An Integrated Design Optimization for Monolithic Mechanical Amplifier in PZT Nano-Positioning Stage

[[abstract]]In order to satisfy the accelerating nanotechnology of high-tech precision manufacturing, it is essential to develop the efficient integration of amplifying device producing very fine resolution. This paper proposes such a development using topological optimal synthesis to design a monolithic mechanical amplifying lever actuated by a PZT in single-axis nano-positioning stage. This one-piece compound compliant mechanism consists of an amplifier and nano-motion bed. The resultant amplifier yields to a larger magnification factor than that in original design. The completed design implementation shows that the presenting design optimization is practical to apply. In addition, it provides a creative computational aided design (CAD) environment and integrated design process for mechanical amplifier and nano-positioning stage.[[notice]]補正完畢[[booktype]]紙

Replication and Meta-Analysis of GWAS Identified Susceptibility Loci in Kawasaki Disease Confirm the Importance of B Lymphoid Tyrosine Kinase (BLK) in Disease Susceptibility

10.1371/journal.pone.0072037PLoS ONE88-POLN

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Experimental Optimization and Analysis of Intake and Exhaust Pipeline for Small Engine Motorcycle

[[abstract]]In this paper, the investigation on the effects of intake and exhaust pipeline of a 125 cc small engine motorcycle is presented. The formal design of experiment (DOE) has been utilized to examine the significances of related parameters of pipelines. Four performance functions including the engine torque, fuel consumption, emission of CO and HC have been constructed by response surface methodology (RSM). The weighting strategy of four-objective optimization in six design cases was employed for analysis, comparison, and discussion. After some experimental investigations which provides some useful guidelines for intake and exhaust pipeline design. The proposed integrated process positively enhances the engine torque of overall speed and reduces the fuel consumption. The torque of low range speed can be particularly increased with the methodology presented in this paper. No clear evidence supports the polluted emission can be effectively deducted by modifying the intake pipeline system.[[notice]]補正完畢[[incitationindex]]E

Structural topology optimization with empirical constraints

[[abstract]]This paper presents an integrated design process of structural topology optimization in minimizing both compliance and structural weight. The material volume fraction is assigned as an additional design variable subjected to the empirical stress constraint in terms of material volume fraction. From the theoretical standpoint, any physical properties related to the volume fraction can be analyzed to construct an explicitly empirical function. This explicit function conveniently can be utilized to calculate its sensitivity information for gradient based optimization, such as the MMA, by the SIMP model. This paper gives a full description and complete instructions for implementation. The proposed integration process is well illustrated by an MBB beam topology design including the approximate empirical stress constraint. The engineer does not require both advanced topology optimization and advanced finite element technique in applying the proposed method. The proposed design procedure is practical and convenient for an engineer to use to solve real‐world topology design optimization problems.[[incitationindex]]SCI[[booktype]]紙

Topological Optimum Design Considering Stress Constraint Using Approximate Function

[[abstract]]This paper presents an integrated process of structural topology optimization in minimizing both compliance and structural weight. The material volume fraction acts an additional design variable subjected to the empirical approximate stress constraint in terms of material volume fraction. This explicitly approximate function can provide a convenient way to calculate its gradient information for numerical optimization. An engineer does not require advanced topology optimization and superior finite element technique in applying proposed method.[[incitationindex]]EI[[booktype]]紙

[[alternative]]模糊結構最佳化設計的替代全域標準逼進法

[[notice]]補正完畢[[notice]]補正完畢[[conferencetype]]國內[[conferencedate]]19931123~1993112