Evolution of the UV LF from z~15 to z~8 Using New JWST NIRCam Medium-Band Observations over the HUDF/XDF

Here we present the first constraints on the prevalence of z>10 galaxies in the Hubble Ultra Deep Field (HUDF) leveraging new NIRCam medium-band observations taken with JWST. These NIRCam observations probe redward of 1.6microns, beyond the wavelength limit of HST, allowing us to search for galaxies to z>10. These observations indicate that the highest redshift candidate identified over the HUDF with HST, UDFj-39546284, has a redshift of z=12.0+/-0.1, as had been suggested in multiple analyses of the HUDF12/XDF data. This source thus appears to be the most distant galaxy discovered by HST in its more than 30 years of operation. Additionally, we identify nine other z~8-13 candidate galaxies over the HUDF, two of which are entirely new discoveries and appear to lie at z~11 and z~12. We use these results to characterize the evolution of the UV luminosity function (LF) from z~15 to z~8.7. While our LF results at z~8.7 and z~10.5 are consistent with previous findings over the HUDF, our new LF estimates at z~12.6 are substantially higher than other results in the literature, potentially pointing to a milder evolution in the UV luminosity density from z~12.6. We emphasize that our LF results are uncertain given the small number of sources in our z~12.6 selection and limited volume probed. The new NIRCam data also indicate that the faint z~8-13 galaxies in the HUDF/XDF show very blue UV-continuum slopes beta~-2.7, high specific star formation rates ~24.5 Gyr$^{-1}$, and high EW (~1300A) [OIII]+Hbeta emission, with two z~8.5 sources showing [OIII]+Hbeta EWs of ~2300 Angstroms.Comment: 19 pages, 14 figures, 7 tables, submitted to MNRAS, with some minor typos correcte

A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE

In this small note we are concerned with the solution of Forward-Backward Stochastic Differential Equations (FBSDE) with drivers that grow quadratically in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem is a comparison result that allows comparing componentwise the signs of the control processes of two different qgFBSDE. As a byproduct one obtains conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resu

Metal and dust evolution in ALMA REBELS galaxies: insights for future JWST observations

Atacama Large Millimeter/submillimeter Array (ALMA) observations revealed the presence of significant amounts of dust in the first Gyr of Cosmic time. However, the metal and dust build-up picture remains very uncertain due to the lack of constraints on metallicity. JWST has started to reveal the metal content of high-redshift targets, which may lead to firmer constraints on high-redshift dusty galaxies evolution. In this work, we use detailed chemical and dust evolution models to explore the evolution of galaxies within the ALMA Reionization Era Bright Emission Line Survey (REBELS) survey, testing different metallicity scenarios that could be inferred from JWST observations. In the models, we track the build-up of stellar mass using non-parametric star formation histories for REBELS galaxies. Different scenarios for metal and dust evolution are simulated by allowing different prescriptions for gas flows and dust processes. The model outputs are compared with measured dust scaling relations, by employing metallicity-dependent calibrations for the gas mass based on the [C II] 158 μm line. Independently of the galaxies metal content, we found no need for extreme dust prescriptions to explain the dust masses revealed by ALMA. However, different levels of metal enrichment will lead to different dominant dust production mechanisms, with stardust production dominant over other interstellar medium dust processes only in the metal-poor case. This points out how metallicity measurements from JWST will significantly improve our understanding of the dust build-up in high-redshift galaxies. We also show that models struggle to reproduce observables such as dust-to-gas and dust-to-stellar ratios simultaneously, possibly indicating an overestimation of the gas mass through current calibrations, especially at high metallicities.MP, IDL, and SvdG acknowledge funding support from ERC starting grant 851622 DustOrigin. MP also thank Laura Sommovigo for providing data adopted in this paper. MR acknowledges financial support by the research projects AYA2017-84897-P and PID2020-113689GB-I00, financed by MCIN/AEI/10.13039/501100011033. PD acknowledges support from the NWO grant 016.VIDI.189.162 (ODIN) and from the European Commission’s and University of Groningen’s CO-FUND Rosalind Franklin programme. HSBA and HI acknowledge support from the NAOJ ALMA Scientific Research Grant Code 2021–19A. MA acknowledges support from FONDECYT grant 1211951 and ANID BASAL project FB210003. RB acknowledges support from an STFC Ernest Rutherford Fellowship (grant number ST/T003596/1). JH acknowledges support from the ERC Consolidator Grant 101088676 (VOYAJ) and the VIDI research programme with project number 639.042.611, which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO).Peer reviewe

Cold dust and low [O iii]/[C ii] ratios: an evolved star-forming population at redshift 7

