593 research outputs found
Exploring How Narrative and Symbolic Art Impacts Artist, Researcher, Teacher and Communicates Meaning in Art to Students
This educational study on narrative and symbolic art and its impact on me as artist, researcher, and teacher and ultimately how the use of narrative and symbolism impacts student learning was conducted throughout the school year 2013-2014 in the environment of both my home and my classroom in a south metro Atlanta high school. The research is based on my reflections of my artistic processes, my research of family history, and my observations as I introduced narrative and symbolic art in the classroom.
The findings of the study reveal that the roles of artist, teacher, and researcher are significantly interrelated and enhance one another; I also believe that my students’ learning was impacted.
While students are at first assigned narrative and symbolic art projects, many begin to extrapolate that art is more meaningful to them when it has a story to tell or includes symbolism with which they associate importance
Intercollegiate Women\u27s Choral Festival
KSU School of Music presents Intercollegiate Women\u27s Choral Festival.https://digitalcommons.kennesaw.edu/musicprograms/1097/thumbnail.jp
Small-Scale Structure in the SDSS and LCDM: Isolated L* Galaxies with Bright Satellites
We use a volume-limited spectroscopic sample of isolated galaxies in the
Sloan Digital Sky Survey (SDSS) to investigate the frequency and radial
distribution of luminous (M_r <~ -18.3) satellites like the Large Magellanic
Cloud (LMC) around ~L* Milky Way analogs and compare our results
object-by-object to LCDM predictions based on abundance matching in
simulations. We show that 12% of Milky Way-like galaxies host an LMC-like
satellite within 75 kpc (projected), and 42 % within 250 kpc (projected). This
implies ~10% have a satellite within the distance of the LMC, and ~40% of L*
galaxies host a bright satellite within the virialized extent of their dark
matter halos. Remarkably, the simulation reproduces the observed frequency,
radial dependence, velocity distribution, and luminosity function of observed
secondaries exceptionally well, suggesting that LCDM provides an accurate
reproduction of the observed Universe to galaxies as faint as L~10^9 Lsun on
~50 kpc scales. When stacked, the observed projected pairwise velocity
dispersion of these satellites is sigma~160 km/s, in agreement with
abundance-matching expectations for their host halo masses. Finally, bright
satellites around L* primaries are significantly redder than typical galaxies
in their luminosity range, indicating that environmental quenching is operating
within galaxy-size dark matter halos that typically contain only a single
bright satellite. This redness trend is in stark contrast to the Milky Way's
LMC, which is unusually blue even for a field galaxy. We suggest that the LMC's
discrepant color might be further evidence that it is undergoing a triggered
star-formation event upon first infall.Comment: 14 pages, 11 figures; accepted to Ap
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells
Background: The molecular chaperone, heat shock protein 90 (Hsp90) has been shown to be overexpressed in a
number of cancers, including prostate cancer, making it an important target for drug discovery. Unfortunately,
results with N-terminal inhibitors from initial clinical trials have been disappointing, as toxicity and resistance
resulting from induction of the heat shock response (HSR) has led to both scheduling and administration concerns.
Therefore, Hsp90 inhibitors that do not induce the heat shock response represent a promising new direction for
the treatment of prostate cancer. Herein, the development of a C-terminal Hsp90 inhibitor, KU174, is described,
which demonstrates anti-cancer activity in prostate cancer cells in the absence of a HSR and describe a novel
approach to characterize Hsp90 inhibition in cancer cells.
Methods: PC3-MM2 and LNCaP-LN3 cells were used in both direct and indirect in vitro Hsp90 inhibition assays
(DARTS, Surface Plasmon Resonance, co-immunoprecipitation, luciferase, Western blot, anti-proliferative, cytotoxicity
and size exclusion chromatography) to characterize the effects of KU174 in prostate cancer cells. Pilot in vivo
efficacy studies were also conducted with KU174 in PC3-MM2 xenograft studies.
Results: KU174 exhibits robust anti-proliferative and cytotoxic activity along with client protein degradation and
disruption of Hsp90 native complexes without induction of a HSR. Furthermore, KU174 demonstrates direct binding
to the Hsp90 protein and Hsp90 complexes in cancer cells. In addition, in pilot in-vivo proof-of-concept studies
KU174 demonstrates efficacy at 75 mg/kg in a PC3-MM2 rat tumor model.
Conclusions: Overall, these findings suggest C-terminal Hsp90 inhibitors have potential as therapeutic agents for
the treatment of prostate cancer
Modeling the System Parameters of 2M1533+3759: A New Longer-Period Low-Mass Eclipsing sdB+dM Binary
We present new photometric and spectroscopic observations for 2M 1533+3759 (=
NSVS 07826147). It has an orbital period of 0.16177042 day, significantly
longer than the 2.3--3.0 hour periods of the other known eclipsing sdB+dM
systems. Spectroscopic analysis of the hot primary yields Teff = 29230 +/- 125
K, log g = 5.58 +/- 0.03 and log N(He)/N(H) = -2.37 +/- 0.05. The sdB velocity
amplitude is K1 = 71.1 +/- 1.0 km/s. The only detectable light contribution
from the secondary is due to the surprisingly strong reflection effect. Light
curve modeling produced several solutions corresponding to different values of
the system mass ratio, q(M2/M1), but only one is consistent with a core helium
burning star, q=0.301. The orbital inclination is 86.6 degree. The sdB primary
mass is M1 = 0.376 +/- 0.055 Msun and its radius is R1 = 0.166 +/- 0.007 Rsun.
