Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Cancer immunotherapy can induce long lasting responses in patients with metastatic cancers of a wide range of histologies. Broadening the clinical applicability of these treatments requires an improved understanding of the mechanisms limiting cancer immunotherapy. The interactions between the immune system and cancer cells are continuous, dynamic, and evolving from the initial establishment of a cancer cell to the development of metastatic disease, which is dependent on immune evasion. As the molecular mechanisms of resistance to immunotherapy are elucidated, actionable strategies to prevent or treat them may be derived to improve clinical outcomes for patients

Spectral similarities in galaxies through an unsupervised classification of spaxels

International audienceWe present the first unsupervised classification of spaxels in hyperspectral images of individual galaxies. Classes identify regions by spectral similarity and thus take all the information into account that is contained in the data cubes (spatial and spectral).We used Gaussian mixture models in a latent discriminant subspace to find clusters of spaxels. The spectra were corrected for small-scale motions within the galaxy based on emission lines with an automatic algorithm. Our data consist of two MUSE/VLT data cubes of JKB 18 and NGC 1068 and one NIRSpec/JWST data cube of NGC 4151.Our classes identify many regions that are most often easily interpreted. Most of the 11 classes that we find for JKB 18 are identified as photoionised by stars. Some of them are known HII regions, but we mapped them as extended, with gradients of ionisation intensities. One compact structure has not been reported before, and according to diagnostic diagrams, it might be a planetary nebula or a denser HII region. For NGC 1068, our 16 classes are of active galactic nucleus-type (AGN) or star-forming regions. Their spatial distribution corresponds perfectly to well-known structures such as spiral arms and a ring with giant molecular clouds. A subclassification in the nuclear region reveals several structures and gradients in the AGN spectra. Our unsupervised classification of the MUSE data of NGC 1068 helps visualise the complex interaction of the AGN and the jet with the interstellar medium in a single map. The centre of NGC 4151 is very complex, but our classes can easily be related to ionisation cones, the jet, or H2 emission. We find a new elongated structure that is ionised by the AGN along the N-S axis perpendicular to the jet direction. It is rotated counterclockwise with respect to the axis of the H2 emission. Our work shows that the unsupervised classification of spaxels takes full advantage of the richness of the information in the data cubes by presenting the spectral and spatial information in a combined and synthetic way

Spectral similarities in galaxies through an unsupervised classification of spaxels

International audienceWe present the first unsupervised classification of spaxels in hyperspectral images of individual galaxies. Classes identify regions by spectral similarity and thus take all the information into account that is contained in the data cubes (spatial and spectral).We used Gaussian mixture models in a latent discriminant subspace to find clusters of spaxels. The spectra were corrected for small-scale motions within the galaxy based on emission lines with an automatic algorithm. Our data consist of two MUSE/VLT data cubes of JKB 18 and NGC 1068 and one NIRSpec/JWST data cube of NGC 4151.Our classes identify many regions that are most often easily interpreted. Most of the 11 classes that we find for JKB 18 are identified as photoionised by stars. Some of them are known HII regions, but we mapped them as extended, with gradients of ionisation intensities. One compact structure has not been reported before, and according to diagnostic diagrams, it might be a planetary nebula or a denser HII region. For NGC 1068, our 16 classes are of active galactic nucleus-type (AGN) or star-forming regions. Their spatial distribution corresponds perfectly to well-known structures such as spiral arms and a ring with giant molecular clouds. A subclassification in the nuclear region reveals several structures and gradients in the AGN spectra. Our unsupervised classification of the MUSE data of NGC 1068 helps visualise the complex interaction of the AGN and the jet with the interstellar medium in a single map. The centre of NGC 4151 is very complex, but our classes can easily be related to ionisation cones, the jet, or H2 emission. We find a new elongated structure that is ionised by the AGN along the N-S axis perpendicular to the jet direction. It is rotated counterclockwise with respect to the axis of the H2 emission. Our work shows that the unsupervised classification of spaxels takes full advantage of the richness of the information in the data cubes by presenting the spectral and spatial information in a combined and synthetic way