Design of the calorimeter and beam dump for the TFTR prototype neutral beam injector

A calorimeter has been designed for use with the TFTR prototype neutral beam injection system. It consists of three vees each having two 18.8-mm-thick (0.75 in.) copper plates at a 6-deg angle, relative to the beam centerline. The maximum power density on a plate with this arrangement will be 2.0 kW/cm/sup 2/, resulting in a front surface temperature rise of about 420/sup 0/C. A support and retraction system moves the calorimeter in and out of the beam centerline. Various factors used in the selection of the absorber plate material will be discussed and also some experimental test results will be presented

Protein kinase C: An attractive target for cancer therapy

Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance