability, the mission orbit of 800 km is selected. The inclination angle of 72 degrees is selected as the results of the trade studies involving the location of receiving stations and the precession rate of the orbit. The dominant factor in the selection of the separation angle among orbit planes is the requirement of distribution of the sounding data uniformly. With the constraint of the deployment period, the separation angle is currently defined as 24 degrees. Furthermore, in order to minimize the downlink confliction among satellite passes at the ground stations, a true anomaly separation of 52.5 degrees between satellites in adjacent orbit planes is selected. The mission life of ROCSAT-3 is 2 years. The constellation will be achieved 13 months after launch. An early phase mission plan has also been developed for the deployment period when the satellites are at lower altitudes. At altitude below 500 km, a pitch-biased attitude control can be used to point either the forward or aft occultation antenna at the desired angle for conducting the experiment

Optimasi dan Aplikasi Multiplex Polymerase Chain Reaction untuk Deteksi Salmonella sp., Vibrio cholerae, dan Pseudomonas aeruginosa pada Air Minum Kemasan sebagai Pengganti Metode Deteksi Konvensional

Bakteri Salmonella sp, Vibrio cholerae, dan Pseudomonas aeruginosa adalah beberapa jenis pathogen waterborn disease yang umum ditemui dalam air yang terkontaminasi. Metode uji yang diterapkan oleh Standar Nasional Indonesia untuk deteksi Salmonella sp, Vibrio cholerae, dan Pseudomonas aeruginosa sampai saat ini masih menggunakan metode konvensional Total Plate Count (TPC) yang memakan waktu cukup lama, oleh karena itu diajukan penggunaan analisis PCR yang secara teoritis lebih efektif, efisien, dan sensitif dibandingkan dengan metode TPC untuk deteksi ketiga bakteri tersehut. Multiplex PCR (mPCR) adalah salah satu aplikasi teknologi PCR yang memungkinkan digunakan untuk deteksi Salmonella sp, Vibrio cholerae, dan Pseudomonas aeruginosa sekaligus dalam sekali reaksi. Penelitian yang telah dilakukan menunjukkan bahwa primer-primer yang digunakan bisa digunakan untuk deteksi masing-masing bakteri uji dengan Single PCR. Multiplex PCR yang bisa diaplikasikan untuk deteksi bakteri dalam sampel air minum kernasan hanyalah Duplex PCR Salmonella sp-Pseudomonas aeruginosa saja. Jika dibandingkan dengan metode TPC, Duplex PCR Salmonella sp-Pseudomonas aeruginosa terbukti sepuluh ribu kali lebih sensitif Peneliti menyarankan untuk menggunakanDuplex PCR Salmonella sp-Pseudomonas aeruginosa untuk deteksi kedua bakteri tersebut dalam sampel air minum kemasan

A prospective clinical trial on the influence of a triamcinolone/demeclocycline and a calcium hydroxide based temporary cement on pain perception

<p>Abstract</p> <p>Introduction</p> <p>The aim of this clinical trial was to compare the degree of short term post-operative irritation after application of a triamcinolone/demeclocycyline based or a calcium hydroxide based provisional cement.</p> <p>Methods</p> <p>A total of 109 patients (55 female and 54 male; mean age: 51 ± 14 years) with primary or secondary dentinal caries were randomly assigned to the two treatment groups of this biomedical clinical trial (phase III). Selection criteria were good systemic health and treated teeth, which were vital and showed no symptoms of pulpitis. Up to three teeth were prepared for indirect metallic restorations, and the provisional restorations were cemented with a triamcinolone/demeclocycyline (Ledermix) or a calcium hydroxide (Provicol) based material. The intensity of post-operative pain experienced was documented according to the VAS (4, 12, 20, 24, and 82 h) and compared to VAS baseline.</p> <p>Results</p> <p>A total of 159 teeth were treated (Ledermix: 83 teeth, Provicol: 76 teeth). The minor irritation of the teeth, experienced prior to treatment, was similar in both groups; however, 4 h after treatment this value was significantly higher in the Provicol group than in the Ledermix group (p < 0.005, t-test). After 12 h, the difference was no longer significant. The number of patients taking analgesics for post-treatment pain was higher in the Provicol group (n = 11/53) than in the Ledermix group (n = 3/56).</p> <p>Conclusions</p> <p>The patients had no long term post-operative pain experience in both groups. However, within the first hours after cementation the sensation of pain was considerably higher in the Provicol group than in the Ledermix group.</p