We present new ALMA Band 8 (rest-frame 90 μm) continuum observations of three massive (M ≈ 1010 M) galaxies at z ≈ 7 previously detected in [C II]158 μm and underlying dust continuum emission in the Reionization Era Bright Emission Line Survey (REBELS). We detect dust emission from two of our targetsin Band 8 (REBELS-25 and REBELS-38), while REBELS-12 remains undetected. Through optically thin modified blackbody fitting, we determine dust temperatures of Tdust ≈ 30 − 35 K in both of the dual-band detected targets, indicating they are colder than most known galaxies at z ∼ 7. Moreover, their inferred dust masses are large (Mdust ≈ 108 M), albeit still consistent with models of high-redshift dust production. We furthermore target and detect [O III]88 μm emission in both REBELS-12 and REBELS-25, and find L[O III]/L[C II] ≈ 1 − 1.5 – low compared to the L[O III]/L[C II] 2 − 10 observed in the known z 6 population thusfar. We argue the lower line ratios are due to a comparatively weaker ionizing radiation field resulting from the less starbursty nature of our targets, although the possibility of REBELS-12 being a merger of an [O III]-bright and [O III]-faint component prevents the unambiguous interpretation of its [O III]/[C II] ratio. Nevertheless, a low burstiness forms a natural explanation for the cold dust temperatures and low [O III]λλ4959, 5007 + H β equivalent widths of REBELS-25 and REBELS-38. Overall, these observations provide evidence for the existence of a massive, dust-rich galaxy population at z ≈ 7 which has previously experienced vigorous star formation, but is currently forming stars in a steady, as opposed to bursty, manner.This work was supported by NAOJ ALMA Scientific Research Grant Code 2021–19A (HSBA and HI). PD acknowledges support from the NWO grant 016.VIDI.189.162 (‘ODIN’) and from the European Commission’s and University of Groningen’s CO-FUND Rosalind Franklin program. MA acknowledges support from FONDECYT grant 1211951 and ANID BASAL project FB210003. IDL and MP acknowledge support from ERC starting grant 851622 DustOrigin. RS acknowledges support from a STFC Ernest Rutherford Fellowship (ST/S004831/1). MS acknowledges support from the CIDEGENT/2021/059 grant, from project PID2019-109592GB-I00/AEI/10.13039/501100011033 from the Spanish Ministerio de Ciencia e Innovación–Agencia Estatal de Investigación, and from Proyecto ASFAE/2022/025 del Ministerio de Ciencia y Innovación en el marco del Plan de Recuperación, Transformación y Resiliencia del Gobierno de España.Peer reviewe

Mapping dusty galaxy growth at z > 5 with FRESCO: detection of Hα in submm galaxy HDF850.1 and the surrounding overdense structures

et al.We report the detection of a 13 σ H α emission line from HDF850.1 at z = 5 . 188 ± 0 . 001 using the FRESCO (First Reionization Era Spectroscopically Complete Observations) NIRCam F 444 W grism observations. Detection of H α in HDF850.1 is noteworthy, given its high far-infrared (IR) luminosity, substantial dust obscuration, and the historical challenges in deriving its redshift. HDF850.1 shows a clear detection in the F 444 W imaging data, distributed between a northern and southern component, mirroring that seen in [C II ] from the Plateau de Bure Interferometer. Modelling the spectral energy distribution of each component separately, we find that the northern component has a higher mass, star formation rate (SFR), and dust extinction than the southern component. The observed H α emission appears to arise entirely from the less-obscured southern component and shows a similar v ∼+ 130 km s −1 velocity offset to that seen for [C II ] relative to the source systemic redshift. Leveraging H α-derived redshifts from FRESCO observations, we find that HDF850.1 is forming in one of the richest environments identified to date at z > 5, with 100 z = 5 . 17–5.20 galaxies distributed across 13 smaller structures and a ∼(15 cMpc) 3 volume. Based on the evolution of analogous structures in cosmological simulations, the z = 5 . 17–5.20 structures seem likely to collapse into a single > 10 14 M cluster by z ∼ 0. Comparing galaxy properties forming within this o v erdensity with those outside, we find the masses, SFRs, and U V luminosities inside the o v erdensity to be clearly higher. The prominence of H α line emission from HDF850.1 and other known highly obscured z > 5 galaxies illustrates the potential of NIRCam-grism programs to map both the early build-up of IR-luminous galaxies and o v erdense structures.This project was made possible in part by the Leiden University Fund/Bouwens Astrophysics Fund. RJB acknowledges support from NWO grants 600.065.140.11N211 (vrij competitie) and TOP grant TOP1.16.057. The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant no. 140. Cloud-based data processing and file storage for this work is provided by the AWS Cloud Credits for Research program. Support for this work was provided by NASA through grant JWST-GO-01895 awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5–26555. RPN acknowledges funding from JWST programs GO-1933 and GO-2279. Support for this work was provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. MS acknowledges support from the CIDEGENT/2021/059 grant, from project PID2019-109592GB-I00/AEI/10.13039/501100011033 from the Spanish Ministerio de Ciencia e Innovación – Agencia Estatal de Investigación. This study forms part of the Astrophysics and High Energy Physics programme and was supported by MCIN with funding from European Union NextGenerationEU (PRTR-C17.I1) and by Generalitat Valenciana under the project n. ASFAE/2022/025. RAM acknowledges support from the ERC Advanced Grant 740246 (Cosmic_Gas) and the Swiss National Science Foundation through project grant 200020_207349.Peer reviewe

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels

Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics

<p>Abstract</p> <p>Background</p> <p>One of the challenges in the interpretation of studies showing associations between environmental and genotypic data with disease outcomes such as neovascular age-related macular degeneration (AMD) is understanding the phenotypic heterogeneity within a patient population with regard to any risk factor associated with the condition. This is critical when considering the potential therapeutic response of patients to any drug developed to treat the condition. In the present study, we identify patient subtypes or clusters which could represent several different targets for treatment development, based on genetic pathways in AMD and cardiovascular pathology.</p> <p>Methods</p> <p>We identified a sample of patients with neovascular AMD, that in previous studies had been shown to be at elevated risk for the disease through environmental factors such as cigarette smoking and genetic variants including the complement factor H gene (<it>CFH</it>) on chromosome 1q25 and variants in the <it>ARMS2</it>/HtrA serine peptidase 1 (<it>HTRA1</it>) gene(s) on chromosome 10q26. We conducted a multivariate segmentation analysis of 253 of these patients utilizing available epidemiologic and genetic data.</p> <p>Results</p> <p>In a multivariate model, cigarette smoking failed to differentiate subtypes of patients. However, four meaningfully distinct clusters of patients were identified that were most strongly differentiated by their cardiovascular health status (histories of hypercholesterolemia and hypertension), and the alleles of <it>ARMS2</it>/<it>HTRA1 </it>rs1049331.</p> <p>Conclusions</p> <p>These results have significant personalized medicine implications for drug developers attempting to determine the effective size of the treatable neovascular AMD population. Patient subtypes or clusters may represent different targets for therapeutic development based on genetic pathways in AMD and cardiovascular pathology, and treatments developed that may elevate CV risk, may be ill advised for certain of the clusters identified.</p

Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C

Background: Individuals with exceptional longevity and their offspring have significantly larger high-density lipoprotein concentrations (HDL-C) particle sizes due to the increased homozygosity for the I405V variant in the cholesteryl ester transfer protein (CETP) gene. In this study, we investigate the association of CETP and HDL-C further to identify novel, independent CETP variants associated with HDL-C in humans. Methods: We performed a meta-analysis of HDL-C within the CETP region using 59,432 individuals imputed with 1000 Genomes data. We performed replication in an independent sample of 47,866 individuals and validation was done by Sanger sequencing. Results: The meta-analysis of HDL-C within the CETP region identified five independent variants, including an exonic variant and a common intronic insertion. We replicated these 5 variants significantly in an independent sample of 47,866 individuals. Sanger sequencing of the insertion within a single family confirmed segregation of this variant. The strongest reported association between HDL-C and CETP variants, was rs3764261; however, after conditioning on the five novel variants we identified the support for rs3764261 was highly reduced (βunadjusted=3.179 mg/dl (P value=5.25×10−509), βadjusted=0.859 mg/dl (P value=9.51×10−25)), and this finding suggests that these five novel variants may partly explain the association of CETP with HDL-C. Indeed, three of the five novel variants (rs34065661, rs5817082, rs7499892) are independent of rs3764261. Conclusions: The causal variants in CETP that account for the association with HDL-C remain unknown. We used studies imputed to the 1000 Genomes reference panel for fine mapping of the CETP region. We identified and validated five variants within this region that may partly account for the association of the known variant (rs3764261), as well as other sources of genetic contribution to HDL-C

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Background So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from similar to 60 000 individuals in the discovery stage and similar to 90 000 samples in the replication stage. Results Our study resulted in the identification of five new associations with circulating lipid levels at four loci. All four loci are within genes that can be linked biologically to lipid metabolism. One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene. Conclusions This study illustrates that GWAS with high-scale imputation may still help us unravel the biological mechanism behind circulating lipid levels.Peer reviewe