Contribución al estudio litológico de los materiales empleados en monumentos de Córdoba de distintas épocas

En este trabajo se estudian los diferentes tipos de materiales de construcción en monumentos de Córdoba durante distintas épocas y culturas. Se han utilizado las técnicas habituales para la determinación mineralógica, química , petroestructural, etc. Los materiales más empleados son las biocalcarenitas del Mioceno. También se han empleado calizas cámbricas, calizas del Titónico, mármoles, granitos, esquistos, ladrillos, tierra prensada, etc. Se citan algunos monumentos realizados en las épocas: romana, árabe, s. XIII al XIX y s. XX.This work studies the different types of construction materials in monuments in Cordova during different eras and cultures. Usual techniques have been used to determine mineralogical, chemical and petrostructural elements, etc. The most used materials are biocalcarenites from the Miocene period. Other materials include Cambrian limestone, Tithonian limestone, marble, granite, slate, bricks, pressed earth, etc. Monuments are cited from Roman and Arabic eras, and from the 8th to the 19th and 20th century

Mineralogical and textural characterization of Tartessian ceramics from Ategua (Córdoba, Spain)

El cerro de Teba situado en la Depresión del Guadalquivir, provincia de Córdoba (España), constituye uno de los yacimientos arqueológicos más interesantes de la época tartésica. En la falda de la colina de Ategua, se han encontrado restos prerromanos (precoloniales, tartesicos e ibéricos) con algunas estructuras de enterramiento y una gran riqueza de piezas cerámicas. Cerámicas de época tartésica hechas a torno (fases II y III “orientalizantes”) son las que se estudian en este trabajo. Se ha estudiado la mineralogía, composición química y la textura de estas piezas para obtener información sobre el posible origen de las materias primas utilizadas en la fabricación de las cerámicas. Algunos minerales así como los restos de fósiles son propios de ciertos ambientes, y su detección en las cerámicas permite abordar el origen de las materias primas con que se elaboraron las piezas. Determinar el origen es siempre uno de los objetivos que se plantea en este tipo de estudios, ya que los datos sobre las piezas y el entorno ayudan a abordar el problema de la autóctonía o aloctonía de las cerámicasTeba hill, located in the Guadalquivir depression (Córdoba, Spain), is one of the most interesting archaeological deposits from the Tartessian period. A number of pre-Roman (pre-colonial, Tartessian and Iberian) remains including some burial structures and a wealth of ceramic pieces have been found on the skirt of the Ategua hill. In this work, have been studied wheel-thrown ceramic pieces from Phases II and III (orientalizing). The mineralogical characteristics, chemical composition and texture of the pieces were used to identify the potential origin of the raw materials used in their production. Some minerals are as well as fossil remains in fact typical of specific environments, so their presence in a ceramic piece can help trace the origin of its components. Elucidating the origin of such materials is a common objective in these studies since accurate information obtained from ceramic pieces and their environment can help one determine whether they are autochthonous or allochthonous

Biocalcarenites as construction materials in Santa Marina de Aguas Santas Church at Cordoba, Spain

Para la caracterización litológica y determinación del grado de alteración de los materiales pétreos se han empleado las siguientes técnicas: difracción de rayos X (método del polvo), microscopía petrográfica (sobre lámina delgada) y microscopía de barrido con EDS (energía dispersiva de rayos X), para determinar la composición química. El estado de degradación del material pétreo se ha cuantificado a partir del índice químico de alteración (CIW). Se han realizado cartografías sobre la fachada oeste: a) de las litologías presentes y b) de los diferentes tipos de alteración observados. La comparación de muestras del edificio con las de antiguas canteras ha permitido identificar la del Naranjo como la posible cantera de origen.This study consisted in characterizing the materials used to build Santa Marina de Aguas Santas Church at Cordoba and locating the original quarries. The techniques used in the lithological and chemical characterization included XRD, petrographic microscopy and electron dispersive scanning microscopy. The chemical index of weathering (CIW) was used to quantify the state of stone decay. The lithology and different types of alterations observed were mapped. A comparison of the material on the building to ancient quarries identified “Naranjo” as the possible site where the stone was originally quarried

Biocalcarenitas como materiales de construcción en la iglesia de Santa Marina de Aguas Santas (Córdoba, España)

