Long-lead ENSO predictability from CMIP5 decadal hindcasts

Using decadal prediction experiments from the WCRP/CMIP5 suite that were initialized every year from 1960-onward, we explore long-lead predictability of ENSO events. Both deterministic and probabilistic skill metrics are used to assess the ability of these decadal prediction systems to reproduce ENSO variability as represented by the NINO3.4 index (EN3.4). Several individual systems as well as the multi-model mean can predict ENSO events 3–4 years in advance, though not for every event during the hindcast period. This long-lead skill is beyond the previously documented predictability limits of initialized prediction systems. As part of the analysis, skill in reproducing the annual cycle of EN3.4, and the annual cycle of its interannual variability is examined. Most of the prediction systems reproduce the seasonal cycle of EN3.4, but are less able to capture the timing and magnitude of the variability. However, for the prediction systems used here, the fidelity of annual cycle characteristics does not appear to be related to the system’s ability to predict ENSO events. In addition, the performance of the multi-model ensemble mean is explored and compared to the multi-model mean based solely on the most skillful systems; the latter is found to yield better results for the deterministic metrics. Finally, an analysis of the near-surface temperature and precipitation teleconnections reveals that the ability of the systems to detect ENSO events far in advance could translate into predictive skill over land for several lead years, though with reduced amplitudes compared to observations

Stratospheric ozone depletion: a key driver of recent precipitation trends in South Eastern South America

On a hemispheric scale, it is now well established that stratospheric ozone depletion has been the principal driver of externally forced atmospheric circulation changes south of the Equator in the last decades of the 20th Century. The impact of ozone depletion has been felt over the entire hemisphere, as reflected in the poleward drift of the midlatitude jet, the southward expansion of the summertime Hadley cell and accompanying precipitation trends deep into the subtropics. On a regional scale, however, surface impacts directly attributable to ozone depletion have yet to be identified. In this paper we focus on South Eastern South America (SESA), a region that has exhibited one of the largest wetting trends during the 20th Century. We study the impact of ozone depletion on SESA precipitation using output from 6 different climate models, spanning a wide range of complexity. In all cases we contrast pairs of model integrations with and without ozone depletion, but with all other forcings identically specified. This allows for unambiguous attribution of the computed precipitation trends. All 6 climate models consistently reveal that stratospheric ozone depletion results in a significant wetting of SESA over the period 1960–1999. Taken as a whole, these model results strongly suggest that the impact of ozone depletion on SESA precipitation has been as large as, and quite possibly larger than, the one caused by increasing greenhouse gases over the same period

The role of targeted climate research at the IRI

Advances in our fundamental understanding of the physical climate system provided the necessary scientific underpinnings for the routine production of reliable seasonal climate forecasts and ultimately, the birth of the International Research Institute for Climate and Society (IRI). While recognizing that the successful adoption of climate information into various decision-making settings requires an iterative approach between the developers and users of that information, since its inception the IRI has also recognized the critical role of basic climate research in generating new climate knowledge. Given its mission, such basic research targets specific regions and questions that are framed by practical considerations of how climate variations are impacting, or may impact, various sectors of society. Analogous to its role in underpinning the development of seasonal forecasts, an enhanced understanding of relevant aspects of the physical climate is viewed as a critical input to the larger process of developing effective strategies for the management of climate-related risks. Here, four examples of targeted climate research undertaken at the IRI are presented covering a range of time scales, from sub-seasonal variability to long-term climate trends. A diverse set of geographic locations is considered, which includes the Sahel, southeastern South America, the Philippines and Indonesia. These four examples were selected to indicate the broad range of use-inspired basic research questions that have been addressed in regions where the IRI is engaged in a broader set of activities to develop actionable climate information. While many institutions are engaged in basic climate research, having the expertise and capacity to do so within the IRI provides it with the necessary flexibility to target its work towards specific climate-related questions in specific regions of the world

A climate generator for agricultural planning in southeastern South America

A method is described for the generation of climate scenarios in a form suitable for driving agricultural models. The scenarios are tailored to the region in southeastern South America bounded by 25–40° S, 45–65° W, denoted here as SESA. SESA has been characterized by increasing summer precipitation, particularly during the late 20th century, which, in the context of favorable market conditions, has enabled increases in agricultural production. Since about year 2000, however, the upward tendency appears to have slowed or possibly stopped, raising questions about future climate inputs to regional agricultural yields. The method is not predictive in the deterministic sense, but rather attempts to characterize uncertainty in near-term future climate, taking into account both forced trends and unforced, natural climate fluctuations. It differs from typical downscaling methods in that GCM information is utilized only at the regional scale, subregional variability being modeled based on the observational record. Output, generated on the monthly time scale, is disaggregated to daily values with a weather generator and used to drive soybean yields in the crop model DSSAT-CSM, for which preliminary results are discussed. The simulations produced permit assessment of the interplay between long-range trends and near-term climate variability in terms of agricultural production

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

Make EU trade with Brazil sustainable

Brazil, home to one of the planet's last great forests, is currently in trade negotiations with its second largest trading partner, the European Union (EU). We urge the EU to seize this critical opportunity to ensure that Brazil protects human rights and the environment

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present