4,128 research outputs found
Architecture as a technology of framing experience : camera obscura, camp, and the confessional
Ankara : The Department of Interior Architecture and Environmental Design and the Institute of Economics and Social Sciences of Bilkent University, 2009.Thesis (Ph.D.) -- Bilkent University, 2009.Includes bibliographical references leaves 149-163Throughout architectural history, the problematic of experience is mostly addressed
within the confines of either deterministic or phenomenological models. Bound as they
are, however, to the transcendental coordinates of a founding structure and a selfcontained
subject figure, neither one of these models seems to provide us with the
necessary tools of engaging with the transgressive aspects of experience in general or
architectural experience in particular. Beginning with the problem of how architecture
can be said to effect the experience of its subjects, the dissertation aims at gaining an
insight into the constructive capacity and functioning of architecture as a technology of
framing, whereby the subject's relation to environment, to other subjects, and to oneself
can be addressed. In order to do this, the author first traces the constituent elements of a
so-called “science of experience,” an experiontology, throughout the historiographic
work of Michel Foucault. Developing a composite framework as such, which facilitates a
historico-critical analysis of the work of architecture in relation to the formation and
transformation of experiential structures, the author thus identifies the logic of
experience as a process of desubjectification at work in and through the triplicate
domains of epistemology, politics, and ethics. Once the terms of this logic are tested and
further enhanced through the analyses of three environmental formations – namely, the
camera obscura, the camp, and the confessional – what is arrived at is a veritable
relationship between architecture and experience in the neighborhood of the categories
of error, resistance, and interiority of the self. The result is a recognition of architecture
as an art of organization of bodily encounters, in accordance with which the
architectural frame becomes the condition of possibility for the production and
reproduction of novel corporealities.Uysal, V ŞafakPh.D
Role of microRNAs in response to cadmium chloride in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal and aggressive malignancies with a 5-year survival rate less than 9%. Early detection is particularly difficult due to the lack of symptoms even in advanced stages. microRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are involved in the pathogenesis of several malignancies including PDAC. Alterations of miR expressions can lead to apoptosis, angiogenesis, and metastasis.
The role of environmental pollutants such as cadmium (Cd) in PDAC has been suggested but not fully understood. This study underlines the role of miRs (miR-221, miR-155, miR-126) in response to cadmium chloride (CdCl2) in vitro. Lethal concentration (LC50) values for CdCl2 resulted in a toxicity series of AsPC-1>HPNE>BxPC3>Panc-1=Panc-10.5. Following the treatment with CdCl2, miR-221 and miR-155 were significantly overexpressed, whereas miR-126 was downregulated.
An increase in epithelial–mesenchymal transition (EMT) via the dysregulation of mesenchymal markers such as Wnt-11,E-cadherin, Snail, and Zeb1 was also observed. Hence, this study has provided evidence to suggest that the environmental pollutant Cd can have a signifcant role in the development of PDAC, suggesting a signifcant correlation between miRs and Cd exposure during PDAC progression. Further studies are needed to investigate the precise role of miRs in PDAC progression as well as the role of Cd and other environmental pollutants
Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types with a limited overall survival rate due to the asymptomatic progression of symptoms in metastatic stages of the malignancy and the lack of an early reliable diagnostic biomarker. MicroRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are closely linked to the development of numerous malignancies comprising PDAC. Recent studies have described the role of environmental pollutants such as nickel (Ni) in PDAC, but the mechanisms of Ni-mediated toxicity in cancer are still not completely understood. Specifically, Ni has been found to alter the expression and function of miRs in several malignancies, leading to changes in target gene expression. In this study, we found that levels of Ni were significantly higher in cancerous tissue, thus implicating Ni in pancreatic carcinogenesis. Hence, in vitro studies followed by using both normal and pancreatic tumor cell lines and increasing Ni concentration increased lethality. Comparing LC50 values, Ni-acetate groups demonstrated lower values needed than in NiCl2 groups, suggesting greater Ni-acetate. Panc-10.05 cell line appeared the most sensitive to Ni compounds. Exposure to Ni-acetate resulted in an increased phospho-AKT, and decreased FOXO1 expression in Panc-10.05 cells, while NiCl2 also increased PTEN expression in Panc-10.05 cells. Specifically, following NiCl2 exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. Hence, our study has suggested pilot insights to indicate that the environmental pollutant Ni plays an important role in the progression of PDAC by promoting an association between miRs and Ni exposure during PDAC pathogenesis
The astrometric Gaia-FUN-SSO observation campaign of 99 942 Apophis
Astrometric observations performed by the Gaia Follow-Up Network for Solar
System Objects (Gaia-FUN-SSO) play a key role in ensuring that moving objects
first detected by ESA's Gaia mission remain recoverable after their discovery.
An observation campaign on the potentially hazardous asteroid (99 942) Apophis
was conducted during the asteroid's latest period of visibility, from
12/21/2012 to 5/2/2013, to test the coordination and evaluate the overall
performance of the Gaia-FUN-SSO . The 2732 high quality astrometric
observations acquired during the Gaia-FUN-SSO campaign were reduced with the
Platform for Reduction of Astronomical Images Automatically (PRAIA), using the
USNO CCD Astrograph Catalogue 4 (UCAC4) as a reference. The astrometric
reduction process and the precision of the newly obtained measurements are
discussed. We compare the residuals of astrometric observations that we
obtained using this reduction process to data sets that were individually
reduced by observers and accepted by the Minor Planet Center. We obtained 2103
previously unpublished astrometric positions and provide these to the
scientific community. Using these data we show that our reduction of this
astrometric campaign with a reliable stellar catalog substantially improves the
quality of the astrometric results. We present evidence that the new data will
help to reduce the orbit uncertainty of Apophis during its close approach in
2029. We show that uncertainties due to geolocations of observing stations, as
well as rounding of astrometric data can introduce an unnecessary degradation
in the quality of the resulting astrometric positions. Finally, we discuss the
impact of our campaign reduction on the recovery process of newly discovered
asteroids.Comment: Accepted for publication in A&
TG7r1 channel model document for high rate PD communications
Purpose Providing channel models which allow a fair comparison of different physical layer (PHY) High Rate PD Communications proposals submitted to TG7r1 in response to the Call for Proposals (CFP). Notice This document has been prepared to assist the IEEE P802.15. It is offered as a basis for discussion and is not binding on the contributing individual(s) or organization(s). The material in this document is subject to change in form and content after further study. The contributor(s) reserve(s) the right to add, amend or withdraw material contained herein
The electric double layer has a life of its own
Using molecular dynamics simulations with recently developed importance
sampling methods, we show that the differential capacitance of a model ionic
liquid based double-layer capacitor exhibits an anomalous dependence on the
applied electrical potential. Such behavior is qualitatively incompatible with
standard mean-field theories of the electrical double layer, but is consistent
with observations made in experiment. The anomalous response results from
structural changes induced in the interfacial region of the ionic liquid as it
develops a charge density to screen the charge induced on the electrode
surface. These structural changes are strongly influenced by the out-of-plane
layering of the electrolyte and are multifaceted, including an abrupt local
ordering of the ions adsorbed in the plane of the electrode surface,
reorientation of molecular ions, and the spontaneous exchange of ions between
different layers of the electrolyte close to the electrode surface. The local
ordering exhibits signatures of a first-order phase transition, which would
indicate a singular charge-density transition in a macroscopic limit
WNT signalling in prostate cancer
Genome sequencing and gene expression analyses of prostate tumours have highlighted the potential importance of genetic and epigenetic changes observed in WNT signalling pathway components in prostate tumours-particularly in the development of castration-resistant prostate cancer. WNT signalling is also important in the prostate tumour microenvironment, in which WNT proteins secreted by the tumour stroma promote resistance to therapy, and in prostate cancer stem or progenitor cells, in which WNT-β-catenin signals promote self-renewal or expansion. Preclinical studies have demonstrated the potential of inhibitors that target WNT receptor complexes at the cell membrane or that block the interaction of β-catenin with lymphoid enhancer-binding factor 1 and the androgen receptor, in preventing prostate cancer progression. Some WNT signalling inhibitors are in phase I trials, but they have yet to be tested in patients with prostate cancer
Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at = 5.02 TeV
Two-particle angular correlations between unidentified charged trigger and
associated particles are measured by the ALICE detector in p-Pb collisions at a
nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum
range 0.7 5.0 GeV/ is examined,
to include correlations induced by jets originating from low
momen\-tum-transfer scatterings (minijets). The correlations expressed as
associated yield per trigger particle are obtained in the pseudorapidity range
. The near-side long-range pseudorapidity correlations observed in
high-multiplicity p-Pb collisions are subtracted from both near-side
short-range and away-side correlations in order to remove the non-jet-like
components. The yields in the jet-like peaks are found to be invariant with
event multiplicity with the exception of events with low multiplicity. This
invariance is consistent with the particles being produced via the incoherent
fragmentation of multiple parton--parton scatterings, while the yield related
to the previously observed ridge structures is not jet-related. The number of
uncorrelated sources of particle production is found to increase linearly with
multiplicity, suggesting no saturation of the number of multi-parton
interactions even in the highest multiplicity p-Pb collisions. Further, the
number scales in the intermediate multiplicity region with the number of binary
nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/161
Multi-particle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider
Measurements of multi-particle azimuthal correlations (cumulants) for charged
particles in p-Pb and Pb-Pb collisions are presented. They help address the
question of whether there is evidence for global, flow-like, azimuthal
correlations in the p-Pb system. Comparisons are made to measurements from the
larger Pb-Pb system, where such evidence is established. In particular, the
second harmonic two-particle cumulants are found to decrease with multiplicity,
characteristic of a dominance of few-particle correlations in p-Pb collisions.
However, when a gap is placed to suppress such correlations,
the two-particle cumulants begin to rise at high-multiplicity, indicating the
presence of global azimuthal correlations. The Pb-Pb values are higher than the
p-Pb values at similar multiplicities. In both systems, the second harmonic
four-particle cumulants exhibit a transition from positive to negative values
when the multiplicity increases. The negative values allow for a measurement of
to be made, which is found to be higher in Pb-Pb collisions at
similar multiplicities. The second harmonic six-particle cumulants are also
found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find
which is indicative of a Bessel-Gaussian
function for the distribution. For very high-multiplicity Pb-Pb
collisions, we observe that the four- and six-particle cumulants become
consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and
Pb-Pb are measured. These are found to be similar for overlapping
multiplicities, when a gap is placed.Comment: 25 pages, 11 captioned figures, 3 tables, authors from page 20,
published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/87
Charge separation relative to the reaction plane in Pb-Pb collisions at TeV
Measurements of charge dependent azimuthal correlations with the ALICE
detector at the LHC are reported for Pb-Pb collisions at TeV. Two- and three-particle charge-dependent azimuthal correlations in
the pseudo-rapidity range are presented as a function of the
collision centrality, particle separation in pseudo-rapidity, and transverse
momentum. A clear signal compatible with a charge-dependent separation relative
to the reaction plane is observed, which shows little or no collision energy
dependence when compared to measurements at RHIC energies. This provides a new
insight for understanding the nature of the charge dependent azimuthal
correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286
- …