Testing gravitational-wave searches with numerical relativity waveforms: Results from the first Numerical INJection Analysis (NINJA) project

The Numerical INJection Analysis (NINJA) project is a collaborative effort between members of the numerical relativity and gravitational-wave data analysis communities. The purpose of NINJA is to study the sensitivity of existing gravitational-wave search algorithms using numerically generated waveforms and to foster closer collaboration between the numerical relativity and data analysis communities. We describe the results of the first NINJA analysis which focused on gravitational waveforms from binary black hole coalescence. Ten numerical relativity groups contributed numerical data which were used to generate a set of gravitational-wave signals. These signals were injected into a simulated data set, designed to mimic the response of the initial LIGO and Virgo gravitational-wave detectors. Nine groups analysed this data using search and parameter-estimation pipelines. Matched filter algorithms, un-modelled-burst searches and Bayesian parameter estimation and model-selection algorithms were applied to the data. We report the efficiency of these search methods in detecting the numerical waveforms and measuring their parameters. We describe preliminary comparisons between the different search methods and suggest improvements for future NINJA analyses. © 2009 IOP Publishing Ltd

Status of NINJA: The Numerical INJection Analysis project

The 2008 NRDA conference introduced the Numerical INJection Analysis project (NINJA), a new collaborative effort between the numerical relativity community and the data analysis community. NINJA focuses on modeling and searching for gravitational wave signatures from the coalescence of binary system of compact objects. We review the scope of this collaboration and the components of the first NINJA project, where numerical relativity groups, shared waveforms and data analysis teams applied various techniques to detect them when embedded in colored Gaussian noise. © 2009 IOP Publishing Ltd

Testing gravitational-wave searches with numerical relativity waveforms: Results from the first Numerical INJection Analysis (NINJA) project

The Numerical INJection Analysis (NINJA) project is a collaborative effort between members of the numerical relativity and gravitational-wave data analysis communities. The purpose of NINJA is to study the sensitivity of existing gravitational-wave search algorithms using numerically generated waveforms and to foster closer collaboration between the numerical relativity and data analysis communities. We describe the results of the first NINJA analysis which focused on gravitational waveforms from binary black hole coalescence. Ten numerical relativity groups contributed numerical data which were used to generate a set of gravitational-wave signals. These signals were injected into a simulated data set, designed to mimic the response of the Initial LIGO and Virgo gravitational-wave detectors. Nine groups analysed this data using search and parameter-estimation pipelines. Matched filter algorithms, un-modelled-burst searches and Bayesian parameter-estimation and model-selection algorithms were applied to the data. We report the efficiency of these search methods in detecting the numerical waveforms and measuring their parameters. We describe preliminary comparisons between the different search methods and suggest improvements for future NINJA analyses.Comment: 56 pages, 25 figures; various clarifications; accepted to CQ

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

The ARIA-MASK-air® approach

Funding Information: The authors thank Ms Véronique Pretschner for submitting the paper. MASK‐air has been supported by Charité Universitätsmedizin Berlin, EU grants (EU Structural and Development Funds Languedoc Roussillon and Region PACA; POLLAR: EIT Health; Twinning: EIP on AHA; Twinning DHE: H2020; Catalyse: Horizon Europe) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis, Stallergènes‐Greer and Uriach. None for the study. ® Publisher Copyright: © 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.MASK-air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air® results should lead to change management in rhinitis and asthma.publishersversionpublishe