Long-Distance Transport of Finisher Pigs in the Iberian Peninsula:Effects of Season on Thermal and Enthalpy Conditions, Welfare Indicators and Meat pH

Long-distance transport in the global swine industry is more the rule than the exception. We tested the impact on the rates of temperature change and air enthalpy on the stress response and muscle pH in pigs subjected to long-distance travel from Spain to Portugal performed in the summer and winter. We found that winter journeys are more adverse for the animals because during the journey, abrupt variations in rates of temperature change and air enthalpy caused a marked physiological stress response and effects on the meat pH after 45 min. These results indicate the need to develop new environmental control strategies that mitigate abrupt temperature changes during travel to attenuate the biological cost of such long-distance transport on the animals

Reproductive long-term effects, endocrine response and fatty acid profile of rabbit does fed diets supplemented with n-3 fatty acids

The effect of a diet enriched with polyunsaturated n -3 fatty acids (PUFA) on endocrine, reproductive, and productive responses of rabbit females and the litters has been studied. Nulliparous does ( n = 125) were fed ad libitum from rearing to second weaning two diets supplemented with different fat sources: 7.5 g/kg lard for the control diet (group C; n = 63) or 15 g/kg of a commercial supplement containing a 50% ether extract and 35% of total fatty acids (FAs) as PUFA n -3 (Group P; n = 62). Dietary treatments did not affect apparent digestibility coefficients of nutrients, or reproductive variables of does including milk pro- duction, mortality and average daily gain of kits over two lactations. However, on Day 5 and 7 post-induction of ovulation, progesterone of Group P tended to increase to a greater extent than in does of Group C. Total PUFAs, n -6 and n -3 and eicosapentanoic (EPA) contents were greater in adipose tissues of does in Group P than in Group C. Docosapentaenoic acid (DPA), EPA, and docosahexaenoic acid (DHA) concentrations were greater in peri-ovarian than in scapular fat with abdominal fat being intermediate in concentration. In PUFA sup- plemented does, kit mortality at the second parturition tended to be less than in control does. Also, kits born to does of the PUFA-supplemented group weighed more and were of greater length than from does of control group. In conclusion, effectiveness of dietary intervention on reproductive and performance response is greater in the second parity, which suggests an accumulative long-term beneficial effect of n -3 FA supplementation in reproductive rabbit doe

The XMM deep survey in the CDF-S II. a 9-20 keV selection of heavily obscured active galaxies at z>1.7

We present results on a search of heavily obscured active galaxies z>1.7 using the rest-frame 9-20 keV excess for X-ray sources detected in the deep XMM-CDFS survey. Out of 176 sources selected with the conservative detection criteria (>8 sigma) in the first source catalogue of Ranalli et al., 46 objects lie in the redshift range of interest with the median redshift z~2.5. Their typical rest-frame 10-20 keV luminosity is 1e+44 erg/s, as observed. Among optically faint objects that lack spectroscopic redshift, four were found to be strongly absorbed X-ray sources, and the enhanced Fe K emission or absorption features in their X-ray spectra were used to obtain X-ray spectroscopic redshifts. Using the X-ray colour-colour diagram based on the rest-frame 3-5 keV, 5-9 keV, and 9-20 keV bands, seven objects were selected for their 9-20 keV excess and were found to be strongly absorbed X-ray sources with column density of nH > 0.6e+24 cm-2, including two possible Compton thick sources. While they are emitting at quasar luminosity, ~3/4 of the sample objects are found to be absorbed by nH > 1e+22 cm-2. A comparison with local AGN at the matched luminosity suggests an increasing trend of the absorbed source fraction for high-luminosity AGN towards high redshifts.Comment: 9 pages, 7 figures. Accepted for publication in A&

Granuloma Piógeno: Reporte de un caso de lesión hiperplásica reactiva con aspecto tumoral

