La democracia constitucional en El Salvador. Retos y desafíos frente a los poderes absolutos

RESUMEN: La democracia constitucional es constituida como un sistema de gobierno adoptado por un Estado de Derecho que se rige bajo los principios establecidos en la Constitución y el respeto incondicional de los derechos fundamentales. El gobierno salvadoreño es Republicano, Democrático y Representativo, tal y como lo expresa el artículo 85 de la Constitución de la República. En el presente trabajo de investigación se analizan los acontecimientos ocurridos el 9 de febrero de 2020 y los hechos que fueron perpetrados durante la pandemia COVID-19 en El Salvador, con la finalidad de identificar a través de la doctrina y la jurisprudencia, los derechos y principios puestos en peligro como consecuencia de decisiones tomadas por el Presidente de la República Nayib Bukele, categorizadas como anticonstitucionales. ABSTRACT: Constitutional democracy is constituted as a system of government adopted by a State of Law that is governed by the principles established in the Constitution and the unconditional respect of fundamental rights. The Salvadoran government is Republican, Democratic and Representative, as expressed in Article 85 of the Constitution of the Republic. This research work analyzes the events that occurred on February 9, 2020 and the events that were perpetrated during the COVID-19 pandemic in El Salvador, in order to identify through doctrine and jurisprudence, the rights and principles endangered as a result of decisions made by the President of the Republic Nayib Bukele, categorized as unconstitutiona

Potencial de riesgo asociado al uso de pesticidas organoclorados en la Reserva de la Biósfera de la Barranca de Metztitlán, Hidalgo

En el presente trabajo se determinó la presencia y concentraciones de los pesticidas organoclorados (PO), en agua y sedimentos de Laguna de Metztitlán, Hidalgo; con el objetivo de identificar el uso de estos compuestos como un factor de presión sobre la biodiversidad y un potencial de riesgo asociado a la salud, problemática que se acentúa debido a que inmerso en la reserva hay asentamientos humanos y que la principal actividad económica de la región es la agricultura. Para su evaluación se tomaron cinco muestras compuestas de agua en la Laguna de Metztitlán en el 2016 y una en la desembocadura del Río Metztitlán, tanto en época de sequía como de lluvia, bajo los lineamientos de la NMX-AA-003-1980. Se analizaron de manera individual por triplicado por cromatografía de gases y espectrofotometría de masas. Los resultados corroboran lo reportado bibliográficamente, además de que a las concentraciones observadas hay un potencial de riesgo para la salud y la biodiversidad, lo cual implica la necesidad de monitorear la zona permanentemente para evaluar la presencia y concentración de estos compuestos, así como su potencial impacto en el ambiente y en la población

MAREJADAS RURALES Y LUCHAS POR LA VIDA, VOL. III: VAIVENES DEL ESTADO Y LA SOCIEDAD RURAL.

Volumen 3. Vaivenes del Estado y la Sociedad Rural, coordinado por: Francisco Herrera Tapia, Gladys Karina Sánchez Juárez, e Ignacio López Moreno, el texto está constituído por 12 capítulos, los autores abordan problemas derivados de la aplicación de las políticas públicas y reformas legislativas relacionadas con el campo, y con las instituciones de gobierno, la gobernabilidad, los acuerdos comunitarios y también los conflictos, son estudios de caso que evidencian estos procesos y las formas en que se complejizan o se resuelven en el medio rural.ASOCIACIÓN MEXICANA DE ESTUDIOS RURALES A.C., INSTITUTO DE CIENCIAS AGROPECUARIAS Y RURALES (ICAR), UNIVERSIDAD DE GUADALAJARA, EL COLEGIO DE MICHOACÁN A.C., UNIVERSIDAD MICHOACANA DE SAN NICOLAS HIDALGO, CUCOSTA SUR GRANA, ECOSUR, FACULTAD DE ESTUDIOS SUPERIORES ACATLÁN-UNA

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

Measurement of B-c(2S)(+) and B-c*(2S)(+) cross section ratios in proton-proton collisions at root s=13 TeV

Peer reviewe

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe