Investigation on the Aha-Experience as an Indicator of Correct Solutions in Functional Analysis in Engineering Design

The functional analysis of technical systems is an important part of the design process. To further improve the design process, especially the functional analysis, it must not be viewed as a monodisciplinary process. To this end, cognitive factors such as the aha-experience must also be included in studies of analysis processes to a greater extent. This paper investigates the relationship between the occurrence of aha-experiences and the correctness of solutions in the analysis of a technical system. An aha-experience is a strong feeling of subjective certainty that accompanies the cognitive process of suddenly finding a previously unknown solution. For this purpose, a study on the functional analysis was evaluated. The results show that many identified subfunctions of the system under investigation were identified with an aha-experience and that these subfunctions are more often correct. The results also suggest that aha-experiences occur more often among students than among experienced design engineers. Especially among students, a positive relation of aha-experiences on the correctness of the identified subfunction can be seen. This offers potential for further investigations to make aha-experiences useful in design methods

Ida-Tallinna Keskhaiglas 2020. aastal teostatud koloskoopiate vastavus Euroopa Gastrointestinaalse Endoskoopia Ühingu kvaliteediparameetritele

Jämesoolevähk on sage haigus, mille esinemissagedus Eestis on kasvutendentsiga. Osa jämesoolevähkidest diagnoositakse intervallvähina – koloskoopial võivad vähieelsed seisundid jääda märkamata ja vähk diagnoositakse 3–5 aastat peale protseduuri. Seega on protseduuri kvaliteet kriitilise tähtsusega, et paremini hinnata vähieelseid muutusi sooles.Uuringu eesmärk oli hinnata Ida-Tallinna Keskhaiglas (ITK) 2020. aastal läbiviidud koloskoopiate kvaliteeti Euroopa Gastrointestinaalse Endoskoopia Ühingu kvaliteedistandarditest lähtudes. Kliinilisel andmebaasil eHealth põhineva läbilõikeuuringu andmeallikad olid ITKs ajavahemikul 01.01.–31.12.2020 tehtud koloskoopiate saatekirjad, protseduuride kirjeldused ning koloskoopia käigus võetud materjalide histoloogilise uuringu vastused.Kogutud andmed näitavad, et ITK gastroenteroloogia keskuses tehtud koloskoopiad vastavad kolmes olulises punktis – umbsoolde jõudmise määr, koloskoobi väljatoomise aeg ja adenoomide avastamise määr (ADR) – rahvusvahelistele standarditele. Protseduurieelse jämesoole ettevalmistuses kvaliteedieesmärki ei saavutatud

Farmer seed networks make a limited contribution to agriculture? Four common misconceptions

The importance of seed provisioning in food security and nutrition, agricultural development and rural livelihoods, and agrobiodiversity and germplasm conservation is well accepted by policy makers, practitioners and researchers. The role of farmer seed networks is less well understood and yet is central to debates on current issues ranging from seed sovereignty and rights for farmers to GMOs and the conservation of crop germplasm. In this paper we identify four common misconceptions regarding the nature and importance of farmer seed networks today. (1) Farmer seed networks are inefficient for seed dissemination. (2) Farmer seed networks are closed, conservative systems. (3) Farmer seed networks provide ready, egalitarian access to seed. (4) Farmer seed networks are destined to weaken and disappear. We challenge these misconceptions by drawing upon recent research findings and the authors’ collective field experience in studying farmer seed systems in Africa, Europe, Latin America and Oceania. Priorities for future research are suggested that would advance our understanding of seed networks and better inform agricultural and food policy

Early virological response may predict treatment response in sofosbuvir-based combination therapy of chronic hepatitis c in a multi-center “real-life” cohort

Background: The combination of sofosbuvir (SOF), ribavirin (RBV) and peg-interferon-alfa-2a (peg-IFN-alfa-2a) as well as the combination of SOF and RBV for the treatment of patients infected with hepatitis c virus (HCV) has improved rates of sustained virological response (SVR) considerably in recent trials. However, there is only limited data concerning the efficacy and safety in a “real-life” cohort. Methods: We analyzed a cohort of 119 patients with chronic HCV infection treated at four investigational sites in Germany. All patients received either a combination treatment of SOF, RBV and peg-IFN-alfa-2a or SOF and RBV. Results: The rates of SVR at 12 weeks after end of treatment (SVR 12) were as follows: Among 76 patients with genotype 1 infection the SVR 12 rate was 74 % (n = 56), among 14 patients with genotype 2 infection the SVR 12 rate was 79 % (n = 11), among 24 patients with genotype 3 infection the SVR 12 rate was 92 % (n = 22) and among 5 patients with genotype 4 infection the SVR 12 rate was 80 % (n = 4). Of all 26 patients with a relapse in our cohort, 69 % (n = 18) of these patients presented with liver cirrhosis and 58 % (n = 15) were treatment experienced. Notably, the level of HCV-RNA after 4 weeks of treatment was a significant predictor of treatment response in genotype 1 patients. Patients with HCV-RNA levels ≥ 12 IU ml-1 after 4 weeks of treatment achieved SVR 12 only in 30 % (n = 17/56, p < 0.0001) of cases and treatment response was even lower with SVR 12 of 25 % (n = 5/20, p = 0.0016) in the subgroup of patients with cirrhosis. Conclusion: We observed a high rate of SVR 12 with SOF-based treatment regimes, however probably due to the high number of patients with liver cirrhosis and prior treatment experience, treatment response rates were lower than in previously published trials. In genotype 1 patients the analysis of early virological response may predict treatment response in SOF-based combination therapies

Progress in the Design of the Atacama Large Aperture Submillimeter Telescope

The Atacama Large Aperture Submillimeter Telescope (AtLAST) aims to be the premier next generation large diameter (50 meter) single dish observatory capable of observations across the millimeter/submillimeter spectrum, from 30~GHz to 1~THz. AtLAST will be sited in Chile at approximately 5100 meters above sea level, high in the Atacama Desert near Llano de Chajnantor. The novel rocking-chair telescope design allows for a unprecedentedly wide field of view (FoV) of 1-2$^\circ$ diameter, a large receiver cabin housing six major instruments, and high structural stability during fast scanning operations (up to $\sim 3^\circ$ per second in azimuth). Here we describe the current status of, and expected outcomes for, the antenna design study, which will be completed in 2024.Comment: Accepted for the URSI GASS 2023, Sapporo, Japan, 19-26 August 2023. 4 pages, 3 figure

Artificial grammar learning in Williams syndrome and in typical development: the role of rules, familiarity and prosodic cues

Artificial grammar learning (AGL) is an empirical paradigm which investigates basic pattern- and structural processing in different populations. It can inform how higher cognitive functions, such as language use, take place. Our study used AGL to assess how children with Williams syndrome (WS) (n=16) extract patterns in structured sequences of synthetic speech, how they compare to typically developing (TD) children (n=60), and how prosodic cues affect learning. The TD group was divided into: a group whose non-verbal abilities (NVMA) were within the range of the WS group, and a group whose chronological age (CA) was within the range of the WS group. TD children relied mainly on rule-based generalization when making judgements about sequence acceptability, whereas children with WS relied on familiarity with specific stimulus combinations. The TD participants whose NVMA were similar to the WS group, showed less evidence of relying on grammaticality than TD participants whose CA was similar to the WS group. In absence of prosodic cues, the children with WS did not demonstrate evidence of learning. Results suggest that, in WS children, the transition to rule-based processing in language does not keep pace with TD children and may be an indication of differences in neuro-cognitive mechanisms

A Climatic Stability Approach to Prioritizing Global Conservation Investments

Climate change is impacting species and ecosystems globally. Many existing templates to identify the most important areas to conserve terrestrial biodiversity at the global scale neglect the future impacts of climate change. Unstable climatic conditions are predicted to undermine conservation investments in the future. This paper presents an approach to developing a resource allocation algorithm for conservation investment that incorporates the ecological stability of ecoregions under climate change. We discover that allocating funds in this way changes the optimal schedule of global investments both spatially and temporally. This allocation reduces the biodiversity loss of terrestrial endemic species from protected areas due to climate change by 22% for the period of 2002–2052, when compared to allocations that do not consider climate change. To maximize the resilience of global biodiversity to climate change we recommend that funding be increased in ecoregions located in the tropics and/or mid-elevation habitats, where climatic conditions are predicted to remain relatively stable. Accounting for the ecological stability of ecoregions provides a realistic approach to incorporating climate change into global conservation planning, with potential to save more species from extinction in the long term

The IPBES Conceptual Framework - connecting nature and people

The first public product of the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) is its Conceptual Framework. This conceptual and analytical tool, presented here in detail, will underpin all IPBES functions and provide structure and comparability to the syntheses that IPBES will produce at different spatial scales, on different themes, and in different regions. Salient innovative aspects of the IPBES Conceptual Framework are its transparent and participatory construction process and its explicit consideration of diverse scientific disciplines, stakeholders, and knowledge systems, including indigenous and local knowledge. Because the focus on co-construction of integrative knowledge is shared by an increasing number of initiatives worldwide, this framework should be useful beyond IPBES, for the wider research and knowledge-policy communities working on the links between nature and people, such as natural, social and engineering scientists, policy-makers at different levels, and decision-makers in different sectors of society