Development of FEB Configuration Test Board for ATLAS NSW Upgrade

The FEB(front end board) configuration test board is developed aiming at meeting the requirement of testing the new generation ASIC(application-specific integrated circuit) chips and its configuration system for ATLAS NSW(New Small Wheel) upgrade, In this paper, some functions are developed in terms of the configurations of the key chips on the FEB, VMM3 and TDS2 using GBT-SCA. Additionally, a flexible communication protocol is designed, verifying the whole data link. It provides technical reference for prototype FEB key chip configuration and data readout, as well as the final system configuration

miR-122-5p Inhibits the Proliferation, Invasion and Growth of Bile Duct Carcinoma Cells by Targeting ALDOA

Background/Aims: Bile duct cancer, although not among the most common tumors, still accounts for more and more worldwide deaths each year. By attempting to verify an overexpression of ALDOA in cholangiocarcinoma tissues and cells and explore the underlying molecular mechanism regulated by miR-122-5p, this study was designed to provide a potential molecular target in bile duct cancer treatment. Methods: Western blot and immunohistochemistry were performed to detect the ALDOA protein level in duct carcinoma tissues. The transfection efficiency was confirmed by western blot and/or RT-qPCR assay. The proliferation of bile duct carcinoma cells was determined by MTT and colony formation assay. The invasion ability of bile duct carcinoma cells was evaluated with Transwell invasion assay. Flow cytometry detected cell apoptosis of bile duct carcinoma cells. The miRNAs which modulate ALDOA were filtrated from bioinformatics software and clinical specimens. The target relationship was confirmed by dual luciferase reporter assay. Furthermore, a xenograft model was completed to verify the impact of miRNA on inhibition growth of bile duct carcinoma cells. Results: ALDOA was found up-regulated in bile duct carcinoma tissues and cells. Knockdown of ALDOA promoted the apoptosis of cells and inhibited the proliferation and invasion of bile duct carcinoma cells. Bioinformatics and clinical specimens indicated the negative correlation and targeted regulation between miR-122-5p and ALDOA. By down-regulating ALDOA, overexpression of miR-122-5p appeared to promote cell apoptosis and significantly inhibit cell proliferation, invasion in vitro and suppress the tumor growth in vivo. Conclusion: miR-122-5p inhibited proliferation and invasion of bile duct carcinoma cells and promoted cell apoptosis by targeting ALDOA expression

Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed

Deoxynivalenol (DON) is a mycotoxin primarily produced by Fusarium fungi, occurring predominantly in cereal grains. Following the request of the European Commission, the CONTAM Panel assessed the risk to animal and human health related to DON, 3-acetyl-DON (3-Ac-DON), 15-acetyl-DON (15-Ac-DON) and DON-3-glucoside in food and feed. A total of 27,537, 13,892, 7,270 and 2,266 analytical data for DON, 3-Ac-DON, 15-Ac-DON and DON-3-glucoside, respectively, in food, feed and unprocessed grains collected from 2007 to 2014 were used. For human exposure, grains and grain-based products were main sources, whereas in farm and companion animals, cereal grains, cereal by-products and forage maize contributed most. DON is rapidly absorbed, distributed, and excreted. Since 3-Ac-DON and 15-Ac-DON are largely deacetylated and DON-3-glucoside cleaved in the intestines the same toxic effects as DON can be expected. The TDI of 1 μg/kg bw per day, that was established for DON based on reduced body weight gain in mice, was therefore used as a group-TDI for the sum of DON, 3-Ac-DON, 15-Ac-DON and DON-3-glucoside. In order to assess acute human health risk, epidemiological data from mycotoxicoses were assessed and a group-ARfD of 8 μg/kg bw per eating occasion was calculated. Estimates of acute dietary exposures were below this dose and did not raise a health concern in humans. The estimated mean chronic dietary exposure was above the group-TDI in infants, toddlers and other children, and at high exposure also in adolescents and adults, indicating a potential health concern. Based on estimated mean dietary concentrations in ruminants, poultry, rabbits, dogs and cats, most farmed fish species and horses, adverse effects are not expected. At the high dietary concentrations, there is a potential risk for chronic adverse effects in pigs and fish and for acute adverse effects in cats and farmed mink

Characteristics of carbonate cements in sandstone reservoirs: A case from Yanchang Formation, middle and southern Ordos Basin, China

Authigenic carbonate cement is dominant in the Yanchang Formation sandstones of the middle and southern Ordos Basin. The main types of the carbonate cement are calcite, dolomite, ferrodolomite and ferrocalcite and the carbonate cement abundance decreases with depth increasing. Polarizing microscope and SEM reveal that carbonate cement occurs as pore-filling cement, replacement of feldspar, and thin rim surrounding the grains. The isotopic values of carbon and oxygen in the authigenic carbonates indicate that the precipitation of the carbonate cements was long, multi-phased, and varying in temperature. The origin of the substance for carbonate cements include the solution of the detrital carbonate, the illitization of smectite, the expelled fluid flow from the overlying shale, and the decomposition of the unstable dark-color minerals in reservoirs. The occluding of pores, the division of thick reservoir, the formation of calcium layers and the absence of solution of the carbonate cements significantly decrease the reservoir qualities all together. 摘要: ： 自生碳酸盐矿物是鄂尔多斯盆地中南部延长组砂岩储集层中最重要的胶结物，其主要类型有方解石、铁方解石、白云石和铁白云石，在不同层位上分布类型有较大差别，总体含量随地层深度增加而递减。偏光显微镜及SEM研究表明，该区碳酸盐胶结物主要呈充填粒间孔隙、交代矿物以及泥微晶环边赋存。碳、氧同位素分析揭示各种类型自生碳酸盐胶结物具有多期次、长时间的沉淀过程，其沉淀温度范围也存在较大差异。该区碳酸盐胶结物的物质来源主要有海洋碳酸盐岩岩屑的后期溶解、蒙脱石的伊利石化、相邻泥岩的压释流体以及长石和暗色亚稳定矿物的溶解等。由于碳酸盐胶结物较大规模地堵塞了孔隙，在个别部位形成了分割储集层的致密钙质层，且缺乏后期溶解作用，使其成为延长组储集层致密超低渗的一个重要因素。图7表2参36 Key words: Ordos Basin, Yanchang Formation, sandstone reservoir, carbonate cement, carbon isotope, oxygen isotop

Experiment and simulation calculation of micro-cavity dielectric barrier discharge

In order to study the discharge mechanism and discharge parameters evolution of micro-cavity dielectric barrier discharge (MDBD), an experimental platform based on the dielectric panel surface grid micro-structure electrode device was built. Discharge equivalent circuit of the MDBD was established based on the deep analysis of the discharge physical process and experimental results. Then, using Matlab/Simulink and BOLSIG+ software, we solved the Kirchhoff’s voltage equation, Boltzmann equation and the electronic continuity equation to obtain the variation of the discharge characteristic parameters, including air gap voltage, the dielectric surface voltage, the electron density and the electron temperature. The results show that the gas gap voltage and dielectric surface voltage are decreased slightly during discharge, the electron temperature and electron density are consistent with the variation of discharge current. The maximum electron temperature is about 3.0 eV, the average value is about 1.6 eV, and its value is lower than the conventional dielectric barrier discharge (DBD). Keywords: Micro-cavity, Dielectric barrier discharge, Gas gap voltage, Electron density, Electron temperatur