This study consisted in characterizing the materials used to build Santa Marina de Aguas Santas Church at Cordoba and locating the original quarries. The techniques used in the lithological and chemical characterization included XRD, petrographic microscopy and electron dispersive scanning microscopy. The chemical index of weathering (CIW) was used to quantify the state of stone decay. The lithology and different types of alterations observed were mapped. A comparison of the material on the building to ancient quarries identified “Naranjo” as the possible site where the stone was originally quarried.Para la caracterización litológica y determinación del grado de alteración de los materiales pétreos se han empleado las siguientes técnicas: difracción de rayos X (método del polvo), microscopía petrográfica (sobre lámina delgada) y microscopía de barrido con EDS (energía dispersiva de rayos X), para determinar la composición química. El estado de degradación del material pétreo se ha cuantificado a partir del índice químico de alteración (CIW). Se han realizado cartografías sobre la fachada oeste: a) de las litologías presentes y b) de los diferentes tipos de alteración observados. La comparación de muestras del edificio con las de antiguas canteras ha permitido identificar la del Naranjo como la posible cantera de origen

The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

Indexación ScopusDendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders. Evidence from inflammatory colitis mouse models and inflammatory bowel diseases (IBD) patients indicated that gut inflammation in IBD is driven mainly by T-helper-1 (Th1) and Th17 cells, suggesting an essential role for DCs in the development of IBD. Here we show that GSK-J4, a selective inhibitor of the histone demethylase JMJD3/UTX, attenuated inflammatory colitis by reducing the inflammatory potential and increasing the tolerogenic features of DCs. Mechanistic analyses revealed that GSK-J4 increased activating epigenetic signals while reducing repressive marks in the promoter of retinaldehyde dehydrogenase isoforms 1 and 3 in DCs, enhancing the production of retinoic acid. This, in turn, has an impact on regulatory T cells (Treg) increasing their lineage stability and gut tropism as well as potentiating their suppressive activity. Our results open new avenues for the treatment of IBD patients. © 2021, The Author(s).https://www-nature-com.recursosbiblioteca.unab.cl/articles/s41598-020-79122-

Dos estructuras del Bronce Final destinadas a trabajos de producción, próximas al asentamiento prerromano de la Colina de los Quemados de Córdoba

Las estructuras documentadas evidencian una actividad, desarrollada con fuego a baja temperatura, en la zona periférica del yacimiento prerromano de Colina de los Quemados. Realizado un estudio comparativo con otras estructuras similares, se podría deducir que estaban destinadas a la producción, siendo la hipótesis más factible que se trate de dos hornos de pan del Bronce Final, desconociéndose aún si tenían un uso familiar o comunitarioThe documented structures demonstrate an activity in the peripheral zone of the preroman Colina de los Quemados site based on low temperature firing. After doing a comparative study with other similar structures, it is possible to deduce that they were destined for production, being the more feasible hypothesis that they are two bread ovens of the Late Bronze Age. The question whether they had a family or community use or not remains to be answered at presen

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57-1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628-0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.NovartisEli Lilly and CompanyAstraZenecaAbbViePfizer UKCelgeneEisaiGenentechMerck Sharp and DohmeRocheCancer Research UKGovernment of CanadaArray BioPharmaGenome CanadaNational Institutes of HealthEuropean CommissionMinistère de l'Économie, de l’Innovation et des Exportations du QuébecSeventh Framework ProgrammeCanadian Institutes of Health Researc

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57-1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628-0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs

Genome-wide association study of germline variants and breast cancer-specific mortality

BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10

Caracterización mineralógica y textural de Cerámicas Tartésicas de Ategua (Córdoba, España)

El cerro de Teba situado en la Depresión del Guadalquivir, provincia de Córdoba (España), constituye uno de los yacimientos arqueológicos más interesantes de la época tartésica. En la falda de la colina de Ategua, se han encontrado restos prerromanos (precoloniales, tartesicos e ibéricos) con algunas estructuras de enterramiento y una gran riqueza de piezas cerámicas. Cerámicas de época tartésica hechas a torno (fases II y III “orientalizantes”) son las que se estudian en este trabajo. Se ha estudiado la mineralogía, composición química y la textura de estas piezas para obtener información sobre el posible origen de las materias primas utilizadas en la fabricación de las cerámicas. Algunos minerales así como los restos de fósiles son propios de ciertos ambientes, y su detección en las cerámicas permite abordar el origen de las materias primas con que se elaboraron las piezas. Determinar el origen es siempre uno de los objetivos que se plantea en este tipo de estudios, ya que los datos sobre las piezas y el entorno ayudan a abordar el problema de la autóctonía o aloctonía de las cerámicas.Peer reviewe