2M1533+3759 joins PG0911+456 (and possibly also HS2333+3927) in having an
unusually low mass for an sdB star. SdB stars with masses significantly lower
than the canonical value of 0.48 Msun, down to as low as 0.30 Msun, were
theoretically predicted by Han et al. (2002, 2003), but observational evidence
has only recently begun to confirm the existence of such stars. The existence
of core helium burning stars with masses lower than 0.40--0.43 Msun implies
that at least some sdB progenitors have initial main sequence masses of
1.8--2.0 Msun or more, i.e. they are at least main sequence A stars. The
secondary is a main sequence M5 star.Comment: 47 pages, 7 figure
Quantification of juvenile hormone III, vitellogenin, and vitellogenin-mRNA during the oviposition cycle of the lubber grasshopper
Abstract The vitellogenic cycle of the lubber grasshopper (Romalea microptera) was studied by measuring levels of juvenile hormone (JH III), vitellogenin, and vitellogenin-mRNA through the first oviposition cycle. JH III and vitellogenin were measured by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA), respectively. To measure vitellogenin-mRNA, a partial (753 bp) cDNA fragment of vitellogenin was isolated from the fat body of vitellogenic animals. The sequence of this cDNA was related to vitellogenin sequences in other insect species. Using these sequence data, an RT-PCR (reverse transcriptase polymerase chain reaction) assay was developed to quantify vitellogenin-mRNA levels during the oviposition cycle. Vitellogenin-mRNA levels in the fat body tissue from virgin females were measured on specific days after eclosion and compared to hemolymph levels of JH III and vitellogenin from the same individuals. The levels of all three compounds (JH III, vitellogenin, and vitellogenin-mRNA) showed similar changes throughout the oviposition cycle, being undetectable or nearly undetectable initially (day 3), rising to maximum levels on days 23 and 28, and then dropped to lower or undetectable levels on the day of oviposition. The ability to measure these characteristics will be useful for studying the effects of hormonal and nutritional manipulations on reproduction
Mutational analysis of the major soybean UreF paralogue involved in urease activation
The soybean genome duplicated ∼14 and 45 million years ago and has many paralogous genes, including those in urease activation (emplacement of Ni and CO2 in the active site). Activation requires the UreD and UreF proteins, each encoded by two paralogues. UreG, a third essential activation protein, is encoded by the single-copy Eu3, and eu3 mutants lack activity of both urease isozymes. eu2 has the same urease-negative phenotype, consistent with Eu2 being a single-copy gene, possibly encoding a Ni carrier. Unexpectedly, two eu2 alleles co-segregated with missense mutations in the chromosome 2 UreF paralogue (Ch02UreF), suggesting lack of expression/function of Ch14UreF. However, Ch02UreF and Ch14UreF transcripts accumulate at the same level. Further, it had been shown that expression of the Ch14UreF ORF complemented a fungal ureF mutant. A third, nonsense (Q2*) allelic mutant, eu2-c, exhibited 5- to 10-fold more residual urease activity than missense eu2-a or eu2-b, though eu2-c should lack all Ch02UreF protein. It is hypothesized that low-level activation by Ch14UreF is ‘spoiled’ by the altered missense Ch02UreF proteins (‘epistatic dominant-negative’). In agreement with active ‘spoiling’ by eu2-b-encoded Ch02UreF (G31D), eu2-b/eu2-c heterozygotes had less than half the urease activity of eu2-c/eu2-c siblings. Ch02UreF (G31D) could spoil activation by Chr14UreF because of higher affinity for the activation complex, or because Ch02UreF (G31D) is more abundant than Ch14UreF. Here, the latter is favoured, consistent with a reported in-frame AUG in the 5' leader of Chr14UreF transcript. Translational inhibition could represent a form of ‘functional divergence’ of duplicated genes
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A Search for Dark Higgs Bosons
Recent astrophysical and terrestrial experiments have motivated the proposal
of a dark sector with GeV-scale gauge boson force carriers and new Higgs
bosons. We present a search for a dark Higgs boson using 516 fb-1 of data
collected with the BABAR detector. We do not observe a significant signal and
we set 90% confidence level upper limits on the product of the Standard
Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots
for b/w printin
Search for New Physics with Jets and Missing Transverse Momentum in pp collisions at sqrt(s) = 7 TeV
A search for new physics is presented based on an event signature of at least
three jets accompanied by large missing transverse momentum, using a data
sample corresponding to an integrated luminosity of 36 inverse picobarns
collected in proton--proton collisions at sqrt(s)=7 TeV with the CMS detector
at the LHC. No excess of events is observed above the expected standard model
backgrounds, which are all estimated from the data. Exclusion limits are
presented for the constrained minimal supersymmetric extension of the standard
model. Cross section limits are also presented using simplified models with new
particles decaying to an undetected particle and one or two jets
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