11 research outputs found

    Projekt Curriculumforschung: Grundstudium Psychologie (Bielefeld)

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    Geil-Werneburg E, Günther-Boemke G, Günther F, Hermsen H. Projekt Curriculumforschung: Grundstudium Psychologie (Bielefeld). In: Göpel E, ed. Humanisierung des Gesundheitswesens. Arbeitsfeldmaterialien zum Sozial- und Gesundheitsbereich ; 9. Offenbach: Verl. 2000; 1979: 113-116

    Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

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    Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes

    Kontingenzen des Gesundheitsbewusstseins

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    Schul- und Hochschulberatung und die Anforderungen an die Ausbildung in Klinischer Psychologie

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    Hermsen H. Schul- und Hochschulberatung und die Anforderungen an die Ausbildung in Klinischer Psychologie. In: Göpel E, ed. Humanisierung des Gesundheitswesens. Arbeitsfeldmaterialien zum Sozial- und Gesundheitsbereich ; 9. Offenbach: Verl. 2000; 1979: 142-153

    The Ambivalences of the Digital—Humans and Technology Between New Dreams/Spaces of Possibility and (Un)Noticeable Losses

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    Every new technology is used by us humans almost without hesitation. Usually the military use comes first. Examples from recent history are the use of chemical weapons by Germany in the First World War and of atomic bombs in the Second World War by the US. Now, with the rapid advances in microelectronics over the past few decades, a wave of its application, called digitization, is spreading around the world with barely any control mechanisms. In many areas this has simplified and enriched our lives, but it has also encouraged abuse. The adaptation of legislation to contain the obvious excesses of “digitization” such as hate mail and anonymous threats is lagging behind massively. We hear almost nothing about technology assessment through systematic research; it is demanded at most by a few, usually small groups in civil society, which draw attention to the threats to humankind—future and present—and the Earth's ecosystem. One such group, the Federation of German Scientists (VDW) e.V., in the spirit of the responsibility of science for the peaceful and considered application of the possibilities it creates, asked three of its study groups to jointly organize its 2019 Annual Conference. The study groups “Health in Social Change,” “Education and Digitization,” and “Technology Assessment of Digitization” formulated the following position paper for the 2019 VDW Annual Conference, entitled “Ambivalences of the Digital.

    Empfehlungen für eine gesundheitsfördernde und nachhaltige Stadtentwicklung - Fünf Thesen der Arbeitsgruppe Gesundheitsfördernde Gemeinde- und Stadtentwicklung (AGGSE)

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    Die folgenden fünf Thesen sollen Anregungen geben, wie gesundheitsfördernde Kommunalpolitik, die gleichzeitig auf Nachhaltigkeit ausgerichtet ist sowie eine soziale und partizipative Stadt(teil)Entwicklung verfolgt, erreicht bzw. verbessert werden kann. Eine gesundheitsfördernde Gemeinde- und Stadtentwicklung stellt die Lebensqualität des einzelnen Menschen in den Mittelpunkt. Grundvoraussetzung für die Schaffung einer lebenswerten Kommune sind gleiche soziale, ökonomische und politische Teilhabechancen für alle Bewohner*innen. Dies schließt die Berücksichtigung ihrer individuellen Fähigkeiten und Potenziale ein. Gesundheit und Lebensqualität der Bevölkerung sollen gemäß dem ‚Health in All Policies-Ansatz‘ der Weltgesundheitsorganisation (WHO) in allen Politik- und Verwaltungsbereichen berücksichtigt, ausgebaut und verbessert werden. Begonnen hat dieser Prozess mit dem Beschluss der Ottawa-Charta zur Gesundheitsförderung der WHO (1986), mit der zum ers-ten Mal Handlungsstrategien und Handlungsfelder für eine gesundheitsfördernde Gesamtpo-litik benannt wurden, die sich auch in den folgenden Thesen wiederfinden

    Multivalency as a Chemical Organization and Action Principle

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