Pyogenic granuloma is a reactive lesion in response to different local factors, including traumatism, caries dental, hormonal imbalance or poor oral hygiene, which produces an inflammatory proliferation of connective tissue. Pyogenic granuloma is frequently located in oral cavity (gums, tongue, hard palate, lips, and floor of mouth) and skin. Clinically, it presents as a vascularized hyperplastic lesion with a slow-growing pedicled or sessile base of variable size and slow growth. Histologically, shows proliferation of endothelial tissue to a vascular network with signs of chronic inflammation and granulation tissue. This case report aims to identify the clinical, imaging and histopathological characteristics of Pyogenic Granuloma with tumor appearance in the oral cavity in an adult patient of the Clínica Dental Docente Cayetano Heredia in 2017. Clinical and histopathological characteristics of granuloma allow a specific diagnosis, given that their differential diagnoses are similar. The treatment options for pyogenic granuloma include excision, laser pulsed-dye, intralesional injection of ethanol or corticosteroids, sclerotherapy with sodium tetradecyl sulfate, and cryosurgery. Reactive hyperplasia may present a tumor appearance that is ruled out by anatomopathological study. Choosing the correct approach and treatment requires a proper clinical and histopathological diagnosis.El granuloma piógeno es una lesión reactiva en respuesta a diferentes factores locales, su etiología es por traumatismo, caries dental, desequilibrio hormonal, higiene oral deficiente, etc. que produce una proliferación inflamatoria del tejido conectivo, localizada frecuentemente en cavidad oral (encías, lengua, paladar duro, labios y piso de boca) y piel. Clínicamente se presenta como una lesión hiperplásica vascularizada con base pediculada o sésil de tamaño variable y crecimiento lento. Histológicamente presenta proliferación de tejido endotelial a una red vascular con signos de inflamación crónica y tejido de granulación. El presente caso clínico tiene como objetivo identifi car las características clínicas, imagenológicas e histopatológicas de Granuloma Piógeno con aspecto tumoral en la cavidad oral en un paciente adulto de la Clínica Dental Docente Cayetano Heredia en el año 2017. Las características clínicas e histopatológicas de granuloma permiten un diagnóstico concreto, dado que su diagnóstico diferencial es similar. Como opciones de tratamiento además de exéresis, tenemos el pulsed- dye laser, inyección intralesional de etanol o corticoides, escleroterapia con tetradecil sulfato de sodio y criocirugía. Las hiperplasias reactivas pueden presentar aspecto tumoral que se descarta con el estudio anatomopatológico. El abordaje y tratamiento requiere un diagnóstico clínico e histopatológico adecuado

Observational constraints on the co-evolution of supermassive black holes and galaxies

The star formation rate (SFR) and black hole accretion rate (BHAR) functions are measured to be proportional to each other at z < ~3. This close correspondence between SF and BHA would naturally yield a BH mass-galaxy mass correlation, whereas a BH mass-bulge mass correlation is observed. To explore this apparent contradiction we study the SF in spheroid-dominated galaxies between z=1 and the present day. We use 903 galaxies from the COMBO-17 survey with M* >2x10^10M_sun, ultraviolet and infrared-derived SFRs from Spitzer and GALEX, and morphologies from GEMS HST/ACS imaging. Using stacking techniques, we find that <25% of all SF occurs in spheroid-dominated galaxies (Sersic index n>2.5), while the BHAR that we would expect if the global scalings held is three times higher. This rules out the simplest picture of co-evolution, in which SF and BHA trace each other at all times. These results could be explained if SF and BHA occur in the same events, but offset in time, for example at different stages of a merger event. However, one would then expect to see the corresponding star formation activity in early-stage mergers, in conflict with observations. We conclude that the major episodes of SF and BHA occur in different events, with the bulk of SF happening in isolated disks and most BHA occurring in major mergers. The apparent global co-evolution results from the regulation of the BH growth by the potential well of the galactic spheroid, which includes a major contribution from disrupted disk stars.Comment: 14 pages, 5 figures, accepted for publication in Ap

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis

The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration. To identify genetic variants altering risk of ALS, we undertook a two-stage genome-wide association study (GWAS): we followed our initial GWAS of 545 066 SNPs in 553 individuals with ALS and 2338 controls by testing the 7600 most associated SNPs from the first stage in three independent cohorts consisting of 2160 cases and 3008 controls. None of the SNPs selected for replication exceeded the Bonferroni threshold for significance. The two most significantly associated SNPs, rs2708909 and rs2708851 [odds ratio (OR) = 1.17 and 1.18, and P-values = 6.98 x 10–7 and 1.16 x 10–6], were located on chromosome 7p13.3 within a 175 kb linkage disequilibrium block containing the SUNC1, HUS1 and C7orf57 genes. These associations did not achieve genome-wide significance in the original cohort and failed to replicate in an additional independent cohort of 989 US cases and 327 controls (OR = 1.18 and 1.19, P-values = 0.08 and 0.06, respectively). Thus, we chose to cautiously interpret our data as hypothesis-generating requiring additional confirmation, especially as all previously reported loci for ALS have failed to replicate successfully. Indeed, the three loci (FGGY, ITPR2 and DPP6) identified in previous GWAS of sporadic ALS were not significantly associated with disease in our study. Our findings suggest that ALS is more genetically and clinically heterogeneous than previously recognized. Genotype data from our study have been made available online to facilitate such future endeavors

On the co-evolution of supermassive black holes and their host galaxies since z = 3

[Abridged] To investigate the evolution in the relation between galaxy stellar and central black hole mass we construct a volume limited complete sample of 85 AGN with host galaxy stellar masses M_{*} > 10^{10.5} M_{sol}, and specific X-ray luminosities L_{X} > 2.35 x 10^{43} erg s^{-1} at 0.4 < z < 3. We calculate the Eddington limiting masses of the supermassive black holes residing at the centre of these galaxies, and observe an increase in the average Eddington limiting black hole mass with redshift. By assuming that there is no evolution in the Eddington ratio (\mu) and then that there is maximum possible evolution to the Eddington limit, we quantify the maximum possible evolution in the M_{*} / M_{BH} ratio as lying in the range 700 < M_{*}/M_{BH} < 10000, compared with the local value of M_{*}/M_{BH} ~ 1000. We furthermore find that the fraction of galaxies which are AGN (with L_{X} > 2.35 x 10^{43} erg s^{-1}) rises with redshift from 1.2 +/- 0.2 % at z = 0.7 to 7.4 +/- 2.0 % at z = 2.5. We use our results to calculate the maximum timescales for which our sample of AGN can continue to accrete at their observed rates before surpassing the local galaxy-black hole mass relation. We use these timescales to calculate the total fraction of massive galaxies which will be active (with L_{X} > 2.35 x 10^{43} erg s^{-1}) since z = 3, finding that at least ~ 40% of all massive galaxies will be Seyfert luminosity AGN or brighter during this epoch. Further, we calculate the energy density due to AGN activity in the Universe as 1.0 (+/- 0.3) x 10^{57} erg Mpc^{-3} Gyr^{-1}, potentially providing a significant source of energy for AGN feedback on star formation. We also use this method to compute the evolution in the X-ray luminosity density of AGN with redshift, finding that massive galaxy Seyfert luminosity AGN are the dominant source of X-ray emission in the Universe at z < 3.Comment: 25 pages, 10 figures, accepted for publication in MNRA

Observing Supermassive Black Holes across cosmic time: from phenomenology to physics

In the last decade, a combination of high sensitivity, high spatial resolution observations and of coordinated multi-wavelength surveys has revolutionized our view of extra-galactic black hole (BH) astrophysics. We now know that supermassive black holes reside in the nuclei of almost every galaxy, grow over cosmological times by accreting matter, interact and merge with each other, and in the process liberate enormous amounts of energy that influence dramatically the evolution of the surrounding gas and stars, providing a powerful self-regulatory mechanism for galaxy formation. The different energetic phenomena associated to growing black holes and Active Galactic Nuclei (AGN), their cosmological evolution and the observational techniques used to unveil them, are the subject of this chapter. In particular, I will focus my attention on the connection between the theory of high-energy astrophysical processes giving rise to the observed emission in AGN, the observable imprints they leave at different wavelengths, and the methods used to uncover them in a statistically robust way. I will show how such a combined effort of theorists and observers have led us to unveil most of the SMBH growth over a large fraction of the age of the Universe, but that nagging uncertainties remain, preventing us from fully understating the exact role of black holes in the complex process of galaxy and large-scale structure formation, assembly and evolution.Comment: 46 pages, 21 figures. This review article appears as a chapter in the book: "Astrophysical Black Holes", Haardt, F., Gorini, V., Moschella, U and Treves A. (Eds), 2015, Springer International Publishing AG, Cha

Biochemical indices and life traits of loggerhead turtles (Caretta caretta) from Cape Verde Islands

The loggerhead turtle (Caretta caretta) is an endangered marine reptile for whom assessing population health requires knowledge of demographic parameters such as individual growth rate. In Cape Verde, as within several populations, adult female loggerhead sea turtles show a size-related behavioral and trophic dichotomy. While smaller females are associated with oceanic habitats, larger females tend to feed in neritic habitats, which is reflected in their physiological condition and in their offspring. The ratio of RNA/DNA provides a measure of cellular protein synthesis capacity, which varies depending on changes in environmental conditions such as temperature and food availability. The purpose of this study was to evaluate the combined use of morphometric data and biochemical indices as predictors of the physiological condition of the females of distinct sizes and hatchlings during their nesting season and how temperature may influence the physiological condition on the offspring. Here we employed biochemical indices based on nucleic acid derived indices (standardized RNA/DNA ratio-sRD, RNA concentration and DNA concentration) in skin tissue as a potential predictor of recent growth rate in nesting females and hatchling loggerhead turtles. Our major findings were that the physiological condition of all nesting females (sRD) decreased during the nesting season, but that females associated with neritic habitats had a higher physiological condition than females associated with oceanic habitats. In addition, the amount of time required for a hatchling to right itself was negatively correlated with its physiological condition (sRD) and shaded nests produced hatchlings with lower sRD. Overall, our results showed that nucleic acid concentrations and ratios of RNA to DNA are an important tool as potential biomarkers of recent growth in marine turtles. Hence, as biochemical indices of instantaneous growth are likely temperature-, size- and age-dependent, the utility and validation of these indices on marine turtles stocks deserves further study.The authors thank the Cape Verde Ministry of Environment (General Direction for the Environment), INDP (National Fisheries Institution), the Canary Islands Government (D.G. Africa and D.G. Research and Universities), ICCM (Canarian Institution for Marine Sciences), the Andalusian Government (Andalusian Environmental Office) and AEGINA PROJECT (INTERREG IIIB) for funding and hosting them during this study. The authors also thank the European Regional Development Fund (ERDF) through the COMPETE - Operational Competitiveness Programme, and national funds through FCT - PEst-C/MAR/LA0015/2011 for supporting the biochemical analysis

Cancer mortality in a cohort of asbestos textile workers

A cohort of 889 men and 1077 women employed for at least 1 month between 1946 and 1984 by a former Italian leading asbestos (mainly textile) company, characterised by extremely heavy exposures often for short durations, was followed up to 1996, for a total of 53 024 person-years of observation. Employment data were obtained from factory personnel records, while vital status and causes of death were ascertained through municipality registers and local health units. We observed 222 cancer deaths compared with 116.4 expected (standardized mortality ratio, SMR=191). The highest ratios were found for pleural (SMR=4105), peritoneal (SMR=1817) and lung (SMR=282) cancers. We observed direct relationships with duration of employment for lung and peritoneal cancer, and with time since first employment for lung cancer and mesothelioma. Pleural cancer risk was independent from duration (SMR=3428 for employment <1 year, 7659 for 1–4 years, 2979 for 5–9 years and 2130 for ⩾10 years). Corresponding SMRs for lung cancer were 139, 251, 233 and 531. Nonsignificantly increased ratios were found for ovarian (SMR=261), laryngeal (SMR=238) and oro-pharyngeal (SMR=226) cancers. This study confirms and further quantifies the central role of latency in pleural mesothelioma and of cumulative exposure in lung cancer